SNTA1_HUMAN
Evidence for PS localization
Functions
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 257 | Ala | Gly | LongQTsyndrome12(LQT12) | - |
| 390 | Ala | Val | LongQTsyndrome12(LQT12) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNTA1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 41.8605 | 4 | no |
| GO:0046872 | metal ion binding | 39.5349 | 5 | no |
| GO:0030165 | PDZ domain binding | 23.2558 | 4 | yes |
| GO:0043168 | anion binding | 23.2558 | 4 | no |
| GO:0003779 | actin binding | 16.2791 | 4 | yes |
| GO:0017080 | sodium channel regulator activity | 9.3023 | 5 | yes |
| GO:0050998 | nitric-oxide synthase binding | 9.3023 | 4 | yes |
| GO:0099106 | ion channel regulator activity | 9.3023 | 4 | yes |
| GO:0051117 | ATPase binding | 4.6512 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNTA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.8372 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.5349 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 39.5349 | 4 | no |
| GO:0051049 | regulation of transport | 37.2093 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 37.2093 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.8837 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.5581 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.2326 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 30.2326 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.9070 | 4 | yes |
| GO:0044057 | regulation of system process | 27.9070 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.9070 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.5814 | 6 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 25.5814 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.5814 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.5814 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2558 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 23.2558 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.2558 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 23.2558 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 23.2558 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.2558 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.2558 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.2558 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.2558 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.2558 | 4 | no |
| GO:0006936 | muscle contraction | 20.9302 | 4 | yes |
| GO:0008016 | regulation of heart contraction | 20.9302 | 6 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 20.9302 | 6 | yes |
| GO:0010468 | regulation of gene expression | 20.9302 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.9302 | 5 | no |
| GO:0006811 | monoatomic ion transport | 20.9302 | 4 | no |
| GO:0003018 | vascular process in circulatory system | 18.6047 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 16.2791 | 6 | yes |
| GO:0002028 | regulation of sodium ion transport | 13.9535 | 7 | yes |
| GO:0031400 | negative regulation of protein modification process | 13.9535 | 7 | yes |
| GO:0035150 | regulation of tube size | 13.9535 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 13.9535 | 5 | yes |
| GO:0097746 | blood vessel diameter maintenance | 13.9535 | 5 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 13.9535 | 7 | yes |
| GO:0001508 | action potential | 9.3023 | 4 | yes |
| GO:0019229 | regulation of vasoconstriction | 9.3023 | 6 | yes |
| GO:0034330 | cell junction organization | 9.3023 | 4 | yes |
| GO:0050808 | synapse organization | 9.3023 | 5 | yes |
| GO:0086001 | cardiac muscle cell action potential | 9.3023 | 5 | yes |
| GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation | 9.3023 | 8 | yes |
| GO:2000169 | regulation of peptidyl-cysteine S-nitrosylation | 9.3023 | 7 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 6.9767 | 6 | yes |
| GO:0086005 | ventricular cardiac muscle cell action potential | 6.9767 | 7 | yes |
| GO:0003116 | regulation of vasoconstriction by norepinephrine | 4.6512 | 7 | yes |
| GO:0003117 | regulation of vasoconstriction by circulating norepinephrine | 4.6512 | 8 | yes |
| GO:0007528 | neuromuscular junction development | 4.6512 | 6 | yes |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 4.6512 | 5 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 4.6512 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK12_HUMAN | [view interactions] | Low throughput | no | no |
| ADA1D_HUMAN | [view interactions] | Low throughput | no | no |
| DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DTNB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCN1A_HUMAN | [view interactions] | Low throughput | no | no |
| MAGE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MRP4_HUMAN | [view interactions] | Low throughput | no | no |
| SCN4A_HUMAN | [view interactions] | High throughput | no | no |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| EAA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAP40_HUMAN | [view interactions] | High throughput | no | no |
| FABPL_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRLHR_HUMAN | [view interactions] | High throughput | no | no |
| GTR3_HUMAN | [view interactions] | High throughput | no | yes |
| GUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| IL9_HUMAN | [view interactions] | High throughput | no | no |
| KCJ10_HUMAN | [view interactions] | High throughput | no | no |
| KCJ15_HUMAN | [view interactions] | High throughput | no | yes |
| ITB5_HUMAN | [view interactions] | High throughput | no | yes |
| KPSH1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMU_HUMAN | [view interactions] | High throughput | no | no |
| SC6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBTN1_HUMAN | [view interactions] | High throughput | no | no |
| SCTR_HUMAN | [view interactions] | High throughput | no | no |
| SSR1_HUMAN | [view interactions] | High throughput | no | no |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| VATO_HUMAN | [view interactions] | High throughput | no | no |
| AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| SPZ1_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTHD1_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPC3_HUMAN | [view interactions] | High throughput | no | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| MED8_HUMAN | [view interactions] | High throughput | no | yes |
| NPT2C_HUMAN | [view interactions] | High throughput | no | no |
| NEBU_HUMAN | [view interactions] | High throughput | no | no |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAT3_HUMAN | [view interactions] | High throughput | no | no |
| RGS11_HUMAN | [view interactions] | High throughput | no | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCYA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PD2R_HUMAN | [view interactions] | High throughput | no | no |
| FRPD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| SNTG2_HUMAN | [view interactions] | High throughput | no | no |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| SNTG1_HUMAN | [view interactions] | High throughput | no | no |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| CFA69_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2B_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| ADA2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADHX_HUMAN | [view interactions] | High throughput | no | yes |
| AGTR2_HUMAN | [view interactions] | High throughput | no | no |
| ARY1_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATS6_HUMAN | [view interactions] | High throughput | no | no |
| ADRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRB2_HUMAN | [view interactions] | High throughput | no | no |
| AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| CD3E_HUMAN | [view interactions] | High throughput | no | no |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA5_HUMAN | [view interactions] | High throughput | no | no |