SNTA1_HUMAN
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
257 | Ala | Gly | LongQTsyndrome12(LQT12) | - |
390 | Ala | Val | LongQTsyndrome12(LQT12) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SNTA1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 36.3636 | 4 | no |
GO:0030165 | PDZ domain binding | 20.4545 | 4 | yes |
GO:0003779 | actin binding | 18.1818 | 4 | yes |
GO:0017080 | sodium channel regulator activity | 9.0909 | 4 | yes |
GO:0050998 | nitric-oxide synthase binding | 9.0909 | 4 | yes |
GO:0051117 | ATPase binding | 4.5455 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SNTA1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 47.7273 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.9091 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 38.6364 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 38.6364 | 4 | no |
GO:0051049 | regulation of transport | 36.3636 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 34.0909 | 4 | yes |
GO:0044057 | regulation of system process | 29.5455 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 29.5455 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 29.5455 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | yes |
GO:0031399 | regulation of protein modification process | 27.2727 | 6 | yes |
GO:0043269 | regulation of ion transport | 27.2727 | 5 | yes |
GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
GO:0051128 | regulation of cellular component organization | 27.2727 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | yes |
GO:0006936 | muscle contraction | 22.7273 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 22.7273 | 5 | yes |
GO:0010959 | regulation of metal ion transport | 22.7273 | 6 | yes |
GO:1903522 | regulation of blood circulation | 22.7273 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 22.7273 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 22.7273 | 4 | no |
GO:0008016 | regulation of heart contraction | 20.4545 | 6 | yes |
GO:1904062 | regulation of cation transmembrane transport | 20.4545 | 6 | yes |
GO:0009966 | regulation of signal transduction | 20.4545 | 4 | no |
GO:0006811 | ion transport | 20.4545 | 4 | no |
GO:0006996 | organelle organization | 20.4545 | 4 | no |
GO:0007010 | cytoskeleton organization | 20.4545 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 20.4545 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 20.4545 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 20.4545 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 20.4545 | 5 | no |
GO:0048878 | chemical homeostasis | 20.4545 | 4 | no |
GO:0010468 | regulation of gene expression | 20.4545 | 5 | no |
GO:0003018 | vascular process in circulatory system | 18.1818 | 4 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 15.9091 | 5 | yes |
GO:0002028 | regulation of sodium ion transport | 13.6364 | 7 | yes |
GO:0031400 | negative regulation of protein modification process | 13.6364 | 7 | yes |
GO:0035150 | regulation of tube size | 13.6364 | 4 | yes |
GO:0035296 | regulation of tube diameter | 13.6364 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 13.6364 | 6 | yes |
GO:0097746 | blood vessel diameter maintenance | 13.6364 | 5 | yes |
GO:1902305 | regulation of sodium ion transmembrane transport | 13.6364 | 7 | yes |
GO:0001508 | action potential | 9.0909 | 4 | yes |
GO:0019229 | regulation of vasoconstriction | 9.0909 | 6 | yes |
GO:0034330 | cell junction organization | 9.0909 | 4 | yes |
GO:0050808 | synapse organization | 9.0909 | 5 | yes |
GO:0086001 | cardiac muscle cell action potential | 9.0909 | 5 | yes |
GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation | 9.0909 | 8 | yes |
GO:2000169 | regulation of peptidyl-cysteine S-nitrosylation | 9.0909 | 7 | yes |
GO:0086002 | cardiac muscle cell action potential involved in contraction | 6.8182 | 6 | yes |
GO:0086005 | ventricular cardiac muscle cell action potential | 6.8182 | 7 | yes |
GO:0003116 | regulation of vasoconstriction by norepinephrine | 4.5455 | 7 | yes |
GO:0003117 | regulation of vasoconstriction by circulating norepinephrine | 4.5455 | 8 | yes |
GO:0007528 | neuromuscular junction development | 4.5455 | 6 | yes |
GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 4.5455 | 5 | yes |
GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 4.5455 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SNTA1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 13.6364 | 4 | yes |
DOID:0060036 | intrinsic cardiomyopathy | 13.6364 | 5 | yes |
DOID:114 | heart disease | 13.6364 | 3 | yes |
DOID:0080000 | muscular disease | 6.8182 | 3 | no |
DOID:423 | myopathy | 6.8182 | 5 | no |
DOID:66 | muscle tissue disease | 6.8182 | 4 | no |
DOID:9884 | muscular dystrophy | 6.8182 | 6 | no |
DOID:0110653 | long QT syndrome 12 | 4.5455 | 7 | yes |
DOID:2843 | long QT syndrome | 4.5455 | 6 | yes |
DOID:0110274 | autosomal recessive limb-girdle muscular dystrophy | 4.5455 | 8 | no |
DOID:11724 | limb-girdle muscular dystrophy | 4.5455 | 7 | no |
DOID:12930 | dilated cardiomyopathy | 4.5455 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SCN1A_HUMAN | [view interactions] | Low throughput | no | no |
MAGE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AT2B4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AT2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MRP4_HUMAN | [view interactions] | Low throughput | no | no |
ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MK12_HUMAN | [view interactions] | Low throughput | no | no |
ADA1D_HUMAN | [view interactions] | Low throughput | no | no |
DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCN5A_HUMAN | [view interactions] | Low throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DTNB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GLSK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNJ4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MLC1_HUMAN | [view interactions] | High throughput | no | no |
TNS2_HUMAN | [view interactions] | High throughput | no | no |
SNTG2_HUMAN | [view interactions] | High throughput | no | no |
NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA2_HUMAN | [view interactions] | High throughput | no | no |
SNTG1_HUMAN | [view interactions] | High throughput | no | no |
TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
CFA69_HUMAN | [view interactions] | High throughput | no | no |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
5HT2B_HUMAN | [view interactions] | High throughput | no | no |
5HT2C_HUMAN | [view interactions] | High throughput | no | no |
ADA2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADHX_HUMAN | [view interactions] | High throughput | no | yes |
AGTR2_HUMAN | [view interactions] | High throughput | no | no |
ARY1_HUMAN | [view interactions] | High throughput | no | no |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATS6_HUMAN | [view interactions] | High throughput | no | no |
ADRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGRB2_HUMAN | [view interactions] | High throughput | no | no |
AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
C3AR_HUMAN | [view interactions] | High throughput | no | no |
CD3E_HUMAN | [view interactions] | High throughput | no | no |
KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNA5_HUMAN | [view interactions] | High throughput | no | no |
SCN4A_HUMAN | [view interactions] | High throughput | no | no |
COPB_HUMAN | [view interactions] | High throughput | no | yes |
F189B_HUMAN | [view interactions] | High throughput | no | no |
EAA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HAP40_HUMAN | [view interactions] | High throughput | no | no |
FABPL_HUMAN | [view interactions] | High throughput | no | no |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRLHR_HUMAN | [view interactions] | High throughput | no | no |
GTR3_HUMAN | [view interactions] | High throughput | no | yes |
GUAD_HUMAN | [view interactions] | High throughput | no | yes |
TLX3_HUMAN | [view interactions] | High throughput | no | no |
IL2RA_HUMAN | [view interactions] | High throughput | no | no |
IL9_HUMAN | [view interactions] | High throughput | no | no |
KCJ10_HUMAN | [view interactions] | High throughput | no | no |
KCJ15_HUMAN | [view interactions] | High throughput | no | yes |
ITB5_HUMAN | [view interactions] | High throughput | no | yes |
KPSH1_HUMAN | [view interactions] | High throughput | no | yes |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAS_HUMAN | [view interactions] | High throughput | no | no |
MCM7_HUMAN | [view interactions] | High throughput | no | no |
MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NMU_HUMAN | [view interactions] | High throughput | no | no |
SC6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBTN1_HUMAN | [view interactions] | High throughput | no | no |
SCTR_HUMAN | [view interactions] | High throughput | no | no |
SSR1_HUMAN | [view interactions] | High throughput | no | no |
TGFA_HUMAN | [view interactions] | High throughput | no | yes |
VATO_HUMAN | [view interactions] | High throughput | no | no |
AGRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2A_HUMAN | [view interactions] | High throughput | no | no |
HM20A_HUMAN | [view interactions] | High throughput | no | yes |
SPZ1_HUMAN | [view interactions] | High throughput | no | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TENS3_HUMAN | [view interactions] | High throughput | no | no |
PTHD1_HUMAN | [view interactions] | High throughput | no | no |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYPC3_HUMAN | [view interactions] | High throughput | no | no |
XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
MED8_HUMAN | [view interactions] | High throughput | no | yes |
RGS11_HUMAN | [view interactions] | High throughput | no | yes |
STAM1_HUMAN | [view interactions] | High throughput | no | yes |
GNAT3_HUMAN | [view interactions] | High throughput | no | no |
PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEBU_HUMAN | [view interactions] | High throughput | no | no |
NPT2C_HUMAN | [view interactions] | High throughput | no | no |
SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTNL1_HUMAN | [view interactions] | High throughput | no | no |
MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PD2R_HUMAN | [view interactions] | High throughput | no | no |
FRPD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
CLTR2_HUMAN | [view interactions] | High throughput | no | no |
GCYA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCJ12_HUMAN | [view interactions] | High throughput | no | no |
SGCE_HUMAN | [view interactions] | Computational | no | no |
AQP4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SGCA_HUMAN | [view interactions] | Computational | no | yes |
CAV3_HUMAN | [view interactions] | Computational | no | no |
SSPN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SGCB_HUMAN | [view interactions] | Computational | no | no |
DAG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SGCD_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TRPC1_HUMAN | [view interactions] | Computational | no | yes |
SGCG_HUMAN | [view interactions] | Computational | no | no |