Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MOT2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MOT2_HUMAN
GO:0000166 nucleotide binding 38.0952 4 no
GO:0017076 purine nucleotide binding 38.0952 5 no
GO:0032555 purine ribonucleotide binding 38.0952 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.0952 4 no
GO:0043168 anion binding 38.0952 4 no
GO:0003924 GTPase activity 33.3333 7 no
GO:0005525 GTP binding 33.3333 5 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0019001 guanyl nucleotide binding 33.3333 6 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0019900 kinase binding 23.8095 4 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0046943 carboxylic acid transmembrane transporter activity 14.2857 4 yes
GO:0005477 pyruvate secondary active transmembrane transporter activity 9.5238 6 yes
GO:0008028 monocarboxylic acid transmembrane transporter activity 9.5238 5 yes
GO:0015129 lactate transmembrane transporter activity 9.5238 4 yes
GO:0015291 secondary active transmembrane transporter activity 9.5238 4 yes
GO:0015293 symporter activity 9.5238 5 yes
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 9.5238 5 yes
GO:0050833 pyruvate transmembrane transporter activity 9.5238 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MOT2_HUMAN
GO:0048522 positive regulation of cellular process 47.6190 4 no
GO:0071702 organic substance transport 42.8571 4 yes
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007015 actin filament organization 33.3333 5 no
GO:0007264 small GTPase-mediated signal transduction 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0031323 regulation of cellular metabolic process 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0061024 membrane organization 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0007010 cytoskeleton organization 23.8095 5 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0009893 positive regulation of metabolic process 23.8095 4 no
GO:0010468 regulation of gene expression 23.8095 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.8095 5 no
GO:0010604 positive regulation of macromolecule metabolic process 23.8095 5 no
GO:0010646 regulation of cell communication 23.8095 4 no
GO:0010810 regulation of cell-substrate adhesion 23.8095 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0022607 cellular component assembly 23.8095 4 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0030335 positive regulation of cell migration 23.8095 6 no
GO:0031175 neuron projection development 23.8095 6 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0032956 regulation of actin cytoskeleton organization 23.8095 5 no
GO:0032970 regulation of actin filament-based process 23.8095 4 no
GO:0040017 positive regulation of locomotion 23.8095 4 no
GO:0048584 positive regulation of response to stimulus 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051493 regulation of cytoskeleton organization 23.8095 6 no
GO:0060491 regulation of cell projection assembly 23.8095 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 23.8095 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:2000147 positive regulation of cell motility 23.8095 5 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0003018 vascular process in circulatory system 19.0476 4 yes
GO:0015850 organic hydroxy compound transport 19.0476 5 yes
GO:0015711 organic anion transport 14.2857 5 yes
GO:0015849 organic acid transport 14.2857 5 yes
GO:0046942 carboxylic acid transport 14.2857 6 yes
GO:1905039 carboxylic acid transmembrane transport 14.2857 4 yes
GO:0006848 pyruvate transport 9.5238 8 yes
GO:0010232 vascular transport 9.5238 4 yes
GO:0015718 monocarboxylic acid transport 9.5238 7 yes
GO:0015727 lactate transport 9.5238 6 yes
GO:0035873 lactate transmembrane transport 9.5238 5 yes
GO:0035879 plasma membrane lactate transport 9.5238 6 yes
GO:0150104 transport across blood-brain barrier 9.5238 5 yes
GO:1901475 pyruvate transmembrane transport 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
TIM23_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
COMT_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
GPR25_HUMAN [view interactions] High throughput no no
FXYD6_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
SMAGP_HUMAN [view interactions] High throughput no yes
ACSL5_HUMAN [view interactions] High throughput no yes
HMOX1_HUMAN [view interactions] High throughput no no
LEMD1_HUMAN [view interactions] High throughput no no
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes