COMT_HUMAN
Evidence for PS localization
Functions
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COMT_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 28.2609 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.2609 | 5 | no |
| GO:0043168 | anion binding | 28.2609 | 4 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | yes |
| GO:0046872 | metal ion binding | 21.7391 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0000287 | magnesium ion binding | 4.3478 | 6 | yes |
| GO:0008168 | methyltransferase activity | 4.3478 | 4 | yes |
| GO:0008171 | O-methyltransferase activity | 4.3478 | 5 | yes |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 4.3478 | 5 | yes |
| GO:0016206 | catechol O-methyltransferase activity | 4.3478 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COMT_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 41.3043 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 36.9565 | 4 | yes |
| GO:0006996 | organelle organization | 34.7826 | 4 | no |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 32.6087 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 28.2609 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 28.2609 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.0870 | 4 | no |
| GO:0015031 | protein transport | 26.0870 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.0870 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 23.9130 | 4 | no |
| GO:0010646 | regulation of cell communication | 23.9130 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 21.7391 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 21.7391 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.7391 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 21.7391 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 15.2174 | 4 | yes |
| GO:0046903 | secretion | 15.2174 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 13.0435 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 13.0435 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 10.8696 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 10.8696 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 10.8696 | 4 | yes |
| GO:0015850 | organic hydroxy compound transport | 8.6957 | 5 | yes |
| GO:0050890 | cognition | 8.6957 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 8.6957 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 8.6957 | 4 | yes |
| GO:0007612 | learning | 6.5217 | 4 | yes |
| GO:0010467 | gene expression | 6.5217 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 6.5217 | 4 | yes |
| GO:0043279 | response to alkaloid | 6.5217 | 5 | yes |
| GO:0001963 | synaptic transmission, dopaminergic | 4.3478 | 8 | yes |
| GO:0006576 | biogenic amine metabolic process | 4.3478 | 5 | yes |
| GO:0006584 | catecholamine metabolic process | 4.3478 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 4.3478 | 7 | yes |
| GO:0009267 | cellular response to starvation | 4.3478 | 4 | yes |
| GO:0009308 | amine metabolic process | 4.3478 | 4 | yes |
| GO:0009310 | amine catabolic process | 4.3478 | 5 | yes |
| GO:0009712 | catechol-containing compound metabolic process | 4.3478 | 5 | yes |
| GO:0014046 | dopamine secretion | 4.3478 | 5 | yes |
| GO:0015695 | organic cation transport | 4.3478 | 5 | yes |
| GO:0015844 | monoamine transport | 4.3478 | 5 | yes |
| GO:0015872 | dopamine transport | 4.3478 | 7 | yes |
| GO:0015874 | norepinephrine transport | 4.3478 | 6 | yes |
| GO:0016036 | cellular response to phosphate starvation | 4.3478 | 5 | yes |
| GO:0016048 | detection of temperature stimulus | 4.3478 | 4 | yes |
| GO:0018958 | phenol-containing compound metabolic process | 4.3478 | 4 | yes |
| GO:0019336 | phenol-containing compound catabolic process | 4.3478 | 5 | yes |
| GO:0019614 | catechol-containing compound catabolic process | 4.3478 | 6 | yes |
| GO:0023061 | signal release | 4.3478 | 4 | yes |
| GO:0035812 | renal sodium excretion | 4.3478 | 5 | yes |
| GO:0036293 | response to decreased oxygen levels | 4.3478 | 4 | yes |
| GO:0042220 | response to cocaine | 4.3478 | 4 | yes |
| GO:0042402 | cellular biogenic amine catabolic process | 4.3478 | 6 | yes |
| GO:0042415 | norepinephrine metabolic process | 4.3478 | 7 | yes |
| GO:0042417 | dopamine metabolic process | 4.3478 | 7 | yes |
| GO:0042420 | dopamine catabolic process | 4.3478 | 8 | yes |
| GO:0042424 | catecholamine catabolic process | 4.3478 | 7 | yes |
| GO:0046958 | nonassociative learning | 4.3478 | 5 | yes |
| GO:0046959 | habituation | 4.3478 | 6 | yes |
| GO:0048243 | norepinephrine secretion | 4.3478 | 5 | yes |
| GO:0050432 | catecholamine secretion | 4.3478 | 4 | yes |
| GO:0050961 | detection of temperature stimulus involved in sensory perception | 4.3478 | 4 | yes |
| GO:0050965 | detection of temperature stimulus involved in sensory perception of pain | 4.3478 | 5 | yes |
| GO:0051937 | catecholamine transport | 4.3478 | 6 | yes |
| GO:0062149 | detection of stimulus involved in sensory perception of pain | 4.3478 | 4 | yes |
| GO:0071312 | cellular response to alkaloid | 4.3478 | 5 | yes |
| GO:0071314 | cellular response to cocaine | 4.3478 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 4.3478 | 5 | yes |
| GO:0071626 | mastication | 4.3478 | 4 | yes |
| GO:0097254 | renal tubular secretion | 4.3478 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 4.3478 | 6 | yes |
| GO:0099536 | synaptic signaling | 4.3478 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 4.3478 | 5 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 4.3478 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| COMT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| EXO1_HUMAN | [view interactions] | High throughput | no | no |
| CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF8_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| PLPP6_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL1_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| TM14C_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| LAT2_HUMAN | [view interactions] | High throughput | no | no |
| TM50A_HUMAN | [view interactions] | High throughput | no | no |
| CXB5_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM222_HUMAN | [view interactions] | High throughput | no | no |
| TM100_HUMAN | [view interactions] | High throughput | no | yes |
| CC4L_HUMAN | [view interactions] | High throughput | no | no |
| GPR42_HUMAN | [view interactions] | High throughput | no | no |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S1PR3_HUMAN | [view interactions] | High throughput | no | no |
| OTOP3_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTR1_HUMAN | [view interactions] | High throughput | no | no |
| CXB3_HUMAN | [view interactions] | High throughput | no | no |
| SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
| TM205_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR3_HUMAN | [view interactions] | High throughput | no | yes |
| CXB4_HUMAN | [view interactions] | High throughput | no | no |
| S35A4_HUMAN | [view interactions] | High throughput | no | no |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| S39A2_HUMAN | [view interactions] | High throughput | no | yes |
| S35F1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| THS7A_HUMAN | [view interactions] | High throughput | no | yes |
| MADL2_HUMAN | [view interactions] | High throughput | no | no |
| S39A1_HUMAN | [view interactions] | High throughput | no | no |
| BEST2_HUMAN | [view interactions] | High throughput | no | no |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| TM187_HUMAN | [view interactions] | High throughput | no | no |
| GTR5_HUMAN | [view interactions] | High throughput | no | yes |
| TRFR_HUMAN | [view interactions] | High throughput | no | no |
| SELK_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK5_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| GP161_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA4_HUMAN | [view interactions] | High throughput | no | no |
| HRG1_HUMAN | [view interactions] | High throughput | no | yes |
| GET1_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| GBA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP2_HUMAN | [view interactions] | High throughput | no | yes |
| AQP7_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIG1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRBN_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD18_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| AP1G2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| AP1S3_HUMAN | [view interactions] | High throughput | no | yes |
| UFSP2_HUMAN | [view interactions] | High throughput | no | yes |
| CLDN1_HUMAN | [view interactions] | High throughput | no | yes |
| ODR4_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| PEG10_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| MLXPL_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| TRIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| S2513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |