COMT_HUMAN
Evidence for PS localization
Functions
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COMT_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 27.4510 | 4 | yes |
| GO:0000287 | magnesium ion binding | 3.9216 | 5 | yes |
| GO:0008168 | methyltransferase activity | 3.9216 | 4 | yes |
| GO:0008171 | O-methyltransferase activity | 3.9216 | 5 | yes |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 3.9216 | 5 | yes |
| GO:0016206 | catechol O-methyltransferase activity | 3.9216 | 6 | yes |
| GO:0102084 | L-dopa O-methyltransferase activity | 3.9216 | 5 | yes |
| GO:0102938 | orcinol O-methyltransferase activity | 3.9216 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COMT_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 43.1373 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.1765 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.2157 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.2157 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 35.2941 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.3725 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.3725 | 4 | no |
| GO:0008104 | protein localization | 31.3725 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 27.4510 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.4510 | 5 | no |
| GO:0051049 | regulation of transport | 27.4510 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.4510 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4510 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.4902 | 4 | no |
| GO:0010941 | regulation of cell death | 25.4902 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4902 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.4902 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.4902 | 4 | no |
| GO:0006996 | organelle organization | 23.5294 | 4 | no |
| GO:0015031 | protein transport | 23.5294 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.5686 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.5686 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5686 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.5686 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.5686 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.5686 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.5686 | 5 | no |
| GO:0006811 | ion transport | 21.5686 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 21.5686 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 17.6471 | 4 | yes |
| GO:0006576 | cellular biogenic amine metabolic process | 15.6863 | 5 | yes |
| GO:0006584 | catecholamine metabolic process | 15.6863 | 6 | yes |
| GO:0009308 | amine metabolic process | 15.6863 | 4 | yes |
| GO:0009712 | catechol-containing compound metabolic process | 15.6863 | 5 | yes |
| GO:0018958 | phenol-containing compound metabolic process | 15.6863 | 4 | yes |
| GO:0042417 | dopamine metabolic process | 15.6863 | 7 | yes |
| GO:0044106 | cellular amine metabolic process | 15.6863 | 4 | yes |
| GO:0019439 | aromatic compound catabolic process | 11.7647 | 4 | yes |
| GO:0031667 | response to nutrient levels | 11.7647 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 11.7647 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 11.7647 | 4 | yes |
| GO:0009310 | amine catabolic process | 9.8039 | 5 | yes |
| GO:0019336 | phenol-containing compound catabolic process | 9.8039 | 5 | yes |
| GO:0019614 | catechol-containing compound catabolic process | 9.8039 | 6 | yes |
| GO:0042402 | cellular biogenic amine catabolic process | 9.8039 | 6 | yes |
| GO:0042420 | dopamine catabolic process | 9.8039 | 8 | yes |
| GO:0042424 | catecholamine catabolic process | 9.8039 | 7 | yes |
| GO:0042135 | neurotransmitter catabolic process | 7.8431 | 4 | yes |
| GO:0009267 | cellular response to starvation | 3.9216 | 4 | yes |
| GO:0016036 | cellular response to phosphate starvation | 3.9216 | 5 | yes |
| GO:0031669 | cellular response to nutrient levels | 3.9216 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| COMT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| PEG10_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| TRIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
| EXO1_HUMAN | [view interactions] | High throughput | no | no |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF8_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| PLPP6_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL1_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| TM14C_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| LAT2_HUMAN | [view interactions] | High throughput | no | no |
| TM50A_HUMAN | [view interactions] | High throughput | no | no |
| CXB5_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| TM222_HUMAN | [view interactions] | High throughput | no | no |
| TM100_HUMAN | [view interactions] | High throughput | no | yes |
| CC4L_HUMAN | [view interactions] | High throughput | no | no |
| GPR42_HUMAN | [view interactions] | High throughput | no | no |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S1PR3_HUMAN | [view interactions] | High throughput | no | no |
| OTOP3_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SL7A1_HUMAN | [view interactions] | High throughput | no | no |
| CXB3_HUMAN | [view interactions] | High throughput | no | no |
| SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
| TM205_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR3_HUMAN | [view interactions] | High throughput | no | yes |
| CXB4_HUMAN | [view interactions] | High throughput | no | no |
| S35A4_HUMAN | [view interactions] | High throughput | no | no |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| S39A2_HUMAN | [view interactions] | High throughput | no | yes |
| S35F1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| THS7A_HUMAN | [view interactions] | High throughput | no | yes |
| MADL2_HUMAN | [view interactions] | High throughput | no | no |
| S39A1_HUMAN | [view interactions] | High throughput | no | no |
| BEST2_HUMAN | [view interactions] | High throughput | no | no |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| TM187_HUMAN | [view interactions] | High throughput | no | no |
| GTR5_HUMAN | [view interactions] | High throughput | no | yes |
| TRFR_HUMAN | [view interactions] | High throughput | no | no |
| SELK_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK5_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| GP161_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA4_HUMAN | [view interactions] | High throughput | no | no |
| HRG1_HUMAN | [view interactions] | High throughput | no | yes |
| GET1_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| GLCM_HUMAN | [view interactions] | High throughput | no | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP2_HUMAN | [view interactions] | High throughput | no | yes |
| AQP7_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIG1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRBN_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD18_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| AP1G2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| AP1S3_HUMAN | [view interactions] | High throughput | no | yes |
| UFSP2_HUMAN | [view interactions] | High throughput | no | yes |
| CLDN1_HUMAN | [view interactions] | High throughput | no | yes |
| ODR4_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MTHR_HUMAN | [view interactions] | Computational | no | yes |
| AOC2_HUMAN | [view interactions] | Computational | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ADH6_HUMAN | [view interactions] | Computational | no | no |
| BDNF_HUMAN | [view interactions] | Computational | no | yes |
| UD16_HUMAN | [view interactions] | Computational | no | no |
| DRD4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| UD19_HUMAN | [view interactions] | Computational | no | no |
| ADH4_HUMAN | [view interactions] | Computational | no | no |
| UD18_HUMAN | [view interactions] | Computational | no | no |
| UD2B7_HUMAN | [view interactions] | Computational | no | no |
| AOFB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DOPO_HUMAN | [view interactions] | Computational | no | no |
| AOFA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AL3B2_HUMAN | [view interactions] | Computational | no | yes |
| UD2A3_HUMAN | [view interactions] | Computational | no | no |
| CP1A1_HUMAN | [view interactions] | Computational | no | yes |
| AOC3_HUMAN | [view interactions] | Computational | no | no |
| AL3B1_HUMAN | [view interactions] | Computational | no | yes |
| ADH1B_HUMAN | [view interactions] | Computational | no | no |
| AL3A1_HUMAN | [view interactions] | Computational | no | no |
| PNMT_HUMAN | [view interactions] | Computational | no | no |
| UD11_HUMAN | [view interactions] | Computational | no | no |
| CP1B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DDC_HUMAN | [view interactions] | Computational | no | no |
| DRD2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |