HIG1A_HUMAN
Evidence for PS localization
Functions
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HIG1A_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 47.0588 | 4 | no |
| GO:0017076 | purine nucleotide binding | 47.0588 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 47.0588 | 4 | no |
| GO:0043168 | anion binding | 47.0588 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 41.1765 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 35.2941 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 35.2941 | 5 | no |
| GO:0005524 | ATP binding | 29.4118 | 5 | no |
| GO:0043169 | cation binding | 29.4118 | 4 | no |
| GO:0046872 | metal ion binding | 29.4118 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HIG1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.7059 | 4 | no |
| GO:0006996 | organelle organization | 58.8235 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.8235 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.9412 | 4 | no |
| GO:0007010 | cytoskeleton organization | 47.0588 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 47.0588 | 5 | no |
| GO:0023056 | positive regulation of signaling | 47.0588 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.0588 | 4 | no |
| GO:0022607 | cellular component assembly | 41.1765 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 41.1765 | 4 | yes |
| GO:0030030 | cell projection organization | 41.1765 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.1765 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.1765 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 41.1765 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.1765 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.1765 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.1765 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.1765 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.1765 | 5 | no |
| GO:0051049 | regulation of transport | 35.2941 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 29.4118 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 29.4118 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 29.4118 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.4118 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 29.4118 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.4118 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 29.4118 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.4118 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 29.4118 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.4118 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 29.4118 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.4118 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.4118 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.5294 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 23.5294 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 23.5294 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 23.5294 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 23.5294 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.5294 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0006915 | apoptotic process | 23.5294 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.5294 | 4 | no |
| GO:0008104 | protein localization | 23.5294 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0030334 | regulation of cell migration | 23.5294 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 23.5294 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:2000145 | regulation of cell motility | 23.5294 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 23.5294 | 4 | no |
| GO:0010467 | gene expression | 23.5294 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 17.6471 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 17.6471 | 4 | yes |
| GO:0007005 | mitochondrion organization | 11.7647 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 11.7647 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 11.7647 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| FA13B_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| STK31_HUMAN | [view interactions] | High throughput | no | no |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
| SAMD1_HUMAN | [view interactions] | High throughput | no | no |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| TBE_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| IPO13_HUMAN | [view interactions] | High throughput | no | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| PROZ_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| RPC10_HUMAN | [view interactions] | High throughput | no | yes |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIRRM_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |