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KCNA4_HUMAN

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed, PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed, PubMed). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed). [View more on UniProt]

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No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNA4_HUMAN
GO:0046872 metal ion binding 23.5294 4 yes
GO:0046873 metal ion transmembrane transporter activity 20.5882 5 yes
GO:0016301 kinase activity 20.5882 4 no
GO:0003779 actin binding 20.5882 4 no
GO:0008324 cation transmembrane transporter activity 20.5882 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 20.5882 4 yes
GO:0005216 ion channel activity 17.6471 4 yes
GO:0005244 voltage-gated ion channel activity 17.6471 4 yes
GO:0005249 voltage-gated potassium channel activity 17.6471 6 yes
GO:0005261 cation channel activity 17.6471 5 yes
GO:0005267 potassium channel activity 17.6471 6 yes
GO:0015079 potassium ion transmembrane transporter activity 17.6471 6 yes
GO:0015267 channel activity 17.6471 4 yes
GO:0022832 voltage-gated channel activity 17.6471 6 yes
GO:0022836 gated channel activity 17.6471 5 yes
GO:0022843 voltage-gated cation channel activity 17.6471 5 yes
GO:0005251 delayed rectifier potassium channel activity 14.7059 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCNA4_HUMAN
GO:0051049 regulation of transport 52.9412 4 yes
GO:0043269 regulation of ion transport 47.0588 5 yes
GO:0048522 positive regulation of cellular process 47.0588 4 no
GO:0034762 regulation of transmembrane transport 41.1765 4 yes
GO:0034765 regulation of ion transmembrane transport 41.1765 5 yes
GO:0008104 protein localization 38.2353 4 no
GO:0048523 negative regulation of cellular process 35.2941 4 no
GO:0060255 regulation of macromolecule metabolic process 35.2941 4 no
GO:0022607 cellular component assembly 32.3529 4 yes
GO:0010646 regulation of cell communication 32.3529 4 no
GO:0031323 regulation of cellular metabolic process 29.4118 4 no
GO:0051171 regulation of nitrogen compound metabolic process 29.4118 4 no
GO:0080090 regulation of primary metabolic process 29.4118 4 no
GO:0006996 organelle organization 29.4118 4 no
GO:0010959 regulation of metal ion transport 29.4118 6 no
GO:1904062 regulation of cation transmembrane transport 29.4118 6 no
GO:0009893 positive regulation of metabolic process 26.4706 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.4706 5 no
GO:0051128 regulation of cellular component organization 26.4706 4 no
GO:0009966 regulation of signal transduction 26.4706 4 no
GO:0006811 ion transport 23.5294 4 yes
GO:0006812 cation transport 23.5294 5 yes
GO:0030001 metal ion transport 23.5294 6 yes
GO:0043933 protein-containing complex organization 23.5294 4 yes
GO:0065003 protein-containing complex assembly 23.5294 5 yes
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:0072657 protein localization to membrane 23.5294 4 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 5 no
GO:0031399 regulation of protein modification process 20.5882 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.5882 5 no
GO:0051130 positive regulation of cellular component organization 20.5882 5 no
GO:0044057 regulation of system process 20.5882 4 no
GO:0050804 modulation of chemical synaptic transmission 20.5882 5 no
GO:0099177 regulation of trans-synaptic signaling 20.5882 4 no
GO:0006936 muscle contraction 20.5882 4 no
GO:0030030 cell projection organization 20.5882 4 no
GO:0032880 regulation of protein localization 20.5882 5 no
GO:0060341 regulation of cellular localization 20.5882 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.5882 5 no
GO:0023056 positive regulation of signaling 20.5882 4 no
GO:0098655 cation transmembrane transport 17.6471 4 yes
GO:0098660 inorganic ion transmembrane transport 17.6471 4 yes
GO:0098662 inorganic cation transmembrane transport 17.6471 5 yes
GO:0006813 potassium ion transport 14.7059 7 yes
GO:0051259 protein complex oligomerization 14.7059 6 yes
GO:0051260 protein homooligomerization 14.7059 7 yes
GO:0071805 potassium ion transmembrane transport 14.7059 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCNA4_HUMAN
DOID:0050700 cardiomyopathy 11.7647 4 no
DOID:0060036 intrinsic cardiomyopathy 11.7647 5 no
DOID:114 heart disease 11.7647 3 no
DOID:331 central nervous system disease 8.8235 3 no
DOID:1289 neurodegenerative disease 5.8824 4 no
DOID:12930 dilated cardiomyopathy 5.8824 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
LNX1_HUMAN [view interactions] Low throughput no yes
KCNA3_HUMAN [view entry] [view interactions] Low throughput yes no
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA5_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
KCNRG_HUMAN [view interactions] Low throughput no no
KCAB2_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
ERBIN_HUMAN [view entry] [view interactions] Low throughput yes yes
NEUR1_HUMAN [view interactions] Low throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SAT1_HUMAN [view interactions] High throughput no yes
NUA4L_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
UNC5B_HUMAN [view interactions] High throughput no yes
CHSS1_HUMAN [view interactions] High throughput no no
ZNF8_HUMAN [view interactions] High throughput no yes
EXTL3_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
ZF64B_HUMAN [view interactions] High throughput no no
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
PCDG3_HUMAN [view interactions] High throughput no no
ZSC21_HUMAN [view interactions] High throughput no yes
KC1G3_HUMAN [view interactions] High throughput no yes
DTNB_HUMAN [view entry] [view interactions] High throughput yes no
GLT12_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
ZN865_HUMAN [view interactions] High throughput no yes
ZN282_HUMAN [view interactions] High throughput no yes
SALL1_HUMAN [view interactions] High throughput no yes
PLD1_HUMAN [view interactions] High throughput no no
KC1G1_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
CTNL1_HUMAN [view interactions] High throughput no no
EM55_HUMAN [view entry] [view interactions] High throughput yes no
CC112_HUMAN [view interactions] High throughput no no
OBSL1_HUMAN [view interactions] High throughput no yes
ATF1_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
P121A_HUMAN [view interactions] High throughput no yes
GOLM1_HUMAN [view interactions] High throughput no yes
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
CC033_HUMAN [view interactions] High throughput no yes
RPOM_HUMAN [view interactions] High throughput no yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
INT6_HUMAN [view interactions] High throughput no yes
ZN746_HUMAN [view interactions] High throughput no no
ZN655_HUMAN [view interactions] High throughput no yes
ZN101_HUMAN [view interactions] High throughput no no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
KCAB3_HUMAN [view interactions] Computational no no
KCIP2_HUMAN [view interactions] Computational no no
KCNH1_HUMAN [view entry] [view interactions] Computational yes yes
KCNH6_HUMAN [view interactions] Computational no no
KCNH2_HUMAN [view interactions] Computational no no
DPP6_HUMAN [view entry] [view interactions] Computational yes no
KCAB1_HUMAN [view interactions] Computational no no
KCIP1_HUMAN [view interactions] Computational no yes
SGMR1_HUMAN [view entry] [view interactions] Computational yes yes