KCNA4_HUMAN
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed, PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed, PubMed). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed). [View more on UniProt]
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No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCNA4_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 23.5294 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 20.5882 | 5 | yes |
GO:0016301 | kinase activity | 20.5882 | 4 | no |
GO:0003779 | actin binding | 20.5882 | 4 | no |
GO:0008324 | cation transmembrane transporter activity | 20.5882 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 20.5882 | 4 | yes |
GO:0005216 | ion channel activity | 17.6471 | 4 | yes |
GO:0005244 | voltage-gated ion channel activity | 17.6471 | 4 | yes |
GO:0005249 | voltage-gated potassium channel activity | 17.6471 | 6 | yes |
GO:0005261 | cation channel activity | 17.6471 | 5 | yes |
GO:0005267 | potassium channel activity | 17.6471 | 6 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 17.6471 | 6 | yes |
GO:0015267 | channel activity | 17.6471 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 17.6471 | 6 | yes |
GO:0022836 | gated channel activity | 17.6471 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 17.6471 | 5 | yes |
GO:0005251 | delayed rectifier potassium channel activity | 14.7059 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCNA4_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 52.9412 | 4 | yes |
GO:0043269 | regulation of ion transport | 47.0588 | 5 | yes |
GO:0048522 | positive regulation of cellular process | 47.0588 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 41.1765 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 41.1765 | 5 | yes |
GO:0008104 | protein localization | 38.2353 | 4 | no |
GO:0048523 | negative regulation of cellular process | 35.2941 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
GO:0022607 | cellular component assembly | 32.3529 | 4 | yes |
GO:0010646 | regulation of cell communication | 32.3529 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 29.4118 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 29.4118 | 4 | no |
GO:0006996 | organelle organization | 29.4118 | 4 | no |
GO:0010959 | regulation of metal ion transport | 29.4118 | 6 | no |
GO:1904062 | regulation of cation transmembrane transport | 29.4118 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 26.4706 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.4706 | 5 | no |
GO:0051128 | regulation of cellular component organization | 26.4706 | 4 | no |
GO:0009966 | regulation of signal transduction | 26.4706 | 4 | no |
GO:0006811 | ion transport | 23.5294 | 4 | yes |
GO:0006812 | cation transport | 23.5294 | 5 | yes |
GO:0030001 | metal ion transport | 23.5294 | 6 | yes |
GO:0043933 | protein-containing complex organization | 23.5294 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 23.5294 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
GO:0072657 | protein localization to membrane | 23.5294 | 4 | no |
GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
GO:0010468 | regulation of gene expression | 23.5294 | 5 | no |
GO:0031399 | regulation of protein modification process | 20.5882 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.5882 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
GO:0044057 | regulation of system process | 20.5882 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 20.5882 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 20.5882 | 4 | no |
GO:0006936 | muscle contraction | 20.5882 | 4 | no |
GO:0030030 | cell projection organization | 20.5882 | 4 | no |
GO:0032880 | regulation of protein localization | 20.5882 | 5 | no |
GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 20.5882 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.5882 | 4 | no |
GO:0098655 | cation transmembrane transport | 17.6471 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 17.6471 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 17.6471 | 5 | yes |
GO:0006813 | potassium ion transport | 14.7059 | 7 | yes |
GO:0051259 | protein complex oligomerization | 14.7059 | 6 | yes |
GO:0051260 | protein homooligomerization | 14.7059 | 7 | yes |
GO:0071805 | potassium ion transmembrane transport | 14.7059 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCNA4_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 11.7647 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 11.7647 | 5 | no |
DOID:114 | heart disease | 11.7647 | 3 | no |
DOID:331 | central nervous system disease | 8.8235 | 3 | no |
DOID:1289 | neurodegenerative disease | 5.8824 | 4 | no |
DOID:12930 | dilated cardiomyopathy | 5.8824 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LNX1_HUMAN | [view interactions] | Low throughput | no | yes |
KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCNRG_HUMAN | [view interactions] | Low throughput | no | no |
KCAB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NEUR1_HUMAN | [view interactions] | Low throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SAT1_HUMAN | [view interactions] | High throughput | no | yes |
NUA4L_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
CHSS1_HUMAN | [view interactions] | High throughput | no | no |
ZNF8_HUMAN | [view interactions] | High throughput | no | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZF64B_HUMAN | [view interactions] | High throughput | no | no |
KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCDG3_HUMAN | [view interactions] | High throughput | no | no |
ZSC21_HUMAN | [view interactions] | High throughput | no | yes |
KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GLT12_HUMAN | [view interactions] | High throughput | no | yes |
DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN865_HUMAN | [view interactions] | High throughput | no | yes |
ZN282_HUMAN | [view interactions] | High throughput | no | yes |
SALL1_HUMAN | [view interactions] | High throughput | no | yes |
PLD1_HUMAN | [view interactions] | High throughput | no | no |
KC1G1_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
CTNL1_HUMAN | [view interactions] | High throughput | no | no |
EM55_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CC112_HUMAN | [view interactions] | High throughput | no | no |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
ATF1_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P121A_HUMAN | [view interactions] | High throughput | no | yes |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC033_HUMAN | [view interactions] | High throughput | no | yes |
RPOM_HUMAN | [view interactions] | High throughput | no | yes |
DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INT6_HUMAN | [view interactions] | High throughput | no | yes |
ZN746_HUMAN | [view interactions] | High throughput | no | no |
ZN655_HUMAN | [view interactions] | High throughput | no | yes |
ZN101_HUMAN | [view interactions] | High throughput | no | no |
SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCAB3_HUMAN | [view interactions] | Computational | no | no |
KCIP2_HUMAN | [view interactions] | Computational | no | no |
KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNH6_HUMAN | [view interactions] | Computational | no | no |
KCNH2_HUMAN | [view interactions] | Computational | no | no |
DPP6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCAB1_HUMAN | [view interactions] | Computational | no | no |
KCIP1_HUMAN | [view interactions] | Computational | no | yes |
SGMR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |