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KCNA4_HUMAN

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed, PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed, PubMed). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed). [View more on UniProt]

050100150200250300350400450500550600650
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%

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0100200300400500600700
KCNA4_HUMAN
LOADING 67%

KCNA4_HUMAN has binary interactions with 33 proteins

KCNA4_HUMANDMD_HUMANSC6A4_HUMANSCRIB_HUMANKCNA1_HUMANDTNB_HUMANDLGP1_HUMANFYN_HUMANSYGP1_HUMANVAPB_HUMANUBC_HUMANDLG1_HUMANDLG4_HUMANKCNA3_HUMANKCAB2_HUMANSNTB1_HUMANRHEB_HUMANKC1E_HUMANACTN2_HUMANLNX1_HUMANEM55_HUMANVAPA_HUMANSRC_HUMANMPP7_HUMANDLG2_HUMANDTNA_HUMANCNTP2_HUMANCSKP_HUMANUTRN_HUMANSNTB2_HUMANDLG3_HUMANERBIN_HUMANKCNA2_HUMANSNTA1_HUMANKCNA4_HUMANDMD_HUMANSC6A4_HUMANSCRIB_HUMANKCNA1_HUMANDTNB_HUMANDLGP1_HUMANFYN_HUMANSYGP1_HUMANVAPB_HUMANUBC_HUMANDLG1_HUMANDLG4_HUMANKCNA3_HUMANKCAB2_HUMANSNTB1_HUMANRHEB_HUMANKC1E_HUMANACTN2_HUMANLNX1_HUMANEM55_HUMANVAPA_HUMANSRC_HUMANMPP7_HUMANDLG2_HUMANDTNA_HUMANCNTP2_HUMANCSKP_HUMANUTRN_HUMANSNTB2_HUMANDLG3_HUMANERBIN_HUMANKCNA2_HUMANSNTA1_HUMAN
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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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