DTNA_HUMAN
Evidence for PS localization
Functions
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DTNA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.8788 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.8788 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.8788 | 4 | no |
| GO:0046872 | metal ion binding | 25.7576 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.7576 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.7576 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.7576 | 6 | no |
| GO:0019900 | kinase binding | 24.2424 | 4 | no |
| GO:0005524 | ATP binding | 22.7273 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.7273 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.7273 | 5 | no |
| GO:0019901 | protein kinase binding | 21.2121 | 5 | no |
| GO:0008270 | zinc ion binding | 12.1212 | 6 | yes |
| GO:0046914 | transition metal ion binding | 12.1212 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DTNA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.1515 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 46.9697 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.9697 | 5 | no |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0006996 | organelle organization | 45.4545 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0008104 | protein localization | 43.9394 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.9394 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.9091 | 5 | no |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | no |
| GO:0022607 | cellular component assembly | 37.8788 | 4 | no |
| GO:0071310 | cellular response to organic substance | 37.8788 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.8788 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.8788 | 5 | no |
| GO:0051049 | regulation of transport | 36.3636 | 4 | no |
| GO:0071702 | organic substance transport | 36.3636 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.8485 | 5 | no |
| GO:0071705 | nitrogen compound transport | 34.8485 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.8182 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.8182 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.8182 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.8182 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:0007010 | cytoskeleton organization | 28.7879 | 5 | no |
| GO:0030030 | cell projection organization | 28.7879 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.7879 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 27.2727 | 6 | no |
| GO:0015031 | protein transport | 27.2727 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 27.2727 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.7576 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.7576 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.7576 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.7576 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.7576 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.2424 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.2424 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.2424 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.2424 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 24.2424 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.2424 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 24.2424 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.7273 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 22.7273 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.7273 | 7 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.7273 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.7273 | 5 | no |
| GO:0006886 | intracellular protein transport | 21.2121 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
| GO:2000145 | regulation of cell motility | 21.2121 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.2121 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.2121 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2121 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 21.2121 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.2121 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2121 | 6 | no |
| GO:0006936 | muscle contraction | 13.6364 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 7.5758 | 4 | yes |
| GO:0006941 | striated muscle contraction | 6.0606 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 4.5455 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 4.5455 | 5 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 3.0303 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DTNA_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.0606 | 4 | yes |
| DOID:0060036 | intrinsic cardiomyopathy | 6.0606 | 5 | yes |
| DOID:114 | heart disease | 6.0606 | 3 | yes |
| DOID:0080000 | muscular disease | 4.5455 | 3 | no |
| DOID:423 | myopathy | 4.5455 | 5 | no |
| DOID:66 | muscle tissue disease | 4.5455 | 4 | no |
| DOID:0060480 | left ventricular noncompaction | 3.0303 | 6 | yes |
| DOID:9884 | muscular dystrophy | 3.0303 | 6 | no |
| DOID:612 | primary immunodeficiency disease | 3.0303 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNCI_HUMAN | [view interactions] | Low throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYNEM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DTBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNL1_HUMAN | [view interactions] | Low throughput | no | no |
| SNTB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UTRN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HM20A_HUMAN | [view interactions] | Low throughput | no | yes |
| SNTG1_HUMAN | [view interactions] | Low throughput | no | no |
| SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB2_HUMAN | [view interactions] | High throughput | no | no |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| SPZ1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB30_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA4_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIT2_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| ENTD1_HUMAN | [view interactions] | High throughput | no | no |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |