Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GCYA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GCYA2_HUMAN
GO:0019900 kinase binding 50.0000 4 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0000166 nucleotide binding 21.4286 4 yes
GO:0017076 purine nucleotide binding 21.4286 5 yes
GO:0032555 purine ribonucleotide binding 21.4286 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 yes
GO:0043168 anion binding 21.4286 4 yes
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0030165 PDZ domain binding 21.4286 4 no
GO:0005525 GTP binding 14.2857 5 yes
GO:0019001 guanyl nucleotide binding 14.2857 6 yes
GO:0032561 guanyl ribonucleotide binding 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GCYA2_HUMAN
GO:0008104 protein localization 64.2857 4 no
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 no
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0072657 protein localization to membrane 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 50.0000 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0009966 regulation of signal transduction 35.7143 4 yes
GO:0010646 regulation of cell communication 35.7143 4 yes
GO:0022607 cellular component assembly 35.7143 4 no
GO:0033365 protein localization to organelle 35.7143 5 no
GO:0043113 receptor clustering 35.7143 5 no
GO:0043933 protein-containing complex organization 35.7143 4 no
GO:0051049 regulation of transport 35.7143 4 no
GO:0065003 protein-containing complex assembly 35.7143 5 no
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0043085 positive regulation of catalytic activity 35.7143 4 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0015031 protein transport 35.7143 4 no
GO:0071702 organic substance transport 35.7143 4 no
GO:0071705 nitrogen compound transport 35.7143 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 yes
GO:0006936 muscle contraction 28.5714 4 no
GO:0007268 chemical synaptic transmission 28.5714 7 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0098916 anterograde trans-synaptic signaling 28.5714 6 no
GO:0099536 synaptic signaling 28.5714 4 no
GO:0099537 trans-synaptic signaling 28.5714 5 no
GO:1902414 protein localization to cell junction 28.5714 5 no
GO:1990778 protein localization to cell periphery 28.5714 5 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045860 positive regulation of protein kinase activity 28.5714 7 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0023056 positive regulation of signaling 21.4286 4 yes
GO:0002683 negative regulation of immune system process 21.4286 4 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0008016 regulation of heart contraction 21.4286 6 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031334 positive regulation of protein-containing complex assembly 21.4286 6 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0043254 regulation of protein-containing complex assembly 21.4286 5 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0061024 membrane organization 21.4286 4 no
GO:0062237 protein localization to postsynapse 21.4286 7 no
GO:1903522 regulation of blood circulation 21.4286 5 no
GO:1903539 protein localization to postsynaptic membrane 21.4286 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.4286 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.4286 9 no
GO:0061097 regulation of protein tyrosine kinase activity 21.4286 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 21.4286 8 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0072594 establishment of protein localization to organelle 21.4286 4 no
GO:0090150 establishment of protein localization to membrane 21.4286 4 no
GO:0001817 regulation of cytokine production 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0009967 positive regulation of signal transduction 14.2857 5 yes
GO:0010647 positive regulation of cell communication 14.2857 5 yes
GO:0141124 intracellular signaling cassette 14.2857 4 yes
GO:1902531 regulation of intracellular signal transduction 14.2857 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GCYB1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GSC2_HUMAN [view interactions] High throughput no no
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes