Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GCYA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GCYA2_HUMAN
GO:0019900 kinase binding 38.8889 4 no
GO:0017076 purine nucleotide binding 27.7778 4 yes
GO:0032555 purine ribonucleotide binding 27.7778 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 yes
GO:0030554 adenyl nucleotide binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0019001 guanyl nucleotide binding 16.6667 5 yes
GO:0032561 guanyl ribonucleotide binding 16.6667 5 yes
GO:0020037 heme binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GCYA2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0048522 positive regulation of cellular process 55.5556 4 yes
GO:0008104 protein localization 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0072657 protein localization to membrane 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.8889 5 no
GO:0051247 positive regulation of protein metabolic process 38.8889 6 no
GO:0051128 regulation of cellular component organization 38.8889 4 no
GO:0009966 regulation of signal transduction 38.8889 4 yes
GO:0010646 regulation of cell communication 38.8889 4 yes
GO:0051049 regulation of transport 38.8889 4 no
GO:0031401 positive regulation of protein modification process 38.8889 7 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0015031 protein transport 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0043113 receptor clustering 27.7778 5 no
GO:0043549 regulation of kinase activity 27.7778 5 no
GO:0045859 regulation of protein kinase activity 27.7778 6 no
GO:0045860 positive regulation of protein kinase activity 27.7778 7 no
GO:0009889 regulation of biosynthetic process 27.7778 4 no
GO:0009892 negative regulation of metabolic process 27.7778 4 no
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 no
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0031326 regulation of cellular biosynthetic process 27.7778 5 no
GO:0060341 regulation of cellular localization 27.7778 4 no
GO:0023056 positive regulation of signaling 27.7778 4 yes
GO:0048584 positive regulation of response to stimulus 27.7778 4 yes
GO:1902531 regulation of intracellular signal transduction 27.7778 5 yes
GO:0043269 regulation of ion transport 27.7778 5 no
GO:1990778 protein localization to cell periphery 27.7778 5 no
GO:0006886 intracellular protein transport 27.7778 4 no
GO:0006996 organelle organization 27.7778 4 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0033365 protein localization to organelle 27.7778 5 no
GO:0033674 positive regulation of kinase activity 27.7778 6 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0035418 protein localization to synapse 22.2222 6 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0099537 trans-synaptic signaling 22.2222 4 no
GO:1902414 protein localization to cell junction 22.2222 5 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0006936 muscle contraction 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 yes
GO:0010647 positive regulation of cell communication 22.2222 5 yes
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 16.6667 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GCYB1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GSC2_HUMAN [view interactions] High throughput no no
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] Computational no no
ITPA_HUMAN [view interactions] Computational no yes
PDE5A_HUMAN [view interactions] Computational no yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
NOS1_HUMAN [view entry] [view interactions] Computational yes yes
PDE9A_HUMAN [view interactions] Computational no yes
PDE1A_HUMAN [view entry] [view interactions] Computational yes yes
KGP1_HUMAN [view interactions] Computational no yes
GCYA1_HUMAN [view interactions] Computational no yes
AP4A_HUMAN [view interactions] Computational no no
PDE2A_HUMAN [view entry] [view interactions] Computational yes yes