Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FRPD4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FRPD4_HUMAN
GO:0043168 anion binding 29.4118 4 yes
GO:0019902 phosphatase binding 29.4118 4 no
GO:0000166 nucleotide binding 23.5294 4 no
GO:0016301 kinase activity 23.5294 4 no
GO:0001664 G protein-coupled receptor binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0035091 phosphatidylinositol binding 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FRPD4_HUMAN
GO:0048522 positive regulation of cellular process 82.3529 4 yes
GO:0010646 regulation of cell communication 64.7059 4 no
GO:0031323 regulation of cellular metabolic process 64.7059 4 no
GO:0060255 regulation of macromolecule metabolic process 64.7059 4 no
GO:0009966 regulation of signal transduction 58.8235 4 no
GO:0048523 negative regulation of cellular process 58.8235 4 no
GO:0051049 regulation of transport 58.8235 4 no
GO:0051128 regulation of cellular component organization 52.9412 4 yes
GO:0023056 positive regulation of signaling 52.9412 4 no
GO:0080090 regulation of primary metabolic process 52.9412 4 no
GO:0009889 regulation of biosynthetic process 47.0588 4 no
GO:0010468 regulation of gene expression 47.0588 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.0588 5 no
GO:0010647 positive regulation of cell communication 47.0588 5 no
GO:0031326 regulation of cellular biosynthetic process 47.0588 5 no
GO:0098916 anterograde trans-synaptic signaling 41.1765 6 no
GO:0099536 synaptic signaling 41.1765 4 no
GO:0099537 trans-synaptic signaling 41.1765 5 no
GO:0008104 protein localization 41.1765 4 no
GO:0009967 positive regulation of signal transduction 41.1765 5 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0051246 regulation of protein metabolic process 41.1765 5 no
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:0007268 chemical synaptic transmission 41.1765 7 no
GO:0050804 modulation of chemical synaptic transmission 35.2941 5 no
GO:0099177 regulation of trans-synaptic signaling 35.2941 4 no
GO:0051130 positive regulation of cellular component organization 35.2941 5 yes
GO:0009893 positive regulation of metabolic process 35.2941 4 no
GO:0009968 negative regulation of signal transduction 35.2941 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0010648 negative regulation of cell communication 35.2941 5 no
GO:0023057 negative regulation of signaling 35.2941 4 no
GO:0031325 positive regulation of cellular metabolic process 35.2941 5 no
GO:0031399 regulation of protein modification process 35.2941 6 no
GO:0043085 positive regulation of catalytic activity 35.2941 4 no
GO:0048585 negative regulation of response to stimulus 35.2941 4 no
GO:0035418 protein localization to synapse 29.4118 6 no
GO:0043113 receptor clustering 29.4118 5 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0072657 protein localization to membrane 29.4118 4 no
GO:1902414 protein localization to cell junction 29.4118 5 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0010959 regulation of metal ion transport 29.4118 6 no
GO:0034762 regulation of transmembrane transport 29.4118 4 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0043269 regulation of monoatomic ion transport 29.4118 5 no
GO:0043408 regulation of MAPK cascade 29.4118 6 no
GO:0051241 negative regulation of multicellular organismal process 29.4118 4 no
GO:0051338 regulation of transferase activity 29.4118 4 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 no
GO:1902532 negative regulation of intracellular signal transduction 29.4118 6 no
GO:0034330 cell junction organization 23.5294 4 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:0051347 positive regulation of transferase activity 23.5294 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 23.5294 6 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0006936 muscle contraction 23.5294 4 no
GO:0006996 organelle organization 23.5294 4 no
GO:0022607 cellular component assembly 23.5294 4 no
GO:0032880 regulation of protein localization 23.5294 5 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 23.5294 4 no
GO:0043933 protein-containing complex organization 23.5294 4 no
GO:0044057 regulation of system process 23.5294 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 23.5294 5 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0051726 regulation of cell cycle 23.5294 4 no
GO:1903829 positive regulation of protein localization 23.5294 5 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0010038 response to metal ion 23.5294 4 no
GO:0098657 import into cell 23.5294 4 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0008285 negative regulation of cell population proliferation 23.5294 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0030030 cell projection organization 23.5294 4 no
GO:0031175 neuron projection development 23.5294 6 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031344 regulation of cell projection organization 23.5294 5 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.5294 5 no
GO:0036211 protein modification process 23.5294 4 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0042981 regulation of apoptotic process 23.5294 5 no
GO:0043065 positive regulation of apoptotic process 23.5294 6 no
GO:0043067 regulation of programmed cell death 23.5294 4 no
GO:0043068 positive regulation of programmed cell death 23.5294 5 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0043549 regulation of kinase activity 23.5294 5 no
GO:0045859 regulation of protein kinase activity 23.5294 6 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.5294 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 23.5294 9 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0051960 regulation of nervous system development 23.5294 5 no
GO:0070663 regulation of leukocyte proliferation 23.5294 5 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:1904062 regulation of monoatomic cation transmembrane transport 23.5294 6 no
GO:2000026 regulation of multicellular organismal development 23.5294 4 no
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 23.5294 4 no
GO:0007215 glutamate receptor signaling pathway 23.5294 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 23.5294 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0050807 regulation of synapse organization 17.6471 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
GPSM2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
STK36_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RB27A_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no