Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FRPD4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FRPD4_HUMAN
GO:0019900 kinase binding 31.2500 4 no
GO:0019902 phosphatase binding 31.2500 4 no
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0035091 phosphatidylinositol binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FRPD4_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 68.7500 4 no
GO:0010646 regulation of cell communication 68.7500 4 no
GO:0051049 regulation of transport 62.5000 4 no
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 56.2500 4 no
GO:0051246 regulation of protein metabolic process 56.2500 5 no
GO:0080090 regulation of primary metabolic process 56.2500 4 no
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0043269 regulation of ion transport 50.0000 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:0008104 protein localization 43.7500 4 no
GO:0009967 positive regulation of signal transduction 43.7500 5 no
GO:0010647 positive regulation of cell communication 43.7500 5 no
GO:0034762 regulation of transmembrane transport 43.7500 4 no
GO:0034765 regulation of ion transmembrane transport 43.7500 5 no
GO:0048584 positive regulation of response to stimulus 43.7500 4 no
GO:0001932 regulation of protein phosphorylation 43.7500 7 no
GO:0001934 positive regulation of protein phosphorylation 43.7500 8 no
GO:0010562 positive regulation of phosphorus metabolic process 43.7500 6 no
GO:0019220 regulation of phosphate metabolic process 43.7500 6 no
GO:0031401 positive regulation of protein modification process 43.7500 7 no
GO:0042325 regulation of phosphorylation 43.7500 7 no
GO:0042327 positive regulation of phosphorylation 43.7500 8 no
GO:0045937 positive regulation of phosphate metabolic process 43.7500 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 43.7500 5 no
GO:0051174 regulation of phosphorus metabolic process 43.7500 5 no
GO:0051247 positive regulation of protein metabolic process 43.7500 6 no
GO:0051338 regulation of transferase activity 43.7500 4 no
GO:0051347 positive regulation of transferase activity 43.7500 5 no
GO:0007268 chemical synaptic transmission 37.5000 6 no
GO:0010959 regulation of metal ion transport 37.5000 6 no
GO:0098916 anterograde trans-synaptic signaling 37.5000 5 no
GO:0099537 trans-synaptic signaling 37.5000 4 no
GO:1904062 regulation of cation transmembrane transport 37.5000 6 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 yes
GO:0022898 regulation of transmembrane transporter activity 31.2500 4 no
GO:0032412 regulation of ion transmembrane transporter activity 31.2500 5 no
GO:0035418 protein localization to synapse 31.2500 6 no
GO:0044057 regulation of system process 31.2500 4 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:1902414 protein localization to cell junction 31.2500 5 no
GO:0042127 regulation of cell population proliferation 31.2500 4 no
GO:0043113 receptor clustering 31.2500 5 no
GO:0045860 positive regulation of protein kinase activity 31.2500 7 no
GO:0072657 protein localization to membrane 31.2500 4 no
GO:0060627 regulation of vesicle-mediated transport 31.2500 4 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:0043408 regulation of MAPK cascade 31.2500 6 no
GO:0006796 phosphate-containing compound metabolic process 31.2500 4 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0036211 protein modification process 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0009968 negative regulation of signal transduction 31.2500 5 no
GO:0010648 negative regulation of cell communication 31.2500 5 no
GO:0023057 negative regulation of signaling 31.2500 4 no
GO:0048585 negative regulation of response to stimulus 31.2500 4 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:0006936 muscle contraction 25.0000 4 no
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0051966 regulation of synaptic transmission, glutamatergic 25.0000 6 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0010942 positive regulation of cell death 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043065 positive regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043068 positive regulation of programmed cell death 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0070663 regulation of leukocyte proliferation 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006811 ion transport 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0050807 regulation of synapse organization 18.7500 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in FRPD4_HUMAN
DOID:0050753 cerebellar ataxia 12.5000 6 no
DOID:0050951 hereditary ataxia 12.5000 5 no
DOID:1289 neurodegenerative disease 12.5000 4 no
DOID:1441 autosomal dominant cerebellar ataxia 12.5000 7 no
DOID:331 central nervous system disease 12.5000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
GPSM2_HUMAN [view interactions] Low throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
TNKS1_HUMAN [view interactions] High throughput no yes
STK36_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RB27A_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no