Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GPSM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed, PubMed, PubMed). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed). Plays a role in metaphase spindle orientation (PubMed). Also plays an important role in asymmetric cell divisions (PubMed). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GPSM2_HUMAN
GO:0000166 nucleotide binding 50.0000 4 yes
GO:0001664 G protein-coupled receptor binding 43.7500 4 no
GO:0043168 anion binding 43.7500 4 no
GO:0003924 GTPase activity 37.5000 7 no
GO:0005525 GTP binding 37.5000 5 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0019001 guanyl nucleotide binding 37.5000 6 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032561 guanyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043169 cation binding 31.2500 4 no
GO:0046872 metal ion binding 31.2500 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019003 GDP binding 25.0000 5 no
GO:0005092 GDP-dissociation inhibitor activity 12.5000 5 yes
GO:0030695 GTPase regulator activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GPSM2_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0051128 regulation of cellular component organization 68.7500 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0009893 positive regulation of metabolic process 56.2500 4 no
GO:0010646 regulation of cell communication 56.2500 4 no
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0031399 regulation of protein modification process 43.7500 6 no
GO:0031401 positive regulation of protein modification process 43.7500 7 no
GO:0051246 regulation of protein metabolic process 43.7500 5 no
GO:0051247 positive regulation of protein metabolic process 43.7500 6 no
GO:0006996 organelle organization 43.7500 4 yes
GO:1903829 positive regulation of protein localization 37.5000 5 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0032880 regulation of protein localization 37.5000 5 yes
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0051493 regulation of cytoskeleton organization 37.5000 6 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:0141124 intracellular signaling cassette 31.2500 4 yes
GO:1904375 regulation of protein localization to cell periphery 31.2500 6 yes
GO:0009890 negative regulation of biosynthetic process 31.2500 5 no
GO:0009891 positive regulation of biosynthetic process 31.2500 5 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0009894 regulation of catabolic process 31.2500 4 no
GO:0009896 positive regulation of catabolic process 31.2500 5 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.2500 6 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0010628 positive regulation of gene expression 31.2500 7 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0031327 negative regulation of cellular biosynthetic process 31.2500 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.2500 6 no
GO:0048585 negative regulation of response to stimulus 31.2500 4 no
GO:0051252 regulation of RNA metabolic process 31.2500 5 no
GO:0001934 positive regulation of protein phosphorylation 31.2500 8 no
GO:0010562 positive regulation of phosphorus metabolic process 31.2500 6 no
GO:0042327 positive regulation of phosphorylation 31.2500 8 no
GO:0045937 positive regulation of phosphate metabolic process 31.2500 7 no
GO:0044089 positive regulation of cellular component biogenesis 31.2500 5 yes
GO:0051726 regulation of cell cycle 31.2500 4 yes
GO:1904377 positive regulation of protein localization to cell periphery 25.0000 6 yes
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0007264 small GTPase-mediated signal transduction 25.0000 5 yes
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0010638 positive regulation of organelle organization 25.0000 6 yes
GO:0090224 regulation of spindle organization 18.7500 6 yes
GO:1904776 regulation of protein localization to cell cortex 18.7500 7 yes
GO:1904778 positive regulation of protein localization to cell cortex 18.7500 7 yes
GO:0032886 regulation of microtubule-based process 18.7500 4 yes
GO:0051495 positive regulation of cytoskeleton organization 18.7500 7 yes
GO:0060236 regulation of mitotic spindle organization 18.7500 7 yes
GO:0070507 regulation of microtubule cytoskeleton organization 18.7500 5 yes
GO:0090068 positive regulation of cell cycle process 12.5000 6 yes
GO:0090169 regulation of spindle assembly 12.5000 6 yes
GO:1902115 regulation of organelle assembly 12.5000 5 yes
GO:1902117 positive regulation of organelle assembly 12.5000 6 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 12.5000 4 yes
GO:1905832 positive regulation of spindle assembly 12.5000 7 yes
GO:0000132 establishment of mitotic spindle orientation 12.5000 6 yes
GO:0007052 mitotic spindle organization 12.5000 4 yes
GO:0031291 Ran protein signal transduction 12.5000 6 yes
GO:0040001 establishment of mitotic spindle localization 12.5000 5 yes
GO:0045787 positive regulation of cell cycle 12.5000 5 yes
GO:0051293 establishment of spindle localization 12.5000 4 yes
GO:0051294 establishment of spindle orientation 12.5000 5 yes
GO:0051661 maintenance of centrosome location 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GPSM2_HUMAN [view entry] [view interactions] Low throughput yes yes
NUMA1_HUMAN [view interactions] Low throughput no yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
INSC_HUMAN [view interactions] Low throughput no yes
WHRN_HUMAN [view interactions] Low throughput no no
GLIS2_HUMAN [view interactions] Low throughput no no
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
AGR2_HUMAN [view interactions] Low throughput no no
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
FRPD1_HUMAN [view interactions] Low throughput no yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
PAB4L_HUMAN [view interactions] High throughput no no
TF3C2_HUMAN [view interactions] High throughput no no
TTF1_HUMAN [view interactions] High throughput no yes
GEMI6_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
LSM11_HUMAN [view interactions] High throughput no yes
GA2L1_HUMAN [view interactions] High throughput no yes
LRC8E_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
RB22A_HUMAN [view interactions] High throughput no yes
NRIP1_HUMAN [view interactions] High throughput no yes
ARH40_HUMAN [view interactions] High throughput no no
SPAG6_HUMAN [view interactions] High throughput no no
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
ACSF4_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TCAL1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes