GRM1_HUMAN
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed, PubMed, PubMed). May function in the light response in the retina . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
262 | Tyr | Cys | Spinocerebellarataxia44(SCA44) | - |
792 | Tyr | Cys | Spinocerebellarataxia44(SCA44) | - |
454 | Leu | Phe | Spinocerebellarataxia,autosomalrecessive,13(SCAR13) | - |
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001697 | LIG_EVH1_2 | LIG | 1147 | 1151 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GRM1_HUMAN |
---|---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | 35.1852 | 4 | no |
GO:0017076 | purine nucleotide binding | 35.1852 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 35.1852 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.1852 | 4 | no |
GO:0046872 | metal ion binding | 33.3333 | 4 | no |
GO:0005524 | ATP binding | 20.3704 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 20.3704 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.3704 | 5 | no |
GO:0004930 | G protein-coupled receptor activity | 14.8148 | 4 | yes |
GO:0008066 | glutamate receptor activity | 12.9630 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 7.4074 | 4 | yes |
GO:0099530 | G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential | 7.4074 | 5 | yes |
GO:0001640 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | 5.5556 | 6 | yes |
GO:0098988 | G protein-coupled glutamate receptor activity | 5.5556 | 5 | yes |
GO:0099528 | G protein-coupled neurotransmitter receptor activity | 5.5556 | 4 | yes |
GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | 5.5556 | 5 | yes |
GO:0098872 | G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | 3.7037 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GRM1_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 75.9259 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 70.3704 | 4 | yes |
GO:0009966 | regulation of signal transduction | 64.8148 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 57.4074 | 4 | no |
GO:0051049 | regulation of transport | 51.8519 | 4 | no |
GO:0010647 | positive regulation of cell communication | 51.8519 | 5 | yes |
GO:0023056 | positive regulation of signaling | 51.8519 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 46.2963 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 46.2963 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 44.4444 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 44.4444 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 44.4444 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 42.5926 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 42.5926 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 40.7407 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 38.8889 | 5 | no |
GO:0043269 | regulation of ion transport | 37.0370 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.0370 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 37.0370 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.1852 | 5 | no |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
GO:0044057 | regulation of system process | 33.3333 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 31.4815 | 7 | no |
GO:0048585 | negative regulation of response to stimulus | 31.4815 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 29.6296 | 6 | yes |
GO:0010468 | regulation of gene expression | 29.6296 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 29.6296 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 29.6296 | 4 | no |
GO:0010941 | regulation of cell death | 29.6296 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 29.6296 | 6 | yes |
GO:0036211 | protein modification process | 27.7778 | 4 | no |
GO:0043412 | macromolecule modification | 27.7778 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 27.7778 | 4 | no |
GO:0060341 | regulation of cellular localization | 27.7778 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 27.7778 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 27.7778 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 27.7778 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 27.7778 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 27.7778 | 7 | no |
GO:0051050 | positive regulation of transport | 27.7778 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 27.7778 | 4 | no |
GO:0043410 | positive regulation of MAPK cascade | 27.7778 | 7 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 25.9259 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.9259 | 4 | no |
GO:0051094 | positive regulation of developmental process | 25.9259 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.9259 | 8 | no |
GO:0008104 | protein localization | 25.9259 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.9259 | 5 | no |
GO:0016192 | vesicle-mediated transport | 25.9259 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.9259 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 25.9259 | 7 | no |
GO:0042981 | regulation of apoptotic process | 25.9259 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.9259 | 5 | no |
GO:0099537 | trans-synaptic signaling | 24.0741 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 24.0741 | 6 | no |
GO:0010243 | response to organonitrogen compound | 24.0741 | 4 | no |
GO:0022607 | cellular component assembly | 24.0741 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 24.0741 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 24.0741 | 5 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 24.0741 | 4 | no |
GO:0007268 | chemical synaptic transmission | 24.0741 | 6 | yes |
GO:0031644 | regulation of nervous system process | 24.0741 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 24.0741 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
GO:0051924 | regulation of calcium ion transport | 22.2222 | 7 | no |
GO:0050890 | cognition | 22.2222 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 22.2222 | 6 | no |
GO:2000145 | regulation of cell motility | 22.2222 | 4 | no |
GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
GO:0007215 | glutamate receptor signaling pathway | 22.2222 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.3704 | 6 | no |
GO:0050806 | positive regulation of synaptic transmission | 20.3704 | 5 | no |
GO:0060548 | negative regulation of cell death | 20.3704 | 5 | no |
GO:0032880 | regulation of protein localization | 20.3704 | 5 | no |
GO:0006996 | organelle organization | 20.3704 | 4 | no |
GO:0006468 | protein phosphorylation | 20.3704 | 5 | no |
GO:0016310 | phosphorylation | 20.3704 | 5 | no |
GO:0030334 | regulation of cell migration | 20.3704 | 5 | no |
GO:0043549 | regulation of kinase activity | 20.3704 | 5 | no |
GO:0071702 | organic substance transport | 18.5185 | 4 | yes |
GO:0071705 | nitrogen compound transport | 18.5185 | 4 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 14.8148 | 6 | yes |
GO:0006811 | ion transport | 12.9630 | 4 | yes |
GO:0007600 | sensory perception | 12.9630 | 4 | yes |
GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 11.1111 | 4 | yes |
GO:0019233 | sensory perception of pain | 9.2593 | 5 | yes |
GO:0051930 | regulation of sensory perception of pain | 7.4074 | 7 | yes |
GO:0051931 | regulation of sensory perception | 7.4074 | 6 | yes |
GO:1902475 | L-alpha-amino acid transmembrane transport | 3.7037 | 6 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 3.7037 | 4 | yes |
GO:0003333 | amino acid transmembrane transport | 3.7037 | 5 | yes |
GO:0006820 | anion transport | 3.7037 | 5 | yes |
GO:0006835 | dicarboxylic acid transport | 3.7037 | 7 | yes |
GO:0006865 | amino acid transport | 3.7037 | 5 | yes |
GO:0015711 | organic anion transport | 3.7037 | 5 | yes |
GO:0015800 | acidic amino acid transport | 3.7037 | 6 | yes |
GO:0015807 | L-amino acid transport | 3.7037 | 5 | yes |
GO:0015813 | L-glutamate transmembrane transport | 3.7037 | 5 | yes |
GO:0015849 | organic acid transport | 3.7037 | 5 | yes |
GO:0046942 | carboxylic acid transport | 3.7037 | 6 | yes |
GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | 3.7037 | 4 | yes |
GO:0051938 | L-glutamate import | 3.7037 | 6 | yes |
GO:0071257 | cellular response to electrical stimulus | 3.7037 | 4 | yes |
GO:0089718 | amino acid import across plasma membrane | 3.7037 | 4 | yes |
GO:0098656 | anion transmembrane transport | 3.7037 | 4 | yes |
GO:0098657 | import into cell | 3.7037 | 4 | yes |
GO:0098712 | L-glutamate import across plasma membrane | 3.7037 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in GRM1_HUMAN |
---|---|---|---|---|
DOID:0050753 | cerebellar ataxia | 5.5556 | 6 | yes |
DOID:0050951 | hereditary ataxia | 5.5556 | 5 | yes |
DOID:1289 | neurodegenerative disease | 5.5556 | 4 | yes |
DOID:1441 | autosomal dominant cerebellar ataxia | 5.5556 | 7 | yes |
DOID:331 | central nervous system disease | 5.5556 | 3 | yes |
DOID:0050950 | autosomal recessive cerebellar ataxia | 3.7037 | 7 | yes |
DOID:0080062 | autosomal recessive spinocerebellar ataxia 13 | 3.7037 | 8 | yes |
DOID:0080286 | spinocerebellar ataxia 44 | 3.7037 | 8 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CTND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FRPD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PP1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IMA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IMA4_HUMAN | [view interactions] | Low throughput | no | yes |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
GRASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRPC1_HUMAN | [view interactions] | Low throughput | no | yes |
AA1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HOME2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HOME3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KSYK_HUMAN | [view interactions] | Low throughput | no | no |
CABIN_HUMAN | [view interactions] | Low throughput | no | yes |
E41L2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CASR_HUMAN | [view interactions] | Low throughput | no | no |
ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BECN1_HUMAN | [view interactions] | High throughput | no | yes |
CCNE1_HUMAN | [view interactions] | High throughput | no | no |
CDK4_HUMAN | [view interactions] | High throughput | no | no |
CDK6_HUMAN | [view interactions] | High throughput | no | yes |
CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAT2A_HUMAN | [view interactions] | High throughput | no | no |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
MERL_HUMAN | [view interactions] | High throughput | no | yes |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STK11_HUMAN | [view interactions] | High throughput | no | yes |
TERT_HUMAN | [view interactions] | High throughput | no | no |
RASF1_HUMAN | [view interactions] | High throughput | no | yes |
GRM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZMYM3_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MET_HUMAN | [view interactions] | High throughput | no | yes |
OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCND2_HUMAN | [view interactions] | High throughput | no | yes |
CD44_HUMAN | [view interactions] | High throughput | no | yes |
CDN2B_HUMAN | [view interactions] | High throughput | no | no |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
ERD22_HUMAN | [view interactions] | High throughput | no | yes |
MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
TTYH2_HUMAN | [view interactions] | High throughput | no | no |
GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NLGN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TRPC3_HUMAN | [view interactions] | Computational | no | no |
RORA_HUMAN | [view interactions] | Computational | no | yes |
SPTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NLGN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SHAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GABR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAMP2_HUMAN | [view interactions] | Computational | no | no |
GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA12_HUMAN | [view interactions] | Computational | no | no |
KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAMP3_HUMAN | [view interactions] | Computational | no | no |
GRM4_HUMAN | [view interactions] | Computational | no | no |
PLCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAT5_HUMAN | [view interactions] | Computational | no | yes |
GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CALRL_HUMAN | [view interactions] | Computational | no | yes |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ESR1_HUMAN | [view interactions] | Computational | no | no |
KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAMP1_HUMAN | [view interactions] | Computational | no | no |
GPER1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |