Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM1_HUMAN

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed, PubMed, PubMed). May function in the light response in the retina . [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
262 Tyr Cys Spinocerebellarataxia44(SCA44) -
792 Tyr Cys Spinocerebellarataxia44(SCA44) -
454 Leu Phe Spinocerebellarataxia,autosomalrecessive,13(SCAR13) -
ELM instance Name Type Start End Partner
ELMI001697 LIG_EVH1_2 LIG 1147 1151 -

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM1_HUMAN
GO:0001664 G protein-coupled receptor binding 35.1852 4 no
GO:0017076 purine nucleotide binding 35.1852 4 no
GO:0032555 purine ribonucleotide binding 35.1852 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.1852 4 no
GO:0046872 metal ion binding 33.3333 4 no
GO:0005524 ATP binding 20.3704 5 no
GO:0030554 adenyl nucleotide binding 20.3704 5 no
GO:0032559 adenyl ribonucleotide binding 20.3704 5 no
GO:0004930 G protein-coupled receptor activity 14.8148 4 yes
GO:0008066 glutamate receptor activity 12.9630 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 7.4074 4 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 7.4074 5 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 5.5556 6 yes
GO:0098988 G protein-coupled glutamate receptor activity 5.5556 5 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 5.5556 4 yes
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 5.5556 5 yes
GO:0098872 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 3.7037 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM1_HUMAN
GO:0010646 regulation of cell communication 75.9259 4 yes
GO:0048522 positive regulation of cellular process 70.3704 4 yes
GO:0009966 regulation of signal transduction 64.8148 4 yes
GO:0048523 negative regulation of cellular process 57.4074 4 no
GO:0051049 regulation of transport 51.8519 4 no
GO:0010647 positive regulation of cell communication 51.8519 5 yes
GO:0023056 positive regulation of signaling 51.8519 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 46.2963 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.2963 4 no
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 yes
GO:1902531 regulation of intracellular signal transduction 42.5926 5 yes
GO:0009967 positive regulation of signal transduction 42.5926 5 yes
GO:0051246 regulation of protein metabolic process 40.7407 5 no
GO:0031325 positive regulation of cellular metabolic process 38.8889 5 no
GO:0043269 regulation of ion transport 37.0370 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.0370 5 no
GO:0043085 positive regulation of catalytic activity 37.0370 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.1852 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0044057 regulation of system process 33.3333 4 yes
GO:0042325 regulation of phosphorylation 31.4815 7 no
GO:0048585 negative regulation of response to stimulus 31.4815 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.6296 6 yes
GO:0010468 regulation of gene expression 29.6296 5 no
GO:0001932 regulation of protein phosphorylation 29.6296 7 no
GO:0009892 negative regulation of metabolic process 29.6296 4 no
GO:0010941 regulation of cell death 29.6296 4 no
GO:0043408 regulation of MAPK cascade 29.6296 6 yes
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0051240 positive regulation of multicellular organismal process 27.7778 4 no
GO:0060341 regulation of cellular localization 27.7778 4 no
GO:0009889 regulation of biosynthetic process 27.7778 4 no
GO:0009968 negative regulation of signal transduction 27.7778 5 no
GO:0010562 positive regulation of phosphorus metabolic process 27.7778 6 no
GO:0031326 regulation of cellular biosynthetic process 27.7778 5 no
GO:0042327 positive regulation of phosphorylation 27.7778 8 no
GO:0045937 positive regulation of phosphate metabolic process 27.7778 7 no
GO:0051050 positive regulation of transport 27.7778 4 no
GO:0051130 positive regulation of cellular component organization 27.7778 5 no
GO:0051336 regulation of hydrolase activity 27.7778 4 no
GO:0043410 positive regulation of MAPK cascade 27.7778 7 yes
GO:0006796 phosphate-containing compound metabolic process 25.9259 4 no
GO:0042127 regulation of cell population proliferation 25.9259 4 no
GO:0051094 positive regulation of developmental process 25.9259 4 no
GO:0001934 positive regulation of protein phosphorylation 25.9259 8 no
GO:0008104 protein localization 25.9259 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.9259 5 no
GO:0016192 vesicle-mediated transport 25.9259 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.9259 5 no
GO:0031401 positive regulation of protein modification process 25.9259 7 no
GO:0042981 regulation of apoptotic process 25.9259 6 no
GO:0043067 regulation of programmed cell death 25.9259 5 no
GO:0099537 trans-synaptic signaling 24.0741 4 yes
GO:0010959 regulation of metal ion transport 24.0741 6 no
GO:0010243 response to organonitrogen compound 24.0741 4 no
GO:0022607 cellular component assembly 24.0741 4 no
GO:0034762 regulation of transmembrane transport 24.0741 4 no
GO:0034765 regulation of ion transmembrane transport 24.0741 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 24.0741 4 no
GO:0007268 chemical synaptic transmission 24.0741 6 yes
GO:0031644 regulation of nervous system process 24.0741 5 yes
GO:0098916 anterograde trans-synaptic signaling 24.0741 5 yes
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0050890 cognition 22.2222 4 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0007215 glutamate receptor signaling pathway 22.2222 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.3704 6 no
GO:0050806 positive regulation of synaptic transmission 20.3704 5 no
GO:0060548 negative regulation of cell death 20.3704 5 no
GO:0032880 regulation of protein localization 20.3704 5 no
GO:0006996 organelle organization 20.3704 4 no
GO:0006468 protein phosphorylation 20.3704 5 no
GO:0016310 phosphorylation 20.3704 5 no
GO:0030334 regulation of cell migration 20.3704 5 no
GO:0043549 regulation of kinase activity 20.3704 5 no
GO:0071702 organic substance transport 18.5185 4 yes
GO:0071705 nitrogen compound transport 18.5185 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 14.8148 6 yes
GO:0006811 ion transport 12.9630 4 yes
GO:0007600 sensory perception 12.9630 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 11.1111 4 yes
GO:0019233 sensory perception of pain 9.2593 5 yes
GO:0051930 regulation of sensory perception of pain 7.4074 7 yes
GO:0051931 regulation of sensory perception 7.4074 6 yes
GO:1902475 L-alpha-amino acid transmembrane transport 3.7037 6 yes
GO:1905039 carboxylic acid transmembrane transport 3.7037 4 yes
GO:0003333 amino acid transmembrane transport 3.7037 5 yes
GO:0006820 anion transport 3.7037 5 yes
GO:0006835 dicarboxylic acid transport 3.7037 7 yes
GO:0006865 amino acid transport 3.7037 5 yes
GO:0015711 organic anion transport 3.7037 5 yes
GO:0015800 acidic amino acid transport 3.7037 6 yes
GO:0015807 L-amino acid transport 3.7037 5 yes
GO:0015813 L-glutamate transmembrane transport 3.7037 5 yes
GO:0015849 organic acid transport 3.7037 5 yes
GO:0046942 carboxylic acid transport 3.7037 6 yes
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 3.7037 4 yes
GO:0051938 L-glutamate import 3.7037 6 yes
GO:0071257 cellular response to electrical stimulus 3.7037 4 yes
GO:0089718 amino acid import across plasma membrane 3.7037 4 yes
GO:0098656 anion transmembrane transport 3.7037 4 yes
GO:0098657 import into cell 3.7037 4 yes
GO:0098712 L-glutamate import across plasma membrane 3.7037 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in GRM1_HUMAN
DOID:0050753 cerebellar ataxia 5.5556 6 yes
DOID:0050951 hereditary ataxia 5.5556 5 yes
DOID:1289 neurodegenerative disease 5.5556 4 yes
DOID:1441 autosomal dominant cerebellar ataxia 5.5556 7 yes
DOID:331 central nervous system disease 5.5556 3 yes
DOID:0050950 autosomal recessive cerebellar ataxia 3.7037 7 yes
DOID:0080062 autosomal recessive spinocerebellar ataxia 13 3.7037 8 yes
DOID:0080286 spinocerebellar ataxia 44 3.7037 8 yes
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
CTND2_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1A_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA5_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA4_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
OPTN_HUMAN [view interactions] Low throughput no yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPC1_HUMAN [view interactions] Low throughput no yes
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
PSA2_HUMAN [view interactions] Low throughput no yes
PRS8_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
KSYK_HUMAN [view interactions] Low throughput no no
CABIN_HUMAN [view interactions] Low throughput no yes
E41L2_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CASR_HUMAN [view interactions] Low throughput no no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
BECN1_HUMAN [view interactions] High throughput no yes
CCNE1_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
CDK6_HUMAN [view interactions] High throughput no yes
CDN2C_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
KAT2A_HUMAN [view interactions] High throughput no no
LATS2_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
STK11_HUMAN [view interactions] High throughput no yes
TERT_HUMAN [view interactions] High throughput no no
RASF1_HUMAN [view interactions] High throughput no yes
GRM5_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
ZMYM3_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
MET_HUMAN [view interactions] High throughput no yes
OPRM_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CCND2_HUMAN [view interactions] High throughput no yes
CD44_HUMAN [view interactions] High throughput no yes
CDN2B_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
FGFR4_HUMAN [view interactions] High throughput no no
ERD22_HUMAN [view interactions] High throughput no yes
MP2K5_HUMAN [view interactions] High throughput no yes
TTYH2_HUMAN [view interactions] High throughput no no
GNA13_HUMAN [view entry] [view interactions] Computational yes yes
NLGN3_HUMAN [view entry] [view interactions] Computational yes yes
TRPC3_HUMAN [view interactions] Computational no no
RORA_HUMAN [view interactions] Computational no yes
SPTN2_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
NLGN2_HUMAN [view entry] [view interactions] Computational yes yes
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes
DLGP1_HUMAN [view entry] [view interactions] Computational yes no
GABR2_HUMAN [view entry] [view interactions] Computational yes yes
RAMP2_HUMAN [view interactions] Computational no no
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
GNA12_HUMAN [view interactions] Computational no no
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
RAMP3_HUMAN [view interactions] Computational no no
GRM4_HUMAN [view interactions] Computational no no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
KAT5_HUMAN [view interactions] Computational no yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
CALRL_HUMAN [view interactions] Computational no yes
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
ESR1_HUMAN [view interactions] Computational no no
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
RAMP1_HUMAN [view interactions] Computational no no
GPER1_HUMAN [view entry] [view interactions] Computational yes yes