Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed, PubMed, PubMed). May function in the light response in the retina . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
262 Tyr Cys Spinocerebellarataxia44(SCA44) -
792 Tyr Cys Spinocerebellarataxia44(SCA44) -
454 Leu Phe Spinocerebellarataxia,autosomalrecessive,13(SCAR13) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI001697 LIG_EVH1_2 LIG 1147 1151 -
ELMI001697 LIG_EVH1_2 LIG 1147 1151 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM1_HUMAN
GO:0043168 anion binding 36.8421 4 no
GO:0001664 G protein-coupled receptor binding 26.3158 4 no
GO:0019900 kinase binding 26.3158 4 no
GO:0000166 nucleotide binding 23.6842 4 no
GO:0005524 ATP binding 23.6842 5 no
GO:0017076 purine nucleotide binding 23.6842 5 no
GO:0030554 adenyl nucleotide binding 23.6842 6 no
GO:0032555 purine ribonucleotide binding 23.6842 4 no
GO:0032559 adenyl ribonucleotide binding 23.6842 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.6842 4 no
GO:0043169 cation binding 23.6842 4 no
GO:0046872 metal ion binding 23.6842 5 no
GO:0016301 kinase activity 21.0526 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0004930 G protein-coupled receptor activity 15.7895 4 yes
GO:0008066 glutamate receptor activity 15.7895 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 13.1579 4 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 10.5263 5 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 7.8947 6 yes
GO:0098988 G protein-coupled glutamate receptor activity 7.8947 5 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 7.8947 4 yes
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 7.8947 5 yes
GO:0098872 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 5.2632 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM1_HUMAN
GO:0048522 positive regulation of cellular process 78.9474 4 yes
GO:0010646 regulation of cell communication 76.3158 4 yes
GO:0009966 regulation of signal transduction 68.4211 4 yes
GO:0048523 negative regulation of cellular process 63.1579 4 no
GO:0010647 positive regulation of cell communication 60.5263 5 yes
GO:0023056 positive regulation of signaling 60.5263 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.5263 4 no
GO:0031323 regulation of cellular metabolic process 57.8947 4 no
GO:0051049 regulation of transport 55.2632 4 no
GO:0048584 positive regulation of response to stimulus 52.6316 4 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010648 negative regulation of cell communication 44.7368 5 no
GO:0023057 negative regulation of signaling 44.7368 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.7368 5 no
GO:0031325 positive regulation of cellular metabolic process 44.7368 5 no
GO:0051128 regulation of cellular component organization 42.1053 4 no
GO:0009889 regulation of biosynthetic process 42.1053 4 no
GO:0051246 regulation of protein metabolic process 42.1053 5 no
GO:0050804 modulation of chemical synaptic transmission 39.4737 5 yes
GO:0099177 regulation of trans-synaptic signaling 39.4737 4 yes
GO:0048585 negative regulation of response to stimulus 39.4737 4 no
GO:0031326 regulation of cellular biosynthetic process 39.4737 5 no
GO:0019220 regulation of phosphate metabolic process 39.4737 6 no
GO:0031399 regulation of protein modification process 39.4737 6 no
GO:0051174 regulation of phosphorus metabolic process 39.4737 5 no
GO:0051247 positive regulation of protein metabolic process 39.4737 6 no
GO:0043408 regulation of MAPK cascade 36.8421 6 yes
GO:1902533 positive regulation of intracellular signal transduction 36.8421 6 yes
GO:0009968 negative regulation of signal transduction 36.8421 5 no
GO:0001932 regulation of protein phosphorylation 36.8421 7 no
GO:0010556 regulation of macromolecule biosynthetic process 36.8421 5 no
GO:0010562 positive regulation of phosphorus metabolic process 36.8421 6 no
GO:0031401 positive regulation of protein modification process 36.8421 7 no
GO:0042325 regulation of phosphorylation 36.8421 7 no
GO:0045937 positive regulation of phosphate metabolic process 36.8421 7 no
GO:0043410 positive regulation of MAPK cascade 34.2105 7 yes
GO:0001934 positive regulation of protein phosphorylation 34.2105 8 no
GO:0009892 negative regulation of metabolic process 34.2105 4 no
GO:0010468 regulation of gene expression 34.2105 6 no
GO:0042327 positive regulation of phosphorylation 34.2105 8 no
GO:0036211 protein modification process 31.5789 4 no
GO:0043412 macromolecule modification 31.5789 4 no
GO:0008104 protein localization 31.5789 4 no
GO:0051050 positive regulation of transport 28.9474 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.9474 5 no
GO:0042981 regulation of apoptotic process 28.9474 5 no
GO:0043067 regulation of programmed cell death 28.9474 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.9474 5 no
GO:0043085 positive regulation of catalytic activity 28.9474 4 no
GO:0007268 chemical synaptic transmission 26.3158 7 yes
GO:0044057 regulation of system process 26.3158 4 yes
GO:0098916 anterograde trans-synaptic signaling 26.3158 6 yes
GO:0099536 synaptic signaling 26.3158 4 yes
GO:0099537 trans-synaptic signaling 26.3158 5 yes
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0042127 regulation of cell population proliferation 26.3158 4 no
GO:0043066 negative regulation of apoptotic process 26.3158 6 no
GO:0043069 negative regulation of programmed cell death 26.3158 5 no
GO:0043269 regulation of monoatomic ion transport 26.3158 5 no
GO:0007215 glutamate receptor signaling pathway 23.6842 4 yes
GO:0098657 import into cell 23.6842 4 yes
GO:0006796 phosphate-containing compound metabolic process 23.6842 4 no
GO:0031328 positive regulation of cellular biosynthetic process 23.6842 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.6842 6 no
GO:1902532 negative regulation of intracellular signal transduction 23.6842 6 no
GO:0006996 organelle organization 23.6842 4 no
GO:0022607 cellular component assembly 23.6842 4 no
GO:0050890 cognition 23.6842 4 no
GO:0051338 regulation of transferase activity 23.6842 4 no
GO:0010959 regulation of metal ion transport 23.6842 6 no
GO:0034762 regulation of transmembrane transport 23.6842 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.0526 6 yes
GO:0071702 organic substance transport 21.0526 4 yes
GO:0071705 nitrogen compound transport 21.0526 4 yes
GO:0006468 protein phosphorylation 21.0526 5 no
GO:0016310 phosphorylation 21.0526 5 no
GO:0051241 negative regulation of multicellular organismal process 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0051094 positive regulation of developmental process 21.0526 4 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0080134 regulation of response to stress 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0009890 negative regulation of biosynthetic process 21.0526 5 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0051924 regulation of calcium ion transport 21.0526 7 no
GO:0050806 positive regulation of synaptic transmission 21.0526 5 no
GO:0031644 regulation of nervous system process 18.4211 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 15.7895 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 15.7895 4 yes
GO:0007600 sensory perception 13.1579 4 yes
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 10.5263 5 yes
GO:0019233 sensory perception of pain 7.8947 5 yes
GO:0051930 regulation of sensory perception of pain 7.8947 7 yes
GO:0051931 regulation of sensory perception 7.8947 6 yes
GO:0006835 dicarboxylic acid transport 5.2632 7 yes
GO:0006865 amino acid transport 5.2632 5 yes
GO:0015711 organic anion transport 5.2632 5 yes
GO:0015800 acidic amino acid transport 5.2632 6 yes
GO:0015807 L-amino acid transport 5.2632 5 yes
GO:0015813 L-glutamate transmembrane transport 5.2632 5 yes
GO:0015849 organic acid transport 5.2632 5 yes
GO:0046942 carboxylic acid transport 5.2632 6 yes
GO:0051938 L-glutamate import 5.2632 6 yes
GO:0071257 cellular response to electrical stimulus 5.2632 4 yes
GO:0089718 amino acid import across plasma membrane 5.2632 4 yes
GO:0098712 L-glutamate import across plasma membrane 5.2632 5 yes
GO:1902475 L-alpha-amino acid transmembrane transport 5.2632 4 yes
GO:1905039 carboxylic acid transmembrane transport 5.2632 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA5_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA4_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
OPTN_HUMAN [view interactions] Low throughput no yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
PSA2_HUMAN [view interactions] Low throughput no yes
PRS8_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
KSYK_HUMAN [view interactions] Low throughput no no
CABIN_HUMAN [view interactions] Low throughput no yes
E41L2_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CASR_HUMAN [view interactions] Low throughput no no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
CTND2_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1A_HUMAN [view entry] [view interactions] Low throughput yes no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] Low throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
ZMYM3_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
MET_HUMAN [view interactions] High throughput no yes
OPRM_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF6_HUMAN [view interactions] High throughput no no
CCND2_HUMAN [view interactions] High throughput no yes
CD44_HUMAN [view entry] [view interactions] High throughput yes yes
CDN2B_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
FGFR4_HUMAN [view interactions] High throughput no no
ERD22_HUMAN [view interactions] High throughput no yes
MP2K5_HUMAN [view interactions] High throughput no yes
TTYH2_HUMAN [view interactions] High throughput no no
BECN1_HUMAN [view interactions] High throughput no yes
CCNE1_HUMAN [view interactions] High throughput no no
CDK4_HUMAN [view interactions] High throughput no no
CDK6_HUMAN [view interactions] High throughput no yes
CDN2C_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
KAT2A_HUMAN [view interactions] High throughput no no
LATS2_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
STK11_HUMAN [view interactions] High throughput no yes
TERT_HUMAN [view interactions] High throughput no no
RASF1_HUMAN [view interactions] High throughput no yes
GRM5_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes