Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TRPC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TRPC1_HUMAN
GO:0043168 anion binding 57.1429 4 yes
GO:0000166 nucleotide binding 35.7143 4 no
GO:0017076 purine nucleotide binding 35.7143 5 no
GO:0019900 kinase binding 35.7143 4 no
GO:0019901 protein kinase binding 35.7143 5 no
GO:0032555 purine ribonucleotide binding 35.7143 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.7143 4 no
GO:0043169 cation binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0005216 monoatomic ion channel activity 21.4286 4 yes
GO:0005261 monoatomic cation channel activity 21.4286 5 yes
GO:0005262 calcium channel activity 21.4286 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 21.4286 4 yes
GO:0015085 calcium ion transmembrane transporter activity 21.4286 6 yes
GO:0015267 channel activity 21.4286 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 21.4286 4 yes
GO:0046873 metal ion transmembrane transporter activity 21.4286 5 yes
GO:0051117 ATPase binding 21.4286 4 yes
GO:0070679 inositol 1,4,5 trisphosphate binding 21.4286 4 yes
GO:0035254 glutamate receptor binding 21.4286 4 no
GO:0016301 kinase activity 21.4286 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.4286 4 no
GO:0046872 metal ion binding 21.4286 5 no
GO:0003723 RNA binding 21.4286 4 no
GO:0015279 store-operated calcium channel activity 14.2857 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TRPC1_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0010646 regulation of cell communication 71.4286 4 no
GO:0048523 negative regulation of cellular process 71.4286 4 no
GO:0009966 regulation of signal transduction 64.2857 4 no
GO:0010647 positive regulation of cell communication 57.1429 5 no
GO:0023056 positive regulation of signaling 57.1429 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:1902531 regulation of intracellular signal transduction 57.1429 5 no
GO:0044057 regulation of system process 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0051050 positive regulation of transport 42.8571 4 yes
GO:1903522 regulation of blood circulation 42.8571 5 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0006811 monoatomic ion transport 35.7143 4 yes
GO:0006812 monoatomic cation transport 35.7143 5 yes
GO:0010959 regulation of metal ion transport 35.7143 6 yes
GO:0030001 metal ion transport 35.7143 6 yes
GO:0043269 regulation of monoatomic ion transport 35.7143 5 yes
GO:0051924 regulation of calcium ion transport 35.7143 7 yes
GO:0008104 protein localization 35.7143 4 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 no
GO:0080090 regulation of primary metabolic process 35.7143 4 no
GO:1902532 negative regulation of intracellular signal transduction 35.7143 6 no
GO:1902533 positive regulation of intracellular signal transduction 35.7143 6 no
GO:0031344 regulation of cell projection organization 35.7143 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.7143 6 no
GO:0009890 negative regulation of biosynthetic process 35.7143 5 no
GO:0006816 calcium ion transport 28.5714 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 yes
GO:0006874 intracellular calcium ion homeostasis 28.5714 5 yes
GO:0008016 regulation of heart contraction 28.5714 6 yes
GO:0010038 response to metal ion 28.5714 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 yes
GO:0034762 regulation of transmembrane transport 28.5714 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 28.5714 5 yes
GO:0051282 regulation of sequestering of calcium ion 28.5714 4 yes
GO:0055074 calcium ion homeostasis 28.5714 4 yes
GO:0055080 monoatomic cation homeostasis 28.5714 4 yes
GO:0070588 calcium ion transmembrane transport 28.5714 5 yes
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 yes
GO:0098662 inorganic cation transmembrane transport 28.5714 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 28.5714 6 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010628 positive regulation of gene expression 28.5714 7 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0018958 phenol-containing compound metabolic process 21.4286 4 yes
GO:0043270 positive regulation of monoatomic ion transport 21.4286 5 yes
GO:0051592 response to calcium ion 21.4286 5 yes
GO:0051928 positive regulation of calcium ion transport 21.4286 6 yes
GO:1901362 organic cyclic compound biosynthetic process 21.4286 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 21.4286 7 yes
GO:0001817 regulation of cytokine production 21.4286 4 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0007268 chemical synaptic transmission 21.4286 7 no
GO:0010564 regulation of cell cycle process 21.4286 5 no
GO:0010720 positive regulation of cell development 21.4286 6 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0032465 regulation of cytokinesis 21.4286 5 no
GO:0032467 positive regulation of cytokinesis 21.4286 6 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0036293 response to decreased oxygen levels 21.4286 4 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0045597 positive regulation of cell differentiation 21.4286 5 no
GO:0045787 positive regulation of cell cycle 21.4286 5 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051223 regulation of protein transport 21.4286 5 no
GO:0051302 regulation of cell division 21.4286 4 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0051781 positive regulation of cell division 21.4286 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.4286 6 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0070201 regulation of establishment of protein localization 21.4286 6 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0090068 positive regulation of cell cycle process 21.4286 6 no
GO:0098916 anterograde trans-synaptic signaling 21.4286 6 no
GO:0099536 synaptic signaling 21.4286 4 no
GO:0099537 trans-synaptic signaling 21.4286 5 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0007215 glutamate receptor signaling pathway 21.4286 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0003018 vascular process in circulatory system 21.4286 4 no
GO:0010632 regulation of epithelial cell migration 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0030335 positive regulation of cell migration 21.4286 6 no
GO:0030518 intracellular steroid hormone receptor signaling pathway 21.4286 5 no
GO:0033043 regulation of organelle organization 21.4286 5 no
GO:0040017 positive regulation of locomotion 21.4286 4 no
GO:0043254 regulation of protein-containing complex assembly 21.4286 5 no
GO:0043401 steroid hormone mediated signaling pathway 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0141193 nuclear receptor signaling pathway 21.4286 4 no
GO:2000147 positive regulation of cell motility 21.4286 5 no
GO:0034764 positive regulation of transmembrane transport 14.2857 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 14.2857 6 yes
GO:0042438 melanin biosynthetic process 14.2857 4 yes
GO:0046189 phenol-containing compound biosynthetic process 14.2857 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 14.2857 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 14.2857 6 yes
GO:0051480 regulation of cytosolic calcium ion concentration 14.2857 6 yes
GO:1901617 organic hydroxy compound biosynthetic process 14.2857 4 yes
GO:1903779 regulation of cardiac conduction 14.2857 7 yes
GO:1904064 positive regulation of cation transmembrane transport 14.2857 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 14.2857 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAV1_HUMAN [view interactions] Low throughput no no
MX1_HUMAN [view interactions] Low throughput no yes
PKD2_HUMAN [view interactions] Low throughput no yes
PODO_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
STIM1_HUMAN [view interactions] Low throughput no yes
CRCM1_HUMAN [view interactions] Low throughput no yes
ENKUR_HUMAN [view interactions] Low throughput no no
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME3_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPC6_HUMAN [view interactions] Low throughput no no
TRPC3_HUMAN [view interactions] Low throughput no no
TRPC4_HUMAN [view interactions] Low throughput no no
TRPC5_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR3_HUMAN [view interactions] Low throughput no yes
TP4AP_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
BMPR2_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV4_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF23_HUMAN [view interactions] High throughput no yes
TRPC1_HUMAN [view entry] [view interactions] High throughput yes yes