Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CTND2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed). Involved in the regulation of Wnt signaling (PubMed). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation . Functions as a transcriptional activator when bound to ZBTB33 . May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003529 LIG_PDZ_Wminus1_1 LIG 1223 1225 -
ELMI003529 LIG_PDZ_Wminus1_1 LIG 1223 1225 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CTND2_HUMAN
GO:0043169 cation binding 34.2105 4 no
GO:0046872 metal ion binding 34.2105 5 no
GO:0019900 kinase binding 26.3158 4 no
GO:0043168 anion binding 23.6842 4 no
GO:0000166 nucleotide binding 21.0526 4 no
GO:0016301 kinase activity 21.0526 4 no
GO:0017076 purine nucleotide binding 21.0526 5 no
GO:0030554 adenyl nucleotide binding 21.0526 6 no
GO:0032555 purine ribonucleotide binding 21.0526 4 no
GO:0032559 adenyl ribonucleotide binding 21.0526 5 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0045296 cadherin binding 18.4211 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CTND2_HUMAN
GO:0048522 positive regulation of cellular process 68.4211 4 no
GO:0010646 regulation of cell communication 68.4211 4 yes
GO:0009966 regulation of signal transduction 65.7895 4 yes
GO:0051128 regulation of cellular component organization 63.1579 4 no
GO:0008104 protein localization 52.6316 4 no
GO:0060255 regulation of macromolecule metabolic process 52.6316 4 no
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 47.3684 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 no
GO:0031323 regulation of cellular metabolic process 47.3684 4 no
GO:0023056 positive regulation of signaling 44.7368 4 no
GO:0022607 cellular component assembly 42.1053 4 yes
GO:0048584 positive regulation of response to stimulus 42.1053 4 no
GO:0051246 regulation of protein metabolic process 42.1053 5 no
GO:0051247 positive regulation of protein metabolic process 42.1053 6 no
GO:0030030 cell projection organization 39.4737 4 yes
GO:0009967 positive regulation of signal transduction 39.4737 5 no
GO:0010647 positive regulation of cell communication 39.4737 5 no
GO:0022603 regulation of anatomical structure morphogenesis 39.4737 4 no
GO:1902531 regulation of intracellular signal transduction 39.4737 5 no
GO:0051130 positive regulation of cellular component organization 39.4737 5 no
GO:0006996 organelle organization 36.8421 4 no
GO:0031344 regulation of cell projection organization 36.8421 5 no
GO:0050804 modulation of chemical synaptic transmission 36.8421 5 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0099177 regulation of trans-synaptic signaling 36.8421 4 no
GO:0120036 plasma membrane bounded cell projection organization 34.2105 5 yes
GO:0031325 positive regulation of cellular metabolic process 34.2105 5 no
GO:0036211 protein modification process 34.2105 4 no
GO:0043412 macromolecule modification 34.2105 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 34.2105 6 no
GO:0010975 regulation of neuron projection development 31.5789 7 no
GO:0031399 regulation of protein modification process 31.5789 6 no
GO:0072657 protein localization to membrane 31.5789 4 no
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0048585 negative regulation of response to stimulus 31.5789 4 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0031401 positive regulation of protein modification process 28.9474 7 no
GO:0099536 synaptic signaling 28.9474 4 no
GO:0099537 trans-synaptic signaling 28.9474 5 no
GO:0009889 regulation of biosynthetic process 28.9474 4 no
GO:0010468 regulation of gene expression 28.9474 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.9474 5 no
GO:0031326 regulation of cellular biosynthetic process 28.9474 5 no
GO:0043085 positive regulation of catalytic activity 28.9474 4 no
GO:0034330 cell junction organization 26.3158 4 yes
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0043408 regulation of MAPK cascade 26.3158 6 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0007268 chemical synaptic transmission 26.3158 7 no
GO:0098916 anterograde trans-synaptic signaling 26.3158 6 no
GO:0033043 regulation of organelle organization 26.3158 5 no
GO:0050807 regulation of synapse organization 26.3158 5 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0042981 regulation of apoptotic process 26.3158 5 no
GO:0043067 regulation of programmed cell death 26.3158 4 no
GO:0044087 regulation of cellular component biogenesis 26.3158 4 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0031175 neuron projection development 23.6842 6 yes
GO:0141124 intracellular signaling cassette 23.6842 4 no
GO:0043113 receptor clustering 23.6842 5 no
GO:0006508 proteolysis 23.6842 4 no
GO:0009057 macromolecule catabolic process 23.6842 4 no
GO:0009890 negative regulation of biosynthetic process 23.6842 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.6842 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.6842 6 no
GO:0044057 regulation of system process 23.6842 4 no
GO:0050890 cognition 23.6842 4 no
GO:0051960 regulation of nervous system development 23.6842 5 no
GO:2000026 regulation of multicellular organismal development 23.6842 4 no
GO:0051240 positive regulation of multicellular organismal process 23.6842 4 no
GO:0030111 regulation of Wnt signaling pathway 21.0526 5 yes
GO:0034329 cell junction assembly 21.0526 5 yes
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:0042127 regulation of cell population proliferation 21.0526 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.0526 6 no
GO:0009894 regulation of catabolic process 21.0526 4 no
GO:0043933 protein-containing complex organization 21.0526 4 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0051129 negative regulation of cellular component organization 21.0526 5 no
GO:0051241 negative regulation of multicellular organismal process 21.0526 4 no
GO:0060284 regulation of cell development 21.0526 5 no
GO:1902532 negative regulation of intracellular signal transduction 21.0526 6 no
GO:0098657 import into cell 21.0526 4 no
GO:0006355 regulation of DNA-templated transcription 21.0526 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0048812 neuron projection morphogenesis 18.4211 5 yes
GO:0050808 synapse organization 18.4211 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 18.4211 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 18.4211 4 yes
GO:0016055 Wnt signaling pathway 18.4211 4 yes
GO:0106027 neuron projection organization 15.7895 6 yes
GO:0045216 cell-cell junction organization 10.5263 5 yes
GO:0097061 dendritic spine organization 10.5263 5 yes
GO:0099173 postsynapse organization 10.5263 4 yes
GO:0007043 cell-cell junction assembly 10.5263 6 yes
GO:0060997 dendritic spine morphogenesis 7.8947 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRC7_HUMAN [view entry] [view interactions] Low throughput yes no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PDZD2_HUMAN [view interactions] Low throughput no yes
ATN1_HUMAN [view interactions] Low throughput no yes
KAISO_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
KAT2B_HUMAN [view interactions] Low throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
CPSF5_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
HTRA1_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
DACT2_HUMAN [view interactions] High throughput no yes
DACT1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
PE2R4_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NCAM2_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
MCM2_HUMAN [view interactions] High throughput no no
LNX2_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
NUD12_HUMAN [view interactions] High throughput no yes
TRI47_HUMAN [view entry] [view interactions] High throughput yes yes
THUM3_HUMAN [view interactions] High throughput no yes
ZMY19_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
BRSK2_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes