CTND2_HUMAN
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed). Involved in the regulation of Wnt signaling (PubMed). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation . Functions as a transcriptional activator when bound to ZBTB33 . May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003529 | LIG_PDZ_Wminus1_1 | LIG | 1223 | 1225 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CTND2_HUMAN |
---|---|---|---|---|
GO:0045296 | cadherin binding | 37.0370 | 4 | yes |
GO:0019900 | kinase binding | 29.6296 | 4 | no |
GO:0019901 | protein kinase binding | 29.6296 | 5 | no |
GO:0046872 | metal ion binding | 25.9259 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CTND2_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 77.7778 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 77.7778 | 4 | no |
GO:0009966 | regulation of signal transduction | 70.3704 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 62.9630 | 4 | no |
GO:0008104 | protein localization | 62.9630 | 4 | no |
GO:0051128 | regulation of cellular component organization | 59.2593 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 51.8519 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 51.8519 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.8519 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 51.8519 | 4 | no |
GO:0030030 | cell projection organization | 48.1481 | 4 | yes |
GO:0023056 | positive regulation of signaling | 48.1481 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 48.1481 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 44.4444 | 5 | no |
GO:0022607 | cellular component assembly | 44.4444 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 44.4444 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 44.4444 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 44.4444 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.4444 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 44.4444 | 5 | no |
GO:0031344 | regulation of cell projection organization | 40.7407 | 5 | no |
GO:0051049 | regulation of transport | 40.7407 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 40.7407 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 40.7407 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 40.7407 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 40.7407 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 37.0370 | 5 | no |
GO:0010975 | regulation of neuron projection development | 37.0370 | 7 | no |
GO:0072657 | protein localization to membrane | 37.0370 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 37.0370 | 6 | no |
GO:0009968 | negative regulation of signal transduction | 37.0370 | 5 | no |
GO:0010648 | negative regulation of cell communication | 37.0370 | 5 | no |
GO:0023057 | negative regulation of signaling | 37.0370 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 37.0370 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 37.0370 | 4 | no |
GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0034330 | cell junction organization | 33.3333 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 29.6296 | 4 | no |
GO:0031399 | regulation of protein modification process | 29.6296 | 6 | no |
GO:0031175 | neuron projection development | 29.6296 | 6 | yes |
GO:0034329 | cell junction assembly | 29.6296 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 29.6296 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.6296 | 5 | no |
GO:0010941 | regulation of cell death | 25.9259 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.9259 | 5 | no |
GO:0042981 | regulation of apoptotic process | 25.9259 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.9259 | 5 | no |
GO:0043113 | receptor clustering | 25.9259 | 5 | no |
GO:0051050 | positive regulation of transport | 25.9259 | 4 | no |
GO:0010243 | response to organonitrogen compound | 25.9259 | 4 | no |
GO:1990778 | protein localization to cell periphery | 25.9259 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.9259 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 25.9259 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.9259 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 25.9259 | 4 | no |
GO:0030111 | regulation of Wnt signaling pathway | 25.9259 | 5 | yes |
GO:0006355 | regulation of DNA-templated transcription | 25.9259 | 6 | no |
GO:0009894 | regulation of catabolic process | 25.9259 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.9259 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.9259 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 25.9259 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 25.9259 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.9259 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.9259 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
GO:0051960 | regulation of nervous system development | 22.2222 | 5 | no |
GO:0060284 | regulation of cell development | 22.2222 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.2222 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
GO:0010942 | positive regulation of cell death | 22.2222 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
GO:0016055 | Wnt signaling pathway | 22.2222 | 5 | yes |
GO:0032990 | cell part morphogenesis | 22.2222 | 4 | yes |
GO:0045216 | cell-cell junction organization | 22.2222 | 5 | yes |
GO:0048812 | neuron projection morphogenesis | 22.2222 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 22.2222 | 5 | yes |
GO:0050808 | synapse organization | 22.2222 | 5 | yes |
GO:0060828 | regulation of canonical Wnt signaling pathway | 22.2222 | 6 | yes |
GO:0106027 | neuron projection organization | 22.2222 | 6 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 22.2222 | 6 | yes |
GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 22.2222 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 22.2222 | 6 | no |
GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
GO:0007268 | chemical synaptic transmission | 22.2222 | 6 | no |
GO:0044057 | regulation of system process | 22.2222 | 4 | no |
GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 5 | no |
GO:0099537 | trans-synaptic signaling | 22.2222 | 4 | no |
GO:0007043 | cell-cell junction assembly | 18.5185 | 6 | yes |
GO:0097061 | dendritic spine organization | 14.8148 | 5 | yes |
GO:0099173 | postsynapse organization | 14.8148 | 4 | yes |
GO:0060997 | dendritic spine morphogenesis | 11.1111 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDZD2_HUMAN | [view interactions] | Low throughput | no | yes |
ATN1_HUMAN | [view interactions] | Low throughput | no | yes |
KAISO_HUMAN | [view interactions] | Low throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
TTHY_HUMAN | [view interactions] | High throughput | no | no |
HTRA1_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DACT2_HUMAN | [view interactions] | High throughput | no | yes |
PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
LNX2_HUMAN | [view interactions] | High throughput | no | yes |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
NUD12_HUMAN | [view interactions] | High throughput | no | yes |
TRI47_HUMAN | [view interactions] | High throughput | no | yes |
THUM3_HUMAN | [view interactions] | High throughput | no | yes |
ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LEF1_HUMAN | [view interactions] | Computational | no | no |
CAD17_HUMAN | [view interactions] | Computational | no | no |
TCF7_HUMAN | [view interactions] | Computational | no | no |
TF7L1_HUMAN | [view interactions] | Computational | no | no |
RHG05_HUMAN | [view interactions] | Computational | no | yes |
CTNA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |