Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DACT1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway . The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
356 Asn Lys Neuraltubedefects(NTD) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DACT1_HUMAN
GO:0019900 kinase binding 48.0000 4 yes
GO:0019901 protein kinase binding 48.0000 5 yes
GO:0140297 DNA-binding transcription factor binding 32.0000 4 yes
GO:0045296 cadherin binding 28.0000 4 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 24.0000 5 yes
GO:0042826 histone deacetylase binding 16.0000 4 yes
GO:0005080 protein kinase C binding 12.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DACT1_HUMAN
GO:0048523 negative regulation of cellular process 84.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 84.0000 4 yes
GO:0031323 regulation of cellular metabolic process 80.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 76.0000 4 yes
GO:0080090 regulation of primary metabolic process 76.0000 4 yes
GO:0010646 regulation of cell communication 72.0000 4 yes
GO:0048522 positive regulation of cellular process 68.0000 4 yes
GO:0009966 regulation of signal transduction 64.0000 4 yes
GO:0009892 negative regulation of metabolic process 60.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 60.0000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 60.0000 5 yes
GO:0051246 regulation of protein metabolic process 60.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 56.0000 5 yes
GO:0010468 regulation of gene expression 52.0000 5 yes
GO:0051128 regulation of cellular component organization 52.0000 4 yes
GO:0008104 protein localization 52.0000 4 no
GO:0009893 positive regulation of metabolic process 48.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.0000 5 yes
GO:0051049 regulation of transport 48.0000 4 no
GO:0048585 negative regulation of response to stimulus 44.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 44.0000 5 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0009968 negative regulation of signal transduction 40.0000 5 yes
GO:0010648 negative regulation of cell communication 40.0000 5 yes
GO:0023057 negative regulation of signaling 40.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 yes
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0051248 negative regulation of protein metabolic process 40.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.0000 5 yes
GO:0016055 Wnt signaling pathway 36.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.0000 5 yes
GO:0051726 regulation of cell cycle 36.0000 4 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 36.0000 4 yes
GO:0036211 protein modification process 36.0000 4 no
GO:0043412 macromolecule modification 36.0000 4 no
GO:0045595 regulation of cell differentiation 36.0000 4 no
GO:0060341 regulation of cellular localization 36.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 36.0000 5 no
GO:0031400 negative regulation of protein modification process 36.0000 7 no
GO:0006355 regulation of DNA-templated transcription 32.0000 6 yes
GO:0009894 regulation of catabolic process 32.0000 4 yes
GO:0010647 positive regulation of cell communication 32.0000 5 yes
GO:0023056 positive regulation of signaling 32.0000 4 yes
GO:0030111 regulation of Wnt signaling pathway 32.0000 5 yes
GO:0048584 positive regulation of response to stimulus 32.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 32.0000 6 yes
GO:0051252 regulation of RNA metabolic process 32.0000 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 32.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 32.0000 6 yes
GO:0042127 regulation of cell population proliferation 32.0000 4 no
GO:0019220 regulation of phosphate metabolic process 32.0000 6 no
GO:0022607 cellular component assembly 32.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 32.0000 5 no
GO:0032880 regulation of protein localization 32.0000 5 no
GO:0009890 negative regulation of biosynthetic process 28.0000 5 yes
GO:0009967 positive regulation of signal transduction 28.0000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 28.0000 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.0000 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 28.0000 6 yes
GO:0042176 regulation of protein catabolic process 28.0000 5 yes
GO:0006796 phosphate-containing compound metabolic process 28.0000 4 no
GO:0051094 positive regulation of developmental process 28.0000 4 no
GO:0006886 intracellular protein transport 28.0000 4 no
GO:0015031 protein transport 28.0000 4 no
GO:0071702 organic substance transport 28.0000 4 no
GO:0071705 nitrogen compound transport 28.0000 4 no
GO:0010941 regulation of cell death 28.0000 4 no
GO:0030162 regulation of proteolysis 28.0000 6 no
GO:0042981 regulation of apoptotic process 28.0000 6 no
GO:0043066 negative regulation of apoptotic process 28.0000 7 no
GO:0043067 regulation of programmed cell death 28.0000 5 no
GO:0043069 negative regulation of programmed cell death 28.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 28.0000 5 no
GO:0060548 negative regulation of cell death 28.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 28.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 28.0000 6 no
GO:0045936 negative regulation of phosphate metabolic process 28.0000 7 no
GO:0006357 regulation of transcription by RNA polymerase II 24.0000 7 yes
GO:0007346 regulation of mitotic cell cycle 24.0000 5 yes
GO:0009896 positive regulation of catabolic process 24.0000 5 yes
GO:0010564 regulation of cell cycle process 24.0000 5 yes
GO:0043393 regulation of protein binding 24.0000 4 yes
GO:0045892 negative regulation of DNA-templated transcription 24.0000 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 24.0000 6 yes
GO:0051253 negative regulation of RNA metabolic process 24.0000 6 yes
GO:0060828 regulation of canonical Wnt signaling pathway 24.0000 6 yes
GO:0080134 regulation of response to stress 24.0000 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 24.0000 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 24.0000 8 yes
GO:0032386 regulation of intracellular transport 24.0000 5 no
GO:0045597 positive regulation of cell differentiation 24.0000 5 no
GO:0006468 protein phosphorylation 24.0000 5 no
GO:0016310 phosphorylation 24.0000 5 no
GO:0030030 cell projection organization 24.0000 4 no
GO:0033365 protein localization to organelle 24.0000 5 no
GO:0051050 positive regulation of transport 24.0000 4 no
GO:1903829 positive regulation of protein localization 24.0000 5 no
GO:0071310 cellular response to organic substance 24.0000 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 24.0000 7 no
GO:0000122 negative regulation of transcription by RNA polymerase II 20.0000 8 yes
GO:0030178 negative regulation of Wnt signaling pathway 20.0000 6 yes
GO:0032091 negative regulation of protein binding 20.0000 5 yes
GO:0045732 positive regulation of protein catabolic process 20.0000 6 yes
GO:0051100 negative regulation of binding 20.0000 4 yes
GO:0080135 regulation of cellular response to stress 20.0000 4 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 20.0000 7 yes
GO:1902531 regulation of intracellular signal transduction 20.0000 5 yes
GO:0030177 positive regulation of Wnt signaling pathway 16.0000 6 yes
GO:0043408 regulation of MAPK cascade 16.0000 6 yes
GO:0044087 regulation of cellular component biogenesis 16.0000 4 yes
GO:0051099 positive regulation of binding 16.0000 4 yes
GO:0051129 negative regulation of cellular component organization 16.0000 5 yes
GO:0060429 epithelium development 16.0000 4 yes
GO:2000027 regulation of animal organ morphogenesis 16.0000 5 yes
GO:0021915 neural tube development 12.0000 4 yes
GO:0031333 negative regulation of protein-containing complex assembly 12.0000 6 yes
GO:0032092 positive regulation of protein binding 12.0000 5 yes
GO:0043254 regulation of protein-containing complex assembly 12.0000 5 yes
GO:0045786 negative regulation of cell cycle 12.0000 5 yes
GO:0045930 negative regulation of mitotic cell cycle 12.0000 6 yes
GO:0090175 regulation of establishment of planar polarity 12.0000 6 yes
GO:1901987 regulation of cell cycle phase transition 12.0000 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 12.0000 6 yes
GO:1902532 negative regulation of intracellular signal transduction 12.0000 6 yes
GO:1902806 regulation of cell cycle G1/S phase transition 12.0000 7 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 12.0000 7 yes
GO:0010948 negative regulation of cell cycle process 8.0000 6 yes
GO:0032872 regulation of stress-activated MAPK cascade 8.0000 6 yes
GO:0032873 negative regulation of stress-activated MAPK cascade 8.0000 7 yes
GO:0043409 negative regulation of MAPK cascade 8.0000 7 yes
GO:0046328 regulation of JNK cascade 8.0000 7 yes
GO:0046329 negative regulation of JNK cascade 8.0000 8 yes
GO:0048619 embryonic hindgut morphogenesis 8.0000 4 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 8.0000 5 yes
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 8.0000 6 yes
GO:0090263 positive regulation of canonical Wnt signaling pathway 8.0000 7 yes
GO:1901988 negative regulation of cell cycle phase transition 8.0000 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 8.0000 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 8.0000 8 yes
GO:1904863 regulation of beta-catenin-TCF complex assembly 8.0000 6 yes
GO:1904864 negative regulation of beta-catenin-TCF complex assembly 8.0000 7 yes
GO:2000050 regulation of non-canonical Wnt signaling pathway 8.0000 6 yes
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 8.0000 7 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 8.0000 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
DVL2_HUMAN [view interactions] Low throughput no yes
VANG2_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC1_HUMAN [view interactions] Low throughput no no
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
AXIN1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
LEF1_HUMAN [view interactions] Low throughput no no
ZBT17_HUMAN [view interactions] Low throughput no yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
CG025_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
KITH_HUMAN [view interactions] High throughput no yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
DACT3_HUMAN [view interactions] High throughput no yes
DACT1_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR1_HUMAN [view interactions] High throughput no no
DACT2_HUMAN [view interactions] High throughput no yes
DVL3_HUMAN [view interactions] High throughput no yes
VANG1_HUMAN [view interactions] High throughput no no
GSK3A_HUMAN [view interactions] High throughput no yes
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CBX6_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
GRSF1_HUMAN [view interactions] High throughput no yes
BECN1_HUMAN [view interactions] High throughput no yes
PK3C3_HUMAN [view interactions] High throughput no yes
BAKOR_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
MICA1_HUMAN [view interactions] High throughput no yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
KCNE3_HUMAN [view interactions] High throughput no yes
SAHH3_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
ESF1_HUMAN [view interactions] High throughput no yes
KI20B_HUMAN [view entry] [view interactions] High throughput yes yes
RTL9_HUMAN [view interactions] High throughput no no
TOPZ1_HUMAN [view interactions] High throughput no no
ZMYM4_HUMAN [view interactions] High throughput no yes
PPR3A_HUMAN [view interactions] High throughput no no
ULK2_HUMAN [view interactions] High throughput no yes