VANG2_HUMAN
Evidence for PS localization
Functions
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VANG2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.3636 | 4 | no |
| GO:0000166 | nucleotide binding | 34.8485 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.8182 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.7879 | 6 | no |
| GO:0016462 | pyrophosphatase activity | 28.7879 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.7879 | 4 | no |
| GO:0019900 | kinase binding | 25.7576 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 24.2424 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 24.2424 | 5 | no |
| GO:0043169 | cation binding | 24.2424 | 4 | no |
| GO:0046872 | metal ion binding | 24.2424 | 5 | no |
| GO:0003924 | GTPase activity | 24.2424 | 7 | no |
| GO:0005525 | GTP binding | 24.2424 | 5 | no |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VANG2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.0909 | 4 | no |
| GO:0008104 | protein localization | 51.5152 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 46.9697 | 4 | yes |
| GO:0051049 | regulation of transport | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.4242 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.3939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.8485 | 5 | no |
| GO:0071702 | organic substance transport | 34.8485 | 4 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.8182 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.8182 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:0071705 | nitrogen compound transport | 31.8182 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3030 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.3030 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3030 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.7879 | 5 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 27.2727 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 27.2727 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 27.2727 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.7576 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.7576 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7576 | 5 | no |
| GO:0015031 | protein transport | 25.7576 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.2424 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.2424 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.7273 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2121 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 21.2121 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.2121 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.2121 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
| GO:0072657 | protein localization to membrane | 21.2121 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.2121 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 21.2121 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.2121 | 6 | no |
| GO:0031175 | neuron projection development | 16.6667 | 6 | yes |
| GO:0002009 | morphogenesis of an epithelium | 12.1212 | 4 | yes |
| GO:0016055 | Wnt signaling pathway | 12.1212 | 4 | yes |
| GO:0030031 | cell projection assembly | 12.1212 | 5 | yes |
| GO:0070925 | organelle assembly | 10.6061 | 5 | yes |
| GO:0035567 | non-canonical Wnt signaling pathway | 9.0909 | 5 | yes |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 9.0909 | 6 | yes |
| GO:0060562 | epithelial tube morphogenesis | 9.0909 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 9.0909 | 6 | yes |
| GO:0007411 | axon guidance | 6.0606 | 8 | yes |
| GO:0097485 | neuron projection guidance | 6.0606 | 7 | yes |
| GO:0001843 | neural tube closure | 4.5455 | 5 | yes |
| GO:0001947 | heart looping | 4.5455 | 5 | yes |
| GO:0003143 | embryonic heart tube morphogenesis | 4.5455 | 4 | yes |
| GO:0060606 | tube closure | 4.5455 | 4 | yes |
| GO:0045176 | apical protein localization | 3.0303 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYJ2B_HUMAN | [view interactions] | Low throughput | no | no |
| KBTB7_HUMAN | [view interactions] | Low throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | Low throughput | no | yes |
| SFRP2_HUMAN | [view interactions] | Low throughput | no | no |
| ARFRP_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUL_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DVL3_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DACT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VANG1_HUMAN | [view interactions] | Low throughput | no | no |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FZD3_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| I20RA_HUMAN | [view interactions] | High throughput | no | no |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RP9_HUMAN | [view interactions] | High throughput | no | yes |
| HFE_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| CTLA4_HUMAN | [view interactions] | High throughput | no | no |
| ABT1_HUMAN | [view interactions] | High throughput | no | no |
| TMED7_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| MOB2_HUMAN | [view interactions] | High throughput | no | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| DACT3_HUMAN | [view interactions] | High throughput | no | yes |
| DACT2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA5_HUMAN | [view interactions] | High throughput | no | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNS3_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| SV2C_HUMAN | [view interactions] | High throughput | no | no |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POPD2_HUMAN | [view interactions] | High throughput | no | no |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| LUC7L_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| FGF8_HUMAN | [view interactions] | High throughput | no | no |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| S39A8_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TNF18_HUMAN | [view interactions] | High throughput | no | no |
| NXF2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |