PLCD3_HUMAN
Evidence for PS localization
Functions
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLCD3_HUMAN |
|---|---|---|---|---|
| GO:0016301 | kinase activity | 22.2222 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 22.2222 | 4 | no |
| GO:0043168 | anion binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 7.4074 | 4 | yes |
| GO:0046872 | metal ion binding | 7.4074 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLCD3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9630 | 4 | no |
| GO:0006996 | organelle organization | 51.8519 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.1481 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.1481 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | no |
| GO:0008104 | protein localization | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | no |
| GO:0022607 | cellular component assembly | 40.7407 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0016050 | vesicle organization | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 29.6296 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.6296 | 5 | no |
| GO:0036211 | protein modification process | 25.9259 | 4 | no |
| GO:0043412 | macromolecule modification | 25.9259 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.9259 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.9259 | 6 | no |
| GO:0030030 | cell projection organization | 25.9259 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.9259 | 5 | no |
| GO:0015031 | protein transport | 25.9259 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.9259 | 4 | no |
| GO:0070925 | organelle assembly | 25.9259 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.2222 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
| GO:0016055 | Wnt signaling pathway | 22.2222 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0006886 | intracellular protein transport | 22.2222 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 18.5185 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SKIL_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFNB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC46_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFF4_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| GPAM1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| AFF1_HUMAN | [view interactions] | High throughput | no | no |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| ARK2N_HUMAN | [view interactions] | High throughput | no | yes |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| KANK1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR26_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| SHQ1_HUMAN | [view interactions] | High throughput | no | no |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT81_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| IFT52_HUMAN | [view interactions] | High throughput | no | no |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| ELL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| IFT74_HUMAN | [view interactions] | High throughput | no | yes |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| WDR70_HUMAN | [view interactions] | High throughput | no | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VANG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENL_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELL_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD9_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| TCAM2_HUMAN | [view interactions] | High throughput | no | no |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| IGDC4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAT1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| TR19L_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRPC6_HUMAN | [view interactions] | High throughput | no | no |
| PLCL2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCZ1_HUMAN | [view interactions] | High throughput | no | no |