PI42B_HUMAN
Evidence for PS localization
Functions
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed, PubMed). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed). Its GTP-sensing activity is critical for metabolic adaptation (PubMed). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PI42B_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 33.3333 | 5 | yes |
| GO:0016301 | kinase activity | 33.3333 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 30.3030 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 24.2424 | 4 | no |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | 15.1515 | 5 | yes |
| GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity | 12.1212 | 6 | yes |
| GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity | 9.0909 | 6 | yes |
| GO:0042803 | protein homodimerization activity | 9.0909 | 4 | yes |
| GO:0005525 | GTP binding | 6.0606 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 6.0606 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 6.0606 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PI42B_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 51.5152 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.5152 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 42.4242 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.4242 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.4242 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 42.4242 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.4242 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 39.3939 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0006996 | organelle organization | 36.3636 | 4 | yes |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 33.3333 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 33.3333 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 33.3333 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 33.3333 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.3030 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 30.3030 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 30.3030 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0051726 | regulation of cell cycle | 27.2727 | 4 | no |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.2727 | 5 | no |
| GO:0048015 | phosphatidylinositol-mediated signaling | 24.2424 | 5 | no |
| GO:0048017 | inositol lipid-mediated signaling | 24.2424 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.2424 | 5 | no |
| GO:0051049 | regulation of transport | 24.2424 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
| GO:0022607 | cellular component assembly | 24.2424 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.2424 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 24.2424 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 24.2424 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 24.2424 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 24.2424 | 5 | yes |
| GO:0061024 | membrane organization | 24.2424 | 4 | yes |
| GO:0015031 | protein transport | 24.2424 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.2424 | 4 | no |
| GO:0006915 | apoptotic process | 24.2424 | 4 | no |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 21.2121 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.2121 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.2121 | 4 | no |
| GO:0072657 | protein localization to membrane | 21.2121 | 4 | no |
| GO:0006661 | phosphatidylinositol biosynthetic process | 21.2121 | 6 | yes |
| GO:0008610 | lipid biosynthetic process | 21.2121 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 21.2121 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.2121 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 21.2121 | 7 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.2121 | 4 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 21.2121 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 21.2121 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 21.2121 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 21.2121 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | no |
| GO:0010941 | regulation of cell death | 21.2121 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.2121 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 18.1818 | 5 | yes |
| GO:0010506 | regulation of autophagy | 18.1818 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 18.1818 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 18.1818 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 18.1818 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 15.1515 | 6 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 15.1515 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 15.1515 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 15.1515 | 5 | yes |
| GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 15.1515 | 7 | yes |
| GO:0010508 | positive regulation of autophagy | 12.1212 | 7 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 12.1212 | 6 | yes |
| GO:0016050 | vesicle organization | 12.1212 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 12.1212 | 7 | yes |
| GO:0033673 | negative regulation of kinase activity | 12.1212 | 6 | yes |
| GO:0042326 | negative regulation of phosphorylation | 12.1212 | 8 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 12.1212 | 7 | yes |
| GO:0051348 | negative regulation of transferase activity | 12.1212 | 5 | yes |
| GO:0006906 | vesicle fusion | 9.0909 | 6 | yes |
| GO:0016239 | positive regulation of macroautophagy | 9.0909 | 8 | yes |
| GO:0019216 | regulation of lipid metabolic process | 9.0909 | 5 | yes |
| GO:0043550 | regulation of lipid kinase activity | 9.0909 | 6 | yes |
| GO:0044088 | regulation of vacuole organization | 9.0909 | 6 | yes |
| GO:0044090 | positive regulation of vacuole organization | 9.0909 | 7 | yes |
| GO:0045833 | negative regulation of lipid metabolic process | 9.0909 | 5 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 9.0909 | 5 | yes |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | 9.0909 | 6 | yes |
| GO:0048284 | organelle fusion | 9.0909 | 5 | yes |
| GO:0061025 | membrane fusion | 9.0909 | 5 | yes |
| GO:0061909 | autophagosome-lysosome fusion | 9.0909 | 7 | yes |
| GO:0090174 | organelle membrane fusion | 9.0909 | 6 | yes |
| GO:0090215 | regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity | 9.0909 | 7 | yes |
| GO:0090217 | negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity | 9.0909 | 7 | yes |
| GO:0090219 | negative regulation of lipid kinase activity | 9.0909 | 6 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 9.0909 | 4 | yes |
| GO:1900077 | negative regulation of cellular response to insulin stimulus | 9.0909 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 9.0909 | 5 | yes |
| GO:1902117 | positive regulation of organelle assembly | 9.0909 | 6 | yes |
| GO:1902633 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process | 9.0909 | 7 | yes |
| GO:1902635 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process | 9.0909 | 8 | yes |
| GO:2000785 | regulation of autophagosome assembly | 9.0909 | 6 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 9.0909 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PI42B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| SPOP_HUMAN | [view interactions] | Low throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG4C_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| PAGE1_HUMAN | [view interactions] | High throughput | no | no |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| MED18_HUMAN | [view interactions] | High throughput | no | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| MYL9_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| SCOC_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| NEMP1_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN428_HUMAN | [view interactions] | High throughput | no | yes |
| SPY4_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| HMBX1_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| IN80B_HUMAN | [view interactions] | High throughput | no | no |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CDA7L_HUMAN | [view interactions] | High throughput | no | yes |
| ZN131_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| AR6P4_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| PLCH2_HUMAN | [view interactions] | Computational | no | yes |
| PK3CG_HUMAN | [view interactions] | Computational | no | yes |
| P4K2B_HUMAN | [view interactions] | Computational | no | yes |
| PI51B_HUMAN | [view interactions] | Computational | no | yes |
| P55G_HUMAN | [view interactions] | Computational | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP4P1_HUMAN | [view interactions] | Computational | no | yes |
| MP2K6_HUMAN | [view interactions] | Computational | no | yes |
| PK3CB_HUMAN | [view interactions] | Computational | no | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P4K2A_HUMAN | [view interactions] | Computational | no | yes |
| PI3R6_HUMAN | [view interactions] | Computational | no | yes |
| PP4P2_HUMAN | [view interactions] | Computational | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLCE1_HUMAN | [view interactions] | Computational | no | yes |
| PI3R5_HUMAN | [view interactions] | Computational | no | no |
| PLCD4_HUMAN | [view interactions] | Computational | no | no |
| PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PI51A_HUMAN | [view interactions] | Computational | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CD_HUMAN | [view interactions] | Computational | no | no |
| PLCZ1_HUMAN | [view interactions] | Computational | no | no |
| FYV1_HUMAN | [view interactions] | Computational | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P85B_HUMAN | [view interactions] | Computational | no | yes |
| PLCH1_HUMAN | [view interactions] | Computational | no | no |