Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG22_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG22_HUMAN
GO:0017076 purine nucleotide binding 44.4444 4 no
GO:0032555 purine ribonucleotide binding 44.4444 4 no
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 no
GO:0005525 GTP binding 27.7778 5 no
GO:0019001 guanyl nucleotide binding 27.7778 5 no
GO:0032561 guanyl ribonucleotide binding 27.7778 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0003723 RNA binding 22.2222 4 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0005524 ATP binding 22.2222 5 no
GO:0016301 kinase activity 22.2222 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 no
GO:0030554 adenyl nucleotide binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0046872 metal ion binding 22.2222 4 no
GO:0005096 GTPase activator activity 11.1111 4 yes
GO:0030695 GTPase regulator activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG22_HUMAN
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 61.1111 4 no
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 no
GO:0010646 regulation of cell communication 55.5556 4 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 no
GO:0061024 membrane organization 44.4444 4 no
GO:0009892 negative regulation of metabolic process 38.8889 4 no
GO:0010647 positive regulation of cell communication 38.8889 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.8889 5 no
GO:0033043 regulation of organelle organization 38.8889 5 no
GO:0045595 regulation of cell differentiation 38.8889 4 no
GO:0045597 positive regulation of cell differentiation 38.8889 5 no
GO:0048584 positive regulation of response to stimulus 38.8889 4 no
GO:0051094 positive regulation of developmental process 38.8889 4 no
GO:0051130 positive regulation of cellular component organization 38.8889 5 no
GO:0006996 organelle organization 38.8889 4 no
GO:0022607 cellular component assembly 38.8889 4 no
GO:0006796 phosphate-containing compound metabolic process 38.8889 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 27.7778 5 yes
GO:0001932 regulation of protein phosphorylation 27.7778 7 no
GO:0001934 positive regulation of protein phosphorylation 27.7778 8 no
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 no
GO:0016192 vesicle-mediated transport 27.7778 4 no
GO:0031399 regulation of protein modification process 27.7778 6 no
GO:0031401 positive regulation of protein modification process 27.7778 7 no
GO:0051129 negative regulation of cellular component organization 27.7778 5 no
GO:0051252 regulation of RNA metabolic process 27.7778 5 no
GO:0071702 organic substance transport 27.7778 4 no
GO:0009894 regulation of catabolic process 27.7778 4 no
GO:0031329 regulation of cellular catabolic process 27.7778 5 no
GO:0031344 regulation of cell projection organization 27.7778 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.7778 6 no
GO:0010638 positive regulation of organelle organization 27.7778 6 no
GO:0016055 Wnt signaling pathway 27.7778 5 no
GO:0030030 cell projection organization 27.7778 4 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 27.7778 4 no
GO:0050807 regulation of synapse organization 22.2222 5 yes
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0045785 positive regulation of cell adhesion 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0031331 positive regulation of cellular catabolic process 22.2222 6 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:1902115 regulation of organelle assembly 22.2222 5 no
GO:0043085 positive regulation of catalytic activity 16.6667 4 yes
GO:0051336 regulation of hydrolase activity 16.6667 4 yes
GO:0043087 regulation of GTPase activity 11.1111 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.1111 6 yes
GO:0051345 positive regulation of hydrolase activity 11.1111 5 yes
GO:0099175 regulation of postsynapse organization 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IRPL1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
CAC1A_HUMAN [view interactions] High throughput no no
FGD3_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
CCDB1_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
DEFI6_HUMAN [view interactions] High throughput no no
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
PI42C_HUMAN [view interactions] High throughput no yes
ATF1_HUMAN [view interactions] High throughput no yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
KDM6A_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
CAF17_HUMAN [view interactions] High throughput no no
DOC11_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
ATF2_HUMAN [view interactions] High throughput no yes
SRBD1_HUMAN [view interactions] High throughput no yes
DAXX_HUMAN [view interactions] High throughput no yes
RAE1L_HUMAN [view interactions] High throughput no no
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
JUND_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
PP2BC_HUMAN [view interactions] High throughput no yes
CREB1_HUMAN [view interactions] High throughput no yes
SSBP2_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
TFCP2_HUMAN [view interactions] High throughput no no
PDD2L_HUMAN [view interactions] High throughput no yes
ERI3_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
CSTF2_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
RCN1_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
CIRBP_HUMAN [view interactions] High throughput no no
PABP2_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
CCD86_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
RBM6_HUMAN [view interactions] High throughput no yes
RS29_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
CIC_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
COAA1_HUMAN [view interactions] High throughput no no
NUP62_HUMAN [view interactions] High throughput no yes
MAEA_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
RHG28_HUMAN [view interactions] High throughput no no
RHG29_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes