Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG22_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG22_HUMAN
GO:0000166 nucleotide binding 42.1053 4 no
GO:0017076 purine nucleotide binding 42.1053 5 no
GO:0032555 purine ribonucleotide binding 42.1053 4 no
GO:0035639 purine ribonucleoside triphosphate binding 42.1053 4 no
GO:0043168 anion binding 42.1053 4 no
GO:0043169 cation binding 26.3158 4 no
GO:0046872 metal ion binding 26.3158 5 no
GO:0005525 GTP binding 26.3158 5 no
GO:0019001 guanyl nucleotide binding 26.3158 6 no
GO:0032561 guanyl ribonucleotide binding 26.3158 5 no
GO:0005524 ATP binding 21.0526 5 no
GO:0016301 kinase activity 21.0526 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.0526 4 no
GO:0030554 adenyl nucleotide binding 21.0526 6 no
GO:0032559 adenyl ribonucleotide binding 21.0526 5 no
GO:0042803 protein homodimerization activity 21.0526 4 no
GO:0003723 RNA binding 21.0526 4 no
GO:0003924 GTPase activity 21.0526 7 no
GO:0016462 pyrophosphatase activity 21.0526 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.0526 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.0526 6 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0005096 GTPase activator activity 10.5263 4 yes
GO:0030695 GTPase regulator activity 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG22_HUMAN
GO:0010646 regulation of cell communication 68.4211 4 yes
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0048523 negative regulation of cellular process 63.1579 4 no
GO:0051128 regulation of cellular component organization 57.8947 4 yes
GO:0009893 positive regulation of metabolic process 57.8947 4 no
GO:0031323 regulation of cellular metabolic process 57.8947 4 no
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0009966 regulation of signal transduction 52.6316 4 yes
GO:0080090 regulation of primary metabolic process 52.6316 4 no
GO:0008104 protein localization 47.3684 4 no
GO:0009889 regulation of biosynthetic process 47.3684 4 no
GO:0010468 regulation of gene expression 47.3684 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 no
GO:0031325 positive regulation of cellular metabolic process 47.3684 5 no
GO:0031326 regulation of cellular biosynthetic process 47.3684 5 no
GO:0006996 organelle organization 47.3684 4 no
GO:0010647 positive regulation of cell communication 42.1053 5 no
GO:0022607 cellular component assembly 42.1053 4 no
GO:0044087 regulation of cellular component biogenesis 42.1053 4 no
GO:0061024 membrane organization 42.1053 4 no
GO:0009967 positive regulation of signal transduction 36.8421 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 no
GO:0023056 positive regulation of signaling 36.8421 4 no
GO:0048584 positive regulation of response to stimulus 36.8421 4 no
GO:0071702 organic substance transport 36.8421 4 no
GO:0051130 positive regulation of cellular component organization 36.8421 5 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 yes
GO:0015031 protein transport 31.5789 4 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0071705 nitrogen compound transport 31.5789 4 no
GO:0044089 positive regulation of cellular component biogenesis 31.5789 5 no
GO:0033043 regulation of organelle organization 31.5789 5 no
GO:0048585 negative regulation of response to stimulus 31.5789 4 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0033365 protein localization to organelle 26.3158 5 no
GO:0051252 regulation of RNA metabolic process 26.3158 5 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.3158 6 no
GO:0098657 import into cell 26.3158 4 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:0006796 phosphate-containing compound metabolic process 26.3158 4 no
GO:0009894 regulation of catabolic process 26.3158 4 no
GO:0009896 positive regulation of catabolic process 26.3158 5 no
GO:0009968 negative regulation of signal transduction 26.3158 5 no
GO:0010638 positive regulation of organelle organization 26.3158 6 no
GO:0010648 negative regulation of cell communication 26.3158 5 no
GO:0023057 negative regulation of signaling 26.3158 4 no
GO:0036211 protein modification process 26.3158 4 no
GO:0043412 macromolecule modification 26.3158 4 no
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0016055 Wnt signaling pathway 26.3158 4 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0050807 regulation of synapse organization 21.0526 5 yes
GO:0006355 regulation of DNA-templated transcription 21.0526 7 no
GO:0006886 intracellular protein transport 21.0526 4 no
GO:0009891 positive regulation of biosynthetic process 21.0526 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0030100 regulation of endocytosis 21.0526 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.0526 6 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0051050 positive regulation of transport 21.0526 4 no
GO:0051051 negative regulation of transport 21.0526 4 no
GO:0072594 establishment of protein localization to organelle 21.0526 4 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0016310 phosphorylation 21.0526 5 no
GO:1902115 regulation of organelle assembly 21.0526 5 no
GO:0030030 cell projection organization 21.0526 4 no
GO:0030155 regulation of cell adhesion 21.0526 4 no
GO:0045785 positive regulation of cell adhesion 21.0526 5 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0051241 negative regulation of multicellular organismal process 21.0526 4 no
GO:0051493 regulation of cytoskeleton organization 21.0526 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.0526 5 no
GO:0010629 negative regulation of gene expression 21.0526 7 no
GO:0031327 negative regulation of cellular biosynthetic process 21.0526 6 no
GO:0043933 protein-containing complex organization 21.0526 4 no
GO:0099175 regulation of postsynapse organization 15.7895 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 10.5263 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IRPL1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
AAPK1_HUMAN [view interactions] High throughput no no
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
FGD3_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
CCDB1_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
DEFI6_HUMAN [view interactions] High throughput no no
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
PI42C_HUMAN [view interactions] High throughput no yes
ATF1_HUMAN [view interactions] High throughput no yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
KDM6A_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
CAF17_HUMAN [view interactions] High throughput no no
DOC11_HUMAN [view interactions] High throughput no yes
PLCD3_HUMAN [view entry] [view interactions] High throughput yes yes
ATF2_HUMAN [view interactions] High throughput no yes
SRBD1_HUMAN [view interactions] High throughput no yes
DAXX_HUMAN [view interactions] High throughput no yes
RAE1L_HUMAN [view interactions] High throughput no no
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
JUND_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
PP2BC_HUMAN [view interactions] High throughput no yes
CREB1_HUMAN [view interactions] High throughput no yes
SSBP2_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
TFCP2_HUMAN [view interactions] High throughput no no
PDD2L_HUMAN [view interactions] High throughput no yes
ERI3_HUMAN [view interactions] High throughput no yes
ARMC8_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
CSTF2_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
RCN1_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
CIRBP_HUMAN [view interactions] High throughput no no
PABP2_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
CCD86_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
PSPC1_HUMAN [view interactions] High throughput no yes
RBM6_HUMAN [view interactions] High throughput no yes
RS29_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
CIC_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
COAA1_HUMAN [view interactions] High throughput no no
NUP62_HUMAN [view interactions] High throughput no yes
MAEA_HUMAN [view interactions] High throughput no yes
PLD1_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
RHG28_HUMAN [view interactions] High throughput no no
RHG29_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes