Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IRPL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed). May activate the MAP kinase JNK (PubMed). Plays a role in neurite outgrowth . During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IRPL1_HUMAN
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 25.0000 4 yes
GO:0050135 NADP+ nucleosidase activity 25.0000 5 yes
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating 25.0000 5 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in IRPL1_HUMAN
GO:0051128 regulation of cellular component organization 75.0000 4 yes
GO:0031344 regulation of cell projection organization 62.5000 5 yes
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0048523 negative regulation of cellular process 62.5000 4 yes
GO:0099536 synaptic signaling 62.5000 4 yes
GO:0099537 trans-synaptic signaling 62.5000 5 yes
GO:0010975 regulation of neuron projection development 50.0000 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0022604 regulation of cell morphogenesis 50.0000 5 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0031346 positive regulation of cell projection organization 50.0000 6 yes
GO:0050807 regulation of synapse organization 50.0000 5 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0099175 regulation of postsynapse organization 50.0000 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 37.5000 5 yes
GO:0010720 positive regulation of cell development 37.5000 6 yes
GO:0010770 positive regulation of cell morphogenesis 37.5000 6 yes
GO:0030182 neuron differentiation 37.5000 4 yes
GO:0044087 regulation of cellular component biogenesis 37.5000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 37.5000 5 yes
GO:0045595 regulation of cell differentiation 37.5000 4 yes
GO:0045597 positive regulation of cell differentiation 37.5000 5 yes
GO:0048814 regulation of dendrite morphogenesis 37.5000 5 yes
GO:0050767 regulation of neurogenesis 37.5000 6 yes
GO:0050769 positive regulation of neurogenesis 37.5000 6 yes
GO:0050773 regulation of dendrite development 37.5000 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 37.5000 6 yes
GO:0051049 regulation of transport 37.5000 4 yes
GO:0051051 negative regulation of transport 37.5000 4 yes
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 yes
GO:0051960 regulation of nervous system development 37.5000 5 yes
GO:0051962 positive regulation of nervous system development 37.5000 5 yes
GO:0051963 regulation of synapse assembly 37.5000 6 yes
GO:0051965 positive regulation of synapse assembly 37.5000 6 yes
GO:0060284 regulation of cell development 37.5000 5 yes
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 yes
GO:0061024 membrane organization 37.5000 4 yes
GO:0071709 membrane assembly 37.5000 5 yes
GO:0097090 presynaptic membrane organization 37.5000 5 yes
GO:0097105 presynaptic membrane assembly 37.5000 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 37.5000 4 yes
GO:0099545 trans-synaptic signaling by trans-synaptic complex 37.5000 6 yes
GO:1901888 regulation of cell junction assembly 37.5000 5 yes
GO:1901890 positive regulation of cell junction assembly 37.5000 6 yes
GO:2000026 regulation of multicellular organismal development 37.5000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 no
GO:0017157 regulation of exocytosis 25.0000 5 yes
GO:0045920 negative regulation of exocytosis 25.0000 6 yes
GO:0051046 regulation of secretion 25.0000 5 yes
GO:0051048 negative regulation of secretion 25.0000 5 yes
GO:0099174 regulation of presynapse organization 25.0000 6 yes
GO:1903530 regulation of secretion by cell 25.0000 4 yes
GO:1903531 negative regulation of secretion by cell 25.0000 5 yes
GO:1905606 regulation of presynapse assembly 25.0000 7 yes
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0007268 chemical synaptic transmission 25.0000 7 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
NCS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG22_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
IRPL1_HUMAN [view entry] [view interactions] Low throughput yes no
TUSC3_HUMAN [view interactions] Low throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes