Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IRPL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed). May activate the MAP kinase JNK (PubMed). Plays a role in neurite outgrowth . During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IRPL1_HUMAN
GO:0019901 protein kinase binding 22.2222 5 no
GO:0035254 glutamate receptor binding 22.2222 4 no
GO:0035255 ionotropic glutamate receptor binding 22.2222 5 no
GO:0046872 metal ion binding 22.2222 4 no
GO:0003953 NAD+ nucleosidase activity 22.2222 5 yes
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 22.2222 4 yes
GO:0050135 NAD(P)+ nucleosidase activity 22.2222 5 yes
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating 22.2222 6 yes
GO:0005096 GTPase activator activity 22.2222 4 no
GO:0030695 GTPase regulator activity 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IRPL1_HUMAN
GO:0051128 regulation of cellular component organization 77.7778 4 yes
GO:0022607 cellular component assembly 55.5556 4 yes
GO:0031344 regulation of cell projection organization 55.5556 5 yes
GO:0048522 positive regulation of cellular process 55.5556 4 yes
GO:0048523 negative regulation of cellular process 55.5556 4 yes
GO:0010975 regulation of neuron projection development 44.4444 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 44.4444 4 yes
GO:0022604 regulation of cell morphogenesis 44.4444 5 yes
GO:0030182 neuron differentiation 44.4444 4 yes
GO:0031346 positive regulation of cell projection organization 44.4444 6 yes
GO:0050807 regulation of synapse organization 44.4444 5 yes
GO:0051049 regulation of transport 44.4444 4 yes
GO:0051094 positive regulation of developmental process 44.4444 4 yes
GO:0051130 positive regulation of cellular component organization 44.4444 5 yes
GO:0060627 regulation of vesicle-mediated transport 44.4444 4 yes
GO:0099175 regulation of postsynapse organization 44.4444 6 yes
GO:0099537 trans-synaptic signaling 44.4444 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 yes
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 33.3333 5 yes
GO:0010720 positive regulation of cell development 33.3333 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 33.3333 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 33.3333 7 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 yes
GO:0045595 regulation of cell differentiation 33.3333 4 yes
GO:0045597 positive regulation of cell differentiation 33.3333 5 yes
GO:0048814 regulation of dendrite morphogenesis 33.3333 5 yes
GO:0050767 regulation of neurogenesis 33.3333 6 yes
GO:0050769 positive regulation of neurogenesis 33.3333 6 yes
GO:0050773 regulation of dendrite development 33.3333 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 33.3333 6 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 yes
GO:0051960 regulation of nervous system development 33.3333 5 yes
GO:0051962 positive regulation of nervous system development 33.3333 5 yes
GO:0051963 regulation of synapse assembly 33.3333 6 yes
GO:0051965 positive regulation of synapse assembly 33.3333 6 yes
GO:0060284 regulation of cell development 33.3333 5 yes
GO:0061024 membrane organization 33.3333 4 yes
GO:0071709 membrane assembly 33.3333 5 yes
GO:0097090 presynaptic membrane organization 33.3333 5 yes
GO:0097105 presynaptic membrane assembly 33.3333 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 yes
GO:0099174 regulation of presynapse organization 33.3333 6 yes
GO:0099545 trans-synaptic signaling by trans-synaptic complex 33.3333 5 yes
GO:1901888 regulation of cell junction assembly 33.3333 5 yes
GO:1901890 positive regulation of cell junction assembly 33.3333 6 yes
GO:1905606 regulation of presynapse assembly 33.3333 7 yes
GO:2000026 regulation of multicellular organismal development 33.3333 4 yes
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0017157 regulation of exocytosis 22.2222 5 yes
GO:0045920 negative regulation of exocytosis 22.2222 6 yes
GO:0051046 regulation of secretion 22.2222 5 yes
GO:0051048 negative regulation of secretion 22.2222 5 yes
GO:1903530 regulation of secretion by cell 22.2222 4 yes
GO:1903531 negative regulation of secretion by cell 22.2222 5 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0002090 regulation of receptor internalization 22.2222 7 no
GO:0006996 organelle organization 22.2222 4 no
GO:0007399 nervous system development 22.2222 4 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0048259 regulation of receptor-mediated endocytosis 22.2222 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
NCS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG22_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
TUSC3_HUMAN [view interactions] Low throughput no yes
IRPL1_HUMAN [view entry] [view interactions] Low throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
MK08_HUMAN [view interactions] Computational no yes
IL1FA_HUMAN [view interactions] Computational no no
OPHN1_HUMAN [view entry] [view interactions] Computational yes yes