AGAP3_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGAP3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 37.5000 | 4 | yes |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0019887 | protein kinase regulator activity | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.8333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.8333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.8333 | 4 | yes |
| GO:0003723 | RNA binding | 20.8333 | 4 | no |
| GO:0005509 | calcium ion binding | 20.8333 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 16.6667 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.6667 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.6667 | 6 | yes |
| GO:0003924 | GTPase activity | 12.5000 | 7 | yes |
| GO:0005096 | GTPase activator activity | 12.5000 | 4 | yes |
| GO:0005525 | GTP binding | 12.5000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 12.5000 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 12.5000 | 4 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 12.5000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGAP3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 58.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 54.1667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.1667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 54.1667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 45.8333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.8333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 45.8333 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 45.8333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 45.8333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | no |
| GO:0008104 | protein localization | 41.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0051049 | regulation of transport | 41.6667 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 37.5000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 37.5000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 37.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 33.3333 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 33.3333 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 33.3333 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0051338 | regulation of transferase activity | 33.3333 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0050807 | regulation of synapse organization | 33.3333 | 5 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 29.1667 | 8 | no |
| GO:0015031 | protein transport | 29.1667 | 4 | no |
| GO:0042326 | negative regulation of phosphorylation | 29.1667 | 8 | no |
| GO:0043549 | regulation of kinase activity | 29.1667 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 29.1667 | 6 | no |
| GO:0071310 | cellular response to organic substance | 29.1667 | 4 | no |
| GO:0071702 | organic substance transport | 29.1667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.1667 | 4 | no |
| GO:0051050 | positive regulation of transport | 29.1667 | 4 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0099175 | regulation of postsynapse organization | 25.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.8333 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.8333 | 5 | no |
| GO:0010941 | regulation of cell death | 20.8333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.8333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.8333 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.8333 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 20.8333 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 20.8333 | 6 | no |
| GO:0033674 | positive regulation of kinase activity | 20.8333 | 6 | no |
| GO:0043270 | positive regulation of ion transport | 20.8333 | 5 | no |
| GO:0045860 | positive regulation of protein kinase activity | 20.8333 | 7 | no |
| GO:0051051 | negative regulation of transport | 20.8333 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.8333 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 20.8333 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.8333 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.8333 | 5 | no |
| GO:0006996 | organelle organization | 20.8333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0050890 | cognition | 20.8333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.8333 | 6 | no |
| GO:0000302 | response to reactive oxygen species | 12.5000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 8.3333 | 4 | yes |
| GO:0030163 | protein catabolic process | 8.3333 | 4 | yes |
| GO:0034599 | cellular response to oxidative stress | 8.3333 | 4 | yes |
| GO:0034614 | cellular response to reactive oxygen species | 8.3333 | 5 | yes |
| GO:0062197 | cellular response to chemical stress | 8.3333 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 8.3333 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AGAP3_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 8.3333 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 8.3333 | 5 | no |
| DOID:114 | heart disease | 8.3333 | 3 | no |
| DOID:2843 | long QT syndrome | 8.3333 | 6 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 8.3333 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 8.3333 | 6 | no |
| DOID:1289 | neurodegenerative disease | 8.3333 | 4 | no |
| DOID:231 | motor neuron disease | 8.3333 | 5 | no |
| DOID:331 | central nervous system disease | 8.3333 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| T22D3_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| MIER2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| RHG22_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| SPXN2_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| PAGE1_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| SKDA1_HUMAN | [view interactions] | High throughput | no | no |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CETN2_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| NCKP5_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |