Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

E41L3_HUMAN

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in E41L3_HUMAN
GO:0035639 purine ribonucleoside triphosphate binding 32.9670 4 no
GO:0017076 purine nucleotide binding 32.9670 4 no
GO:0032555 purine ribonucleotide binding 32.9670 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 26.3736 5 no
GO:0046872 metal ion binding 23.0769 4 no
GO:0005524 ATP binding 20.8791 5 no
GO:0030554 adenyl nucleotide binding 20.8791 5 no
GO:0032559 adenyl ribonucleotide binding 20.8791 5 no
GO:0003779 actin binding 16.4835 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in E41L3_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0060255 regulation of macromolecule metabolic process 60.4396 4 no
GO:0080090 regulation of primary metabolic process 59.3407 4 no
GO:0031323 regulation of cellular metabolic process 58.2418 4 no
GO:0048523 negative regulation of cellular process 58.2418 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0010646 regulation of cell communication 56.0440 4 no
GO:0009893 positive regulation of metabolic process 49.4505 4 no
GO:0009966 regulation of signal transduction 49.4505 4 no
GO:0051128 regulation of cellular component organization 47.2527 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.0549 5 no
GO:0051246 regulation of protein metabolic process 45.0549 5 no
GO:0006996 organelle organization 43.9560 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.7582 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.7582 5 no
GO:0010468 regulation of gene expression 40.6593 5 no
GO:0008104 protein localization 39.5604 4 yes
GO:0009892 negative regulation of metabolic process 39.5604 4 no
GO:0022607 cellular component assembly 38.4615 4 yes
GO:0019220 regulation of phosphate metabolic process 37.3626 6 no
GO:0051174 regulation of phosphorus metabolic process 37.3626 5 no
GO:0031324 negative regulation of cellular metabolic process 36.2637 5 no
GO:0051049 regulation of transport 36.2637 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.1648 5 no
GO:0031399 regulation of protein modification process 34.0659 6 no
GO:0042325 regulation of phosphorylation 34.0659 7 no
GO:0009889 regulation of biosynthetic process 34.0659 4 no
GO:0031326 regulation of cellular biosynthetic process 34.0659 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 32.9670 5 no
GO:0071702 organic substance transport 32.9670 4 no
GO:0048584 positive regulation of response to stimulus 32.9670 4 no
GO:0051247 positive regulation of protein metabolic process 31.8681 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8681 5 no
GO:0071705 nitrogen compound transport 31.8681 4 no
GO:0030030 cell projection organization 30.7692 4 yes
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 no
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 no
GO:0010941 regulation of cell death 29.6703 4 no
GO:0051130 positive regulation of cellular component organization 29.6703 5 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 27.4725 5 no
GO:0042981 regulation of apoptotic process 27.4725 6 no
GO:0043067 regulation of programmed cell death 27.4725 5 no
GO:0033043 regulation of organelle organization 27.4725 5 no
GO:0051094 positive regulation of developmental process 27.4725 4 no
GO:0007010 cytoskeleton organization 26.3736 5 yes
GO:0051050 positive regulation of transport 26.3736 4 no
GO:0031344 regulation of cell projection organization 26.3736 5 no
GO:0044087 regulation of cellular component biogenesis 26.3736 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.2747 6 no
GO:0042327 positive regulation of phosphorylation 25.2747 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.2747 7 no
GO:0051248 negative regulation of protein metabolic process 25.2747 6 no
GO:0015031 protein transport 25.2747 4 no
GO:0009967 positive regulation of signal transduction 25.2747 5 no
GO:0045595 regulation of cell differentiation 25.2747 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.2747 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.2747 5 no
GO:0016192 vesicle-mediated transport 25.2747 4 no
GO:0071310 cellular response to organic substance 25.2747 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.1758 4 yes
GO:0043085 positive regulation of catalytic activity 24.1758 4 no
GO:0043412 macromolecule modification 24.1758 4 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0043269 regulation of ion transport 23.0769 5 no
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0051338 regulation of transferase activity 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 6 no
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043549 regulation of kinase activity 21.9780 5 no
GO:0009894 regulation of catabolic process 21.9780 4 no
GO:0048585 negative regulation of response to stimulus 21.9780 4 no
GO:0060548 negative regulation of cell death 21.9780 5 no
GO:0009891 positive regulation of biosynthetic process 21.9780 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.9780 6 no
GO:0031175 neuron projection development 20.8791 6 no
GO:0010648 negative regulation of cell communication 20.8791 5 no
GO:0023057 negative regulation of signaling 20.8791 4 no
GO:0032880 regulation of protein localization 20.8791 5 no
GO:0060341 regulation of cellular localization 20.8791 4 no
GO:0061024 membrane organization 18.6813 4 yes
GO:0034330 cell junction organization 17.5824 4 yes
GO:0022604 regulation of cell morphogenesis 16.4835 5 yes
GO:0001558 regulation of cell growth 14.2857 4 yes
GO:0006915 apoptotic process 13.1868 4 yes
GO:0032990 cell part morphogenesis 12.0879 4 yes
GO:0048812 neuron projection morphogenesis 12.0879 7 yes
GO:0048858 cell projection morphogenesis 12.0879 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 12.0879 6 yes
GO:0034329 cell junction assembly 10.9890 5 yes
GO:0072657 protein localization to membrane 10.9890 4 yes
GO:0008360 regulation of cell shape 9.8901 6 yes
GO:0030865 cortical cytoskeleton organization 9.8901 6 yes
GO:0045216 cell-cell junction organization 7.6923 5 yes
GO:1990778 protein localization to cell periphery 7.6923 5 yes
GO:0031032 actomyosin structure organization 6.5934 4 yes
GO:0030866 cortical actin cytoskeleton organization 5.4945 4 yes
GO:0072659 protein localization to plasma membrane 5.4945 5 yes
GO:0007043 cell-cell junction assembly 4.3956 6 yes
GO:0030913 paranodal junction assembly 3.2967 4 yes
GO:0071205 protein localization to juxtaparanode region of axon 3.2967 6 yes
GO:0099612 protein localization to axon 3.2967 5 yes
GO:0002175 protein localization to paranode region of axon 2.1978 6 yes
GO:0007009 plasma membrane organization 2.1978 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in E41L3_HUMAN
DOID:114 heart disease 3.2967 3 no
DOID:0050700 cardiomyopathy 2.1978 4 no
DOID:0060036 intrinsic cardiomyopathy 2.1978 5 no
DOID:2843 long QT syndrome 2.1978 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
SPTB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] Low throughput yes yes
CADM1_HUMAN [view entry] [view interactions] Low throughput yes no
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
SMYD2_HUMAN [view interactions] Low throughput no yes
KIF1C_HUMAN [view interactions] High throughput no yes
MDEAS_HUMAN [view interactions] High throughput no yes
KIF7_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
MISP_HUMAN [view interactions] High throughput no no
PRIC3_HUMAN [view interactions] High throughput no yes
RSMN_HUMAN [view interactions] High throughput no yes
CCG5_HUMAN [view entry] [view interactions] High throughput yes no
CP2S1_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
SPTA1_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
R144A_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
UCHL3_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
SMHD1_HUMAN [view interactions] High throughput no yes
ERP44_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
SR140_HUMAN [view interactions] High throughput no yes
TAF4_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
HS12B_HUMAN [view interactions] High throughput no yes
RTF1_HUMAN [view interactions] High throughput no yes
CLK2_HUMAN [view interactions] High throughput no yes
NKAP_HUMAN [view interactions] High throughput no yes
NACAD_HUMAN [view interactions] High throughput no yes
DACH1_HUMAN [view interactions] High throughput no no
COPRS_HUMAN [view interactions] High throughput no yes
BD1L1_HUMAN [view interactions] High throughput no yes
AFF4_HUMAN [view interactions] High throughput no yes
AGAP1_HUMAN [view entry] [view interactions] High throughput yes no
TAF1B_HUMAN [view interactions] High throughput no no
AP3B2_HUMAN [view entry] [view interactions] High throughput yes yes
TAF1C_HUMAN [view interactions] High throughput no no
TAF1A_HUMAN [view interactions] High throughput no yes
E41L5_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
CHD9_HUMAN [view interactions] High throughput no yes
PPIG_HUMAN [view interactions] High throughput no yes
CXXC1_HUMAN [view interactions] High throughput no yes
RFWD3_HUMAN [view interactions] High throughput no yes
AFF1_HUMAN [view interactions] High throughput no no
ENL_HUMAN [view interactions] High throughput no yes
VANG2_HUMAN [view interactions] High throughput no no
NO40_HUMAN [view interactions] High throughput no yes
TNC18_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
TAF1D_HUMAN [view interactions] High throughput no yes
CBPC1_HUMAN [view interactions] High throughput no yes
AP3S2_HUMAN [view entry] [view interactions] High throughput yes no
SMD3_HUMAN [view interactions] High throughput no yes
KT222_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
CD6_HUMAN [view interactions] High throughput no no
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
PALS1_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
PIGR_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
AKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
GSKIP_HUMAN [view interactions] High throughput no yes
PRUN1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RHBL4_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
UN13A_HUMAN [view entry] [view interactions] High throughput yes no
CE152_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
MEIKN_HUMAN [view interactions] High throughput no no
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
SLX4_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
NUMA1_HUMAN [view interactions] High throughput no yes
GPTC8_HUMAN [view interactions] High throughput no yes
KANK1_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
VANG1_HUMAN [view interactions] High throughput no no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
SRRM1_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
PI42A_HUMAN [view entry] [view interactions] High throughput yes yes
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
WDR26_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
ICLN_HUMAN [view interactions] High throughput no yes
SAP18_HUMAN [view interactions] High throughput no yes
PININ_HUMAN [view interactions] High throughput no yes
ZRAB2_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
MMTA2_HUMAN [view interactions] High throughput no yes
DCAF1_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
PI42B_HUMAN [view entry] [view interactions] High throughput yes no
CWC22_HUMAN [view interactions] High throughput no yes
PRP4B_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
ENY2_HUMAN [view interactions] High throughput no yes
PG12A_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
LYAR_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
SRRM2_HUMAN [view interactions] High throughput no yes
SCML1_HUMAN [view interactions] High throughput no no
RSMB_HUMAN [view interactions] High throughput no yes
RBFA_HUMAN [view interactions] High throughput no yes
SCOC_HUMAN [view interactions] High throughput no yes
AF9_HUMAN [view interactions] High throughput no yes
AP3M1_HUMAN [view interactions] High throughput no yes
NAF1_HUMAN [view interactions] High throughput no yes
TAF2_HUMAN [view interactions] High throughput no no
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
DKC1_HUMAN [view interactions] High throughput no yes
CWC27_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
EI2BD_HUMAN [view interactions] High throughput no yes
SET1A_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ACINU_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
GID8_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
KIBRA_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
RHG33_HUMAN [view interactions] High throughput no yes
ARHGG_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
EF2K_HUMAN [view entry] [view interactions] High throughput yes no
NUAK1_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
HASP_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CDC5L_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
IGS21_HUMAN [view entry] [view interactions] High throughput yes no
KDM4C_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
MBIP1_HUMAN [view interactions] High throughput no yes
ATX1L_HUMAN [view interactions] High throughput no no
PAXI1_HUMAN [view interactions] High throughput no no
ITF2_HUMAN [view interactions] High throughput no yes
SPXN2_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
ASB3_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
DDAH2_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] Computational yes yes
SPTN1_HUMAN [view entry] [view interactions] Computational yes yes
CNTP1_HUMAN [view entry] [view interactions] Computational yes yes
GLPC_HUMAN [view interactions] Computational no yes