AP3M2_HUMAN

G2C

SynGO

SynaptomeDB

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 37%

Interacting region for partners were not defined.

Download full PS network for entry.

Interacting regions

Canonical [AP3M2_HUMAN]

Isoform [E7ER80] alignment

Isoform [E7ER80] sequence

Isoform [H0YBA0] alignment

Isoform [H0YBA0] sequence

Isoform [H0YAY4] alignment

Isoform [H0YAY4] sequence

Isoform [H0YBM0] alignment

Isoform [H0YBM0] sequence

Isoform [P53677-2] alignment

Isoform [P53677-2] sequence

Isoform [A0A1D5RMS9] alignment

Isoform [A0A1D5RMS9] sequence

Isoform [E5RI83] alignment

Isoform [E5RI83] sequence

Isoform [E5RJ52] alignment

Isoform [E5RJ52] sequence

Isoform [E5RGF3] alignment

Isoform [E5RGF3] sequence

LOADING 20%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

No data found.

Biological process

Show entries

Search:

Term	Name	%	Distance from top the of the tree	Annotated in AP3M2_HUMAN
GO:0008104	protein localization	66.6667	4	yes
GO:0006996	organelle organization	60.0000	4	yes
GO:0071702	organic substance transport	60.0000	4	yes
GO:0071705	nitrogen compound transport	60.0000	4	yes
GO:0006886	intracellular protein transport	53.3333	4	yes
GO:0015031	protein transport	53.3333	4	yes
GO:0008088	axo-dendritic transport	46.6667	5	yes
GO:0008089	anterograde axonal transport	46.6667	7	yes
GO:0010970	transport along microtubule	46.6667	4	yes
GO:0016050	vesicle organization	46.6667	5	yes
GO:0030705	cytoskeleton-dependent intracellular transport	46.6667	4	yes
GO:0035459	vesicle cargo loading	46.6667	4	yes
GO:0035652	clathrin-coated vesicle cargo loading	46.6667	5	yes
GO:0035654	clathrin-coated vesicle cargo loading, AP-3-mediated	46.6667	6	yes
GO:0047496	vesicle transport along microtubule	46.6667	5	yes
GO:0048490	anterograde synaptic vesicle transport	46.6667	5	yes
GO:0051650	establishment of vesicle localization	46.6667	4	yes
GO:0072384	organelle transport along microtubule	46.6667	4	yes
GO:0097479	synaptic vesicle localization	46.6667	4	yes
GO:0098930	axonal transport	46.6667	6	yes
GO:0099111	microtubule-based transport	46.6667	4	yes
GO:0099517	synaptic vesicle transport along microtubule	46.6667	4	yes
GO:0099518	vesicle cytoskeletal trafficking	46.6667	5	yes
GO:0022607	cellular component assembly	46.6667	4	no
GO:0007034	vacuolar transport	40.0000	4	no

Showing 1 to 25 of 39 entries

Disease

No data found.

Show entries

Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
ANS1B_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP3B1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP3B2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP3D1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
AP3M1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP3S1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
AP3S2_HUMAN	[view entry] [view interactions]	High throughput	yes	no
ATG9A_HUMAN	[view interactions]	High throughput	no	yes
BL1S2_HUMAN	[view interactions]	High throughput	no	yes
CAMKV_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
DHDH_HUMAN	[view interactions]	High throughput	no	no
E41L3_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
EDA_HUMAN	[view interactions]	High throughput	no	no
GRK5_HUMAN	[view interactions]	High throughput	no	yes
IQCF1_HUMAN	[view interactions]	High throughput	no	no
LYPD4_HUMAN	[view interactions]	High throughput	no	no
MEOX2_HUMAN	[view interactions]	High throughput	no	no
NKG2A_HUMAN	[view interactions]	High throughput	no	no
PLCD3_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
PRKN_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
RFA2_HUMAN	[view interactions]	High throughput	no	yes
RFA3_HUMAN	[view interactions]	High throughput	no	yes
SMAD4_HUMAN	[view interactions]	High throughput	no	yes
SNAPN_HUMAN	[view interactions]	High throughput	no	yes
SSR3_HUMAN	[view interactions]	High throughput	no	yes

Showing 1 to 25 of 31 entries

AP3M2_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

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Molecular function

Biological process

Disease

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