Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP3B2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000451 LIG_Clathr_ClatBox_1 LIG 808 812 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP3B2_HUMAN
GO:0008324 cation transmembrane transporter activity 20.8333 4 no
GO:0022890 inorganic cation transmembrane transporter activity 20.8333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP3B2_HUMAN
GO:0008104 protein localization 58.3333 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0016192 vesicle-mediated transport 45.8333 4 yes
GO:0071702 organic substance transport 45.8333 4 yes
GO:0071705 nitrogen compound transport 45.8333 4 yes
GO:0051128 regulation of cellular component organization 45.8333 4 no
GO:0015031 protein transport 41.6667 4 yes
GO:0006886 intracellular protein transport 37.5000 4 yes
GO:0022607 cellular component assembly 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0008088 axo-dendritic transport 33.3333 5 yes
GO:0010970 transport along microtubule 33.3333 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 33.3333 4 yes
GO:0072384 organelle transport along microtubule 33.3333 4 yes
GO:0098930 axonal transport 33.3333 6 yes
GO:0099111 microtubule-based transport 33.3333 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0008089 anterograde axonal transport 29.1667 7 yes
GO:0047496 vesicle transport along microtubule 29.1667 5 yes
GO:0048489 synaptic vesicle transport 29.1667 4 yes
GO:0048490 anterograde synaptic vesicle transport 29.1667 7 yes
GO:0051650 establishment of vesicle localization 29.1667 4 yes
GO:0097479 synaptic vesicle localization 29.1667 4 yes
GO:0099514 synaptic vesicle cytoskeletal transport 29.1667 5 yes
GO:0099517 synaptic vesicle transport along microtubule 29.1667 6 yes
GO:0099518 vesicle cytoskeletal trafficking 29.1667 5 yes
GO:0043269 regulation of ion transport 29.1667 5 no
GO:0006996 organelle organization 29.1667 4 no
GO:0009966 regulation of signal transduction 29.1667 4 no
GO:0010468 regulation of gene expression 29.1667 5 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0050804 modulation of chemical synaptic transmission 29.1667 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0099177 regulation of trans-synaptic signaling 29.1667 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0043933 protein-containing complex organization 20.8333 4 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:0009889 regulation of biosynthetic process 20.8333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.8333 5 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 20.8333 6 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0031344 regulation of cell projection organization 20.8333 5 no
GO:0031399 regulation of protein modification process 20.8333 6 no
GO:0034330 cell junction organization 20.8333 4 no
GO:0036211 protein modification process 20.8333 4 no
GO:0042325 regulation of phosphorylation 20.8333 7 no
GO:0042327 positive regulation of phosphorylation 20.8333 8 no
GO:0043412 macromolecule modification 20.8333 4 no
GO:0045937 positive regulation of phosphate metabolic process 20.8333 7 no
GO:0050890 cognition 20.8333 4 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0051246 regulation of protein metabolic process 20.8333 5 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:0010647 positive regulation of cell communication 20.8333 5 no
GO:0023056 positive regulation of signaling 20.8333 4 no
GO:0032990 cell part morphogenesis 20.8333 4 no
GO:0048812 neuron projection morphogenesis 20.8333 7 no
GO:0048858 cell projection morphogenesis 20.8333 5 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.8333 6 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ATM_HUMAN [view interactions] Low throughput no yes
RUFY1_HUMAN [view interactions] Low throughput no yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
PREX1_HUMAN [view entry] [view interactions] Low throughput yes no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
AP3M1_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
DAXX_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SEC62_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
CR3L3_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
IKBL1_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
BL1S2_HUMAN [view interactions] High throughput no yes
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
SNAPN_HUMAN [view interactions] High throughput no yes
TNKS1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
ARF3_HUMAN [view entry] [view interactions] Computational yes no
AP4M1_HUMAN [view interactions] Computational no yes
ARF1_HUMAN [view entry] [view interactions] Computational yes yes
AP3B1_HUMAN [view entry] [view interactions] Computational yes yes
AP3S2_HUMAN [view entry] [view interactions] Computational yes no
AP4E1_HUMAN [view interactions] Computational no no