Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP3B2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000451 LIG_Clathr_ClatBox_1 LIG 808 812 -
ELMI000451 LIG_Clathr_ClatBox_1 LIG 808 812 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AP3B2_HUMAN
GO:0005216 monoatomic ion channel activity 25.0000 4 no
GO:0005261 monoatomic cation channel activity 25.0000 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 25.0000 4 no
GO:0015267 channel activity 25.0000 4 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 20.8333 5 no
GO:0019900 kinase binding 20.8333 4 no
GO:0003779 actin binding 20.8333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AP3B2_HUMAN
GO:0022607 cellular component assembly 58.3333 4 no
GO:0048522 positive regulation of cellular process 54.1667 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 45.8333 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0071702 organic substance transport 37.5000 4 yes
GO:0071705 nitrogen compound transport 37.5000 4 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0016050 vesicle organization 33.3333 5 yes
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0008088 axo-dendritic transport 29.1667 5 yes
GO:0010970 transport along microtubule 29.1667 4 yes
GO:0015031 protein transport 29.1667 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 29.1667 4 yes
GO:0051650 establishment of vesicle localization 29.1667 4 yes
GO:0072384 organelle transport along microtubule 29.1667 4 yes
GO:0097479 synaptic vesicle localization 29.1667 4 yes
GO:0098930 axonal transport 29.1667 6 yes
GO:0099111 microtubule-based transport 29.1667 4 yes
GO:0098657 import into cell 29.1667 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.1667 4 no
GO:0051049 regulation of transport 29.1667 4 no
GO:0010647 positive regulation of cell communication 29.1667 5 no
GO:0023056 positive regulation of signaling 29.1667 4 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0051246 regulation of protein metabolic process 29.1667 5 no
GO:0051247 positive regulation of protein metabolic process 29.1667 6 no
GO:0050804 modulation of chemical synaptic transmission 29.1667 5 no
GO:0099177 regulation of trans-synaptic signaling 29.1667 4 no
GO:0006886 intracellular protein transport 25.0000 4 yes
GO:0008089 anterograde axonal transport 25.0000 7 yes
GO:0047496 vesicle transport along microtubule 25.0000 5 yes
GO:0048490 anterograde synaptic vesicle transport 25.0000 5 yes
GO:0099517 synaptic vesicle transport along microtubule 25.0000 4 yes
GO:0099518 vesicle cytoskeletal trafficking 25.0000 5 yes
GO:0006811 monoatomic ion transport 25.0000 4 no
GO:0006812 monoatomic cation transport 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0006901 vesicle coating 20.8333 6 yes
GO:0035459 vesicle cargo loading 20.8333 4 yes
GO:0035652 clathrin-coated vesicle cargo loading 20.8333 5 yes
GO:0035654 clathrin-coated vesicle cargo loading, AP-3-mediated 20.8333 6 yes
GO:0036211 protein modification process 20.8333 4 no
GO:0043412 macromolecule modification 20.8333 4 no
GO:0006355 regulation of DNA-templated transcription 20.8333 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0030001 metal ion transport 20.8333 6 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0070925 organelle assembly 20.8333 5 no
GO:0072657 protein localization to membrane 20.8333 4 no
GO:0098655 monoatomic cation transmembrane transport 20.8333 4 no
GO:0098662 inorganic cation transmembrane transport 20.8333 4 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0044087 regulation of cellular component biogenesis 20.8333 4 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.8333 6 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0009892 negative regulation of metabolic process 20.8333 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0031324 negative regulation of cellular metabolic process 20.8333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0001934 positive regulation of protein phosphorylation 20.8333 8 no
GO:0009967 positive regulation of signal transduction 20.8333 5 no
GO:0050808 synapse organization 20.8333 5 no
GO:0048812 neuron projection morphogenesis 20.8333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.8333 4 no
GO:0050806 positive regulation of synaptic transmission 20.8333 5 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0016183 synaptic vesicle coating 16.6667 7 yes
GO:0036465 synaptic vesicle recycling 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ATM_HUMAN [view interactions] Low throughput no yes
RUFY1_HUMAN [view interactions] Low throughput no yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
PREX1_HUMAN [view entry] [view interactions] Low throughput yes no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
AP3M1_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTCS_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CHD8_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
DAXX_HUMAN [view interactions] High throughput no yes
EDA_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
SEC62_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
CR3L3_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
IKBL1_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
PLD1_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
KAT6A_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
BL1S2_HUMAN [view interactions] High throughput no yes
AP3M2_HUMAN [view entry] [view interactions] High throughput yes yes
SNAPN_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no