SYT2_HUMAN
Evidence for PS localization
Functions
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 307 | Asp | Ala | Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) | - |
| 308 | Pro | Leu | Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) | - |
| 365 | Leu | Pro | Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 28.5714 | 4 | yes |
| GO:0046872 | metal ion binding | 28.5714 | 5 | yes |
| GO:0043168 | anion binding | 24.4898 | 4 | yes |
| GO:0019900 | kinase binding | 20.4082 | 4 | no |
| GO:0005509 | calcium ion binding | 16.3265 | 6 | yes |
| GO:0019905 | syntaxin binding | 16.3265 | 4 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 8.1633 | 4 | yes |
| GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding | 4.0816 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.1020 | 4 | yes |
| GO:0051049 | regulation of transport | 51.0204 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.0204 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.8980 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.8163 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.7755 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.7347 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.7347 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.7347 | 5 | no |
| GO:0006996 | organelle organization | 32.6531 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.6531 | 5 | no |
| GO:0022607 | cellular component assembly | 32.6531 | 4 | no |
| GO:0023056 | positive regulation of signaling | 32.6531 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.6531 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 32.6531 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6531 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.6531 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.6122 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.6122 | 5 | no |
| GO:0098657 | import into cell | 28.5714 | 4 | yes |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.5306 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.5306 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.5306 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.5306 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5306 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.5306 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.5306 | 4 | no |
| GO:0010038 | response to metal ion | 24.4898 | 4 | yes |
| GO:0051046 | regulation of secretion | 24.4898 | 5 | yes |
| GO:0008104 | protein localization | 24.4898 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 24.4898 | 4 | no |
| GO:0071702 | organic substance transport | 24.4898 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.4898 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.4898 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.4898 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 24.4898 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.4898 | 5 | no |
| GO:0010468 | regulation of gene expression | 24.4898 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.4898 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4898 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.4898 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 22.4490 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 22.4490 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 22.4490 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 22.4490 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.4490 | 4 | no |
| GO:0043412 | macromolecule modification | 22.4490 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.4490 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.4490 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.4490 | 7 | no |
| GO:1903530 | regulation of secretion by cell | 20.4082 | 4 | yes |
| GO:0015031 | protein transport | 20.4082 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 20.4082 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 20.4082 | 5 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 20.4082 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
| GO:0036211 | protein modification process | 20.4082 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.4082 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.4082 | 6 | no |
| GO:0051338 | regulation of transferase activity | 20.4082 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.4082 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.4082 | 8 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.4082 | 5 | no |
| GO:0051592 | response to calcium ion | 18.3673 | 5 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 16.3265 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 16.3265 | 5 | yes |
| GO:0023061 | signal release | 16.3265 | 4 | yes |
| GO:0045055 | regulated exocytosis | 16.3265 | 4 | yes |
| GO:0046903 | secretion | 16.3265 | 4 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 16.3265 | 5 | yes |
| GO:0099643 | signal release from synapse | 16.3265 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 16.3265 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 14.2857 | 5 | yes |
| GO:0051952 | regulation of amine transport | 14.2857 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 12.2449 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 12.2449 | 4 | yes |
| GO:0050433 | regulation of catecholamine secretion | 12.2449 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 12.2449 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 12.2449 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 12.2449 | 6 | yes |
| GO:0014059 | regulation of dopamine secretion | 10.2041 | 6 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 10.2041 | 7 | yes |
| GO:0045927 | positive regulation of growth | 10.2041 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 10.2041 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 10.2041 | 5 | yes |
| GO:0001558 | regulation of cell growth | 8.1633 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 8.1633 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 8.1633 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 6.1224 | 5 | yes |
| GO:1903859 | regulation of dendrite extension | 6.1224 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 6.1224 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCAM5_HUMAN | [view interactions] | Low throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
| STON2_HUMAN | [view interactions] | Low throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACADL_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAUF_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| CC167_HUMAN | [view interactions] | High throughput | no | yes |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| S35A1_HUMAN | [view interactions] | High throughput | no | no |
| T229B_HUMAN | [view interactions] | High throughput | no | yes |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| ORML3_HUMAN | [view interactions] | High throughput | no | no |
| ITAM_HUMAN | [view interactions] | High throughput | no | no |
| CKLF3_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO2_HUMAN | [view interactions] | High throughput | no | no |
| THS7B_HUMAN | [view interactions] | High throughput | no | no |
| AQP10_HUMAN | [view interactions] | High throughput | no | no |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT8_HUMAN | [view interactions] | High throughput | no | no |
| CLD4_HUMAN | [view interactions] | High throughput | no | yes |
| FA2H_HUMAN | [view interactions] | High throughput | no | yes |
| PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
| S35A4_HUMAN | [view interactions] | High throughput | no | no |
| FUND2_HUMAN | [view interactions] | High throughput | no | yes |
| TM107_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PMP22_HUMAN | [view interactions] | High throughput | no | no |
| VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAT_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| AFF4_HUMAN | [view interactions] | High throughput | no | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| DACH1_HUMAN | [view interactions] | High throughput | no | no |
| APBA2_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG10_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| SMG5_HUMAN | [view interactions] | High throughput | no | no |
| BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
| AFF3_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| LENG8_HUMAN | [view interactions] | High throughput | no | yes |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| EXOG_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR55_HUMAN | [view interactions] | High throughput | no | yes |
| FIBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| BOD1_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| ENL_HUMAN | [view interactions] | High throughput | no | yes |
| ADNP_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| MIER1_HUMAN | [view interactions] | High throughput | no | no |
| VLDLR_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| MTHR_HUMAN | [view interactions] | High throughput | no | yes |
| ARK2N_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPB_HUMAN | [view interactions] | High throughput | no | yes |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| EAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ERN1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD9_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| DCA16_HUMAN | [view interactions] | High throughput | no | no |
| C2CD5_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| BOP1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| GPTC2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR70_HUMAN | [view interactions] | High throughput | no | no |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L3_HUMAN | [view interactions] | High throughput | no | no |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| UTP25_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| IFT46_HUMAN | [view interactions] | High throughput | no | no |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| UB2Q1_HUMAN | [view interactions] | High throughput | no | no |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KANK1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| CA052_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| SYT5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL3_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |