Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYT2_HUMAN

GO
G2C
SynGO

Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties . May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

Position Amino acid Mutation Disease Overlap with binding region
307 Asp Ala Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) -
308 Pro Leu Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) -
365 Leu Pro Myasthenicsyndrome,congenital,7A,presynaptic,anddistalmotorneuropathy,autosomaldominant(CMS7A) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SYT2_HUMAN
GO:0046872 metal ion binding 30.6122 4 yes
GO:0019900 kinase binding 24.4898 4 no
GO:0005509 calcium ion binding 22.4490 5 yes
GO:0019905 syntaxin binding 16.3265 4 yes
GO:0005544 calcium-dependent phospholipid binding 10.2041 4 yes
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding 4.0816 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYT2_HUMAN
GO:0048522 positive regulation of cellular process 59.1837 4 yes
GO:0010646 regulation of cell communication 55.1020 4 no
GO:0051049 regulation of transport 51.0204 4 yes
GO:0051128 regulation of cellular component organization 46.9388 4 yes
GO:0016192 vesicle-mediated transport 40.8163 4 yes
GO:0050804 modulation of chemical synaptic transmission 40.8163 5 no
GO:0099177 regulation of trans-synaptic signaling 40.8163 4 no
GO:0060255 regulation of macromolecule metabolic process 40.8163 4 no
GO:0043269 regulation of ion transport 38.7755 5 yes
GO:0009966 regulation of signal transduction 38.7755 4 no
GO:0048523 negative regulation of cellular process 34.6939 4 no
GO:0031323 regulation of cellular metabolic process 34.6939 4 no
GO:0051171 regulation of nitrogen compound metabolic process 34.6939 4 no
GO:0080090 regulation of primary metabolic process 34.6939 4 no
GO:0051046 regulation of secretion 32.6531 5 yes
GO:0010647 positive regulation of cell communication 32.6531 5 no
GO:0023056 positive regulation of signaling 32.6531 4 no
GO:0051050 positive regulation of transport 32.6531 4 no
GO:0060627 regulation of vesicle-mediated transport 30.6122 4 yes
GO:0006996 organelle organization 30.6122 4 no
GO:0051246 regulation of protein metabolic process 30.6122 5 no
GO:0010038 response to metal ion 28.5714 4 yes
GO:0046903 secretion 28.5714 4 yes
GO:1903530 regulation of secretion by cell 28.5714 4 yes
GO:0008104 protein localization 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0017157 regulation of exocytosis 26.5306 5 yes
GO:0023061 signal release 26.5306 4 yes
GO:0099643 signal release from synapse 26.5306 5 yes
GO:0022607 cellular component assembly 26.5306 4 no
GO:0010468 regulation of gene expression 26.5306 5 no
GO:0010604 positive regulation of macromolecule metabolic process 26.5306 5 no
GO:0031325 positive regulation of cellular metabolic process 26.5306 5 no
GO:0006887 exocytosis 24.4898 4 yes
GO:0045055 regulated exocytosis 24.4898 5 yes
GO:0099003 vesicle-mediated transport in synapse 24.4898 5 yes
GO:0015031 protein transport 24.4898 4 no
GO:0044087 regulation of cellular component biogenesis 24.4898 4 no
GO:0099537 trans-synaptic signaling 24.4898 4 no
GO:0043270 positive regulation of ion transport 24.4898 5 no
GO:0043412 macromolecule modification 24.4898 4 no
GO:0048584 positive regulation of response to stimulus 24.4898 4 no
GO:0050806 positive regulation of synaptic transmission 24.4898 5 no
GO:0009892 negative regulation of metabolic process 24.4898 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.4898 5 no
GO:0019220 regulation of phosphate metabolic process 24.4898 6 no
GO:0031399 regulation of protein modification process 24.4898 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.4898 5 no
GO:0051174 regulation of phosphorus metabolic process 24.4898 5 no
GO:1902531 regulation of intracellular signal transduction 24.4898 5 no
GO:0006897 endocytosis 22.4490 5 yes
GO:0051094 positive regulation of developmental process 22.4490 4 yes
GO:0007268 chemical synaptic transmission 22.4490 6 no
GO:0043933 protein-containing complex organization 22.4490 4 no
GO:0098916 anterograde trans-synaptic signaling 22.4490 5 no
GO:0010959 regulation of metal ion transport 22.4490 6 no
GO:0034762 regulation of transmembrane transport 22.4490 4 no
GO:0034765 regulation of ion transmembrane transport 22.4490 5 no
GO:0036211 protein modification process 22.4490 4 no
GO:0051336 regulation of hydrolase activity 22.4490 4 no
GO:0061024 membrane organization 22.4490 4 no
GO:0042325 regulation of phosphorylation 22.4490 7 no
GO:0051130 positive regulation of cellular component organization 22.4490 5 no
GO:0051247 positive regulation of protein metabolic process 22.4490 6 no
GO:0016079 synaptic vesicle exocytosis 20.4082 4 yes
GO:0051592 response to calcium ion 20.4082 5 yes
GO:0009967 positive regulation of signal transduction 20.4082 5 no
GO:0022898 regulation of transmembrane transporter activity 20.4082 4 no
GO:1904062 regulation of cation transmembrane transport 20.4082 6 no
GO:0031344 regulation of cell projection organization 20.4082 5 no
GO:0032880 regulation of protein localization 20.4082 5 no
GO:0050890 cognition 20.4082 4 no
GO:0060341 regulation of cellular localization 20.4082 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.4082 6 no
GO:0001932 regulation of protein phosphorylation 20.4082 7 no
GO:0010562 positive regulation of phosphorus metabolic process 20.4082 6 no
GO:0045937 positive regulation of phosphate metabolic process 20.4082 7 no
GO:0031324 negative regulation of cellular metabolic process 20.4082 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.4082 5 no
GO:0051588 regulation of neurotransmitter transport 20.4082 5 no
GO:0017156 calcium-ion regulated exocytosis 18.3673 6 yes
GO:1903305 regulation of regulated secretory pathway 18.3673 6 yes
GO:0048488 synaptic vesicle endocytosis 16.3265 5 yes
GO:0051952 regulation of amine transport 16.3265 5 yes
GO:0071241 cellular response to inorganic substance 16.3265 4 yes
GO:0071248 cellular response to metal ion 16.3265 5 yes
GO:0140238 presynaptic endocytosis 16.3265 4 yes
GO:0050433 regulation of catecholamine secretion 14.2857 5 yes
GO:0014059 regulation of dopamine secretion 12.2449 6 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 12.2449 7 yes
GO:0048638 regulation of developmental growth 10.2041 4 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 10.2041 5 yes
GO:0071277 cellular response to calcium ion 10.2041 6 yes
GO:0001558 regulation of cell growth 8.1633 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 8.1633 4 yes
GO:0030307 positive regulation of cell growth 8.1633 5 yes
GO:0045927 positive regulation of growth 8.1633 4 yes
GO:0048639 positive regulation of developmental growth 8.1633 5 yes
GO:0022604 regulation of cell morphogenesis 6.1224 5 yes
GO:1903859 regulation of dendrite extension 6.1224 5 yes
GO:1903861 positive regulation of dendrite extension 6.1224 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in SYT2_HUMAN
DOID:331 central nervous system disease 6.1224 3 no
DOID:936 brain disease 6.1224 4 no
DOID:1826 epilepsy 4.0816 5 no
DOID:0110659 congenital myasthenic syndrome 7 4.0816 8 yes
DOID:3635 congenital myasthenic syndrome 4.0816 7 yes
DOID:439 neuromuscular junction disease 4.0816 6 yes
DOID:440 neuromuscular disease 4.0816 5 yes
DOID:574 peripheral nervous system disease 4.0816 3 yes
DOID:870 neuropathy 4.0816 4 yes
DOID:0050700 cardiomyopathy 4.0816 4 no
DOID:0060036 intrinsic cardiomyopathy 4.0816 5 no
DOID:114 heart disease 4.0816 3 no
DOID:2843 long QT syndrome 4.0816 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WNK1_HUMAN [view entry] [view interactions] Low throughput yes no
SCAM5_HUMAN [view interactions] Low throughput no yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN1B_HUMAN [view interactions] Low throughput no no
STON2_HUMAN [view interactions] Low throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
ACADL_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
CC167_HUMAN [view interactions] High throughput no yes
MALL_HUMAN [view interactions] High throughput no no
MIP_HUMAN [view interactions] High throughput no no
S35A1_HUMAN [view interactions] High throughput no no
T229B_HUMAN [view interactions] High throughput no yes
TRFE_HUMAN [view interactions] High throughput no no
ORML3_HUMAN [view interactions] High throughput no no
ITAM_HUMAN [view interactions] High throughput no no
CKLF3_HUMAN [view interactions] High throughput no yes
TSPO2_HUMAN [view interactions] High throughput no no
THS7B_HUMAN [view interactions] High throughput no no
AQP10_HUMAN [view interactions] High throughput no no
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT8_HUMAN [view interactions] High throughput no no
CLD4_HUMAN [view interactions] High throughput no yes
FA2H_HUMAN [view interactions] High throughput no yes
PLPP4_HUMAN [view interactions] High throughput no yes
S35A4_HUMAN [view interactions] High throughput no no
FUND2_HUMAN [view interactions] High throughput no yes
TM107_HUMAN [view interactions] High throughput no yes
BNIP2_HUMAN [view interactions] High throughput no yes
PMP22_HUMAN [view interactions] High throughput no no
VAMP4_HUMAN [view interactions] High throughput no yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
LAT_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
ARI1_HUMAN [view interactions] High throughput no yes
AFF4_HUMAN [view interactions] High throughput no yes
NOLC1_HUMAN [view interactions] High throughput no yes
DACH1_HUMAN [view interactions] High throughput no no
APBA2_HUMAN [view interactions] High throughput no yes
PAF1_HUMAN [view interactions] High throughput no yes
RHG10_HUMAN [view interactions] High throughput no no
M4K4_HUMAN [view interactions] High throughput no yes
SAHH3_HUMAN [view interactions] High throughput no yes
SMG5_HUMAN [view interactions] High throughput no no
BRPF1_HUMAN [view interactions] High throughput no yes
AFF3_HUMAN [view interactions] High throughput no yes
ROR1_HUMAN [view interactions] High throughput no no
LENG8_HUMAN [view interactions] High throughput no yes
SIR1_HUMAN [view interactions] High throughput no yes
TM10A_HUMAN [view interactions] High throughput no no
CSN6_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
PPM1G_HUMAN [view interactions] High throughput no no
EXOG_HUMAN [view interactions] High throughput no yes
MADD_HUMAN [view entry] [view interactions] High throughput yes yes
WDR55_HUMAN [view interactions] High throughput no yes
FIBP_HUMAN [view entry] [view interactions] High throughput yes yes
CTDP1_HUMAN [view interactions] High throughput no yes
BOD1_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
EI2BA_HUMAN [view interactions] High throughput no yes
ENL_HUMAN [view interactions] High throughput no yes
ADNP_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
CYBC1_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no yes
DCAF5_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
CWC22_HUMAN [view interactions] High throughput no yes
MIER1_HUMAN [view interactions] High throughput no no
VLDLR_HUMAN [view interactions] High throughput no yes
HDGR2_HUMAN [view interactions] High throughput no yes
MTHR_HUMAN [view interactions] High throughput no yes
CR025_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
RTF1_HUMAN [view interactions] High throughput no yes
CENPB_HUMAN [view interactions] High throughput no yes
AF9_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD18_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
EAF2_HUMAN [view interactions] High throughput no yes
ERN1_HUMAN [view interactions] High throughput no yes
CHD9_HUMAN [view interactions] High throughput no yes
AP3B2_HUMAN [view entry] [view interactions] High throughput yes yes
LEO1_HUMAN [view interactions] High throughput no yes
CSN7A_HUMAN [view interactions] High throughput no yes
DCA16_HUMAN [view interactions] High throughput no no
C2CD5_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
BOP1_HUMAN [view interactions] High throughput no yes
NAF1_HUMAN [view interactions] High throughput no yes
E41L5_HUMAN [view interactions] High throughput no no
GPBL1_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
CERS6_HUMAN [view interactions] High throughput no yes
UB2R2_HUMAN [view interactions] High throughput no no
GPTC2_HUMAN [view interactions] High throughput no yes
WDR70_HUMAN [view interactions] High throughput no no
RBP10_HUMAN [view interactions] High throughput no no
SET1A_HUMAN [view interactions] High throughput no yes
CSN2_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
NP1L3_HUMAN [view interactions] High throughput no no
CTR9_HUMAN [view interactions] High throughput no yes
UTP25_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
NAA15_HUMAN [view interactions] High throughput no yes
IFT46_HUMAN [view interactions] High throughput no no
RBM25_HUMAN [view interactions] High throughput no yes
UB2Q1_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
CSN4_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
KANK1_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
EI2BD_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
GPTC8_HUMAN [view interactions] High throughput no yes
CWC27_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
CA052_HUMAN [view interactions] High throughput no yes
CSN7B_HUMAN [view interactions] High throughput no yes
SYT5_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
CX6A1_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS5_HUMAN [view interactions] High throughput no yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL3_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
SYN1_HUMAN [view entry] [view interactions] Computational yes no
STX1B_HUMAN [view entry] [view interactions] Computational yes yes
VAMP1_HUMAN [view interactions] Computational no no
SCG1_HUMAN [view interactions] Computational no no
SYT11_HUMAN [view entry] [view interactions] Computational yes yes
CMGA_HUMAN [view interactions] Computational no yes
STON1_HUMAN [view interactions] Computational no yes
UN13B_HUMAN [view interactions] Computational no no
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
CPLX1_HUMAN [view entry] [view interactions] Computational yes yes
SYN2_HUMAN [view entry] [view interactions] Computational yes no