SYT5_HUMAN
Evidence for PS localization
Functions
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT5_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 73.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 73.3333 | 5 | yes |
| GO:0005509 | calcium ion binding | 46.6667 | 6 | yes |
| GO:0043168 | anion binding | 40.0000 | 4 | yes |
| GO:0019905 | syntaxin binding | 33.3333 | 4 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 26.6667 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 26.6667 | 4 | no |
| GO:0005261 | monoatomic cation channel activity | 26.6667 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.6667 | 4 | no |
| GO:0015267 | channel activity | 26.6667 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.6667 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 26.6667 | 5 | no |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 20.0000 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 20.0000 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 20.0000 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 20.0000 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 20.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT5_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 80.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0098657 | import into cell | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | no |
| GO:0010038 | response to metal ion | 46.6667 | 4 | yes |
| GO:0051592 | response to calcium ion | 46.6667 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 46.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 46.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.6667 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 46.6667 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 46.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.6667 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 40.0000 | 5 | no |
| GO:0044057 | regulation of system process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0023061 | signal release | 33.3333 | 4 | yes |
| GO:0046903 | secretion | 33.3333 | 4 | yes |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
| GO:0051952 | regulation of amine transport | 33.3333 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 33.3333 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 33.3333 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 33.3333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 33.3333 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 33.3333 | 4 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 33.3333 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 33.3333 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
| GO:0043270 | positive regulation of monoatomic ion transport | 33.3333 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.6667 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.6667 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.6667 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 26.6667 | 4 | no |
| GO:0050890 | cognition | 26.6667 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0048638 | regulation of developmental growth | 26.6667 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 26.6667 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 26.6667 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 26.6667 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
| GO:0014059 | regulation of dopamine secretion | 26.6667 | 6 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 26.6667 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 26.6667 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 26.6667 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 26.6667 | 7 | yes |
| GO:0045055 | regulated exocytosis | 26.6667 | 4 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 26.6667 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 26.6667 | 5 | yes |
| GO:0050433 | regulation of catecholamine secretion | 26.6667 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 26.6667 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 26.6667 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 26.6667 | 6 | yes |
| GO:0099643 | signal release from synapse | 26.6667 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 26.6667 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 26.6667 | 6 | yes |
| GO:0006811 | monoatomic ion transport | 26.6667 | 4 | no |
| GO:0006812 | monoatomic cation transport | 26.6667 | 5 | no |
| GO:0006937 | regulation of muscle contraction | 26.6667 | 6 | no |
| GO:0006942 | regulation of striated muscle contraction | 26.6667 | 7 | no |
| GO:0008016 | regulation of heart contraction | 26.6667 | 6 | no |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 26.6667 | 6 | no |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 26.6667 | 7 | no |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 26.6667 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 26.6667 | 6 | no |
| GO:0019722 | calcium-mediated signaling | 26.6667 | 5 | no |
| GO:0030001 | metal ion transport | 26.6667 | 6 | no |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 26.6667 | 5 | no |
| GO:0051282 | regulation of sequestering of calcium ion | 26.6667 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 26.6667 | 7 | no |
| GO:0055117 | regulation of cardiac muscle contraction | 26.6667 | 7 | no |
| GO:0090257 | regulation of muscle system process | 26.6667 | 5 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 26.6667 | 7 | no |
| GO:1903522 | regulation of blood circulation | 26.6667 | 5 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 26.6667 | 6 | no |
| GO:0000086 | G2/M transition of mitotic cell cycle | 26.6667 | 5 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 26.6667 | 8 | no |
| GO:0005513 | detection of calcium ion | 26.6667 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0010799 | regulation of peptidyl-threonine phosphorylation | 26.6667 | 8 | no |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 26.6667 | 9 | no |
| GO:0031400 | negative regulation of protein modification process | 26.6667 | 7 | no |
| GO:0032411 | positive regulation of transporter activity | 26.6667 | 4 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 26.6667 | 5 | no |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 26.6667 | 6 | no |
| GO:0042326 | negative regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0043549 | regulation of kinase activity | 26.6667 | 5 | no |
| GO:0044772 | mitotic cell cycle phase transition | 26.6667 | 4 | no |
| GO:0044839 | cell cycle G2/M phase transition | 26.6667 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 26.6667 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0050848 | regulation of calcium-mediated signaling | 26.6667 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.6667 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.6667 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 26.6667 | 7 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.0000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 20.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 20.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYT5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RPAB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEUR2_HUMAN | [view interactions] | High throughput | no | no |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |