SYT5_HUMAN
Evidence for PS localization
Functions
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT5_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 59.0909 | 4 | yes |
| GO:0019905 | syntaxin binding | 36.3636 | 4 | yes |
| GO:0005509 | calcium ion binding | 31.8182 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 27.2727 | 5 | no |
| GO:0005261 | cation channel activity | 22.7273 | 5 | no |
| GO:0015267 | channel activity | 22.7273 | 4 | no |
| GO:0017075 | syntaxin-1 binding | 22.7273 | 5 | no |
| GO:0019900 | kinase binding | 22.7273 | 4 | no |
| GO:0005216 | ion channel activity | 22.7273 | 4 | no |
| GO:0005544 | calcium-dependent phospholipid binding | 18.1818 | 4 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 13.6364 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 13.6364 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 13.6364 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 13.6364 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 13.6364 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT5_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 81.8182 | 4 | yes |
| GO:0043269 | regulation of ion transport | 77.2727 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 72.7273 | 4 | no |
| GO:0010646 | regulation of cell communication | 59.0909 | 4 | no |
| GO:0051050 | positive regulation of transport | 54.5455 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 50.0000 | 4 | yes |
| GO:0051046 | regulation of secretion | 50.0000 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 45.4545 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 45.4545 | 4 | no |
| GO:0043270 | positive regulation of ion transport | 45.4545 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 40.9091 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.9091 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 40.9091 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 40.9091 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 40.9091 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 40.9091 | 5 | yes |
| GO:0023061 | signal release | 40.9091 | 4 | yes |
| GO:0046903 | secretion | 40.9091 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 36.3636 | 5 | yes |
| GO:0099643 | signal release from synapse | 36.3636 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 36.3636 | 6 | yes |
| GO:0006996 | organelle organization | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0023056 | positive regulation of signaling | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0006887 | exocytosis | 36.3636 | 4 | yes |
| GO:0006897 | endocytosis | 36.3636 | 5 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 36.3636 | 4 | yes |
| GO:0045055 | regulated exocytosis | 36.3636 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 31.8182 | 6 | no |
| GO:0044057 | regulation of system process | 31.8182 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.8182 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 31.8182 | 6 | no |
| GO:0010038 | response to metal ion | 31.8182 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 31.8182 | 6 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 31.8182 | 7 | yes |
| GO:0051592 | response to calcium ion | 31.8182 | 5 | yes |
| GO:0051952 | regulation of amine transport | 31.8182 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 27.2727 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 27.2727 | 4 | yes |
| GO:0140238 | presynaptic endocytosis | 27.2727 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 27.2727 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 27.2727 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 27.2727 | 5 | no |
| GO:0034767 | positive regulation of ion transmembrane transport | 27.2727 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 27.2727 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.2727 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.2727 | 5 | no |
| GO:0051924 | regulation of calcium ion transport | 27.2727 | 7 | no |
| GO:0080090 | regulation of primary metabolic process | 27.2727 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:2001257 | regulation of cation channel activity | 27.2727 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0071702 | organic substance transport | 27.2727 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | no |
| GO:0072657 | protein localization to membrane | 27.2727 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 27.2727 | 6 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 27.2727 | 5 | yes |
| GO:0032880 | regulation of protein localization | 22.7273 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.7273 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.7273 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 22.7273 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.7273 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 22.7273 | 7 | no |
| GO:0032411 | positive regulation of transporter activity | 22.7273 | 4 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 22.7273 | 5 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 22.7273 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0051726 | regulation of cell cycle | 22.7273 | 4 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 22.7273 | 7 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 22.7273 | 7 | no |
| GO:2001259 | positive regulation of cation channel activity | 22.7273 | 6 | no |
| GO:0015031 | protein transport | 22.7273 | 4 | no |
| GO:0051047 | positive regulation of secretion | 22.7273 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | no |
| GO:0006811 | ion transport | 22.7273 | 4 | no |
| GO:0006812 | cation transport | 22.7273 | 5 | no |
| GO:0030001 | metal ion transport | 22.7273 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 22.7273 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.7273 | 4 | no |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 22.7273 | 5 | yes |
| GO:0050433 | regulation of catecholamine secretion | 22.7273 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 18.1818 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 18.1818 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 18.1818 | 6 | yes |
| GO:0014059 | regulation of dopamine secretion | 18.1818 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYT5_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 9.0909 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 9.0909 | 5 | no |
| DOID:114 | heart disease | 9.0909 | 3 | no |
| DOID:2843 | long QT syndrome | 9.0909 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYT5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RPAB1_HUMAN | [view interactions] | High throughput | no | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| PALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEUR2_HUMAN | [view interactions] | High throughput | no | no |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| INS_HUMAN | [view interactions] | Computational | no | no |