MYPR_HUMAN
Evidence for PS localization
Functions
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYPR_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.7273 | 4 | no |
| GO:0019900 | kinase binding | 20.4545 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYPR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 43.1818 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 36.3636 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.0909 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | yes |
| GO:0006996 | organelle organization | 31.8182 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 31.8182 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.5455 | 5 | yes |
| GO:0030030 | cell projection organization | 29.5455 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.5455 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 29.5455 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.5455 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.5455 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.5455 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.5455 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.5455 | 6 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | yes |
| GO:0031175 | neuron projection development | 27.2727 | 6 | yes |
| GO:0043269 | regulation of ion transport | 27.2727 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0008104 | protein localization | 22.7273 | 4 | no |
| GO:0010941 | regulation of cell death | 22.7273 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.7273 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 22.7273 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.7273 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.4545 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.4545 | 7 | no |
| GO:0010975 | regulation of neuron projection development | 20.4545 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 20.4545 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.4545 | 5 | no |
| GO:0061024 | membrane organization | 20.4545 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 20.4545 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.4545 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.4545 | 4 | no |
| GO:0023056 | positive regulation of signaling | 20.4545 | 4 | no |
| GO:0050890 | cognition | 20.4545 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.4545 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.4545 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 18.1818 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 15.9091 | 6 | yes |
| GO:0030334 | regulation of cell migration | 15.9091 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 15.9091 | 5 | yes |
| GO:0043270 | positive regulation of ion transport | 15.9091 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 15.9091 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 15.9091 | 6 | yes |
| GO:2000145 | regulation of cell motility | 15.9091 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 13.6364 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 13.6364 | 5 | yes |
| GO:0021762 | substantia nigra development | 11.3636 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 11.3636 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 11.3636 | 4 | yes |
| GO:0042552 | myelination | 11.3636 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 11.3636 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 9.0909 | 5 | yes |
| GO:0021782 | glial cell development | 9.0909 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 9.0909 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 9.0909 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 9.0909 | 7 | yes |
| GO:0061564 | axon development | 9.0909 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 9.0909 | 7 | yes |
| GO:0006954 | inflammatory response | 6.8182 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 6.8182 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 6.8182 | 4 | yes |
| GO:0014002 | astrocyte development | 6.8182 | 5 | yes |
| GO:0016053 | organic acid biosynthetic process | 6.8182 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 6.8182 | 6 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 6.8182 | 6 | yes |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 6.8182 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 6.8182 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 6.8182 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 6.8182 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 6.8182 | 7 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 4.5455 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 4.5455 | 4 | yes |
| GO:0006633 | fatty acid biosynthetic process | 4.5455 | 5 | yes |
| GO:0022010 | central nervous system myelination | 4.5455 | 5 | yes |
| GO:0032291 | axon ensheathment in central nervous system | 4.5455 | 4 | yes |
| GO:0042759 | long-chain fatty acid biosynthetic process | 4.5455 | 6 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 4.5455 | 6 | yes |
| GO:0098990 | AMPA selective glutamate receptor signaling pathway | 4.5455 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYPR_HUMAN |
|---|---|---|---|---|
| DOID:440 | neuromuscular disease | 4.5455 | 5 | no |
| DOID:574 | peripheral nervous system disease | 4.5455 | 3 | no |
| DOID:870 | neuropathy | 4.5455 | 4 | no |
| DOID:331 | central nervous system disease | 4.5455 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| MYPR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITAV_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB5_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR_HUMAN | [view interactions] | Low throughput | no | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CATD_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRN_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L13_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
| CLN8_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| TYRP2_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| BIK_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| RNF24_HUMAN | [view interactions] | High throughput | no | yes |
| HYAS3_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| S41A3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR27_HUMAN | [view interactions] | High throughput | no | no |
| FCRL2_HUMAN | [view interactions] | High throughput | no | no |
| TM254_HUMAN | [view interactions] | High throughput | no | yes |
| IR3IP_HUMAN | [view interactions] | High throughput | no | yes |
| T106C_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| TM243_HUMAN | [view interactions] | High throughput | no | no |
| DYSF_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP10_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| MOT8_HUMAN | [view interactions] | High throughput | no | no |
| MS4A3_HUMAN | [view interactions] | High throughput | no | no |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| GPR61_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| PI16_HUMAN | [view interactions] | High throughput | no | no |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| CLD2_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| TM182_HUMAN | [view interactions] | High throughput | no | no |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| CLD20_HUMAN | [view interactions] | High throughput | no | no |
| FNDC9_HUMAN | [view interactions] | High throughput | no | no |
| S35E3_HUMAN | [view interactions] | High throughput | no | no |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| MYADM_HUMAN | [view interactions] | High throughput | no | no |
| SPNS3_HUMAN | [view interactions] | High throughput | no | no |
| AGRG3_HUMAN | [view interactions] | High throughput | no | no |
| CABP8_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| GAST_HUMAN | [view interactions] | High throughput | no | no |
| MUC1_HUMAN | [view interactions] | High throughput | no | no |
| PIGP_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| LEUTX_HUMAN | [view interactions] | High throughput | no | no |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| S35E2_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| SMIM3_HUMAN | [view interactions] | High throughput | no | no |
| APH1A_HUMAN | [view interactions] | High throughput | no | yes |
| APH1B_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GALD1_HUMAN | [view interactions] | High throughput | no | yes |
| STRP1_HUMAN | [view interactions] | High throughput | no | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U2AF1_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX10_HUMAN | [view interactions] | Computational | no | yes |
| PLP2_HUMAN | [view interactions] | Computational | no | yes |
| PLLP_HUMAN | [view entry] [view interactions] | Computational | yes | no |