MYPR_HUMAN
Evidence for PS localization
Functions
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYPR_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 23.9130 | 4 | no |
| GO:0046872 | metal ion binding | 23.9130 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYPR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.6957 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0051049 | regulation of transport | 43.4783 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 36.9565 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 36.9565 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 36.9565 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.9565 | 4 | no |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.6087 | 5 | yes |
| GO:0006996 | organelle organization | 32.6087 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | yes |
| GO:0030030 | cell projection organization | 30.4348 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.2609 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.2609 | 4 | yes |
| GO:0010468 | regulation of gene expression | 28.2609 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2609 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 28.2609 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.2609 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0031175 | neuron projection development | 26.0870 | 6 | yes |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.9130 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.9130 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.9130 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.9130 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 23.9130 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.9130 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.9130 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.9130 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.9130 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 19.5652 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 19.5652 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 19.5652 | 7 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 19.5652 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 17.3913 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 15.2174 | 6 | yes |
| GO:0030334 | regulation of cell migration | 15.2174 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 15.2174 | 5 | yes |
| GO:2000145 | regulation of cell motility | 15.2174 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 13.0435 | 7 | yes |
| GO:0030335 | positive regulation of cell migration | 13.0435 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 13.0435 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 13.0435 | 6 | yes |
| GO:0099536 | synaptic signaling | 13.0435 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 13.0435 | 5 | yes |
| GO:2000147 | positive regulation of cell motility | 13.0435 | 5 | yes |
| GO:0021762 | substantia nigra development | 10.8696 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 10.8696 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 10.8696 | 5 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 10.8696 | 6 | yes |
| GO:0019752 | carboxylic acid metabolic process | 8.6957 | 5 | yes |
| GO:0021782 | glial cell development | 8.6957 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 8.6957 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 8.6957 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 8.6957 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 8.6957 | 7 | yes |
| GO:0061564 | axon development | 8.6957 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 8.6957 | 7 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 6.5217 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 6.5217 | 4 | yes |
| GO:0006954 | inflammatory response | 6.5217 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 6.5217 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 6.5217 | 4 | yes |
| GO:0014002 | astrocyte development | 6.5217 | 5 | yes |
| GO:0016053 | organic acid biosynthetic process | 6.5217 | 4 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 6.5217 | 6 | yes |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | 6.5217 | 4 | yes |
| GO:0042552 | myelination | 6.5217 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 6.5217 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 6.5217 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 6.5217 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 6.5217 | 7 | yes |
| GO:0006633 | fatty acid biosynthetic process | 4.3478 | 5 | yes |
| GO:0022010 | central nervous system myelination | 4.3478 | 5 | yes |
| GO:0032291 | axon ensheathment in central nervous system | 4.3478 | 4 | yes |
| GO:0042759 | long-chain fatty acid biosynthetic process | 4.3478 | 6 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 4.3478 | 6 | yes |
| GO:0098990 | AMPA selective glutamate receptor signaling pathway | 4.3478 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYPR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITAV_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB5_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CATD_HUMAN | [view interactions] | Low throughput | no | yes |
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRN_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L13_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLN8_HUMAN | [view interactions] | High throughput | no | no |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| TYRP2_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| BIK_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| RNF24_HUMAN | [view interactions] | High throughput | no | yes |
| HYAS3_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| S41A3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR27_HUMAN | [view interactions] | High throughput | no | no |
| FCRL2_HUMAN | [view interactions] | High throughput | no | no |
| TM254_HUMAN | [view interactions] | High throughput | no | yes |
| IR3IP_HUMAN | [view interactions] | High throughput | no | yes |
| T106C_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| TM243_HUMAN | [view interactions] | High throughput | no | no |
| DYSF_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP10_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| MOT8_HUMAN | [view interactions] | High throughput | no | no |
| MS4A3_HUMAN | [view interactions] | High throughput | no | no |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| GPR61_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| PI16_HUMAN | [view interactions] | High throughput | no | no |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| CLD2_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| TM182_HUMAN | [view interactions] | High throughput | no | no |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| CLD20_HUMAN | [view interactions] | High throughput | no | no |
| FNDC9_HUMAN | [view interactions] | High throughput | no | no |
| S35E3_HUMAN | [view interactions] | High throughput | no | no |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| MYADM_HUMAN | [view interactions] | High throughput | no | no |
| SPNS3_HUMAN | [view interactions] | High throughput | no | no |
| AGRG3_HUMAN | [view interactions] | High throughput | no | no |
| CABP8_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| GAST_HUMAN | [view interactions] | High throughput | no | no |
| MUC1_HUMAN | [view interactions] | High throughput | no | no |
| PIGP_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| LEUTX_HUMAN | [view interactions] | High throughput | no | no |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| S35E2_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| SMIM3_HUMAN | [view interactions] | High throughput | no | no |
| APH1A_HUMAN | [view interactions] | High throughput | no | yes |
| APH1B_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIKE1_HUMAN | [view interactions] | High throughput | no | yes |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GALD1_HUMAN | [view interactions] | High throughput | no | yes |
| STRP1_HUMAN | [view interactions] | High throughput | no | yes |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U2AF1_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |