AP3S1_HUMAN
Evidence for PS localization
Functions
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP3S1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 21.0526 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP3S1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 59.6491 | 4 | yes |
| GO:0071702 | organic substance transport | 52.6316 | 4 | yes |
| GO:0015031 | protein transport | 50.8772 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.8772 | 4 | yes |
| GO:0006886 | intracellular protein transport | 47.3684 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 47.3684 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 43.8596 | 4 | no |
| GO:0006996 | organelle organization | 40.3509 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.5965 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.5965 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.5965 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.8421 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0877 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.5789 | 4 | no |
| GO:0006897 | endocytosis | 29.8246 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 29.8246 | 4 | no |
| GO:0051049 | regulation of transport | 28.0702 | 4 | no |
| GO:0022607 | cellular component assembly | 26.3158 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.5614 | 5 | no |
| GO:0010646 | regulation of cell communication | 24.5614 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.5614 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5614 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 22.8070 | 6 | no |
| GO:0009966 | regulation of signal transduction | 22.8070 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.8070 | 4 | no |
| GO:0061024 | membrane organization | 22.8070 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.8070 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.8070 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.0526 | 5 | no |
| GO:0010970 | transport along microtubule | 17.5439 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 17.5439 | 4 | yes |
| GO:0099111 | microtubule-based transport | 17.5439 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 15.7895 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 15.7895 | 4 | yes |
| GO:0007034 | vacuolar transport | 14.0351 | 4 | yes |
| GO:0047496 | vesicle transport along microtubule | 14.0351 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 14.0351 | 4 | yes |
| GO:0098930 | axonal transport | 14.0351 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 14.0351 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 12.2807 | 7 | yes |
| GO:0048193 | Golgi vesicle transport | 12.2807 | 5 | yes |
| GO:0048489 | synaptic vesicle transport | 12.2807 | 4 | yes |
| GO:0048490 | anterograde synaptic vesicle transport | 12.2807 | 7 | yes |
| GO:0097479 | synaptic vesicle localization | 12.2807 | 4 | yes |
| GO:0099514 | synaptic vesicle cytoskeletal transport | 12.2807 | 5 | yes |
| GO:0099517 | synaptic vesicle transport along microtubule | 12.2807 | 6 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 10.5263 | 6 | yes |
| GO:0006896 | Golgi to vacuole transport | 8.7719 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 5.2632 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 5.2632 | 5 | yes |
| GO:0008286 | insulin receptor signaling pathway | 3.5088 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RNF13_HUMAN | [view interactions] | Low throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | Low throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
| K1107_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CD14_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK11_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| RN167_HUMAN | [view interactions] | High throughput | no | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGSF6_HUMAN | [view interactions] | High throughput | no | no |
| MUC20_HUMAN | [view interactions] | High throughput | no | no |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS5_HUMAN | [view interactions] | High throughput | no | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHJ1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| CHODL_HUMAN | [view interactions] | High throughput | no | no |
| ZN460_HUMAN | [view interactions] | High throughput | no | no |
| WDR55_HUMAN | [view interactions] | High throughput | no | yes |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| SCOC_HUMAN | [view interactions] | High throughput | no | yes |
| ENY2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AFTIN_HUMAN | [view interactions] | Computational | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TFR1_HUMAN | [view interactions] | Computational | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MPRI_HUMAN | [view interactions] | Computational | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P3C2A_HUMAN | [view interactions] | Computational | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP5S1_HUMAN | [view interactions] | Computational | no | yes |
| AP1M2_HUMAN | [view interactions] | Computational | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP3S2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNX5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NECP1_HUMAN | [view interactions] | Computational | no | no |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OCRL_HUMAN | [view interactions] | Computational | no | yes |
| AP4M1_HUMAN | [view interactions] | Computational | no | yes |
| AP5M1_HUMAN | [view interactions] | Computational | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP5B1_HUMAN | [view interactions] | Computational | no | yes |
| SORT_HUMAN | [view interactions] | Computational | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CBPD_HUMAN | [view interactions] | Computational | no | yes |
| YIPF6_HUMAN | [view interactions] | Computational | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |