AP3S1_HUMAN
Evidence for PS localization
Functions
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP3S1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 36.1702 | 4 | no |
| GO:0043168 | anion binding | 36.1702 | 4 | no |
| GO:0017076 | purine nucleotide binding | 34.0426 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 34.0426 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.7872 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.4043 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.4043 | 5 | no |
| GO:0019900 | kinase binding | 21.2766 | 4 | no |
| GO:0019901 | protein kinase binding | 21.2766 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP3S1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 57.4468 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.0638 | 4 | no |
| GO:0008104 | protein localization | 51.0638 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.9362 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.6809 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.6809 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5532 | 4 | no |
| GO:0071702 | organic substance transport | 42.5532 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.4255 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.4255 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.2979 | 4 | no |
| GO:0015031 | protein transport | 38.2979 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.1702 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.1702 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.1702 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.1702 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0426 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0426 | 6 | no |
| GO:0006886 | intracellular protein transport | 34.0426 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 31.9149 | 5 | no |
| GO:0022607 | cellular component assembly | 31.9149 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.6596 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.5319 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.5319 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.5319 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.5319 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.5319 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.5319 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.5319 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.5319 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.5319 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5319 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.5319 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.4043 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.4043 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.4043 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.4043 | 6 | no |
| GO:0033365 | protein localization to organelle | 23.4043 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.4043 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 23.4043 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.4043 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.4043 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.4043 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.4043 | 4 | no |
| GO:0051049 | regulation of transport | 23.4043 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.4043 | 4 | no |
| GO:0016050 | vesicle organization | 23.4043 | 5 | yes |
| GO:0099111 | microtubule-based transport | 21.2766 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2766 | 4 | no |
| GO:0036211 | protein modification process | 21.2766 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2766 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.2766 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.2766 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.2766 | 5 | no |
| GO:0010970 | transport along microtubule | 21.2766 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 21.2766 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 19.1489 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 19.1489 | 5 | yes |
| GO:0098930 | axonal transport | 17.0213 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 17.0213 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 17.0213 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 17.0213 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 14.8936 | 4 | yes |
| GO:0099517 | synaptic vesicle transport along microtubule | 14.8936 | 4 | yes |
| GO:0007034 | vacuolar transport | 14.8936 | 4 | yes |
| GO:0008089 | anterograde axonal transport | 14.8936 | 7 | yes |
| GO:0048490 | anterograde synaptic vesicle transport | 14.8936 | 5 | yes |
| GO:0070925 | organelle assembly | 14.8936 | 5 | yes |
| GO:0035459 | vesicle cargo loading | 12.7660 | 4 | yes |
| GO:0035652 | clathrin-coated vesicle cargo loading | 12.7660 | 5 | yes |
| GO:0035654 | clathrin-coated vesicle cargo loading, AP-3-mediated | 12.7660 | 6 | yes |
| GO:0032438 | melanosome organization | 10.6383 | 7 | yes |
| GO:0033363 | secretory granule organization | 10.6383 | 6 | yes |
| GO:0048753 | pigment granule organization | 10.6383 | 6 | yes |
| GO:0060155 | platelet dense granule organization | 10.6383 | 7 | yes |
| GO:1903232 | melanosome assembly | 8.5106 | 6 | yes |
| GO:0006901 | vesicle coating | 8.5106 | 6 | yes |
| GO:0016183 | synaptic vesicle coating | 8.5106 | 7 | yes |
| GO:0036465 | synaptic vesicle recycling | 8.5106 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 6.3830 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 6.3830 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 4.2553 | 4 | yes |
| GO:0006896 | Golgi to vacuole transport | 4.2553 | 5 | yes |
| GO:0008286 | insulin receptor signaling pathway | 4.2553 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF13_HUMAN | [view interactions] | Low throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHJ1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| CHODL_HUMAN | [view interactions] | High throughput | no | no |
| ZN460_HUMAN | [view interactions] | High throughput | no | no |
| WDR55_HUMAN | [view interactions] | High throughput | no | yes |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| SCOC_HUMAN | [view interactions] | High throughput | no | yes |
| ENY2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTTG_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| NKAP_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD8_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CD14_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| KLK11_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| AP3B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| RN167_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGSF6_HUMAN | [view interactions] | High throughput | no | no |
| MUC20_HUMAN | [view interactions] | High throughput | no | no |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KB_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS5_HUMAN | [view interactions] | High throughput | no | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |