CCG5_HUMAN
Evidence for PS localization
Functions
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CCG5_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 50.0000 | 4 | yes |
| GO:0005261 | cation channel activity | 50.0000 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0001540 | amyloid-beta binding | 40.0000 | 4 | no |
| GO:0004970 | ionotropic glutamate receptor activity | 40.0000 | 5 | no |
| GO:0004971 | AMPA glutamate receptor activity | 40.0000 | 6 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 40.0000 | 6 | no |
| GO:0008066 | glutamate receptor activity | 40.0000 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 40.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 40.0000 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 40.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 40.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 40.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CCG5_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0008104 | protein localization | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0006897 | endocytosis | 30.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | yes |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0030162 | regulation of proteolysis | 30.0000 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.0000 | 5 | no |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 30.0000 | 7 | no |
| GO:0042176 | regulation of protein catabolic process | 30.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0061136 | regulation of proteasomal protein catabolic process | 30.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 30.0000 | 7 | no |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 30.0000 | 6 | no |
| GO:0007215 | glutamate receptor signaling pathway | 30.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.0000 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 20.0000 | 6 | yes |
| GO:0015031 | protein transport | 20.0000 | 4 | yes |
| GO:0031623 | receptor internalization | 20.0000 | 7 | yes |
| GO:0033365 | protein localization to organelle | 20.0000 | 5 | yes |
| GO:0071702 | organic substance transport | 20.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZN775_HUMAN | [view interactions] | High throughput | no | no |
| ABT1_HUMAN | [view interactions] | High throughput | no | no |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| STN1_HUMAN | [view interactions] | High throughput | no | no |
| HELZ2_HUMAN | [view interactions] | High throughput | no | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| ZC3H3_HUMAN | [view interactions] | High throughput | no | yes |
| M18BP_HUMAN | [view interactions] | High throughput | no | yes |
| ZN770_HUMAN | [view interactions] | High throughput | no | yes |
| TTLL5_HUMAN | [view interactions] | High throughput | no | yes |
| MBLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CTC1_HUMAN | [view interactions] | High throughput | no | no |
| ZN267_HUMAN | [view interactions] | High throughput | no | yes |
| ZN445_HUMAN | [view interactions] | High throughput | no | no |
| ZN142_HUMAN | [view interactions] | High throughput | no | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN865_HUMAN | [view interactions] | High throughput | no | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| SGPL1_HUMAN | [view interactions] | High throughput | no | yes |
| Z324A_HUMAN | [view interactions] | High throughput | no | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| P52K_HUMAN | [view interactions] | High throughput | no | yes |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| RPOM_HUMAN | [view interactions] | High throughput | no | yes |
| ZN316_HUMAN | [view interactions] | High throughput | no | no |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| MCM10_HUMAN | [view interactions] | High throughput | no | no |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| RABEK_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN574_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| CEP78_HUMAN | [view interactions] | High throughput | no | yes |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |