Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG5_HUMAN
GO:0003779 actin binding 33.3333 4 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 33.3333 6 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CCG5_HUMAN
GO:0008104 protein localization 83.3333 4 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0098657 import into cell 50.0000 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0007010 cytoskeleton organization 50.0000 5 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0030162 regulation of proteolysis 50.0000 6 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 50.0000 6 no
GO:0042176 regulation of protein catabolic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0061136 regulation of proteasomal protein catabolic process 50.0000 6 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 50.0000 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 50.0000 5 no
GO:0006886 intracellular protein transport 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0033365 protein localization to organelle 33.3333 5 yes
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0048812 neuron projection morphogenesis 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0090304 nucleic acid metabolic process 33.3333 4 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009896 positive regulation of catabolic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0016055 Wnt signaling pathway 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0030111 regulation of Wnt signaling pathway 33.3333 5 no
GO:0030177 positive regulation of Wnt signaling pathway 33.3333 6 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 33.3333 7 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0045732 positive regulation of protein catabolic process 33.3333 6 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060828 regulation of canonical Wnt signaling pathway 33.3333 6 no
GO:0071363 cellular response to growth factor stimulus 33.3333 4 no
GO:0090263 positive regulation of canonical Wnt signaling pathway 33.3333 7 no
GO:1901800 positive regulation of proteasomal protein catabolic process 33.3333 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 33.3333 8 no
GO:1990089 response to nerve growth factor 33.3333 4 no
GO:1990090 cellular response to nerve growth factor stimulus 33.3333 5 no
GO:2000050 regulation of non-canonical Wnt signaling pathway 33.3333 6 no
GO:2000052 positive regulation of non-canonical Wnt signaling pathway 33.3333 7 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 33.3333 6 no
GO:0022607 cellular component assembly 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ZN316_HUMAN [view interactions] High throughput no no
RPOM_HUMAN [view interactions] High throughput no yes
PLD2_HUMAN [view interactions] High throughput no yes
P52K_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
Z324A_HUMAN [view interactions] High throughput no no
SGPL1_HUMAN [view interactions] High throughput no yes
CISD3_HUMAN [view interactions] High throughput no yes
ZN865_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
PK3CB_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
ZN142_HUMAN [view interactions] High throughput no no
ZN445_HUMAN [view interactions] High throughput no no
ZN267_HUMAN [view interactions] High throughput no yes
CTC1_HUMAN [view interactions] High throughput no no
MBLC2_HUMAN [view interactions] High throughput no yes
TTLL5_HUMAN [view interactions] High throughput no yes
ZN770_HUMAN [view interactions] High throughput no yes
M18BP_HUMAN [view interactions] High throughput no yes
ZC3H3_HUMAN [view interactions] High throughput no yes
RN166_HUMAN [view interactions] High throughput no no
ZN775_HUMAN [view interactions] High throughput no no
HELZ2_HUMAN [view interactions] High throughput no no
STN1_HUMAN [view interactions] High throughput no no
TSR3_HUMAN [view interactions] High throughput no yes
ABT1_HUMAN [view interactions] High throughput no no
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
PLD1_HUMAN [view interactions] High throughput no no
ARG39_HUMAN [view interactions] High throughput no yes
MCM10_HUMAN [view interactions] High throughput no no
TRRAP_HUMAN [view interactions] High throughput no no
RABEK_HUMAN [view interactions] High throughput no yes
JIP4_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
ZN574_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G3_HUMAN [view interactions] High throughput no yes
CEP78_HUMAN [view interactions] High throughput no yes