Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SCAI_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SCAI_HUMAN
GO:0046872 metal ion binding 36.8421 4 no
GO:0003677 DNA binding 26.3158 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0043565 sequence-specific DNA binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SCAI_HUMAN
GO:0048523 negative regulation of cellular process 63.1579 4 yes
GO:0010646 regulation of cell communication 52.6316 4 yes
GO:0048522 positive regulation of cellular process 52.6316 4 no
GO:0009892 negative regulation of metabolic process 47.3684 4 no
GO:0031323 regulation of cellular metabolic process 47.3684 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 no
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0009966 regulation of signal transduction 42.1053 4 yes
GO:0009893 positive regulation of metabolic process 42.1053 4 no
GO:0010468 regulation of gene expression 42.1053 5 no
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 no
GO:0010605 negative regulation of macromolecule metabolic process 42.1053 5 no
GO:0031324 negative regulation of cellular metabolic process 42.1053 5 no
GO:0080090 regulation of primary metabolic process 42.1053 4 no
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0051049 regulation of transport 36.8421 4 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 yes
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051252 regulation of RNA metabolic process 31.5789 5 no
GO:0022607 cellular component assembly 31.5789 4 no
GO:0010648 negative regulation of cell communication 26.3158 5 yes
GO:0023057 negative regulation of signaling 26.3158 4 yes
GO:0048585 negative regulation of response to stimulus 26.3158 4 yes
GO:0090304 nucleic acid metabolic process 26.3158 4 yes
GO:2000145 regulation of cell motility 26.3158 4 yes
GO:0006355 regulation of DNA-templated transcription 26.3158 6 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0031328 positive regulation of cellular biosynthetic process 26.3158 6 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.3158 6 no
GO:0051247 positive regulation of protein metabolic process 26.3158 6 no
GO:1903506 regulation of nucleic acid-templated transcription 26.3158 7 no
GO:2001141 regulation of RNA biosynthetic process 26.3158 6 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0050804 modulation of chemical synaptic transmission 26.3158 5 no
GO:0051726 regulation of cell cycle 26.3158 4 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0099177 regulation of trans-synaptic signaling 26.3158 4 no
GO:0051128 regulation of cellular component organization 26.3158 4 no
GO:0030334 regulation of cell migration 21.0526 5 yes
GO:0046578 regulation of Ras protein signal transduction 21.0526 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 21.0526 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.0526 7 no
GO:0009894 regulation of catabolic process 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0031667 response to nutrient levels 21.0526 4 no
GO:0036211 protein modification process 21.0526 4 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0045893 positive regulation of DNA-templated transcription 21.0526 7 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0051254 positive regulation of RNA metabolic process 21.0526 6 no
GO:1902680 positive regulation of RNA biosynthetic process 21.0526 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 21.0526 8 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0050890 cognition 21.0526 4 no
GO:0051336 regulation of hydrolase activity 21.0526 4 no
GO:0051345 positive regulation of hydrolase activity 21.0526 5 no
GO:0051046 regulation of secretion 21.0526 5 no
GO:1903530 regulation of secretion by cell 21.0526 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.0526 6 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0009968 negative regulation of signal transduction 15.7895 5 yes
GO:0035023 regulation of Rho protein signal transduction 15.7895 8 yes
GO:0040013 negative regulation of locomotion 15.7895 4 yes
GO:1902532 negative regulation of intracellular signal transduction 15.7895 6 yes
GO:2000146 negative regulation of cell motility 15.7895 5 yes
GO:0009059 macromolecule biosynthetic process 10.5263 4 yes
GO:0016070 RNA metabolic process 10.5263 5 yes
GO:0018130 heterocycle biosynthetic process 10.5263 4 yes
GO:0019438 aromatic compound biosynthetic process 10.5263 4 yes
GO:0030336 negative regulation of cell migration 10.5263 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 10.5263 4 yes
GO:0035024 negative regulation of Rho protein signal transduction 10.5263 9 yes
GO:0044271 cellular nitrogen compound biosynthetic process 10.5263 4 yes
GO:0046580 negative regulation of Ras protein signal transduction 10.5263 8 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 10.5263 7 yes
GO:1901362 organic cyclic compound biosynthetic process 10.5263 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AHDC1_HUMAN [view interactions] Low throughput no yes
TP53B_HUMAN [view entry] [view interactions] Low throughput yes yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
DOT1L_HUMAN [view interactions] Low throughput no yes
RPB2_HUMAN [view interactions] Low throughput no yes
RPB1_HUMAN [view interactions] Low throughput no no
REV3L_HUMAN [view entry] [view interactions] Low throughput yes yes
NU153_HUMAN [view interactions] Low throughput no yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
BRCA1_HUMAN [view interactions] Low throughput no yes
CBX5_HUMAN [view interactions] High throughput no yes
CBX1_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
PFKAL_HUMAN [view entry] [view interactions] High throughput yes yes
ICE2_HUMAN [view interactions] High throughput no no
AF10_HUMAN [view interactions] High throughput no no
CAB45_HUMAN [view interactions] High throughput no yes
EVI5L_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view interactions] High throughput no yes
IP3KB_HUMAN [view interactions] High throughput no no
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SOX7_HUMAN [view entry] [view interactions] High throughput yes yes
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
CBX3_HUMAN [view interactions] High throughput no yes
EPHA1_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
CRY2_HUMAN [view interactions] High throughput no yes
LIPB1_HUMAN [view interactions] High throughput no yes
ENTR1_HUMAN [view interactions] High throughput no no
NFAC1_HUMAN [view interactions] High throughput no no
NFAC2_HUMAN [view interactions] High throughput no yes
APBA3_HUMAN [view interactions] High throughput no yes
TNR1A_HUMAN [view interactions] High throughput no yes
CCG5_HUMAN [view entry] [view interactions] High throughput yes no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
LRIF1_HUMAN [view interactions] High throughput no yes
ZN644_HUMAN [view interactions] High throughput no no
ADNP2_HUMAN [view interactions] High throughput no yes
ADNP_HUMAN [view interactions] High throughput no yes
CHAP1_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
NSL1_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
DSN1_HUMAN [view interactions] High throughput no yes
ZSWM9_HUMAN [view interactions] High throughput no no
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
MIS12_HUMAN [view interactions] High throughput no yes
PMF1_HUMAN [view interactions] High throughput no no
CAF1B_HUMAN [view interactions] High throughput no no
ZN292_HUMAN [view interactions] High throughput no yes
Z280D_HUMAN [view interactions] High throughput no yes
DNJC9_HUMAN [view interactions] High throughput no yes
FAXC_HUMAN [view interactions] High throughput no no
CSRN1_HUMAN [view interactions] High throughput no no
CC85A_HUMAN [view interactions] High throughput no yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
BTNL9_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
RBP17_HUMAN [view interactions] High throughput no no
SRF_HUMAN [view interactions] Computational no yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no