Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BSN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis . Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 . Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BSN_HUMAN
GO:0046872 metal ion binding 29.4118 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BSN_HUMAN
GO:0010646 regulation of cell communication 61.7647 4 no
GO:0048522 positive regulation of cellular process 58.8235 4 no
GO:0050804 modulation of chemical synaptic transmission 52.9412 5 no
GO:0099177 regulation of trans-synaptic signaling 52.9412 4 no
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051128 regulation of cellular component organization 47.0588 4 no
GO:0048523 negative regulation of cellular process 47.0588 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.2353 4 no
GO:0080090 regulation of primary metabolic process 38.2353 4 no
GO:0009966 regulation of signal transduction 35.2941 4 no
GO:0010647 positive regulation of cell communication 35.2941 5 no
GO:0023056 positive regulation of signaling 35.2941 4 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0008104 protein localization 32.3529 4 yes
GO:0043933 protein-containing complex organization 32.3529 4 no
GO:0009893 positive regulation of metabolic process 32.3529 4 no
GO:0010468 regulation of gene expression 32.3529 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.3529 5 no
GO:0051246 regulation of protein metabolic process 32.3529 5 no
GO:0016192 vesicle-mediated transport 32.3529 4 no
GO:0043269 regulation of ion transport 29.4118 5 no
GO:0065003 protein-containing complex assembly 29.4118 5 no
GO:0009889 regulation of biosynthetic process 29.4118 4 no
GO:0010556 regulation of macromolecule biosynthetic process 29.4118 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0031326 regulation of cellular biosynthetic process 29.4118 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0051252 regulation of RNA metabolic process 29.4118 5 no
GO:0034330 cell junction organization 29.4118 4 no
GO:0050808 synapse organization 29.4118 5 no
GO:0007268 chemical synaptic transmission 26.4706 6 yes
GO:0098916 anterograde trans-synaptic signaling 26.4706 5 yes
GO:0099537 trans-synaptic signaling 26.4706 4 yes
GO:0034762 regulation of transmembrane transport 26.4706 4 no
GO:0048584 positive regulation of response to stimulus 26.4706 4 no
GO:0051050 positive regulation of transport 26.4706 4 no
GO:0006355 regulation of DNA-templated transcription 26.4706 6 no
GO:0051247 positive regulation of protein metabolic process 26.4706 6 no
GO:1903506 regulation of nucleic acid-templated transcription 26.4706 7 no
GO:2001141 regulation of RNA biosynthetic process 26.4706 6 no
GO:0009892 negative regulation of metabolic process 26.4706 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.4706 5 no
GO:0031324 negative regulation of cellular metabolic process 26.4706 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.4706 5 no
GO:0030030 cell projection organization 26.4706 4 no
GO:0034765 regulation of ion transmembrane transport 23.5294 5 no
GO:0031344 regulation of cell projection organization 23.5294 5 no
GO:0050807 regulation of synapse organization 23.5294 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 no
GO:0050806 positive regulation of synaptic transmission 23.5294 5 no
GO:0006996 organelle organization 23.5294 4 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 no
GO:0009967 positive regulation of signal transduction 20.5882 5 no
GO:0031325 positive regulation of cellular metabolic process 20.5882 5 no
GO:0050890 cognition 20.5882 4 no
GO:0001932 regulation of protein phosphorylation 20.5882 7 no
GO:0019220 regulation of phosphate metabolic process 20.5882 6 no
GO:0042325 regulation of phosphorylation 20.5882 7 no
GO:0048585 negative regulation of response to stimulus 20.5882 4 no
GO:0051174 regulation of phosphorus metabolic process 20.5882 5 no
GO:0051248 negative regulation of protein metabolic process 20.5882 6 no
GO:0071702 organic substance transport 20.5882 4 no
GO:0071705 nitrogen compound transport 20.5882 4 no
GO:0060627 regulation of vesicle-mediated transport 17.6471 4 yes
GO:1990709 presynaptic active zone organization 14.7059 4 yes
GO:0035418 protein localization to synapse 8.8235 6 yes
GO:1902414 protein localization to cell junction 8.8235 5 yes
GO:0099526 presynapse to nucleus signaling pathway 5.8824 4 yes
GO:1904071 presynaptic active zone assembly 5.8824 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
DYN3_HUMAN [view entry] [view interactions] Low throughput yes no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB3A_HUMAN [view entry] [view interactions] Low throughput yes yes
ATG5_HUMAN [view interactions] Low throughput no no
SCAI_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
THB_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] Computational yes yes
TXND9_HUMAN [view interactions] Computational no yes
CTBP2_HUMAN [view interactions] Computational no no
TPRGL_HUMAN [view interactions] Computational no no
VGLU1_HUMAN [view entry] [view interactions] Computational yes no
RB6I2_HUMAN [view entry] [view interactions] Computational yes yes
UN13B_HUMAN [view interactions] Computational no no