Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BSN_HUMAN

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis . Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 . Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import . [View more on UniProt]

05001,0001,5002,0002,5003,0003,500
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 37%

Interacting region for partners were not defined.

BSN_HUMAN has binary interactions with 31 proteins

BSN_HUMANATG5_HUMANPCLO_HUMANSRCN1_HUMANDYN1_HUMANRGS14_HUMANTRIM9_HUMANGCR_HUMANRIMS1_HUMANKCNA3_HUMANFMR1_HUMANHCN1_HUMANSHAN3_HUMANNMDE2_HUMANDYN3_HUMANRAB3A_HUMANERC2_HUMANSHAN2_HUMANANS1B_HUMANNMDZ1_HUMANABI1_HUMANNEB2_HUMANSTAU1_HUMANARRB2_HUMANADA10_HUMANHOME1_HUMANNRX1A_HUMANWASF1_HUMANUN13A_HUMANPRIO_HUMANDYL2_HUMANSCAI_HUMANBSN_HUMANATG5_HUMANPCLO_HUMANSRCN1_HUMANDYN1_HUMANRGS14_HUMANTRIM9_HUMANGCR_HUMANRIMS1_HUMANKCNA3_HUMANFMR1_HUMANHCN1_HUMANSHAN3_HUMANNMDE2_HUMANDYN3_HUMANRAB3A_HUMANERC2_HUMANSHAN2_HUMANANS1B_HUMANNMDZ1_HUMANABI1_HUMANNEB2_HUMANSTAU1_HUMANARRB2_HUMANADA10_HUMANHOME1_HUMANNRX1A_HUMANWASF1_HUMANUN13A_HUMANPRIO_HUMANDYL2_HUMANSCAI_HUMAN
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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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