PCLO_HUMAN
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released . After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts . At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis . Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release . Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy . Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import . [View more on UniProt]
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No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003084 | DOC_MAPK_JIP1_4 | DOC | 4269 | 4275 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PCLO_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 42.8571 | 4 | yes |
GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 21.4286 | 5 | no |
GO:0019900 | kinase binding | 21.4286 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
GO:0005509 | calcium ion binding | 10.7143 | 5 | yes |
GO:0005544 | calcium-dependent phospholipid binding | 7.1429 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PCLO_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 57.1429 | 4 | no |
GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 53.5714 | 4 | no |
GO:0008104 | protein localization | 53.5714 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 53.5714 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.5714 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 50.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0051049 | regulation of transport | 46.4286 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | no |
GO:0051128 | regulation of cellular component organization | 46.4286 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 39.2857 | 5 | no |
GO:0016192 | vesicle-mediated transport | 39.2857 | 4 | yes |
GO:0009966 | regulation of signal transduction | 35.7143 | 4 | no |
GO:0022607 | cellular component assembly | 35.7143 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 35.7143 | 4 | yes |
GO:0071702 | organic substance transport | 35.7143 | 4 | yes |
GO:0071705 | nitrogen compound transport | 35.7143 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 32.1429 | 6 | no |
GO:0031399 | regulation of protein modification process | 32.1429 | 6 | no |
GO:0042325 | regulation of phosphorylation | 32.1429 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 32.1429 | 5 | no |
GO:0015031 | protein transport | 32.1429 | 4 | yes |
GO:0051046 | regulation of secretion | 32.1429 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 32.1429 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
GO:0017157 | regulation of exocytosis | 25.0000 | 5 | yes |
GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
GO:0034330 | cell junction organization | 25.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0050808 | synapse organization | 25.0000 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 21.4286 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.4286 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
GO:0050806 | positive regulation of synaptic transmission | 21.4286 | 5 | no |
GO:0050890 | cognition | 21.4286 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.4286 | 5 | no |
GO:0030030 | cell projection organization | 21.4286 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 21.4286 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 21.4286 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 21.4286 | 7 | no |
GO:0007268 | chemical synaptic transmission | 21.4286 | 6 | no |
GO:0098916 | anterograde trans-synaptic signaling | 21.4286 | 5 | no |
GO:0099537 | trans-synaptic signaling | 21.4286 | 4 | no |
GO:0036211 | protein modification process | 21.4286 | 4 | no |
GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
GO:0006887 | exocytosis | 21.4286 | 4 | yes |
GO:0046903 | secretion | 21.4286 | 4 | yes |
GO:1990709 | presynaptic active zone organization | 21.4286 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
GO:0009306 | protein secretion | 17.8571 | 4 | yes |
GO:0023061 | signal release | 17.8571 | 4 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 17.8571 | 4 | yes |
GO:0045055 | regulated exocytosis | 17.8571 | 5 | yes |
GO:0071692 | protein localization to extracellular region | 17.8571 | 5 | yes |
GO:0002790 | peptide secretion | 14.2857 | 5 | yes |
GO:0009914 | hormone transport | 14.2857 | 4 | yes |
GO:0015833 | peptide transport | 14.2857 | 5 | yes |
GO:0016079 | synaptic vesicle exocytosis | 14.2857 | 4 | yes |
GO:0030072 | peptide hormone secretion | 14.2857 | 6 | yes |
GO:0030073 | insulin secretion | 14.2857 | 5 | yes |
GO:0035418 | protein localization to synapse | 14.2857 | 6 | yes |
GO:0042886 | amide transport | 14.2857 | 5 | yes |
GO:0046879 | hormone secretion | 14.2857 | 5 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 14.2857 | 5 | yes |
GO:0099643 | signal release from synapse | 14.2857 | 5 | yes |
GO:1902414 | protein localization to cell junction | 14.2857 | 5 | yes |
GO:0097091 | synaptic vesicle clustering | 10.7143 | 5 | yes |
GO:0097479 | synaptic vesicle localization | 10.7143 | 4 | yes |
GO:0099526 | presynapse to nucleus signaling pathway | 10.7143 | 4 | yes |
GO:1904071 | presynaptic active zone assembly | 10.7143 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RIMS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIT2_HUMAN | [view interactions] | Low throughput | no | yes |
ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CEP72_HUMAN | [view interactions] | High throughput | no | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
DPPA4_HUMAN | [view interactions] | High throughput | no | no |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
BACD3_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
OTC_HUMAN | [view interactions] | High throughput | no | no |
SURF1_HUMAN | [view interactions] | High throughput | no | yes |
EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HMGN2_HUMAN | [view interactions] | High throughput | no | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H11_HUMAN | [view interactions] | High throughput | no | no |
HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RON_HUMAN | [view interactions] | High throughput | no | yes |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB6I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |