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PCLO_HUMAN

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released . After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts . At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis . Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release . Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy . Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import . [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI003084 DOC_MAPK_JIP1_4 DOC 4269 4275 -

Molecular function

Term Name % Distance from the top of the tree Annotated in PCLO_HUMAN
GO:0046872 metal ion binding 42.8571 4 yes
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 21.4286 5 no
GO:0019900 kinase binding 21.4286 4 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0005509 calcium ion binding 10.7143 5 yes
GO:0005544 calcium-dependent phospholipid binding 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PCLO_HUMAN
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 53.5714 4 no
GO:0008104 protein localization 53.5714 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 53.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 53.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051049 regulation of transport 46.4286 4 yes
GO:0048523 negative regulation of cellular process 46.4286 4 no
GO:0051128 regulation of cellular component organization 46.4286 4 no
GO:0051246 regulation of protein metabolic process 39.2857 5 no
GO:0016192 vesicle-mediated transport 39.2857 4 yes
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:0022607 cellular component assembly 35.7143 4 yes
GO:0060627 regulation of vesicle-mediated transport 35.7143 4 yes
GO:0071702 organic substance transport 35.7143 4 yes
GO:0071705 nitrogen compound transport 35.7143 4 yes
GO:0019220 regulation of phosphate metabolic process 32.1429 6 no
GO:0031399 regulation of protein modification process 32.1429 6 no
GO:0042325 regulation of phosphorylation 32.1429 7 no
GO:0051174 regulation of phosphorus metabolic process 32.1429 5 no
GO:0015031 protein transport 32.1429 4 yes
GO:0051046 regulation of secretion 32.1429 5 yes
GO:1903530 regulation of secretion by cell 32.1429 4 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0017157 regulation of exocytosis 25.0000 5 yes
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0050806 positive regulation of synaptic transmission 21.4286 5 no
GO:0050890 cognition 21.4286 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0007268 chemical synaptic transmission 21.4286 6 no
GO:0098916 anterograde trans-synaptic signaling 21.4286 5 no
GO:0099537 trans-synaptic signaling 21.4286 4 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0006887 exocytosis 21.4286 4 yes
GO:0046903 secretion 21.4286 4 yes
GO:1990709 presynaptic active zone organization 21.4286 4 yes
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0009306 protein secretion 17.8571 4 yes
GO:0023061 signal release 17.8571 4 yes
GO:0035592 establishment of protein localization to extracellular region 17.8571 4 yes
GO:0045055 regulated exocytosis 17.8571 5 yes
GO:0071692 protein localization to extracellular region 17.8571 5 yes
GO:0002790 peptide secretion 14.2857 5 yes
GO:0009914 hormone transport 14.2857 4 yes
GO:0015833 peptide transport 14.2857 5 yes
GO:0016079 synaptic vesicle exocytosis 14.2857 4 yes
GO:0030072 peptide hormone secretion 14.2857 6 yes
GO:0030073 insulin secretion 14.2857 5 yes
GO:0035418 protein localization to synapse 14.2857 6 yes
GO:0042886 amide transport 14.2857 5 yes
GO:0046879 hormone secretion 14.2857 5 yes
GO:0099003 vesicle-mediated transport in synapse 14.2857 5 yes
GO:0099643 signal release from synapse 14.2857 5 yes
GO:1902414 protein localization to cell junction 14.2857 5 yes
GO:0097091 synaptic vesicle clustering 10.7143 5 yes
GO:0097479 synaptic vesicle localization 10.7143 4 yes
GO:0099526 presynapse to nucleus signaling pathway 10.7143 4 yes
GO:1904071 presynaptic active zone assembly 10.7143 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RPGF4_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
RIMS2_HUMAN [view entry] [view interactions] Low throughput yes no
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
PRAF1_HUMAN [view interactions] Low throughput no yes
SIAH1_HUMAN [view interactions] Low throughput no yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT2_HUMAN [view interactions] Low throughput no yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CEP72_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
DPPA4_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW8_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
OTC_HUMAN [view interactions] High throughput no no
SURF1_HUMAN [view interactions] High throughput no yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
HMGN2_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
H11_HUMAN [view interactions] High throughput no no
HMGA1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RON_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RB6I2_HUMAN [view entry] [view interactions] Computational yes yes
RAB3A_HUMAN [view entry] [view interactions] Computational yes yes