PCLO_HUMAN
Evidence for PS localization
Functions
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released . After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts . At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis . Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release . Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy . Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003084 | DOC_MAPK_JIP1_4 | DOC | 4269 | 4275 | - |
| ELMI003084 | DOC_MAPK_JIP1_4 | DOC | 4269 | 4275 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PCLO_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 5 | yes |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0043168 | anion binding | 26.6667 | 4 | no |
| GO:0000166 | nucleotide binding | 23.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.3333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.3333 | 6 | no |
| GO:0019901 | protein kinase binding | 23.3333 | 5 | no |
| GO:0005509 | calcium ion binding | 10.0000 | 6 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PCLO_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 63.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.6667 | 4 | no |
| GO:0008104 | protein localization | 53.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 46.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 43.3333 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 43.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 43.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.6667 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.6667 | 5 | no |
| GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0017157 | regulation of exocytosis | 30.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 30.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.6667 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 26.6667 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0051588 | regulation of neurotransmitter transport | 26.6667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.6667 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
| GO:0034330 | cell junction organization | 26.6667 | 4 | no |
| GO:0015031 | protein transport | 23.3333 | 4 | yes |
| GO:0046903 | secretion | 23.3333 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 23.3333 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.3333 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.3333 | 4 | no |
| GO:0036211 | protein modification process | 23.3333 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.3333 | 8 | no |
| GO:0043412 | macromolecule modification | 23.3333 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.3333 | 7 | no |
| GO:0050890 | cognition | 23.3333 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.3333 | 5 | no |
| GO:0046928 | regulation of neurotransmitter secretion | 23.3333 | 5 | no |
| GO:0050808 | synapse organization | 23.3333 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.3333 | 5 | no |
| GO:0023061 | signal release | 20.0000 | 4 | yes |
| GO:0045055 | regulated exocytosis | 20.0000 | 4 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 16.6667 | 4 | yes |
| GO:0035418 | protein localization to synapse | 16.6667 | 6 | yes |
| GO:0097479 | synaptic vesicle localization | 16.6667 | 4 | yes |
| GO:0099643 | signal release from synapse | 16.6667 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 16.6667 | 5 | yes |
| GO:0002790 | peptide secretion | 13.3333 | 5 | yes |
| GO:0009306 | protein secretion | 13.3333 | 4 | yes |
| GO:0009914 | hormone transport | 13.3333 | 4 | yes |
| GO:0015833 | peptide transport | 13.3333 | 5 | yes |
| GO:0030072 | peptide hormone secretion | 13.3333 | 6 | yes |
| GO:0030073 | insulin secretion | 13.3333 | 5 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 13.3333 | 4 | yes |
| GO:0042886 | amide transport | 13.3333 | 5 | yes |
| GO:0046879 | hormone secretion | 13.3333 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 13.3333 | 5 | yes |
| GO:0097091 | synaptic vesicle clustering | 13.3333 | 5 | yes |
| GO:1990709 | presynaptic active zone organization | 13.3333 | 4 | yes |
| GO:0099526 | presynapse to nucleus signaling pathway | 10.0000 | 4 | yes |
| GO:1904071 | presynaptic active zone assembly | 10.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |