Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SOX7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors . May be required for the survival of both hematopoietic and endothelial precursors during specification . Competes with GATA4 for binding and activation of the FGF3 promoter . Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SOX7_HUMAN
GO:0003677 DNA binding 42.8571 4 yes
GO:0000976 transcription cis-regulatory region binding 28.5714 5 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 28.5714 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 28.5714 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 28.5714 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 28.5714 4 yes
GO:0003690 double-stranded DNA binding 28.5714 5 yes
GO:0043565 sequence-specific DNA binding 28.5714 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 28.5714 6 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0001664 G protein-coupled receptor binding 28.5714 4 no
GO:0005109 frizzled binding 28.5714 5 no
GO:0033130 acetylcholine receptor binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SOX7_HUMAN
GO:0009893 positive regulation of metabolic process 71.4286 4 yes
GO:0009966 regulation of signal transduction 71.4286 4 yes
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0031323 regulation of cellular metabolic process 71.4286 4 yes
GO:0031325 positive regulation of cellular metabolic process 71.4286 5 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 71.4286 4 yes
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 yes
GO:0080090 regulation of primary metabolic process 71.4286 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 57.1429 5 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009891 positive regulation of biosynthetic process 42.8571 5 yes
GO:0010468 regulation of gene expression 42.8571 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 yes
GO:0043085 positive regulation of catalytic activity 42.8571 4 yes
GO:0045893 positive regulation of DNA-templated transcription 42.8571 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 42.8571 6 yes
GO:0051247 positive regulation of protein metabolic process 42.8571 6 yes
GO:0051252 regulation of RNA metabolic process 42.8571 5 yes
GO:0051254 positive regulation of RNA metabolic process 42.8571 6 yes
GO:0051336 regulation of hydrolase activity 42.8571 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 42.8571 7 yes
GO:1903506 regulation of nucleic acid-templated transcription 42.8571 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 42.8571 8 yes
GO:2001141 regulation of RNA biosynthetic process 42.8571 6 yes
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0007612 learning 42.8571 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0022898 regulation of transmembrane transporter activity 42.8571 4 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0031344 regulation of cell projection organization 42.8571 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0032412 regulation of ion transmembrane transporter activity 42.8571 5 no
GO:0034762 regulation of transmembrane transport 42.8571 4 no
GO:0034765 regulation of ion transmembrane transport 42.8571 5 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0043269 regulation of ion transport 42.8571 5 no
GO:0043549 regulation of kinase activity 42.8571 5 no
GO:0045859 regulation of protein kinase activity 42.8571 6 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0050890 cognition 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051130 positive regulation of cellular component organization 42.8571 5 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051338 regulation of transferase activity 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:1904062 regulation of cation transmembrane transport 42.8571 6 no
GO:2001257 regulation of cation channel activity 42.8571 6 no
GO:0006355 regulation of DNA-templated transcription 42.8571 6 yes
GO:0008285 negative regulation of cell population proliferation 28.5714 5 yes
GO:0009890 negative regulation of biosynthetic process 28.5714 5 yes
GO:0009892 negative regulation of metabolic process 28.5714 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 yes
GO:0010950 positive regulation of endopeptidase activity 28.5714 7 yes
GO:0010952 positive regulation of peptidase activity 28.5714 6 yes
GO:0030111 regulation of Wnt signaling pathway 28.5714 5 yes
GO:0030162 regulation of proteolysis 28.5714 6 yes
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 28.5714 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 28.5714 8 yes
GO:0045862 positive regulation of proteolysis 28.5714 7 yes
GO:0045892 negative regulation of DNA-templated transcription 28.5714 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 28.5714 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 28.5714 5 yes
GO:0051253 negative regulation of RNA metabolic process 28.5714 6 yes
GO:0051345 positive regulation of hydrolase activity 28.5714 5 yes
GO:0052547 regulation of peptidase activity 28.5714 5 yes
GO:0052548 regulation of endopeptidase activity 28.5714 6 yes
GO:0060828 regulation of canonical Wnt signaling pathway 28.5714 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 28.5714 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 28.5714 8 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 28.5714 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 28.5714 8 yes
GO:0006915 apoptotic process 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009896 positive regulation of catabolic process 28.5714 5 no
GO:0010821 regulation of mitochondrion organization 28.5714 6 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0010942 positive regulation of cell death 28.5714 5 no
GO:0010970 transport along microtubule 28.5714 4 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 28.5714 4 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0031331 positive regulation of cellular catabolic process 28.5714 6 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043065 positive regulation of apoptotic process 28.5714 7 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0043068 positive regulation of programmed cell death 28.5714 6 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0060548 negative regulation of cell death 28.5714 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 28.5714 7 no
GO:0099111 microtubule-based transport 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0002090 regulation of receptor internalization 28.5714 7 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0030100 regulation of endocytosis 28.5714 5 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0031644 regulation of nervous system process 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0032990 cell part morphogenesis 28.5714 4 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045860 positive regulation of protein kinase activity 28.5714 7 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 28.5714 5 no
GO:0048259 regulation of receptor-mediated endocytosis 28.5714 6 no
GO:0048812 neuron projection morphogenesis 28.5714 7 no
GO:0048858 cell projection morphogenesis 28.5714 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 28.5714 9 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0050885 neuromuscular process controlling balance 28.5714 5 no
GO:0050905 neuromuscular process 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0061097 regulation of protein tyrosine kinase activity 28.5714 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 28.5714 8 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0071241 cellular response to inorganic substance 28.5714 4 no
GO:0071248 cellular response to metal ion 28.5714 5 no
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0099601 regulation of neurotransmitter receptor activity 28.5714 4 no
GO:0106027 neuron projection organization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 6 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:2000310 regulation of NMDA receptor activity 28.5714 5 no
GO:2000463 positive regulation of excitatory postsynaptic potential 28.5714 5 no
GO:0016070 RNA metabolic process 28.5714 5 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0090304 nucleic acid metabolic process 28.5714 4 no
GO:2000145 regulation of cell motility 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD7_HUMAN [view interactions] High throughput no yes
SMAD5_HUMAN [view interactions] High throughput no no
H2AY_HUMAN [view interactions] High throughput no yes
GLRX3_HUMAN [view interactions] High throughput no yes
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
PB1_HUMAN [view interactions] High throughput no yes
KDM2B_HUMAN [view interactions] High throughput no no
CHD7_HUMAN [view interactions] High throughput no no
SMCA2_HUMAN [view interactions] High throughput no yes
ARID2_HUMAN [view interactions] High throughput no no
ARI1A_HUMAN [view interactions] High throughput no yes
ARI1B_HUMAN [view interactions] High throughput no yes
HXD13_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
ZFHX4_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
CASZ1_HUMAN [view interactions] High throughput no no
SUH_HUMAN [view interactions] High throughput no yes
BC11B_HUMAN [view interactions] High throughput no yes
RBM20_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
FOG2_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
CECR2_HUMAN [view interactions] High throughput no yes
BAHC1_HUMAN [view interactions] High throughput no yes
SOX21_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
FOXP1_HUMAN [view interactions] High throughput no yes
NFIB_HUMAN [view interactions] High throughput no yes
RESF1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
SMRD2_HUMAN [view interactions] High throughput no no
ARI5B_HUMAN [view interactions] High throughput no yes
FBRS_HUMAN [view interactions] High throughput no no
MAML1_HUMAN [view interactions] High throughput no yes
ZN608_HUMAN [view interactions] High throughput no yes
NCOA1_HUMAN [view interactions] High throughput no yes
ADNP2_HUMAN [view interactions] High throughput no yes
KDM6A_HUMAN [view interactions] High throughput no yes
FOXP4_HUMAN [view interactions] High throughput no yes
TNC18_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
ZEB2_HUMAN [view interactions] High throughput no yes
ZMIZ2_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
NCOA3_HUMAN [view interactions] High throughput no yes
ZN292_HUMAN [view interactions] High throughput no yes
SOX5_HUMAN [view interactions] High throughput no no
TLE3_HUMAN [view interactions] High throughput no yes
TLE1_HUMAN [view interactions] High throughput no yes
CO039_HUMAN [view interactions] High throughput no yes
PRR12_HUMAN [view entry] [view interactions] High throughput yes yes
BCORL_HUMAN [view interactions] High throughput no no
WIZ_HUMAN [view interactions] High throughput no yes
ZN609_HUMAN [view interactions] High throughput no yes
TET2_HUMAN [view interactions] High throughput no yes
ARI3B_HUMAN [view entry] [view interactions] High throughput yes yes
TRI33_HUMAN [view interactions] High throughput no yes
RREB1_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
BACH2_HUMAN [view interactions] High throughput no yes
Z518B_HUMAN [view interactions] High throughput no yes
TIF1A_HUMAN [view interactions] High throughput no yes
NCOA2_HUMAN [view interactions] High throughput no no
TRPS1_HUMAN [view interactions] High throughput no no
SMCA4_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
JHD2C_HUMAN [view interactions] High throughput no yes
TCF20_HUMAN [view interactions] High throughput no yes
KMT2C_HUMAN [view interactions] High throughput no no
NCOR2_HUMAN [view interactions] High throughput no yes
KMT2D_HUMAN [view interactions] High throughput no yes
BCOR_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
MSRA_HUMAN [view interactions] Computational no no
RP1L1_HUMAN [view interactions] Computational no no