Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SOX7_HUMAN

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors . May be required for the survival of both hematopoietic and endothelial precursors during specification . Competes with GATA4 for binding and activation of the FGF3 promoter . Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5-AACAAT-3. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SOX7_HUMAN
GO:0003677 DNA binding 42.8571 4 yes
GO:0000976 transcription cis-regulatory region binding 28.5714 5 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 28.5714 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 28.5714 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 28.5714 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 28.5714 4 yes
GO:0003690 double-stranded DNA binding 28.5714 5 yes
GO:0043565 sequence-specific DNA binding 28.5714 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 28.5714 6 yes
GO:0019900 kinase binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SOX7_HUMAN
GO:0009893 positive regulation of metabolic process 71.4286 4 yes
GO:0009966 regulation of signal transduction 71.4286 4 yes
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0031323 regulation of cellular metabolic process 71.4286 4 yes
GO:0031325 positive regulation of cellular metabolic process 71.4286 5 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 yes
GO:0080090 regulation of primary metabolic process 71.4286 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0006355 regulation of DNA-templated transcription 42.8571 7 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009891 positive regulation of biosynthetic process 42.8571 5 yes
GO:0010468 regulation of gene expression 42.8571 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 yes
GO:0045893 positive regulation of DNA-templated transcription 42.8571 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0051247 positive regulation of protein metabolic process 42.8571 6 yes
GO:0051252 regulation of RNA metabolic process 42.8571 5 yes
GO:0051254 positive regulation of RNA metabolic process 42.8571 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 42.8571 7 yes
GO:2001141 regulation of RNA biosynthetic process 42.8571 6 yes
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0007612 learning 42.8571 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0022898 regulation of transmembrane transporter activity 42.8571 4 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 42.8571 5 no
GO:0034762 regulation of transmembrane transport 42.8571 4 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0043549 regulation of kinase activity 42.8571 5 no
GO:0045859 regulation of protein kinase activity 42.8571 6 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0050890 cognition 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051130 positive regulation of cellular component organization 42.8571 5 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051338 regulation of transferase activity 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0008285 negative regulation of cell population proliferation 28.5714 5 yes
GO:0009890 negative regulation of biosynthetic process 28.5714 5 yes
GO:0009892 negative regulation of metabolic process 28.5714 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 yes
GO:0030111 regulation of Wnt signaling pathway 28.5714 5 yes
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0043085 positive regulation of catalytic activity 28.5714 4 yes
GO:0051336 regulation of hydrolase activity 28.5714 4 yes
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0006996 organelle organization 28.5714 4 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0031644 regulation of nervous system process 28.5714 5 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 28.5714 5 no
GO:0048812 neuron projection morphogenesis 28.5714 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0050885 neuromuscular process controlling balance 28.5714 5 no
GO:0050905 neuromuscular process 28.5714 4 no
GO:0061097 regulation of protein tyrosine kinase activity 28.5714 7 no
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0099601 regulation of neurotransmitter receptor activity 28.5714 4 no
GO:0106027 neuron projection organization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 no
GO:2000310 regulation of NMDA receptor activity 28.5714 5 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0016070 RNA metabolic process 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0030334 regulation of cell migration 28.5714 5 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0090304 nucleic acid metabolic process 28.5714 4 no
GO:2000145 regulation of cell motility 28.5714 4 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009896 positive regulation of catabolic process 28.5714 5 no
GO:0010970 transport along microtubule 28.5714 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 28.5714 4 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0031331 positive regulation of cellular catabolic process 28.5714 6 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0050848 regulation of calcium-mediated signaling 28.5714 6 no
GO:0099111 microtubule-based transport 28.5714 4 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0045944 positive regulation of transcription by RNA polymerase II 28.5714 9 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD7_HUMAN [view interactions] High throughput no yes
SMAD5_HUMAN [view interactions] High throughput no no
H2AY_HUMAN [view interactions] High throughput no yes
GLRX3_HUMAN [view interactions] High throughput no yes
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1B_HUMAN [view interactions] High throughput no yes
ARI1A_HUMAN [view interactions] High throughput no yes
BCOR_HUMAN [view interactions] High throughput no no
KMT2D_HUMAN [view interactions] High throughput no yes
NCOR2_HUMAN [view interactions] High throughput no yes
KMT2C_HUMAN [view interactions] High throughput no no
TCF20_HUMAN [view interactions] High throughput no yes
ARID2_HUMAN [view interactions] High throughput no no
JHD2C_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
TRPS1_HUMAN [view interactions] High throughput no no
NCOA2_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
Z518B_HUMAN [view interactions] High throughput no yes
SMCA2_HUMAN [view interactions] High throughput no yes
BACH2_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
RREB1_HUMAN [view interactions] High throughput no yes
CHD7_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
ARI3B_HUMAN [view entry] [view interactions] High throughput yes yes
TET2_HUMAN [view interactions] High throughput no yes
ZN609_HUMAN [view interactions] High throughput no yes
WIZ_HUMAN [view interactions] High throughput no yes
BCORL_HUMAN [view interactions] High throughput no no
PRR12_HUMAN [view entry] [view interactions] High throughput yes yes
CO039_HUMAN [view interactions] High throughput no yes
TLE1_HUMAN [view interactions] High throughput no yes
CASZ1_HUMAN [view interactions] High throughput no no
SATB2_HUMAN [view interactions] High throughput no yes
TLE3_HUMAN [view interactions] High throughput no yes
SOX5_HUMAN [view interactions] High throughput no no
ZN292_HUMAN [view interactions] High throughput no yes
KDM2B_HUMAN [view interactions] High throughput no no
NCOA3_HUMAN [view interactions] High throughput no yes
ZFHX4_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
ZMIZ2_HUMAN [view interactions] High throughput no yes
ZEB2_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
TNC18_HUMAN [view interactions] High throughput no yes
FOXP4_HUMAN [view interactions] High throughput no yes
KDM6A_HUMAN [view interactions] High throughput no yes
ADNP2_HUMAN [view interactions] High throughput no yes
NCOA1_HUMAN [view interactions] High throughput no yes
PB1_HUMAN [view interactions] High throughput no yes
ZN608_HUMAN [view interactions] High throughput no yes
FBRS_HUMAN [view interactions] High throughput no no
MAML1_HUMAN [view interactions] High throughput no yes
SALL1_HUMAN [view interactions] High throughput no yes
ARI5B_HUMAN [view interactions] High throughput no yes
SMRD2_HUMAN [view interactions] High throughput no no
RBM14_HUMAN [view interactions] High throughput no yes
RESF1_HUMAN [view interactions] High throughput no yes
HXD13_HUMAN [view interactions] High throughput no no
NFIB_HUMAN [view interactions] High throughput no yes
FOXP1_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
SOX21_HUMAN [view interactions] High throughput no yes
BAHC1_HUMAN [view interactions] High throughput no yes
CECR2_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
FOG2_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
PF21A_HUMAN [view interactions] High throughput no yes
RBM20_HUMAN [view interactions] High throughput no no
BC11B_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes