SESD1_HUMAN
Evidence for PS localization
Functions
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SESD1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 35.2941 | 4 | no |
| GO:0043168 | anion binding | 29.4118 | 4 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 23.5294 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 23.5294 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 23.5294 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 23.5294 | 6 | yes |
| GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
| GO:0043169 | cation binding | 23.5294 | 4 | no |
| GO:0046872 | metal ion binding | 23.5294 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SESD1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 64.7059 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 58.8235 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.9412 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.9412 | 4 | no |
| GO:0006996 | organelle organization | 52.9412 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.0588 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.1765 | 5 | no |
| GO:0008104 | protein localization | 41.1765 | 4 | no |
| GO:0051049 | regulation of transport | 35.2941 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0022607 | cellular component assembly | 35.2941 | 4 | no |
| GO:0030030 | cell projection organization | 35.2941 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.2941 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.4118 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 29.4118 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.4118 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.4118 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.4118 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0031333 | negative regulation of protein-containing complex assembly | 23.5294 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.5294 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0033365 | protein localization to organelle | 23.5294 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.5294 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.5294 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
| GO:0050807 | regulation of synapse organization | 23.5294 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.5294 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 17.6471 | 4 | yes |
| GO:0051051 | negative regulation of transport | 17.6471 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 11.7647 | 6 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 11.7647 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 11.7647 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 11.7647 | 6 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 11.7647 | 5 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 11.7647 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 11.7647 | 7 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 11.7647 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 11.7647 | 7 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 11.7647 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 11.7647 | 6 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 11.7647 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| HSF4_HUMAN | [view interactions] | High throughput | no | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| SSX2_HUMAN | [view interactions] | High throughput | no | no |
| ZN669_HUMAN | [view interactions] | High throughput | no | no |
| ARL11_HUMAN | [view interactions] | High throughput | no | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN830_HUMAN | [view interactions] | High throughput | no | yes |
| STMN2_HUMAN | [view interactions] | High throughput | no | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| DACT3_HUMAN | [view interactions] | High throughput | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF6_HUMAN | [view interactions] | High throughput | no | no |
| FSP1_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |