Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TRI47_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TRI47_HUMAN
GO:0016755 aminoacyltransferase activity 33.3333 4 yes
GO:0043169 cation binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 5 yes
GO:0046914 transition metal ion binding 33.3333 6 yes
GO:0004842 ubiquitin-protein transferase activity 25.0000 4 yes
GO:0008270 zinc ion binding 25.0000 7 yes
GO:0061630 ubiquitin protein ligase activity 25.0000 5 yes
GO:0061659 ubiquitin-like protein ligase activity 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0003677 DNA binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in TRI47_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 no
GO:0036211 protein modification process 75.0000 4 yes
GO:0043412 macromolecule modification 75.0000 4 yes
GO:0022607 cellular component assembly 75.0000 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0009889 regulation of biosynthetic process 58.3333 4 no
GO:0010468 regulation of gene expression 58.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 58.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 58.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 58.3333 5 no
GO:0051252 regulation of RNA metabolic process 58.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 58.3333 6 no
GO:0009966 regulation of signal transduction 58.3333 4 no
GO:0010646 regulation of cell communication 58.3333 4 no
GO:0006355 regulation of DNA-templated transcription 58.3333 7 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0006996 organelle organization 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0060341 regulation of cellular localization 41.6667 4 no
GO:0008104 protein localization 41.6667 4 no
GO:0042127 regulation of cell population proliferation 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0043933 protein-containing complex organization 41.6667 4 no
GO:0009890 negative regulation of biosynthetic process 41.6667 5 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 41.6667 6 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 41.6667 5 no
GO:0031327 negative regulation of cellular biosynthetic process 41.6667 6 no
GO:0051726 regulation of cell cycle 41.6667 4 no
GO:0043687 post-translational protein modification 41.6667 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 41.6667 8 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0006508 proteolysis 33.3333 4 no
GO:0007346 regulation of mitotic cell cycle 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010629 negative regulation of gene expression 33.3333 7 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0070647 protein modification by small protein conjugation or removal 33.3333 6 yes
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0010564 regulation of cell cycle process 25.0000 5 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 8 no
GO:0045931 positive regulation of mitotic cell cycle 25.0000 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0090068 positive regulation of cell cycle process 25.0000 6 no
GO:1901987 regulation of cell cycle phase transition 25.0000 6 no
GO:1901989 positive regulation of cell cycle phase transition 25.0000 7 no
GO:1901990 regulation of mitotic cell cycle phase transition 25.0000 6 no
GO:1901992 positive regulation of mitotic cell cycle phase transition 25.0000 7 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0016567 protein ubiquitination 25.0000 8 yes
GO:0032446 protein modification by small protein conjugation 25.0000 7 yes
GO:0016055 Wnt signaling pathway 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYLD_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD4_HUMAN [view interactions] Low throughput no yes
NLRP3_HUMAN [view interactions] Low throughput no no
PPM1A_HUMAN [view interactions] Low throughput no yes
FOXO1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
F16P1_HUMAN [view interactions] Low throughput no no
UB2D2_HUMAN [view interactions] Low throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
TRI44_HUMAN [view interactions] High throughput no yes
NUDC1_HUMAN [view interactions] High throughput no no
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
UBE2U_HUMAN [view interactions] High throughput no no
TRIM8_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
SATB1_HUMAN [view interactions] High throughput no yes
BLMH_HUMAN [view interactions] High throughput no yes
MOFA1_HUMAN [view interactions] High throughput no yes
TERF2_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL2_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
MT21E_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
XAF1_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
NHLC1_HUMAN [view interactions] High throughput no no
ZN444_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1A_HUMAN [view interactions] High throughput no yes
DNPEP_HUMAN [view interactions] High throughput no yes
GANAB_HUMAN [view interactions] High throughput no yes
PTN12_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
CUL1_HUMAN [view interactions] High throughput no yes
NUDT5_HUMAN [view interactions] High throughput no no
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
TPP2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes