Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC6A3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Amine transporter (PubMed, PubMed, PubMed). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals . Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SC6A3_HUMAN
GO:0043169 cation binding 52.3810 4 yes
GO:0046872 metal ion binding 47.6190 5 yes
GO:0099106 ion channel regulator activity 23.8095 4 no
GO:0003779 actin binding 23.8095 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 19.0476 4 yes
GO:0015081 sodium ion transmembrane transporter activity 19.0476 6 yes
GO:0015291 secondary active transmembrane transporter activity 19.0476 4 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 19.0476 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 19.0476 4 yes
GO:0046873 metal ion transmembrane transporter activity 19.0476 5 yes
GO:0002020 protease binding 14.2857 4 yes
GO:0008504 monoamine transmembrane transporter activity 14.2857 4 yes
GO:0008509 monoatomic anion transmembrane transporter activity 14.2857 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 14.2857 4 yes
GO:0015108 chloride transmembrane transporter activity 14.2857 5 yes
GO:0015293 symporter activity 14.2857 5 yes
GO:0015294 solute:monoatomic cation symporter activity 14.2857 5 yes
GO:0015296 monoatomic anion:monoatomic cation symporter activity 14.2857 5 yes
GO:0015370 solute:sodium symporter activity 14.2857 6 yes
GO:0015373 monoatomic anion:sodium symporter activity 14.2857 6 yes
GO:0015377 chloride:monoatomic cation symporter activity 14.2857 6 yes
GO:0015378 sodium:chloride symporter activity 14.2857 7 yes
GO:0035240 dopamine binding 14.2857 4 yes
GO:0005330 dopamine:sodium symporter activity 9.5238 4 yes
GO:0005334 norepinephrine:sodium symporter activity 9.5238 4 yes
GO:0019902 phosphatase binding 9.5238 4 yes
GO:0019903 protein phosphatase binding 9.5238 5 yes
GO:0051721 protein phosphatase 2A binding 9.5238 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC6A3_HUMAN
GO:0071702 organic substance transport 57.1429 4 yes
GO:0071705 nitrogen compound transport 57.1429 4 yes
GO:0051049 regulation of transport 57.1429 4 no
GO:0098657 import into cell 52.3810 4 yes
GO:0048522 positive regulation of cellular process 52.3810 4 no
GO:0080090 regulation of primary metabolic process 47.6190 4 yes
GO:0010646 regulation of cell communication 47.6190 4 no
GO:0051050 positive regulation of transport 47.6190 4 no
GO:0060255 regulation of macromolecule metabolic process 47.6190 4 no
GO:0046903 secretion 42.8571 4 yes
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0060341 regulation of cellular localization 42.8571 4 no
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0031323 regulation of cellular metabolic process 38.0952 4 no
GO:0048523 negative regulation of cellular process 38.0952 4 no
GO:0009966 regulation of signal transduction 38.0952 4 no
GO:0010647 positive regulation of cell communication 38.0952 5 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0051588 regulation of neurotransmitter transport 38.0952 5 no
GO:0051046 regulation of secretion 38.0952 5 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:1903530 regulation of secretion by cell 38.0952 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0006836 neurotransmitter transport 33.3333 4 yes
GO:0015844 monoamine transport 33.3333 5 yes
GO:0048585 negative regulation of response to stimulus 28.5714 4 yes
GO:0051937 catecholamine transport 28.5714 6 yes
GO:0098810 neurotransmitter reuptake 28.5714 4 yes
GO:0099536 synaptic signaling 28.5714 4 no
GO:0099537 trans-synaptic signaling 28.5714 5 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010959 regulation of metal ion transport 28.5714 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043269 regulation of monoatomic ion transport 28.5714 5 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0050808 synapse organization 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0001504 neurotransmitter uptake 28.5714 5 yes
GO:0010038 response to metal ion 28.5714 4 yes
GO:0015850 organic hydroxy compound transport 28.5714 5 yes
GO:0015872 dopamine transport 28.5714 7 yes
GO:0042417 dopamine metabolic process 23.8095 7 yes
GO:0051583 dopamine uptake involved in synaptic transmission 23.8095 6 yes
GO:0051934 catecholamine uptake involved in synaptic transmission 23.8095 5 yes
GO:0090493 catecholamine uptake 23.8095 7 yes
GO:0090494 dopamine uptake 23.8095 8 yes
GO:0007268 chemical synaptic transmission 23.8095 7 no
GO:0023061 signal release 23.8095 4 no
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 no
GO:0098916 anterograde trans-synaptic signaling 23.8095 6 no
GO:0006357 regulation of transcription by RNA polymerase II 23.8095 8 no
GO:0034762 regulation of transmembrane transport 23.8095 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 23.8095 5 no
GO:0043086 negative regulation of catalytic activity 23.8095 4 no
GO:0044057 regulation of system process 23.8095 4 no
GO:0051051 negative regulation of transport 23.8095 4 no
GO:0051580 regulation of neurotransmitter uptake 23.8095 6 no
GO:1904062 regulation of monoatomic cation transmembrane transport 23.8095 6 no
GO:0015031 protein transport 23.8095 4 no
GO:0046928 regulation of neurotransmitter secretion 23.8095 5 no
GO:0050708 regulation of protein secretion 23.8095 5 no
GO:0051223 regulation of protein transport 23.8095 5 no
GO:0070201 regulation of establishment of protein localization 23.8095 6 no
GO:0022607 cellular component assembly 23.8095 4 no
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0031400 negative regulation of protein modification process 23.8095 7 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051248 negative regulation of protein metabolic process 23.8095 6 no
GO:0006576 biogenic amine metabolic process 23.8095 5 yes
GO:0006584 catecholamine metabolic process 23.8095 6 yes
GO:0006811 monoatomic ion transport 23.8095 4 yes
GO:0006812 monoatomic cation transport 23.8095 5 yes
GO:0009308 amine metabolic process 23.8095 4 yes
GO:0009712 catechol-containing compound metabolic process 23.8095 5 yes
GO:0010243 response to organonitrogen compound 23.8095 4 yes
GO:0014070 response to organic cyclic compound 23.8095 4 yes
GO:0018958 phenol-containing compound metabolic process 23.8095 4 yes
GO:0030001 metal ion transport 23.8095 6 yes
GO:0045927 positive regulation of growth 19.0476 4 yes
GO:0048638 regulation of developmental growth 19.0476 4 yes
GO:0048639 positive regulation of developmental growth 19.0476 5 yes
GO:0051094 positive regulation of developmental process 19.0476 4 yes
GO:0051240 positive regulation of multicellular organismal process 19.0476 4 yes
GO:1901362 organic cyclic compound biosynthetic process 19.0476 4 yes
GO:1901565 organonitrogen compound catabolic process 19.0476 4 yes
GO:1901566 organonitrogen compound biosynthetic process 19.0476 4 yes
GO:0010039 response to iron ion 19.0476 5 yes
GO:0032101 regulation of response to external stimulus 19.0476 4 yes
GO:0042069 regulation of catecholamine metabolic process 14.2857 5 yes
GO:0042220 response to cocaine 14.2857 4 yes
GO:0042401 biogenic amine biosynthetic process 14.2857 6 yes
GO:0042416 dopamine biosynthetic process 14.2857 8 yes
GO:0042423 catecholamine biosynthetic process 14.2857 7 yes
GO:0043279 response to alkaloid 14.2857 5 yes
GO:0046189 phenol-containing compound biosynthetic process 14.2857 5 yes
GO:0060134 prepulse inhibition 14.2857 6 yes
GO:0098655 monoatomic cation transmembrane transport 14.2857 4 yes
GO:0098662 inorganic cation transmembrane transport 14.2857 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 14.2857 4 yes
GO:0007600 sensory perception 14.2857 4 yes
GO:0007606 sensory perception of chemical stimulus 14.2857 5 yes
GO:0007608 sensory perception of smell 14.2857 6 yes
GO:0009309 amine biosynthetic process 14.2857 5 yes
GO:0009713 catechol-containing compound biosynthetic process 14.2857 6 yes
GO:0015695 organic cation transport 14.2857 5 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0033238 regulation of amine metabolic process 14.2857 4 yes
GO:0040014 regulation of multicellular organism growth 14.2857 4 yes
GO:0040018 positive regulation of multicellular organism growth 14.2857 5 yes
GO:0042053 regulation of dopamine metabolic process 14.2857 6 yes
GO:0042402 cellular biogenic amine catabolic process 9.5238 6 yes
GO:0042420 dopamine catabolic process 9.5238 8 yes
GO:0042424 catecholamine catabolic process 9.5238 7 yes
GO:0045471 response to ethanol 9.5238 5 yes
GO:0046683 response to organophosphorus 9.5238 4 yes
GO:0051591 response to cAMP 9.5238 4 yes
GO:0097305 response to alcohol 9.5238 4 yes
GO:1901361 organic cyclic compound catabolic process 9.5238 4 yes
GO:1901616 organic hydroxy compound catabolic process 9.5238 4 yes
GO:0006814 sodium ion transport 9.5238 7 yes
GO:0007589 body fluid secretion 9.5238 4 yes
GO:0007595 lactation 9.5238 5 yes
GO:0009310 amine catabolic process 9.5238 5 yes
GO:0014074 response to purine-containing compound 9.5238 5 yes
GO:0015874 norepinephrine transport 9.5238 6 yes
GO:0019336 phenol-containing compound catabolic process 9.5238 5 yes
GO:0019614 catechol-containing compound catabolic process 9.5238 6 yes
GO:0035725 sodium ion transmembrane transport 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RIT2_HUMAN [view interactions] Low throughput no yes
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
GPR37_HUMAN [view interactions] Low throughput no no
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
VMAT2_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
TPPP_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFI1_HUMAN [view interactions] Low throughput no no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SNG3_HUMAN [view entry] [view interactions] Low throughput yes no
NOS1_HUMAN [view entry] [view interactions] High throughput yes yes
INADL_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB1_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
4F2_HUMAN [view entry] [view interactions] High throughput yes no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC2_HUMAN [view interactions] High throughput no yes
FBXL2_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no