Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC6A3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Amine transporter (PubMed, PubMed, PubMed). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals . Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SC6A3_HUMAN
GO:0046872 metal ion binding 43.7500 4 yes
GO:0017076 purine nucleotide binding 21.8750 4 no
GO:0032555 purine ribonucleotide binding 21.8750 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.8750 4 no
GO:0035240 dopamine binding 18.7500 4 yes
GO:0002020 protease binding 12.5000 4 yes
GO:0008324 cation transmembrane transporter activity 9.3750 4 yes
GO:0008504 monoamine transmembrane transporter activity 9.3750 4 yes
GO:0008509 anion transmembrane transporter activity 9.3750 4 yes
GO:0015081 sodium ion transmembrane transporter activity 9.3750 6 yes
GO:0015103 inorganic anion transmembrane transporter activity 9.3750 4 yes
GO:0015108 chloride transmembrane transporter activity 9.3750 5 yes
GO:0015291 secondary active transmembrane transporter activity 9.3750 4 yes
GO:0015293 symporter activity 9.3750 5 yes
GO:0015294 solute:cation symporter activity 9.3750 5 yes
GO:0015296 anion:cation symporter activity 9.3750 5 yes
GO:0015370 solute:sodium symporter activity 9.3750 6 yes
GO:0015373 anion:sodium symporter activity 9.3750 6 yes
GO:0015377 cation:chloride symporter activity 9.3750 6 yes
GO:0015378 sodium:chloride symporter activity 9.3750 7 yes
GO:0022853 active ion transmembrane transporter activity 9.3750 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 9.3750 4 yes
GO:0046873 metal ion transmembrane transporter activity 9.3750 5 yes
GO:0005330 dopamine:sodium symporter activity 6.2500 4 yes
GO:0005334 norepinephrine:sodium symporter activity 6.2500 4 yes
GO:0015101 organic cation transmembrane transporter activity 6.2500 5 yes
GO:0019902 phosphatase binding 6.2500 4 yes
GO:0019903 protein phosphatase binding 6.2500 5 yes
GO:0051721 protein phosphatase 2A binding 6.2500 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC6A3_HUMAN
GO:0048522 positive regulation of cellular process 65.6250 4 no
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0051049 regulation of transport 59.3750 4 no
GO:0051171 regulation of nitrogen compound metabolic process 59.3750 4 yes
GO:0080090 regulation of primary metabolic process 59.3750 4 yes
GO:0031323 regulation of cellular metabolic process 56.2500 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.1250 4 no
GO:0051246 regulation of protein metabolic process 46.8750 5 no
GO:0099177 regulation of trans-synaptic signaling 43.7500 4 no
GO:0051050 positive regulation of transport 43.7500 4 no
GO:0071702 organic substance transport 43.7500 4 yes
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0050804 modulation of chemical synaptic transmission 43.7500 5 no
GO:0010647 positive regulation of cell communication 40.6250 5 no
GO:0023056 positive regulation of signaling 40.6250 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051046 regulation of secretion 34.3750 5 no
GO:0051588 regulation of neurotransmitter transport 34.3750 5 no
GO:1903530 regulation of secretion by cell 34.3750 4 no
GO:0009889 regulation of biosynthetic process 34.3750 4 no
GO:0051252 regulation of RNA metabolic process 34.3750 5 no
GO:0010243 response to organonitrogen compound 34.3750 4 yes
GO:0014070 response to organic cyclic compound 34.3750 4 yes
GO:0009893 positive regulation of metabolic process 34.3750 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.3750 5 no
GO:0031399 regulation of protein modification process 34.3750 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0060627 regulation of vesicle-mediated transport 31.2500 4 no
GO:0006355 regulation of DNA-templated transcription 31.2500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:1903506 regulation of nucleic acid-templated transcription 31.2500 7 no
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0010959 regulation of metal ion transport 31.2500 6 no
GO:0036211 protein modification process 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0099537 trans-synaptic signaling 28.1250 4 no
GO:0016192 vesicle-mediated transport 28.1250 4 no
GO:0006576 cellular biogenic amine metabolic process 28.1250 5 yes
GO:0006584 catecholamine metabolic process 28.1250 6 yes
GO:0006811 ion transport 28.1250 4 yes
GO:0009308 amine metabolic process 28.1250 4 yes
GO:0009712 catechol-containing compound metabolic process 28.1250 5 yes
GO:0018958 phenol-containing compound metabolic process 28.1250 4 yes
GO:0042417 dopamine metabolic process 28.1250 7 yes
GO:0044106 cellular amine metabolic process 28.1250 4 yes
GO:0046903 secretion 28.1250 4 yes
GO:0051240 positive regulation of multicellular organismal process 28.1250 4 yes
GO:0009892 negative regulation of metabolic process 28.1250 4 no
GO:0031325 positive regulation of cellular metabolic process 28.1250 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:0006812 cation transport 25.0000 5 yes
GO:0010038 response to metal ion 25.0000 4 yes
GO:0051094 positive regulation of developmental process 25.0000 4 yes
GO:0007268 chemical synaptic transmission 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0046928 regulation of neurotransmitter secretion 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 21.8750 6 no
GO:0061024 membrane organization 21.8750 4 no
GO:0032880 regulation of protein localization 21.8750 5 no
GO:0043270 positive regulation of ion transport 21.8750 5 no
GO:0051223 regulation of protein transport 21.8750 5 no
GO:0070201 regulation of establishment of protein localization 21.8750 6 no
GO:0050808 synapse organization 21.8750 5 no
GO:0001932 regulation of protein phosphorylation 21.8750 7 no
GO:0019220 regulation of phosphate metabolic process 21.8750 6 no
GO:0042325 regulation of phosphorylation 21.8750 7 no
GO:0051174 regulation of phosphorus metabolic process 21.8750 5 no
GO:0051580 regulation of neurotransmitter uptake 21.8750 4 no
GO:1902531 regulation of intracellular signal transduction 21.8750 5 no
GO:0051051 negative regulation of transport 21.8750 4 no
GO:0010648 negative regulation of cell communication 21.8750 5 no
GO:0023057 negative regulation of signaling 21.8750 4 no
GO:0006836 neurotransmitter transport 21.8750 4 yes
GO:0015844 monoamine transport 21.8750 5 yes
GO:0032101 regulation of response to external stimulus 21.8750 4 yes
GO:0048585 negative regulation of response to stimulus 21.8750 4 yes
GO:1901565 organonitrogen compound catabolic process 21.8750 4 yes
GO:0006796 phosphate-containing compound metabolic process 21.8750 4 no
GO:0009894 regulation of catabolic process 21.8750 4 no
GO:0010941 regulation of cell death 21.8750 4 no
GO:0017157 regulation of exocytosis 21.8750 5 no
GO:0015850 organic hydroxy compound transport 18.7500 5 yes
GO:0015872 dopamine transport 18.7500 6 yes
GO:0051937 catecholamine transport 18.7500 6 yes
GO:0001504 neurotransmitter uptake 15.6250 4 yes
GO:0033238 regulation of cellular amine metabolic process 15.6250 5 yes
GO:0042053 regulation of dopamine metabolic process 15.6250 6 yes
GO:0042069 regulation of catecholamine metabolic process 15.6250 5 yes
GO:0043279 response to alkaloid 15.6250 5 yes
GO:0045927 positive regulation of growth 15.6250 4 yes
GO:0048638 regulation of developmental growth 15.6250 4 yes
GO:0048639 positive regulation of developmental growth 15.6250 5 yes
GO:0098657 import into cell 15.6250 4 yes
GO:0009310 amine catabolic process 12.5000 5 yes
GO:0010039 response to iron ion 12.5000 5 yes
GO:0019336 phenol-containing compound catabolic process 12.5000 5 yes
GO:0019439 aromatic compound catabolic process 12.5000 4 yes
GO:0019614 catechol-containing compound catabolic process 12.5000 6 yes
GO:0030001 metal ion transport 12.5000 6 yes
GO:0032102 negative regulation of response to external stimulus 12.5000 5 yes
GO:0042220 response to cocaine 12.5000 4 yes
GO:0042402 cellular biogenic amine catabolic process 12.5000 6 yes
GO:0042420 dopamine catabolic process 12.5000 8 yes
GO:0042424 catecholamine catabolic process 12.5000 7 yes
GO:0044271 cellular nitrogen compound biosynthetic process 12.5000 4 yes
GO:0051583 dopamine uptake involved in synaptic transmission 12.5000 6 yes
GO:0051934 catecholamine uptake involved in synaptic transmission 12.5000 5 yes
GO:0060134 prepulse inhibition 12.5000 6 yes
GO:0090493 catecholamine uptake 12.5000 5 yes
GO:0090494 dopamine uptake 12.5000 6 yes
GO:0098810 neurotransmitter reuptake 12.5000 4 yes
GO:1901361 organic cyclic compound catabolic process 12.5000 4 yes
GO:1901616 organic hydroxy compound catabolic process 12.5000 4 yes
GO:0007600 sensory perception 9.3750 4 yes
GO:0007606 sensory perception of chemical stimulus 9.3750 5 yes
GO:0007608 sensory perception of smell 9.3750 6 yes
GO:0009309 amine biosynthetic process 9.3750 5 yes
GO:0009713 catechol-containing compound biosynthetic process 9.3750 6 yes
GO:0019438 aromatic compound biosynthetic process 9.3750 4 yes
GO:0040014 regulation of multicellular organism growth 9.3750 4 yes
GO:0040018 positive regulation of multicellular organism growth 9.3750 5 yes
GO:0042401 cellular biogenic amine biosynthetic process 9.3750 6 yes
GO:0042416 dopamine biosynthetic process 9.3750 8 yes
GO:0042423 catecholamine biosynthetic process 9.3750 7 yes
GO:0046189 phenol-containing compound biosynthetic process 9.3750 5 yes
GO:0097305 response to alcohol 9.3750 4 yes
GO:0098655 cation transmembrane transport 9.3750 4 yes
GO:0098660 inorganic ion transmembrane transport 9.3750 4 yes
GO:0098662 inorganic cation transmembrane transport 9.3750 5 yes
GO:1901362 organic cyclic compound biosynthetic process 9.3750 4 yes
GO:1901566 organonitrogen compound biosynthetic process 9.3750 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 9.3750 4 yes
GO:0006814 sodium ion transport 6.2500 7 yes
GO:0007589 body fluid secretion 6.2500 4 yes
GO:0007595 lactation 6.2500 5 yes
GO:0014074 response to purine-containing compound 6.2500 5 yes
GO:0015695 organic cation transport 6.2500 5 yes
GO:0015874 norepinephrine transport 6.2500 6 yes
GO:0035725 sodium ion transmembrane transport 6.2500 6 yes
GO:0045471 response to ethanol 6.2500 5 yes
GO:0046683 response to organophosphorus 6.2500 4 yes
GO:0051591 response to cAMP 6.2500 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RIT2_HUMAN [view interactions] Low throughput no yes
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
GPR37_HUMAN [view interactions] Low throughput no no
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
VMAT2_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
TPPP_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFI1_HUMAN [view interactions] Low throughput no no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SNG3_HUMAN [view entry] [view interactions] Low throughput yes no
INADL_HUMAN [view interactions] High throughput no no
NOS1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB1_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] Computational yes yes
DISC1_HUMAN [view entry] [view interactions] Computational yes no
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
DRD4_HUMAN [view entry] [view interactions] Computational yes no
DRD1_HUMAN [view entry] [view interactions] Computational yes no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
DRD5_HUMAN [view entry] [view interactions] Computational yes no
FLOT2_HUMAN [view entry] [view interactions] Computational yes yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
AOFA_HUMAN [view entry] [view interactions] Computational yes yes
CADH1_HUMAN [view entry] [view interactions] Computational yes no
TY3H_HUMAN [view interactions] Computational no no
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
COMT_HUMAN [view entry] [view interactions] Computational yes yes