EPN1_HUMAN
Evidence for PS localization
Functions
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations . Regulates receptor-mediated endocytosis (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001142 | LIG_EH_1 | LIG | 501 | 505 | - |
| ELMI001143 | LIG_EH_1 | LIG | 517 | 521 | - |
| ELMI001144 | LIG_EH_1 | LIG | 571 | 575 | - |
| ELMI001209 | TRG_AP2beta_CARGO_1 | TRG | 402 | 411 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPN1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.4151 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.4151 | 4 | no |
| GO:0046872 | metal ion binding | 24.5283 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.5283 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5283 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPN1_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 60.3774 | 4 | yes |
| GO:0006897 | endocytosis | 47.1698 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 47.1698 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.2830 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3962 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.5094 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.5094 | 4 | no |
| GO:0006996 | organelle organization | 39.6226 | 4 | no |
| GO:0008104 | protein localization | 37.7358 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.7358 | 4 | no |
| GO:0071702 | organic substance transport | 37.7358 | 4 | no |
| GO:0071705 | nitrogen compound transport | 37.7358 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.8491 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.0755 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.0755 | 4 | no |
| GO:0015031 | protein transport | 32.0755 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 32.0755 | 6 | no |
| GO:0022607 | cellular component assembly | 30.1887 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.3019 | 5 | no |
| GO:0051049 | regulation of transport | 28.3019 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.3019 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.3019 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.4151 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.4151 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 26.4151 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.4151 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.4151 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.5283 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5283 | 5 | no |
| GO:0072583 | clathrin-dependent endocytosis | 24.5283 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 22.6415 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.6415 | 5 | no |
| GO:0036211 | protein modification process | 22.6415 | 4 | no |
| GO:0043412 | macromolecule modification | 22.6415 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.7547 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.7547 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.7547 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.7547 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.7547 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.7547 | 5 | no |
| GO:0010941 | regulation of cell death | 20.7547 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.7547 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 15.0943 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 11.3208 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 7.5472 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 7.5472 | 4 | yes |
| GO:0045765 | regulation of angiogenesis | 5.6604 | 5 | yes |
| GO:1901342 | regulation of vasculature development | 5.6604 | 5 | yes |
| GO:0016525 | negative regulation of angiogenesis | 3.7736 | 6 | yes |
| GO:1901343 | negative regulation of vasculature development | 3.7736 | 5 | yes |
| GO:2000181 | negative regulation of blood vessel morphogenesis | 3.7736 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | Low throughput | no | yes |
| EPN3_HUMAN | [view interactions] | Low throughput | no | no |
| IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
| DVL2_HUMAN | [view interactions] | Low throughput | no | yes |
| LRP6_HUMAN | [view interactions] | Low throughput | no | yes |
| FZD7_HUMAN | [view interactions] | Low throughput | no | yes |
| FZD8_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| F1892_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD2_HUMAN | [view interactions] | Low throughput | no | no |
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TF3A_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| OCLN_HUMAN | [view interactions] | Low throughput | no | no |
| SCNNA_HUMAN | [view interactions] | Low throughput | no | yes |
| SCNNB_HUMAN | [view interactions] | Low throughput | no | yes |
| SCNNG_HUMAN | [view interactions] | Low throughput | no | no |
| AP1M2_HUMAN | [view interactions] | Low throughput | no | no |
| DLL1_HUMAN | [view interactions] | Low throughput | no | no |
| UBQL2_HUMAN | [view interactions] | Low throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A_HUMAN | [view interactions] | Low throughput | no | no |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| GTR14_HUMAN | [view interactions] | High throughput | no | no |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33B_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| F189B_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD5_HUMAN | [view interactions] | High throughput | no | no |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| LAPM5_HUMAN | [view interactions] | High throughput | no | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| ARRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TAD2B_HUMAN | [view interactions] | High throughput | no | yes |
| PLPR2_HUMAN | [view interactions] | High throughput | no | yes |
| FLVC2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| MED31_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| SYNRG_HUMAN | [view interactions] | Computational | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FCHO2_HUMAN | [view interactions] | Computational | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CBL_HUMAN | [view interactions] | Computational | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EGF_HUMAN | [view interactions] | Computational | no | no |
| PTN3_HUMAN | [view interactions] | Computational | no | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP2BC_HUMAN | [view interactions] | Computational | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLH2_HUMAN | [view interactions] | Computational | no | no |