DPYL1_HUMAN
Evidence for PS localization
Functions
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed). Plays a role in axon guidance (PubMed). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed). Involved in invasive growth and cell migration (PubMed). May participate in cytokinesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DPYL1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 26.9841 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.9841 | 5 | no |
| GO:0046872 | metal ion binding | 25.3968 | 5 | no |
| GO:0043168 | anion binding | 25.3968 | 4 | no |
| GO:0043169 | cation binding | 25.3968 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.8095 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.6349 | 5 | no |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | 7.9365 | 4 | yes |
| GO:0031005 | filamin binding | 6.3492 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DPYL1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.5556 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.7937 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.7937 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 49.2063 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 49.2063 | 4 | no |
| GO:0022607 | cellular component assembly | 47.6190 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.4444 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.2698 | 5 | no |
| GO:0010646 | regulation of cell communication | 41.2698 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.2698 | 5 | no |
| GO:0010468 | regulation of gene expression | 38.0952 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 36.5079 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.5079 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.9206 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.9206 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 31.7460 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.7460 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 31.7460 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.7460 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.9841 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.3968 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.3968 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.3968 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.3968 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.3968 | 4 | no |
| GO:0008104 | protein localization | 25.3968 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.3968 | 6 | no |
| GO:0030030 | cell projection organization | 25.3968 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.3968 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.8095 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.8095 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.8095 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6349 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 20.6349 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.6349 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.6349 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.6349 | 5 | no |
| GO:0031346 | positive regulation of cell projection organization | 20.6349 | 6 | no |
| GO:0051049 | regulation of transport | 20.6349 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.6349 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 20.6349 | 7 | no |
| GO:0060341 | regulation of cellular localization | 20.6349 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 17.4603 | 7 | yes |
| GO:0007399 | nervous system development | 9.5238 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 7.9365 | 7 | yes |
| GO:0031345 | negative regulation of cell projection organization | 7.9365 | 6 | yes |
| GO:0032091 | negative regulation of protein binding | 6.3492 | 5 | yes |
| GO:0043393 | regulation of protein binding | 6.3492 | 4 | yes |
| GO:0051100 | negative regulation of binding | 6.3492 | 4 | yes |
| GO:1904529 | regulation of actin filament binding | 3.1746 | 6 | yes |
| GO:1904530 | negative regulation of actin filament binding | 3.1746 | 7 | yes |
| GO:1904616 | regulation of actin binding | 3.1746 | 5 | yes |
| GO:1904617 | negative regulation of actin binding | 3.1746 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DPYL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| GLCNE_HUMAN | [view interactions] | Low throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| PITH1_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1B_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP110_HUMAN | [view interactions] | High throughput | no | yes |
| AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| PA1B3_HUMAN | [view interactions] | High throughput | no | no |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| SPB9_HUMAN | [view interactions] | High throughput | no | no |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD2_HUMAN | [view interactions] | High throughput | no | no |
| CCL18_HUMAN | [view interactions] | High throughput | no | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| NAT9_HUMAN | [view interactions] | High throughput | no | no |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| CC106_HUMAN | [view interactions] | High throughput | no | no |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| RGL2_HUMAN | [view interactions] | High throughput | no | yes |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPS1_HUMAN | [view interactions] | High throughput | no | yes |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NVL_HUMAN | [view interactions] | High throughput | no | no |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL33_HUMAN | [view interactions] | High throughput | no | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| PA2GA_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XAGE3_HUMAN | [view interactions] | High throughput | no | no |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM1_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGEE3_HUMAN | [view interactions] | High throughput | no | no |
| TTLL6_HUMAN | [view interactions] | High throughput | no | no |
| CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SWP70_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BID_HUMAN | [view interactions] | High throughput | no | no |
| YAE1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |