DPYL1_HUMAN
Evidence for PS localization
Functions
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed). Plays a role in axon guidance (PubMed). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed). Involved in invasive growth and cell migration (PubMed). May participate in cytokinesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DPYL1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.3158 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.5614 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5614 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.8070 | 5 | no |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
| GO:0005524 | ATP binding | 21.0526 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.0526 | 5 | no |
| GO:0031005 | filamin binding | 7.0175 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DPYL1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.8947 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.3860 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.8772 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.8772 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.8772 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.1228 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.1228 | 4 | no |
| GO:0006996 | organelle organization | 47.3684 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.1053 | 5 | no |
| GO:0010468 | regulation of gene expression | 38.5965 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 38.5965 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.5965 | 4 | no |
| GO:0022607 | cellular component assembly | 38.5965 | 4 | no |
| GO:0007010 | cytoskeleton organization | 36.8421 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.8421 | 5 | no |
| GO:0030030 | cell projection organization | 35.0877 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 35.0877 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.0877 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5789 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.8246 | 4 | no |
| GO:0009894 | regulation of catabolic process | 29.8246 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.8246 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.8246 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.0702 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 28.0702 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 26.3158 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.5614 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.5614 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.5614 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.5614 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.5614 | 4 | no |
| GO:0031175 | neuron projection development | 22.8070 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 22.8070 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 22.8070 | 6 | no |
| GO:0010941 | regulation of cell death | 22.8070 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 22.8070 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.8070 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.8070 | 7 | no |
| GO:0060341 | regulation of cellular localization | 22.8070 | 4 | no |
| GO:0008104 | protein localization | 22.8070 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8070 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 21.0526 | 6 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.0526 | 6 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.0526 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 21.0526 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 19.2982 | 7 | yes |
| GO:0043393 | regulation of protein binding | 14.0351 | 4 | yes |
| GO:0097485 | neuron projection guidance | 14.0351 | 7 | yes |
| GO:0007411 | axon guidance | 12.2807 | 8 | yes |
| GO:0010977 | negative regulation of neuron projection development | 12.2807 | 7 | yes |
| GO:0031345 | negative regulation of cell projection organization | 12.2807 | 6 | yes |
| GO:0007399 | nervous system development | 10.5263 | 4 | yes |
| GO:0032091 | negative regulation of protein binding | 10.5263 | 5 | yes |
| GO:0051100 | negative regulation of binding | 10.5263 | 4 | yes |
| GO:1904529 | regulation of actin filament binding | 3.5088 | 6 | yes |
| GO:1904530 | negative regulation of actin filament binding | 3.5088 | 7 | yes |
| GO:1904616 | regulation of actin binding | 3.5088 | 5 | yes |
| GO:1904617 | negative regulation of actin binding | 3.5088 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DPYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| GLCNE_HUMAN | [view interactions] | Low throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPYL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| PA1B3_HUMAN | [view interactions] | High throughput | no | no |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| SPB9_HUMAN | [view interactions] | High throughput | no | no |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |
| ARL15_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD2_HUMAN | [view interactions] | High throughput | no | no |
| CCL18_HUMAN | [view interactions] | High throughput | no | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| NAT9_HUMAN | [view interactions] | High throughput | no | no |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| CC106_HUMAN | [view interactions] | High throughput | no | no |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| RGL2_HUMAN | [view interactions] | High throughput | no | yes |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPS1_HUMAN | [view interactions] | High throughput | no | yes |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NVL_HUMAN | [view interactions] | High throughput | no | no |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL33_HUMAN | [view interactions] | High throughput | no | yes |
| DDX18_HUMAN | [view interactions] | High throughput | no | yes |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| PA2GA_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 4EBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XAGE3_HUMAN | [view interactions] | High throughput | no | no |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM1_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGEE3_HUMAN | [view interactions] | High throughput | no | no |
| TTLL6_HUMAN | [view interactions] | High throughput | no | no |
| CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SWP70_HUMAN | [view interactions] | High throughput | no | no |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BID_HUMAN | [view interactions] | High throughput | no | no |
| YAE1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP7A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| PITH1_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| SEM3A_HUMAN | [view interactions] | Computational | no | no |
| CDK5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |