Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ALDH2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ALDH2_HUMAN
GO:0003723 RNA binding 25.0000 4 no
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 10.2941 4 yes
GO:0004029 aldehyde dehydrogenase (NAD+) activity 7.3529 6 yes
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 7.3529 5 yes
GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity 5.8824 5 yes
GO:0051287 NAD binding 5.8824 4 yes
GO:0052689 carboxylic ester hydrolase activity 4.4118 4 yes
GO:0008957 phenylacetaldehyde dehydrogenase activity 2.9412 7 yes
GO:0016663 oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor 2.9412 4 yes
GO:0018547 nitroglycerin reductase activity 2.9412 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ALDH2_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 yes
GO:0080090 regulation of primary metabolic process 41.1765 4 yes
GO:0048522 positive regulation of cellular process 41.1765 4 no
GO:0031323 regulation of cellular metabolic process 39.7059 4 yes
GO:0048523 negative regulation of cellular process 39.7059 4 no
GO:0060255 regulation of macromolecule metabolic process 36.7647 4 no
GO:0010646 regulation of cell communication 33.8235 4 no
GO:0008104 protein localization 29.4118 4 no
GO:0071702 organic substance transport 29.4118 4 no
GO:0071705 nitrogen compound transport 29.4118 4 no
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0019752 carboxylic acid metabolic process 27.9412 5 no
GO:0043436 oxoacid metabolic process 27.9412 4 no
GO:0009892 negative regulation of metabolic process 27.9412 4 no
GO:0051246 regulation of protein metabolic process 27.9412 5 no
GO:0015031 protein transport 27.9412 4 no
GO:0009966 regulation of signal transduction 27.9412 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.4706 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.4706 5 no
GO:0022607 cellular component assembly 26.4706 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0009889 regulation of biosynthetic process 23.5294 4 yes
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 yes
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0006996 organelle organization 23.5294 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.5294 5 no
GO:0051128 regulation of cellular component organization 22.0588 4 no
GO:0051049 regulation of transport 22.0588 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.0588 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.5882 5 no
GO:0031325 positive regulation of cellular metabolic process 20.5882 5 no
GO:0010941 regulation of cell death 20.5882 4 no
GO:1901616 organic hydroxy compound catabolic process 10.2941 4 yes
GO:0034308 primary alcohol metabolic process 8.8235 4 yes
GO:0033238 regulation of cellular amine metabolic process 7.3529 5 yes
GO:0042053 regulation of dopamine metabolic process 5.8824 6 yes
GO:0042069 regulation of catecholamine metabolic process 5.8824 5 yes
GO:0046164 alcohol catabolic process 5.8824 4 yes
GO:0046185 aldehyde catabolic process 4.4118 4 yes
GO:1903179 regulation of dopamine biosynthetic process 4.4118 6 yes
GO:0006067 ethanol metabolic process 2.9412 5 yes
GO:0006068 ethanol catabolic process 2.9412 6 yes
GO:0034310 primary alcohol catabolic process 2.9412 5 yes
GO:1905627 regulation of serotonin biosynthetic process 2.9412 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ALDH2_HUMAN
DOID:1289 neurodegenerative disease 2.9412 4 no
DOID:331 central nervous system disease 2.9412 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALDH2_HUMAN [view entry] [view interactions] Low throughput yes no
CH60_HUMAN [view entry] [view interactions] Low throughput yes yes
CH10_HUMAN [view interactions] Low throughput no yes
AOC3_HUMAN [view interactions] Low throughput no no
TOM20_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR3_HUMAN [view interactions] Low throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
OSMR_HUMAN [view interactions] High throughput no yes
ERG28_HUMAN [view interactions] High throughput no yes
CENPR_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
S35F6_HUMAN [view interactions] High throughput no yes
IGS21_HUMAN [view entry] [view interactions] High throughput yes no
U119A_HUMAN [view interactions] High throughput no no
DEN10_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
RB33B_HUMAN [view interactions] High throughput no no
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB19_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
AL1A2_HUMAN [view interactions] High throughput no yes
A1AT_HUMAN [view interactions] High throughput no no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
FIBA_HUMAN [view interactions] High throughput no no
FBW1A_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TADBP_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MT21E_HUMAN [view interactions] High throughput no no
AL1B1_HUMAN [view interactions] High throughput no yes
PKP1_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1A_HUMAN [view interactions] High throughput no yes
XRCC3_HUMAN [view interactions] High throughput no no
ATAD5_HUMAN [view interactions] High throughput no no
APC_HUMAN [view entry] [view interactions] High throughput yes no
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDH6A_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
RPE_HUMAN [view interactions] High throughput no yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
ESTD_HUMAN [view interactions] High throughput no yes
PDC6I_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
GRPE1_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
ACOX1_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
HEXA_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
PAFA2_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
NADC_HUMAN [view interactions] High throughput no yes
RD23A_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
PFD3_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CPNS1_HUMAN [view interactions] High throughput no yes
MCAT_HUMAN [view interactions] High throughput no yes
LKHA4_HUMAN [view interactions] High throughput no yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
ADRO_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
MPC2_HUMAN [view interactions] High throughput no yes
FHIT_HUMAN [view interactions] High throughput no yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
UFC1_HUMAN [view interactions] High throughput no yes
UFM1_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CHCH1_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET17_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
AL1A1_HUMAN [view entry] [view interactions] High throughput yes yes
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
SIR4_HUMAN [view interactions] High throughput no yes
SPB5_HUMAN [view interactions] High throughput no no
IGHG4_HUMAN [view interactions] High throughput no no
CALL5_HUMAN [view entry] [view interactions] High throughput yes no
MMSA_HUMAN [view entry] [view interactions] High throughput yes no
TRFE_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
APOA1_HUMAN [view interactions] High throughput no no
IGHA1_HUMAN [view entry] [view interactions] High throughput yes yes
IGHG3_HUMAN [view interactions] High throughput no no
IGHG1_HUMAN [view interactions] High throughput no no
IGKC_HUMAN [view interactions] High throughput no no
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TOP1_HUMAN [view interactions] High throughput no yes
TR10A_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
MYLK_HUMAN [view interactions] High throughput no no
NEK7_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
KCNH2_HUMAN [view interactions] High throughput no no
NEU2_HUMAN [view interactions] Computational no no
AL3A2_HUMAN [view entry] [view interactions] Computational yes yes
ACS2L_HUMAN [view interactions] Computational no yes
ODB2_HUMAN [view entry] [view interactions] Computational yes yes
ACSF3_HUMAN [view interactions] Computational no no
CP2E1_HUMAN [view interactions] Computational no no
3HIDH_HUMAN [view interactions] Computational no yes
ACSS3_HUMAN [view interactions] Computational no no
ECHP_HUMAN [view interactions] Computational no no
ADH1B_HUMAN [view interactions] Computational no no
ADH1A_HUMAN [view interactions] Computational no no
AOFA_HUMAN [view entry] [view interactions] Computational yes yes
GLCTK_HUMAN [view interactions] Computational no yes
CNDP2_HUMAN [view entry] [view interactions] Computational yes yes
AK1A1_HUMAN [view entry] [view interactions] Computational yes no
AOFB_HUMAN [view entry] [view interactions] Computational yes yes
CNDP1_HUMAN [view interactions] Computational no yes
COMT_HUMAN [view entry] [view interactions] Computational yes yes
BODG_HUMAN [view interactions] Computational no no
GLNA_HUMAN [view entry] [view interactions] Computational yes yes
GATM_HUMAN [view interactions] Computational no no
ADH4_HUMAN [view interactions] Computational no no
ASMT_HUMAN [view interactions] Computational no no
GADL1_HUMAN [view interactions] Computational no no
AGT2_HUMAN [view interactions] Computational no no
ALDR_HUMAN [view interactions] Computational no no
ADH7_HUMAN [view interactions] Computational no no
BUP1_HUMAN [view interactions] Computational no no
ACSA_HUMAN [view interactions] Computational no no
GABT_HUMAN [view interactions] Computational no yes
CRNS1_HUMAN [view interactions] Computational no no
TPIS_HUMAN [view entry] [view interactions] Computational yes yes
AOC1_HUMAN [view interactions] Computational no no
ADH1G_HUMAN [view interactions] Computational no yes
ACADS_HUMAN [view interactions] Computational no yes
AL4A1_HUMAN [view entry] [view interactions] Computational yes yes
ACO12_HUMAN [view interactions] Computational no no
CATA_HUMAN [view entry] [view interactions] Computational yes no
ECHD1_HUMAN [view interactions] Computational no no
ADH6_HUMAN [view interactions] Computational no no
ADHX_HUMAN [view interactions] Computational no yes
AOC2_HUMAN [view interactions] Computational no no