ALDH2_HUMAN
Evidence for PS localization
Functions
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 504 | Glu | Lys | AMEDsyndrome,digenic(AMEDS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ALDH2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.6452 | 4 | no |
| GO:0000166 | nucleotide binding | 25.8065 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.8065 | 5 | yes |
| GO:0043168 | anion binding | 20.9677 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 16.1290 | 6 | yes |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 8.0645 | 4 | yes |
| GO:0051287 | NAD binding | 8.0645 | 7 | yes |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity | 4.8387 | 6 | yes |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | 4.8387 | 5 | yes |
| GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity | 4.8387 | 5 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 4.8387 | 4 | yes |
| GO:0008957 | phenylacetaldehyde dehydrogenase activity | 3.2258 | 7 | yes |
| GO:0016663 | oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor | 3.2258 | 4 | yes |
| GO:0018547 | nitroglycerin reductase activity | 3.2258 | 5 | yes |
| GO:0106435 | carboxylesterase activity | 3.2258 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ALDH2_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 48.3871 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 46.7742 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.1613 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.5484 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.9355 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.7097 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.0968 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.4839 | 4 | yes |
| GO:0008104 | protein localization | 35.4839 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.8710 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.8710 | 5 | no |
| GO:0006996 | organelle organization | 33.8710 | 4 | no |
| GO:0022607 | cellular component assembly | 33.8710 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.8710 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.2581 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 32.2581 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.6452 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.6452 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.6452 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.6452 | 5 | no |
| GO:0071702 | organic substance transport | 29.0323 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.0323 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.4194 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4194 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.8065 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.8065 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.8065 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.8065 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.8065 | 4 | no |
| GO:0015031 | protein transport | 25.8065 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 24.1935 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.1935 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.1935 | 5 | no |
| GO:0051049 | regulation of transport | 24.1935 | 4 | no |
| GO:0080134 | regulation of response to stress | 24.1935 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.5806 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.5806 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.5806 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 20.9677 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.9677 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.9677 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.9677 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.9677 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.9677 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.9677 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.9677 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.9677 | 6 | no |
| GO:0033238 | regulation of amine metabolic process | 8.0645 | 4 | yes |
| GO:0042053 | regulation of dopamine metabolic process | 6.4516 | 6 | yes |
| GO:0042069 | regulation of catecholamine metabolic process | 6.4516 | 5 | yes |
| GO:0034308 | primary alcohol metabolic process | 4.8387 | 4 | yes |
| GO:0046164 | alcohol catabolic process | 4.8387 | 4 | yes |
| GO:1901616 | organic hydroxy compound catabolic process | 4.8387 | 4 | yes |
| GO:1903179 | regulation of dopamine biosynthetic process | 4.8387 | 5 | yes |
| GO:0006067 | ethanol metabolic process | 3.2258 | 5 | yes |
| GO:0006068 | ethanol catabolic process | 3.2258 | 6 | yes |
| GO:0034310 | primary alcohol catabolic process | 3.2258 | 5 | yes |
| GO:0046185 | aldehyde catabolic process | 3.2258 | 4 | yes |
| GO:1905627 | regulation of serotonin biosynthetic process | 3.2258 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ALDH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CH60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CH10_HUMAN | [view interactions] | Low throughput | no | yes |
| AOC3_HUMAN | [view interactions] | Low throughput | no | no |
| TOM20_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR3_HUMAN | [view interactions] | Low throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KCNH2_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| CENPR_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35F6_HUMAN | [view interactions] | High throughput | no | yes |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| DEN10_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33B_HUMAN | [view interactions] | High throughput | no | no |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB19_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| AL1A2_HUMAN | [view interactions] | High throughput | no | yes |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| ATAD5_HUMAN | [view interactions] | High throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| NADC_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| MCAT_HUMAN | [view interactions] | High throughput | no | yes |
| LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| FHIT_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| AL1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| IGKC_HUMAN | [view interactions] | High throughput | no | no |
| IGHG1_HUMAN | [view interactions] | High throughput | no | no |
| IGHG3_HUMAN | [view interactions] | High throughput | no | no |
| IGHG4_HUMAN | [view interactions] | High throughput | no | no |
| IGHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| MMSA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |