Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FIBG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004235 LIG_Integrin_KxxGD_FGGC_5 LIG 432 437 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FIBG_HUMAN
GO:0046872 metal ion binding 44.8276 4 yes
GO:0017076 purine nucleotide binding 27.5862 4 no
GO:0030554 adenyl nucleotide binding 27.5862 5 no
GO:0032555 purine ribonucleotide binding 27.5862 4 no
GO:0032559 adenyl ribonucleotide binding 27.5862 5 no
GO:0019900 kinase binding 20.6897 4 no
GO:0019901 protein kinase binding 20.6897 5 no
GO:0005524 ATP binding 20.6897 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.6897 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in FIBG_HUMAN
GO:0048523 negative regulation of cellular process 68.9655 4 yes
GO:0010646 regulation of cell communication 58.6207 4 yes
GO:0022607 cellular component assembly 55.1724 4 yes
GO:0048522 positive regulation of cellular process 48.2759 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 48.2759 4 no
GO:0080090 regulation of primary metabolic process 48.2759 4 no
GO:0060255 regulation of macromolecule metabolic process 44.8276 4 no
GO:0009966 regulation of signal transduction 44.8276 4 yes
GO:0043933 protein-containing complex organization 41.3793 4 yes
GO:0051049 regulation of transport 41.3793 4 yes
GO:0065003 protein-containing complex assembly 41.3793 5 yes
GO:0031323 regulation of cellular metabolic process 41.3793 4 no
GO:0010648 negative regulation of cell communication 41.3793 5 yes
GO:0023057 negative regulation of signaling 41.3793 4 yes
GO:0048584 positive regulation of response to stimulus 37.9310 4 yes
GO:0051240 positive regulation of multicellular organismal process 37.9310 4 yes
GO:0051246 regulation of protein metabolic process 37.9310 5 no
GO:0008104 protein localization 37.9310 4 yes
GO:0048585 negative regulation of response to stimulus 34.4828 4 yes
GO:0051050 positive regulation of transport 34.4828 4 yes
GO:0010243 response to organonitrogen compound 34.4828 4 no
GO:0009967 positive regulation of signal transduction 34.4828 5 yes
GO:0009968 negative regulation of signal transduction 34.4828 5 yes
GO:0010647 positive regulation of cell communication 34.4828 5 yes
GO:0023056 positive regulation of signaling 34.4828 4 yes
GO:0042981 regulation of apoptotic process 31.0345 6 yes
GO:0043067 regulation of programmed cell death 31.0345 5 yes
GO:0045595 regulation of cell differentiation 31.0345 4 yes
GO:0051094 positive regulation of developmental process 31.0345 4 yes
GO:0071310 cellular response to organic substance 31.0345 4 yes
GO:1902531 regulation of intracellular signal transduction 31.0345 5 yes
GO:0014070 response to organic cyclic compound 31.0345 4 no
GO:0010468 regulation of gene expression 31.0345 5 no
GO:0010941 regulation of cell death 31.0345 4 yes
GO:0032880 regulation of protein localization 27.5862 5 yes
GO:0044057 regulation of system process 27.5862 4 yes
GO:0060341 regulation of cellular localization 27.5862 4 yes
GO:0060548 negative regulation of cell death 27.5862 5 yes
GO:0071702 organic substance transport 27.5862 4 yes
GO:0071705 nitrogen compound transport 27.5862 4 yes
GO:1902533 positive regulation of intracellular signal transduction 27.5862 6 yes
GO:0043269 regulation of ion transport 27.5862 5 no
GO:0009892 negative regulation of metabolic process 27.5862 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5862 5 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.5862 5 no
GO:0043066 negative regulation of apoptotic process 24.1379 7 yes
GO:0043069 negative regulation of programmed cell death 24.1379 6 yes
GO:0080134 regulation of response to stress 24.1379 4 yes
GO:1903522 regulation of blood circulation 24.1379 5 yes
GO:0009889 regulation of biosynthetic process 24.1379 4 no
GO:0009893 positive regulation of metabolic process 24.1379 4 no
GO:0010604 positive regulation of macromolecule metabolic process 24.1379 5 no
GO:0031326 regulation of cellular biosynthetic process 24.1379 5 no
GO:0050804 modulation of chemical synaptic transmission 24.1379 5 no
GO:0099177 regulation of trans-synaptic signaling 24.1379 4 no
GO:0032101 regulation of response to external stimulus 20.6897 4 yes
GO:0043408 regulation of MAPK cascade 20.6897 6 yes
GO:0045597 positive regulation of cell differentiation 20.6897 5 yes
GO:0045785 positive regulation of cell adhesion 20.6897 5 yes
GO:0051223 regulation of protein transport 20.6897 5 yes
GO:0051241 negative regulation of multicellular organismal process 20.6897 4 yes
GO:0060627 regulation of vesicle-mediated transport 20.6897 4 yes
GO:0070201 regulation of establishment of protein localization 20.6897 6 yes
GO:1903829 positive regulation of protein localization 20.6897 5 yes
GO:0034762 regulation of transmembrane transport 20.6897 4 no
GO:0034765 regulation of ion transmembrane transport 20.6897 5 no
GO:0048878 chemical homeostasis 20.6897 4 no
GO:0006996 organelle organization 20.6897 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.6897 5 no
GO:0030334 regulation of cell migration 20.6897 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 20.6897 5 no
GO:0051247 positive regulation of protein metabolic process 20.6897 6 no
GO:2000145 regulation of cell motility 20.6897 4 no
GO:0051128 regulation of cellular component organization 20.6897 4 no
GO:0001932 regulation of protein phosphorylation 20.6897 7 no
GO:0019220 regulation of phosphate metabolic process 20.6897 6 no
GO:0031399 regulation of protein modification process 20.6897 6 no
GO:0042325 regulation of phosphorylation 20.6897 7 no
GO:0050890 cognition 20.6897 4 no
GO:0051174 regulation of phosphorus metabolic process 20.6897 5 no
GO:0010038 response to metal ion 20.6897 4 yes
GO:0015031 protein transport 20.6897 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.6897 4 yes
GO:0030155 regulation of cell adhesion 20.6897 4 yes
GO:0032102 negative regulation of response to external stimulus 17.2414 5 yes
GO:0043410 positive regulation of MAPK cascade 17.2414 7 yes
GO:0050865 regulation of cell activation 17.2414 4 yes
GO:0051046 regulation of secretion 17.2414 5 yes
GO:0051222 positive regulation of protein transport 17.2414 5 yes
GO:0051592 response to calcium ion 17.2414 5 yes
GO:0061041 regulation of wound healing 17.2414 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 17.2414 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 17.2414 8 yes
GO:1903034 regulation of response to wounding 17.2414 5 yes
GO:1904951 positive regulation of establishment of protein localization 17.2414 6 yes
GO:0003018 vascular process in circulatory system 17.2414 4 yes
GO:0007160 cell-matrix adhesion 17.2414 4 yes
GO:0010810 regulation of cell-substrate adhesion 17.2414 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 17.2414 6 yes
GO:0030193 regulation of blood coagulation 13.7931 4 yes
GO:0030195 negative regulation of blood coagulation 13.7931 5 yes
GO:0034097 response to cytokine 13.7931 4 yes
GO:0034109 homotypic cell-cell adhesion 13.7931 4 yes
GO:0035150 regulation of tube size 13.7931 4 yes
GO:0035296 regulation of tube diameter 13.7931 5 yes
GO:0050708 regulation of protein secretion 13.7931 5 yes
GO:0050818 regulation of coagulation 13.7931 4 yes
GO:0050819 negative regulation of coagulation 13.7931 5 yes
GO:0051047 positive regulation of secretion 13.7931 5 yes
GO:0051604 protein maturation 13.7931 4 yes
GO:0060284 regulation of cell development 13.7931 5 yes
GO:0061045 negative regulation of wound healing 13.7931 6 yes
GO:0070527 platelet aggregation 13.7931 5 yes
GO:0070555 response to interleukin-1 13.7931 5 yes
GO:0097746 blood vessel diameter maintenance 13.7931 5 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 13.7931 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 13.7931 7 yes
GO:1900047 negative regulation of hemostasis 13.7931 4 yes
GO:1903035 negative regulation of response to wounding 13.7931 5 yes
GO:1903530 regulation of secretion by cell 13.7931 4 yes
GO:0010720 positive regulation of cell development 13.7931 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 13.7931 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 13.7931 7 yes
GO:0022407 regulation of cell-cell adhesion 13.7931 5 yes
GO:0022409 positive regulation of cell-cell adhesion 13.7931 6 yes
GO:0022604 regulation of cell morphogenesis 13.7931 5 yes
GO:0031638 zymogen activation 10.3448 6 yes
GO:0031639 plasminogen activation 10.3448 7 yes
GO:0034114 regulation of heterotypic cell-cell adhesion 10.3448 6 yes
GO:0034116 positive regulation of heterotypic cell-cell adhesion 10.3448 7 yes
GO:0042730 fibrinolysis 10.3448 6 yes
GO:0045907 positive regulation of vasoconstriction 10.3448 5 yes
GO:0045921 positive regulation of exocytosis 10.3448 6 yes
GO:0046883 regulation of hormone secretion 10.3448 4 yes
GO:0046887 positive regulation of hormone secretion 10.3448 5 yes
GO:0050714 positive regulation of protein secretion 10.3448 6 yes
GO:0050866 negative regulation of cell activation 10.3448 5 yes
GO:0051258 protein polymerization 10.3448 6 yes
GO:0071345 cellular response to cytokine stimulus 10.3448 5 yes
GO:0071347 cellular response to interleukin-1 10.3448 6 yes
GO:0072376 protein activation cascade 10.3448 5 yes
GO:0072378 blood coagulation, fibrin clot formation 10.3448 6 yes
GO:0090087 regulation of peptide transport 10.3448 5 yes
GO:0090276 regulation of peptide hormone secretion 10.3448 5 yes
GO:0090277 positive regulation of peptide hormone secretion 10.3448 6 yes
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 10.3448 7 yes
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 10.3448 8 yes
GO:1903532 positive regulation of secretion by cell 10.3448 5 yes
GO:1904035 regulation of epithelial cell apoptotic process 10.3448 7 yes
GO:1904036 negative regulation of epithelial cell apoptotic process 10.3448 8 yes
GO:2000351 regulation of endothelial cell apoptotic process 10.3448 8 yes
GO:2000352 negative regulation of endothelial cell apoptotic process 10.3448 9 yes
GO:2001233 regulation of apoptotic signaling pathway 10.3448 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 10.3448 6 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 10.3448 6 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 10.3448 7 yes
GO:0002791 regulation of peptide secretion 10.3448 6 yes
GO:0002793 positive regulation of peptide secretion 10.3448 6 yes
GO:0006508 proteolysis 10.3448 4 yes
GO:0010543 regulation of platelet activation 10.3448 5 yes
GO:0010544 negative regulation of platelet activation 10.3448 6 yes
GO:0016485 protein processing 10.3448 5 yes
GO:0017157 regulation of exocytosis 10.3448 5 yes
GO:0019229 regulation of vasoconstriction 10.3448 6 yes
GO:0034110 regulation of homotypic cell-cell adhesion 6.8966 6 yes
GO:0034111 negative regulation of homotypic cell-cell adhesion 6.8966 7 yes
GO:0035592 establishment of protein localization to extracellular region 6.8966 4 yes
GO:0036345 platelet maturation 6.8966 4 yes
GO:0046903 secretion 6.8966 4 yes
GO:0070741 response to interleukin-6 6.8966 5 yes
GO:0071354 cellular response to interleukin-6 6.8966 6 yes
GO:0071692 protein localization to extracellular region 6.8966 5 yes
GO:0090330 regulation of platelet aggregation 6.8966 6 yes
GO:0090331 negative regulation of platelet aggregation 6.8966 7 yes
GO:0007162 negative regulation of cell adhesion 6.8966 5 yes
GO:0009306 protein secretion 6.8966 4 yes
GO:0022408 negative regulation of cell-cell adhesion 6.8966 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in FIBG_HUMAN
DOID:0050700 cardiomyopathy 6.8966 4 no
DOID:0060036 intrinsic cardiomyopathy 6.8966 5 no
DOID:114 heart disease 6.8966 3 no
DOID:331 central nervous system disease 6.8966 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRP1B_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
FIBB_HUMAN [view entry] [view interactions] Low throughput yes no
FIBG_HUMAN [view entry] [view interactions] Low throughput yes no
ITA2B_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
ITA5_HUMAN [view entry] [view interactions] Low throughput yes no
X3CL1_HUMAN [view interactions] Low throughput no yes
F13B_HUMAN [view interactions] Low throughput no no
FIBA_HUMAN [view interactions] Low throughput no no
CDK15_HUMAN [view interactions] High throughput no no
CCYL1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
HPT_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
CRDL2_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
GCYA1_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
TFPT_HUMAN [view interactions] High throughput no yes
BL1S1_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
FNDC1_HUMAN [view interactions] High throughput no yes
TXD11_HUMAN [view interactions] High throughput no yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
SIA7F_HUMAN [view interactions] High throughput no yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
2ABB_HUMAN [view interactions] High throughput no yes
GLRA3_HUMAN [view entry] [view interactions] High throughput yes no
DSCR6_HUMAN [view interactions] High throughput no no
EDEM2_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
SL9A5_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
KLK10_HUMAN [view interactions] High throughput no no
PHF11_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
UBE2U_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
GP141_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
ADAT2_HUMAN [view interactions] High throughput no yes
PLCA_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
CP343_HUMAN [view interactions] High throughput no no
CERS3_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
LRC17_HUMAN [view interactions] High throughput no no
PIGT_HUMAN [view interactions] High throughput no no
PDE6D_HUMAN [view interactions] High throughput no yes
CIR1_HUMAN [view interactions] High throughput no yes
SG1D1_HUMAN [view interactions] High throughput no no
MATN2_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
HMGC2_HUMAN [view interactions] High throughput no no
P2RX6_HUMAN [view entry] [view interactions] High throughput yes no
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
GBG10_HUMAN [view interactions] High throughput no no
CHD9_HUMAN [view interactions] High throughput no yes
NUP93_HUMAN [view interactions] High throughput no yes
PLMN_HUMAN [view interactions] High throughput no no
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
ANT3_HUMAN [view interactions] High throughput no no
HEMO_HUMAN [view interactions] High throughput no no
F13A_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
SOST_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITAV_HUMAN [view interactions] High throughput no yes
ICAM1_HUMAN [view interactions] High throughput no no
VKOR1_HUMAN [view interactions] High throughput no yes
KHDR2_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
ASB6_HUMAN [view interactions] High throughput no yes
ASB7_HUMAN [view entry] [view interactions] High throughput yes yes
ASB12_HUMAN [view interactions] High throughput no no
CAH8_HUMAN [view interactions] High throughput no no
ASCC1_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
KPYM_HUMAN [view interactions] High throughput no yes
H2B1J_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
RING1_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
TSP1_HUMAN [view interactions] Computational no no
FGL1_HUMAN [view interactions] Computational no no
ITB2_HUMAN [view interactions] Computational no no
FETUA_HUMAN [view interactions] Computational no no
A2AP_HUMAN [view interactions] Computational no no
VTDB_HUMAN [view interactions] Computational no yes
HRG_HUMAN [view interactions] Computational no no
HABP2_HUMAN [view interactions] Computational no no
PTN1_HUMAN [view interactions] Computational no yes
ITAM_HUMAN [view interactions] Computational no no
PEBP1_HUMAN [view entry] [view interactions] Computational yes yes
APOB_HUMAN [view interactions] Computational no no
APOC3_HUMAN [view interactions] Computational no no
PROZ_HUMAN [view interactions] Computational no no
CO8A_HUMAN [view interactions] Computational no no
HAOX1_HUMAN [view interactions] Computational no no
APOA_HUMAN [view interactions] Computational no no
APOA2_HUMAN [view interactions] Computational no no
ITIH2_HUMAN [view interactions] Computational no no
HEP2_HUMAN [view interactions] Computational no no
FTCD_HUMAN [view interactions] Computational no no
AMBP_HUMAN [view interactions] Computational no no
ALBU_HUMAN [view interactions] Computational no no
ITB1_HUMAN [view entry] [view interactions] Computational yes no
FETUB_HUMAN [view interactions] Computational no no
UPAR_HUMAN [view interactions] Computational no yes
CO9_HUMAN [view interactions] Computational no no
UROK_HUMAN [view interactions] Computational no no
PROC_HUMAN [view interactions] Computational no no
APOH_HUMAN [view interactions] Computational no no
IPSP_HUMAN [view interactions] Computational no no
CBPB2_HUMAN [view interactions] Computational no no
APOA4_HUMAN [view interactions] Computational no no
APOA1_HUMAN [view interactions] Computational no no
APOM_HUMAN [view interactions] Computational no no