Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ASB7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ASB7_HUMAN
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0004842 ubiquitin-protein transferase activity 22.2222 4 no
GO:0046872 metal ion binding 22.2222 4 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in ASB7_HUMAN
GO:0006508 proteolysis 44.4444 4 no
GO:0048522 positive regulation of cellular process 44.4444 4 no
GO:0048523 negative regulation of cellular process 44.4444 4 no
GO:0032880 regulation of protein localization 44.4444 5 no
GO:0060341 regulation of cellular localization 44.4444 4 no
GO:0016567 protein ubiquitination 33.3333 7 yes
GO:0032446 protein modification by small protein conjugation 33.3333 6 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0070647 protein modification by small protein conjugation or removal 33.3333 5 yes
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0007160 cell-matrix adhesion 33.3333 4 no
GO:0010810 regulation of cell-substrate adhesion 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0034109 homotypic cell-cell adhesion 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:0070527 platelet aggregation 33.3333 5 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:1904951 positive regulation of establishment of protein localization 33.3333 6 no
GO:0050708 regulation of protein secretion 22.2222 5 no
GO:0050714 positive regulation of protein secretion 22.2222 6 no
GO:0050818 regulation of coagulation 22.2222 4 no
GO:0050819 negative regulation of coagulation 22.2222 5 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051047 positive regulation of secretion 22.2222 5 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051258 protein polymerization 22.2222 6 no
GO:0051592 response to calcium ion 22.2222 5 no
GO:0051604 protein maturation 22.2222 4 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0061041 regulation of wound healing 22.2222 6 no
GO:0061045 negative regulation of wound healing 22.2222 6 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 22.2222 8 no
GO:0070555 response to interleukin-1 22.2222 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0071345 cellular response to cytokine stimulus 22.2222 5 no
GO:0071347 cellular response to interleukin-1 22.2222 6 no
GO:0072376 protein activation cascade 22.2222 5 no
GO:0072378 blood coagulation, fibrin clot formation 22.2222 6 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0090087 regulation of peptide transport 22.2222 5 no
GO:0090276 regulation of peptide hormone secretion 22.2222 5 no
GO:0090277 positive regulation of peptide hormone secretion 22.2222 6 no
GO:0097746 blood vessel diameter maintenance 22.2222 5 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 22.2222 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 22.2222 7 no
GO:1900047 negative regulation of hemostasis 22.2222 4 no
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 22.2222 7 no
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 22.2222 8 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1903034 regulation of response to wounding 22.2222 5 no
GO:1903035 negative regulation of response to wounding 22.2222 5 no
GO:1903522 regulation of blood circulation 22.2222 5 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:1903532 positive regulation of secretion by cell 22.2222 5 no
GO:1904035 regulation of epithelial cell apoptotic process 22.2222 7 no
GO:1904036 negative regulation of epithelial cell apoptotic process 22.2222 8 no
GO:2000351 regulation of endothelial cell apoptotic process 22.2222 8 no
GO:2000352 negative regulation of endothelial cell apoptotic process 22.2222 9 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 22.2222 6 no
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 22.2222 7 no
GO:0006511 ubiquitin-dependent protein catabolic process 22.2222 7 no
GO:0009057 macromolecule catabolic process 22.2222 4 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010498 proteasomal protein catabolic process 22.2222 5 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0019941 modification-dependent protein catabolic process 22.2222 6 no
GO:0030163 protein catabolic process 22.2222 4 no
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 22.2222 7 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 22.2222 6 no
GO:0043632 modification-dependent macromolecule catabolic process 22.2222 5 no
GO:0044265 cellular macromolecule catabolic process 22.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 22.2222 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051603 proteolysis involved in protein catabolic process 22.2222 5 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:0008104 protein localization 22.2222 4 no
GO:0051128 regulation of cellular component organization 22.2222 4 no
GO:0002791 regulation of peptide secretion 22.2222 6 no
GO:0002793 positive regulation of peptide secretion 22.2222 6 no
GO:0003018 vascular process in circulatory system 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0010769 regulation of cell morphogenesis involved in differentiation 22.2222 6 no
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 22.2222 7 no
GO:0010811 positive regulation of cell-substrate adhesion 22.2222 6 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0016485 protein processing 22.2222 5 no
GO:0017157 regulation of exocytosis 22.2222 5 no
GO:0019229 regulation of vasoconstriction 22.2222 6 no
GO:0022407 regulation of cell-cell adhesion 22.2222 5 no
GO:0022409 positive regulation of cell-cell adhesion 22.2222 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0030193 regulation of blood coagulation 22.2222 4 no
GO:0030195 negative regulation of blood coagulation 22.2222 5 no
GO:0031638 zymogen activation 22.2222 6 no
GO:0031639 plasminogen activation 22.2222 7 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0032102 negative regulation of response to external stimulus 22.2222 5 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0034114 regulation of heterotypic cell-cell adhesion 22.2222 6 no
GO:0034116 positive regulation of heterotypic cell-cell adhesion 22.2222 7 no
GO:0035150 regulation of tube size 22.2222 4 no
GO:0035296 regulation of tube diameter 22.2222 5 no
GO:0042730 fibrinolysis 22.2222 6 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045785 positive regulation of cell adhesion 22.2222 5 no
GO:0045907 positive regulation of vasoconstriction 22.2222 5 no
GO:0045921 positive regulation of exocytosis 22.2222 6 no
GO:0046883 regulation of hormone secretion 22.2222 4 no
GO:0046887 positive regulation of hormone secretion 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CUL5_HUMAN [view entry] [view interactions] Low throughput yes yes
PSRC1_HUMAN [view interactions] Low throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
RBX2_HUMAN [view interactions] High throughput no yes
MD1L1_HUMAN [view interactions] High throughput no yes
SALL2_HUMAN [view interactions] High throughput no yes
UXT_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
PDRG1_HUMAN [view interactions] High throughput no yes
DAA10_HUMAN [view interactions] High throughput no yes
AN13A_HUMAN [view interactions] High throughput no yes
WDR75_HUMAN [view interactions] High throughput no no
CH034_HUMAN [view interactions] High throughput no no
TRIPB_HUMAN [view interactions] High throughput no yes
NPAT_HUMAN [view interactions] High throughput no no
RPA1_HUMAN [view interactions] High throughput no yes
RPC1_HUMAN [view interactions] High throughput no no
KI13B_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
HAUS1_HUMAN [view interactions] High throughput no yes
SEPT1_HUMAN [view interactions] High throughput no no
ADA33_HUMAN [view interactions] High throughput no yes
AGRP_HUMAN [view interactions] High throughput no no
MIME_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
ATF4_HUMAN [view interactions] High throughput no no
HMBX1_HUMAN [view interactions] High throughput no yes
CC136_HUMAN [view interactions] High throughput no yes
ZFN2B_HUMAN [view interactions] High throughput no yes
SRRM1_HUMAN [view interactions] High throughput no yes
ELOC_HUMAN [view interactions] High throughput no no
ELOB_HUMAN [view interactions] High throughput no no
ASB4_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FIBA_HUMAN [view interactions] High throughput no no
GANAB_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
COL11_HUMAN [view interactions] High throughput no no
KI13A_HUMAN [view interactions] High throughput no yes
RMP_HUMAN [view interactions] High throughput no yes
KMT2A_HUMAN [view interactions] High throughput no yes
RABE2_HUMAN [view interactions] High throughput no yes
RPAP3_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
CPSF2_HUMAN [view entry] [view interactions] High throughput yes yes
RBX1_HUMAN [view entry] [view interactions] High throughput yes no
TAZ_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes