CPSF2_HUMAN
Evidence for PS localization
Functions
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPSF2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 39.1304 | 4 | yes |
| GO:0019900 | kinase binding | 26.0870 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
| GO:0046872 | metal ion binding | 26.0870 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPSF2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.5652 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 65.2174 | 4 | no |
| GO:0010468 | regulation of gene expression | 56.5217 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.5217 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.5217 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 52.1739 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.1739 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 47.8261 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.4783 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.4783 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4783 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 43.4783 | 5 | no |
| GO:0036211 | protein modification process | 39.1304 | 4 | no |
| GO:0043412 | macromolecule modification | 39.1304 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 39.1304 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.1304 | 4 | no |
| GO:0009894 | regulation of catabolic process | 34.7826 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.7826 | 4 | no |
| GO:0071702 | organic substance transport | 34.7826 | 4 | no |
| GO:0071705 | nitrogen compound transport | 34.7826 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 30.4348 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.4348 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.4348 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0016070 | RNA metabolic process | 26.0870 | 5 | yes |
| GO:0009416 | response to light stimulus | 26.0870 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 26.0870 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 26.0870 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.0870 | 5 | no |
| GO:0051726 | regulation of cell cycle | 26.0870 | 4 | no |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 26.0870 | 6 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:0006396 | RNA processing | 21.7391 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.7391 | 4 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.7391 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:1903311 | regulation of mRNA metabolic process | 21.7391 | 6 | no |
| GO:0006417 | regulation of translation | 21.7391 | 6 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 21.7391 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.7391 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.7391 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.7391 | 6 | no |
| GO:0045787 | positive regulation of cell cycle | 21.7391 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.7391 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0016071 | mRNA metabolic process | 17.3913 | 6 | yes |
| GO:0006397 | mRNA processing | 13.0435 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CPSF3_HUMAN | [view interactions] | Low throughput | no | yes |
| CSTF2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | Low throughput | no | yes |
| FIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAPOA_HUMAN | [view interactions] | Low throughput | no | yes |
| STPAP_HUMAN | [view interactions] | Low throughput | no | no |
| WDR33_HUMAN | [view interactions] | Low throughput | no | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF1_HUMAN | [view interactions] | Low throughput | no | no |
| CLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | Low throughput | no | yes |
| RBBP6_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF4_HUMAN | [view interactions] | Low throughput | no | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| LSM10_HUMAN | [view interactions] | Low throughput | no | no |
| RUXF_HUMAN | [view interactions] | Low throughput | no | no |
| SMD3_HUMAN | [view interactions] | Low throughput | no | yes |
| RSMB_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM11_HUMAN | [view interactions] | Low throughput | no | yes |
| RUXE_HUMAN | [view interactions] | Low throughput | no | no |
| RUXG_HUMAN | [view interactions] | Low throughput | no | yes |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CLK2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA1_HUMAN | [view interactions] | High throughput | no | no |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| UNKL_HUMAN | [view interactions] | High throughput | no | no |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| TBP_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| NGDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| ASB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| TF3C6_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| SMRD3_HUMAN | [view interactions] | High throughput | no | no |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISY1_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| INT11_HUMAN | [view interactions] | Computational | no | yes |
| NUP98_HUMAN | [view interactions] | Computational | no | no |
| NU160_HUMAN | [view interactions] | Computational | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NUP54_HUMAN | [view interactions] | Computational | no | yes |
| PO210_HUMAN | [view interactions] | Computational | no | yes |
| NUP43_HUMAN | [view interactions] | Computational | no | yes |
| ZC3H4_HUMAN | [view interactions] | Computational | no | yes |
| MEP50_HUMAN | [view interactions] | Computational | no | yes |
| NUP62_HUMAN | [view interactions] | Computational | no | yes |
| PAPOB_HUMAN | [view interactions] | Computational | no | no |
| THOC5_HUMAN | [view interactions] | Computational | no | no |
| YTDC2_HUMAN | [view interactions] | Computational | no | no |
| RAE1L_HUMAN | [view interactions] | Computational | no | no |
| CPSF5_HUMAN | [view interactions] | Computational | no | yes |
| NU107_HUMAN | [view interactions] | Computational | no | no |
| WDR82_HUMAN | [view interactions] | Computational | no | no |
| NUP93_HUMAN | [view interactions] | Computational | no | yes |
| NUP85_HUMAN | [view interactions] | Computational | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NUP35_HUMAN | [view interactions] | Computational | no | yes |
| P121A_HUMAN | [view interactions] | Computational | no | yes |
| NU133_HUMAN | [view interactions] | Computational | no | yes |
| CPSF7_HUMAN | [view interactions] | Computational | no | yes |
| NUP37_HUMAN | [view interactions] | Computational | no | yes |
| NU153_HUMAN | [view interactions] | Computational | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P121C_HUMAN | [view interactions] | Computational | no | yes |
| NU155_HUMAN | [view interactions] | Computational | no | yes |
| NU205_HUMAN | [view interactions] | Computational | no | no |
| NUP88_HUMAN | [view interactions] | Computational | no | yes |
| NU214_HUMAN | [view interactions] | Computational | no | no |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| NUP42_HUMAN | [view interactions] | Computational | no | no |
| CSTF3_HUMAN | [view interactions] | Computational | no | yes |
| CSTF1_HUMAN | [view interactions] | Computational | no | yes |
| NUP50_HUMAN | [view interactions] | Computational | no | yes |
| NDC1_HUMAN | [view interactions] | Computational | no | yes |
| PAPOG_HUMAN | [view interactions] | Computational | no | yes |
| NU188_HUMAN | [view interactions] | Computational | no | yes |
| PABP2_HUMAN | [view interactions] | Computational | no | yes |
| YTDC1_HUMAN | [view interactions] | Computational | no | yes |
| TPR_HUMAN | [view interactions] | Computational | no | yes |
| AAAS_HUMAN | [view interactions] | Computational | no | yes |
| CPS4L_HUMAN | [view interactions] | Computational | no | no |
| NUP58_HUMAN | [view interactions] | Computational | no | yes |
| RBP2_HUMAN | [view interactions] | Computational | no | yes |