CPSF2_HUMAN
Evidence for PS localization
Functions
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004622 | LIG_ARS2_EDGEI_1 | LIG | 649 | 656 | - |
| ELMI004622 | LIG_ARS2_EDGEI_1 | LIG | 649 | 656 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPSF2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 42.8571 | 4 | yes |
| GO:0043169 | cation binding | 32.1429 | 4 | no |
| GO:0046872 | metal ion binding | 32.1429 | 5 | no |
| GO:0000166 | nucleotide binding | 28.5714 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.4286 | 6 | no |
| GO:0003729 | mRNA binding | 21.4286 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPSF2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.8571 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 60.7143 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 57.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 53.5714 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 53.5714 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 53.5714 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 42.8571 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 42.8571 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 42.8571 | 6 | no |
| GO:0009966 | regulation of signal transduction | 39.2857 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.2857 | 5 | no |
| GO:0036211 | protein modification process | 39.2857 | 4 | no |
| GO:0043412 | macromolecule modification | 39.2857 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.2857 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.2857 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 39.2857 | 5 | no |
| GO:0071702 | organic substance transport | 39.2857 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 35.7143 | 4 | yes |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.7143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.7143 | 6 | no |
| GO:0071705 | nitrogen compound transport | 35.7143 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 32.1429 | 5 | no |
| GO:0023057 | negative regulation of signaling | 32.1429 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.1429 | 5 | no |
| GO:0009894 | regulation of catabolic process | 32.1429 | 4 | no |
| GO:0016070 | RNA metabolic process | 28.5714 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 28.5714 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 28.5714 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 28.5714 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043687 | post-translational protein modification | 25.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.4286 | 8 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 21.4286 | 9 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.4286 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.4286 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0006396 | RNA processing | 17.8571 | 6 | yes |
| GO:0016071 | mRNA metabolic process | 14.2857 | 6 | yes |
| GO:0006397 | mRNA processing | 10.7143 | 7 | yes |
| GO:0141188 | nucleic acid catabolic process | 7.1429 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| RUXG_HUMAN | [view interactions] | Low throughput | no | yes |
| RSMB_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM11_HUMAN | [view interactions] | Low throughput | no | yes |
| RUXF_HUMAN | [view interactions] | Low throughput | no | no |
| RUXE_HUMAN | [view interactions] | Low throughput | no | no |
| LSM10_HUMAN | [view interactions] | Low throughput | no | no |
| SMD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF3_HUMAN | [view interactions] | Low throughput | no | yes |
| CSTF2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | Low throughput | no | yes |
| FIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAPOA_HUMAN | [view interactions] | Low throughput | no | yes |
| STPAP_HUMAN | [view interactions] | Low throughput | no | no |
| WDR33_HUMAN | [view interactions] | Low throughput | no | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF1_HUMAN | [view interactions] | Low throughput | no | no |
| CLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSTFT_HUMAN | [view interactions] | Low throughput | no | yes |
| RBBP6_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF4_HUMAN | [view interactions] | Low throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| TF3C6_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| SMRD3_HUMAN | [view interactions] | High throughput | no | no |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISY1_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SAP30_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| TAGAP_HUMAN | [view interactions] | High throughput | no | yes |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CLK2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA1_HUMAN | [view interactions] | High throughput | no | no |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| UNKL_HUMAN | [view interactions] | High throughput | no | no |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| TBP_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| NGDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| ASB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |