Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GLRA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed, PubMed). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Contributes to increased pain perception in response to increased prostaglandin E2 levels . Plays a role in cellular responses to ethanol . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GLRA3_HUMAN
GO:0005216 monoatomic ion channel activity 66.6667 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 66.6667 6 yes
GO:0005253 monoatomic anion channel activity 66.6667 5 yes
GO:0005254 chloride channel activity 66.6667 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 66.6667 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 66.6667 4 yes
GO:0015108 chloride transmembrane transporter activity 66.6667 5 yes
GO:0015267 channel activity 66.6667 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 66.6667 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 66.6667 5 yes
GO:0022834 ligand-gated channel activity 66.6667 6 yes
GO:0022835 transmitter-gated channel activity 66.6667 4 yes
GO:0022836 gated channel activity 66.6667 5 yes
GO:0043168 anion binding 66.6667 4 yes
GO:0043169 cation binding 66.6667 4 yes
GO:0099095 ligand-gated monoatomic anion channel activity 66.6667 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 50.0000 7 yes
GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity 50.0000 7 yes
GO:0016933 extracellularly glycine-gated ion channel activity 50.0000 8 yes
GO:0016934 extracellularly glycine-gated chloride channel activity 50.0000 7 yes
GO:0031406 carboxylic acid binding 50.0000 4 yes
GO:0046872 metal ion binding 50.0000 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes
GO:0022852 glycine-gated chloride ion channel activity 33.3333 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GLRA3_HUMAN
GO:0022607 cellular component assembly 83.3333 4 yes
GO:0006811 monoatomic ion transport 66.6667 4 yes
GO:0006820 monoatomic anion transport 66.6667 5 yes
GO:0006821 chloride transport 66.6667 5 yes
GO:0015698 inorganic anion transport 66.6667 4 yes
GO:0043933 protein-containing complex organization 66.6667 4 yes
GO:0065003 protein-containing complex assembly 66.6667 5 yes
GO:0098656 monoatomic anion transmembrane transport 66.6667 4 yes
GO:0098661 inorganic anion transmembrane transport 66.6667 4 yes
GO:1902476 chloride transmembrane transport 66.6667 5 yes
GO:0043200 response to amino acid 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0071310 cellular response to organic substance 50.0000 4 no
GO:0051259 protein complex oligomerization 33.3333 6 yes
GO:0051260 protein homooligomerization 33.3333 7 yes
GO:0015031 protein transport 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0071407 cellular response to organic cyclic compound 33.3333 5 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GLRA3_HUMAN [view entry] [view interactions] Low throughput yes no
KCTD2_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
KCD17_HUMAN [view interactions] High throughput no yes
TBL2_HUMAN [view interactions] High throughput no no
GCNT3_HUMAN [view interactions] High throughput no no
GBRB3_HUMAN [view entry] [view interactions] High throughput yes no
FIBG_HUMAN [view entry] [view interactions] High throughput yes no
CBX6_HUMAN [view interactions] High throughput no yes