Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AL1A1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal . May have a broader specificity and oxidize other aldehydes in vivo (PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AL1A1_HUMAN
GO:0004029 aldehyde dehydrogenase (NAD+) activity 42.8571 6 yes
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 42.8571 5 yes
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 42.8571 4 yes
GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity 42.8571 5 yes
GO:0051287 NAD binding 42.8571 4 yes
GO:0001758 retinal dehydrogenase activity 28.5714 5 yes
GO:0005096 GTPase activator activity 28.5714 4 yes
GO:0018479 benzaldehyde dehydrogenase (NAD+) activity 28.5714 7 yes
GO:0019115 benzaldehyde dehydrogenase [NAD(P)+] activity 28.5714 6 yes
GO:0019145 aminobutyraldehyde dehydrogenase activity 28.5714 7 yes
GO:0030695 GTPase regulator activity 28.5714 4 yes
GO:0106373 3-deoxyglucosone dehydrogenase activity 28.5714 7 yes
GO:0019900 kinase binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AL1A1_HUMAN
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0001523 retinoid metabolic process 42.8571 7 yes
GO:0006720 isoprenoid metabolic process 42.8571 4 yes
GO:0006721 terpenoid metabolic process 42.8571 5 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0016101 diterpenoid metabolic process 42.8571 6 yes
GO:0034308 primary alcohol metabolic process 42.8571 4 yes
GO:0051241 negative regulation of multicellular organismal process 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0001894 tissue homeostasis 28.5714 5 yes
GO:0006040 amino sugar metabolic process 28.5714 4 yes
GO:0008652 cellular amino acid biosynthetic process 28.5714 4 yes
GO:0009448 gamma-aminobutyric acid metabolic process 28.5714 4 yes
GO:0009449 gamma-aminobutyric acid biosynthetic process 28.5714 5 yes
GO:0016053 organic acid biosynthetic process 28.5714 4 yes
GO:0019752 carboxylic acid metabolic process 28.5714 5 yes
GO:0030389 fructosamine metabolic process 28.5714 5 yes
GO:0030392 fructosamine catabolic process 28.5714 6 yes
GO:0032787 monocarboxylic acid metabolic process 28.5714 6 yes
GO:0036438 maintenance of lens transparency 28.5714 6 yes
GO:0042572 retinol metabolic process 28.5714 4 yes
GO:0043436 oxoacid metabolic process 28.5714 4 yes
GO:0046348 amino sugar catabolic process 28.5714 5 yes
GO:0046394 carboxylic acid biosynthetic process 28.5714 5 yes
GO:0060249 anatomical structure homeostasis 28.5714 4 yes
GO:0120163 negative regulation of cold-induced thermogenesis 28.5714 4 yes
GO:1901136 carbohydrate derivative catabolic process 28.5714 4 yes
GO:1901566 organonitrogen compound biosynthetic process 28.5714 4 yes
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0046164 alcohol catabolic process 28.5714 4 no
GO:1901616 organic hydroxy compound catabolic process 28.5714 4 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0010977 negative regulation of neuron projection development 28.5714 7 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0030162 regulation of proteolysis 28.5714 6 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0031345 negative regulation of cell projection organization 28.5714 6 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0045862 positive regulation of proteolysis 28.5714 7 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0050767 regulation of neurogenesis 28.5714 6 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0060291 long-term synaptic potentiation 28.5714 4 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AL1A1_HUMAN [view entry] [view interactions] Low throughput yes yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
POTE1_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
DOPO_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
JPH3_HUMAN [view interactions] High throughput no no
NOS2_HUMAN [view interactions] High throughput no yes
IL21_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
EIF3F_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
O13C3_HUMAN [view interactions] High throughput no no
GTR3_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
COE2_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
PTSS1_HUMAN [view interactions] High throughput no no
ALG8_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
CPSF4_HUMAN [view interactions] High throughput no yes
AL1A2_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
UPK1A_HUMAN [view interactions] High throughput no no
FGF4_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ITLN2_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
ZDH19_HUMAN [view interactions] High throughput no no
MMTA2_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
CHIN_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
P4K2A_HUMAN [view interactions] High throughput no yes
P3C2A_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view interactions] High throughput no yes
DHRS9_HUMAN [view interactions] Computational no yes
ADH4_HUMAN [view interactions] Computational no no
RDH16_HUMAN [view interactions] Computational no no
RDHE2_HUMAN [view interactions] Computational no yes
BCDO1_HUMAN [view interactions] Computational no no
CD44_HUMAN [view interactions] Computational no yes
DHRS3_HUMAN [view interactions] Computational no yes
AOXA_HUMAN [view interactions] Computational no no
RDH11_HUMAN [view interactions] Computational no no
CP26A_HUMAN [view interactions] Computational no no
CP4AB_HUMAN [view interactions] Computational no no
CP4AM_HUMAN [view interactions] Computational no no
RDH10_HUMAN [view interactions] Computational no no
RDH12_HUMAN [view interactions] Computational no no
CP1A1_HUMAN [view interactions] Computational no yes
H17B6_HUMAN [view interactions] Computational no yes
ADH1A_HUMAN [view interactions] Computational no no
RDH5_HUMAN [view interactions] Computational no no
AL1A3_HUMAN [view interactions] Computational no yes
ADH1B_HUMAN [view interactions] Computational no no
CP2A6_HUMAN [view interactions] Computational no no
ADH6_HUMAN [view interactions] Computational no no
ADHX_HUMAN [view interactions] Computational no yes
CP2S1_HUMAN [view interactions] Computational no no
CP26B_HUMAN [view interactions] Computational no yes
DHRS4_HUMAN [view entry] [view interactions] Computational yes no
CP1A2_HUMAN [view interactions] Computational no no
ADH1G_HUMAN [view interactions] Computational no yes
CP2B6_HUMAN [view interactions] Computational no no
CP3A5_HUMAN [view interactions] Computational no no
PROM1_HUMAN [view interactions] Computational no no
CD24_HUMAN [view interactions] Computational no yes
ADH7_HUMAN [view interactions] Computational no no