Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AL1A1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal . May have a broader specificity and oxidize other aldehydes in vivo (PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AL1A1_HUMAN
GO:0000166 nucleotide binding 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 5 yes
GO:0030554 adenyl nucleotide binding 50.0000 6 yes
GO:0004029 aldehyde dehydrogenase (NAD+) activity 30.0000 6 yes
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 30.0000 5 yes
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 30.0000 4 yes
GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity 30.0000 5 yes
GO:0051287 NAD binding 30.0000 7 yes
GO:0031625 ubiquitin protein ligase binding 30.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 30.0000 4 no
GO:0001758 retinal dehydrogenase activity 20.0000 5 yes
GO:0005096 GTPase activator activity 20.0000 4 yes
GO:0018479 benzaldehyde dehydrogenase (NAD+) activity 20.0000 7 yes
GO:0019115 benzaldehyde dehydrogenase [NAD(P)+] activity 20.0000 6 yes
GO:0019145 aminobutyraldehyde dehydrogenase activity 20.0000 7 yes
GO:0030695 GTPase regulator activity 20.0000 4 yes
GO:0106373 3-deoxyglucosone dehydrogenase activity 20.0000 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AL1A1_HUMAN
GO:0080090 regulation of primary metabolic process 80.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 no
GO:0009889 regulation of biosynthetic process 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0051241 negative regulation of multicellular organismal process 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0030162 regulation of proteolysis 40.0000 6 no
GO:0008104 protein localization 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0036211 protein modification process 40.0000 4 no
GO:0043412 macromolecule modification 40.0000 4 no
GO:0044087 regulation of cellular component biogenesis 40.0000 4 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:0051603 proteolysis involved in protein catabolic process 30.0000 5 no
GO:0051960 regulation of nervous system development 30.0000 5 no
GO:0060284 regulation of cell development 30.0000 5 no
GO:0070647 protein modification by small protein conjugation or removal 30.0000 6 no
GO:1901873 regulation of post-translational protein modification 30.0000 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 30.0000 8 no
GO:2000026 regulation of multicellular organismal development 30.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0006996 organelle organization 30.0000 4 no
GO:0007010 cytoskeleton organization 30.0000 5 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0043085 positive regulation of catalytic activity 30.0000 4 no
GO:0045862 positive regulation of proteolysis 30.0000 7 no
GO:0001894 tissue homeostasis 30.0000 4 yes
GO:0034308 primary alcohol metabolic process 30.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 30.0000 7 no
GO:0006508 proteolysis 30.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 30.0000 7 no
GO:0008284 positive regulation of cell population proliferation 30.0000 5 no
GO:0009057 macromolecule catabolic process 30.0000 4 no
GO:0009059 macromolecule biosynthetic process 30.0000 4 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0009968 negative regulation of signal transduction 30.0000 5 no
GO:0010468 regulation of gene expression 30.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0010648 negative regulation of cell communication 30.0000 5 no
GO:0019941 modification-dependent protein catabolic process 30.0000 6 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0023057 negative regulation of signaling 30.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0032446 protein modification by small protein conjugation 30.0000 7 no
GO:0042127 regulation of cell population proliferation 30.0000 4 no
GO:0043632 modification-dependent macromolecule catabolic process 30.0000 5 no
GO:0043687 post-translational protein modification 30.0000 5 no
GO:0045595 regulation of cell differentiation 30.0000 4 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0048585 negative regulation of response to stimulus 30.0000 4 no
GO:0050767 regulation of neurogenesis 30.0000 6 no
GO:0050807 regulation of synapse organization 30.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0001523 retinoid metabolic process 20.0000 7 yes
GO:0006040 amino sugar metabolic process 20.0000 4 yes
GO:0006720 isoprenoid metabolic process 20.0000 4 yes
GO:0006721 terpenoid metabolic process 20.0000 5 yes
GO:0008652 amino acid biosynthetic process 20.0000 4 yes
GO:0009448 gamma-aminobutyric acid metabolic process 20.0000 5 yes
GO:0009449 gamma-aminobutyric acid biosynthetic process 20.0000 5 yes
GO:0016053 organic acid biosynthetic process 20.0000 4 yes
GO:0016101 diterpenoid metabolic process 20.0000 6 yes
GO:0019752 carboxylic acid metabolic process 20.0000 5 yes
GO:0030389 fructosamine metabolic process 20.0000 5 yes
GO:0030392 fructosamine catabolic process 20.0000 6 yes
GO:0032787 monocarboxylic acid metabolic process 20.0000 6 yes
GO:0036438 maintenance of lens transparency 20.0000 5 yes
GO:0043436 oxoacid metabolic process 20.0000 4 yes
GO:0046348 amino sugar catabolic process 20.0000 5 yes
GO:0046394 carboxylic acid biosynthetic process 20.0000 5 yes
GO:0120161 regulation of cold-induced thermogenesis 20.0000 4 yes
GO:0120163 negative regulation of cold-induced thermogenesis 20.0000 5 yes
GO:0170041 non-proteinogenic amino acid metabolic process 20.0000 4 yes
GO:0170043 non-proteinogenic amino acid biosynthetic process 20.0000 5 yes
GO:1901136 carbohydrate derivative catabolic process 20.0000 4 yes
GO:1901566 organonitrogen compound biosynthetic process 20.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AL1A1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
NUPR1_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
DOPO_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
JPH3_HUMAN [view interactions] High throughput no no
NOS2_HUMAN [view interactions] High throughput no yes
IL21_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
EIF3F_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
O13C3_HUMAN [view interactions] High throughput no no
GTR3_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
COE2_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
PTSS1_HUMAN [view interactions] High throughput no no
ALG8_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
CPSF4_HUMAN [view interactions] High throughput no yes
AL1A2_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
UPK1A_HUMAN [view interactions] High throughput no no
FGF4_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ITLN2_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
ZDH19_HUMAN [view interactions] High throughput no no
MMTA2_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
CHIN_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
P4K2A_HUMAN [view interactions] High throughput no yes
P3C2A_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes