SNG3_HUMAN
Evidence for PS localization
Functions
May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNG3_HUMAN |
|---|---|---|---|---|
| GO:0042169 | SH2 domain binding | 25.0000 | 4 | yes |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0019902 | phosphatase binding | 25.0000 | 4 | no |
| GO:0019903 | protein phosphatase binding | 25.0000 | 5 | no |
| GO:0051721 | protein phosphatase 2A binding | 25.0000 | 6 | no |
| GO:0016301 | kinase activity | 25.0000 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022853 | active ion transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNG3_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 62.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 37.5000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 37.5000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 37.5000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 37.5000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 37.5000 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 37.5000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 37.5000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0033673 | negative regulation of kinase activity | 25.0000 | 6 | no |
| GO:0034329 | cell junction assembly | 25.0000 | 5 | no |
| GO:0034330 | cell junction organization | 25.0000 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043086 | negative regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 25.0000 | 5 | no |
| GO:0045927 | positive regulation of growth | 25.0000 | 4 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0048638 | regulation of developmental growth | 25.0000 | 4 | no |
| GO:0048639 | positive regulation of developmental growth | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051348 | negative regulation of transferase activity | 25.0000 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0006811 | ion transport | 25.0000 | 4 | no |
| GO:0006812 | cation transport | 25.0000 | 5 | no |
| GO:0098655 | cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 5 | no |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 25.0000 | 5 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0001504 | neurotransmitter uptake | 25.0000 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 25.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0046903 | secretion | 25.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 25.0000 | 4 | yes |
| GO:0098657 | import into cell | 25.0000 | 4 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0010506 | regulation of autophagy | 25.0000 | 6 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| TTPA_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHP_HUMAN | [view interactions] | High throughput | no | no |
| EM55_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| DCE2_HUMAN | [view interactions] | High throughput | no | yes |
| HSBPL_HUMAN | [view interactions] | High throughput | no | yes |
| ACSF2_HUMAN | [view interactions] | High throughput | no | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| IRF3_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| AT1B4_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NKG2C_HUMAN | [view interactions] | High throughput | no | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |