DOCK2_HUMAN
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
751 | Arg | Ser | Immunodeficiency40(IMD40) | - |
1104 | Arg | Trp | Immunodeficiency40(IMD40) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DOCK2_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 38.4615 | 4 | no |
GO:0019901 | protein kinase binding | 38.4615 | 5 | no |
GO:0051020 | GTPase binding | 30.7692 | 4 | yes |
GO:0000166 | nucleotide binding | 30.7692 | 4 | no |
GO:0017076 | purine nucleotide binding | 30.7692 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.7692 | 4 | no |
GO:0043168 | anion binding | 30.7692 | 4 | no |
GO:0031267 | small GTPase binding | 23.0769 | 5 | yes |
GO:0003723 | RNA binding | 23.0769 | 4 | no |
GO:0045296 | cadherin binding | 23.0769 | 4 | no |
GO:0017124 | SH3 domain binding | 23.0769 | 4 | no |
GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | no |
GO:0005085 | guanyl-nucleotide exchange factor activity | 15.3846 | 5 | yes |
GO:0005096 | GTPase activator activity | 15.3846 | 4 | yes |
GO:0030695 | GTPase regulator activity | 15.3846 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DOCK2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 76.9231 | 4 | yes |
GO:0010646 | regulation of cell communication | 61.5385 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 61.5385 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | no |
GO:0009966 | regulation of signal transduction | 61.5385 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 53.8462 | 5 | yes |
GO:0006996 | organelle organization | 53.8462 | 4 | yes |
GO:0141124 | intracellular signaling cassette | 46.1538 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 46.1538 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 46.1538 | 5 | no |
GO:0022607 | cellular component assembly | 46.1538 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 46.1538 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 46.1538 | 5 | no |
GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 46.1538 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
GO:0007264 | small GTPase-mediated signal transduction | 46.1538 | 5 | yes |
GO:0051049 | regulation of transport | 38.4615 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 38.4615 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 38.4615 | 4 | yes |
GO:0002684 | positive regulation of immune system process | 38.4615 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 38.4615 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 38.4615 | 5 | no |
GO:0010468 | regulation of gene expression | 38.4615 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 38.4615 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 38.4615 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 38.4615 | 5 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 38.4615 | 6 | no |
GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
GO:0030100 | regulation of endocytosis | 30.7692 | 5 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 30.7692 | 6 | yes |
GO:0061024 | membrane organization | 30.7692 | 4 | yes |
GO:0002685 | regulation of leukocyte migration | 30.7692 | 4 | no |
GO:0006915 | apoptotic process | 30.7692 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 30.7692 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
GO:0010629 | negative regulation of gene expression | 30.7692 | 7 | no |
GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
GO:0023056 | positive regulation of signaling | 30.7692 | 4 | no |
GO:0030155 | regulation of cell adhesion | 30.7692 | 4 | no |
GO:0030334 | regulation of cell migration | 30.7692 | 5 | no |
GO:0030335 | positive regulation of cell migration | 30.7692 | 6 | no |
GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
GO:0040017 | positive regulation of locomotion | 30.7692 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
GO:2000145 | regulation of cell motility | 30.7692 | 4 | no |
GO:2000147 | positive regulation of cell motility | 30.7692 | 5 | no |
GO:0007015 | actin filament organization | 30.7692 | 5 | no |
GO:0097435 | supramolecular fiber organization | 30.7692 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 30.7692 | 4 | no |
GO:0032103 | positive regulation of response to external stimulus | 30.7692 | 5 | no |
GO:0007010 | cytoskeleton organization | 30.7692 | 5 | yes |
GO:0045807 | positive regulation of endocytosis | 23.0769 | 5 | yes |
GO:0051050 | positive regulation of transport | 23.0769 | 4 | yes |
GO:0098657 | import into cell | 23.0769 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 23.0769 | 8 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.0769 | 4 | no |
GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 23.0769 | 5 | no |
GO:0008284 | positive regulation of cell population proliferation | 23.0769 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.0769 | 6 | no |
GO:0010810 | regulation of cell-substrate adhesion | 23.0769 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
GO:0030030 | cell projection organization | 23.0769 | 4 | no |
GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 23.0769 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 23.0769 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
GO:0060326 | cell chemotaxis | 23.0769 | 4 | no |
GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
GO:0036211 | protein modification process | 23.0769 | 4 | no |
GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
GO:0042981 | regulation of apoptotic process | 23.0769 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 23.0769 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.0769 | 4 | no |
GO:0043069 | negative regulation of programmed cell death | 23.0769 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
GO:0002687 | positive regulation of leukocyte migration | 23.0769 | 5 | no |
GO:0002688 | regulation of leukocyte chemotaxis | 23.0769 | 5 | no |
GO:0002690 | positive regulation of leukocyte chemotaxis | 23.0769 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
GO:0050920 | regulation of chemotaxis | 23.0769 | 4 | no |
GO:0050921 | positive regulation of chemotaxis | 23.0769 | 5 | no |
GO:0031579 | membrane raft organization | 15.3846 | 5 | yes |
GO:0031580 | membrane raft distribution | 15.3846 | 5 | yes |
GO:0032943 | mononuclear cell proliferation | 15.3846 | 4 | yes |
GO:0042098 | T cell proliferation | 15.3846 | 5 | yes |
GO:0042110 | T cell activation | 15.3846 | 4 | yes |
GO:0044351 | macropinocytosis | 15.3846 | 5 | yes |
GO:0045059 | positive thymic T cell selection | 15.3846 | 4 | yes |
GO:0045060 | negative thymic T cell selection | 15.3846 | 4 | yes |
GO:0046631 | alpha-beta T cell activation | 15.3846 | 5 | yes |
GO:0046633 | alpha-beta T cell proliferation | 15.3846 | 6 | yes |
GO:0046651 | lymphocyte proliferation | 15.3846 | 4 | yes |
GO:0050764 | regulation of phagocytosis | 15.3846 | 6 | yes |
GO:0050766 | positive regulation of phagocytosis | 15.3846 | 6 | yes |
GO:0051665 | membrane raft localization | 15.3846 | 4 | yes |
GO:0001766 | membrane raft polarization | 15.3846 | 6 | yes |
GO:0001767 | establishment of lymphocyte polarity | 15.3846 | 4 | yes |
GO:0001768 | establishment of T cell polarity | 15.3846 | 5 | yes |
GO:0001771 | immunological synapse formation | 15.3846 | 4 | yes |
GO:0001773 | myeloid dendritic cell activation | 15.3846 | 4 | yes |
GO:0002275 | myeloid cell activation involved in immune response | 15.3846 | 4 | yes |
GO:0002277 | myeloid dendritic cell activation involved in immune response | 15.3846 | 5 | yes |
GO:0006907 | pinocytosis | 15.3846 | 4 | yes |
GO:0007520 | myoblast fusion | 15.3846 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FYB1_HUMAN | [view interactions] | Low throughput | no | no |
CD3Z_HUMAN | [view interactions] | Low throughput | no | no |
CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAV_HUMAN | [view interactions] | Low throughput | no | no |
PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LRCH2_HUMAN | [view interactions] | Low throughput | no | no |
DOCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ELMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KRA42_HUMAN | [view interactions] | High throughput | no | no |
NT2NA_HUMAN | [view interactions] | High throughput | no | no |
MDFI_HUMAN | [view interactions] | High throughput | no | no |
KRA94_HUMAN | [view interactions] | High throughput | no | no |
KRA92_HUMAN | [view interactions] | High throughput | no | no |
CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
K1H1_HUMAN | [view interactions] | High throughput | no | no |
KRA93_HUMAN | [view interactions] | High throughput | no | no |
KR123_HUMAN | [view interactions] | High throughput | no | no |
KR107_HUMAN | [view interactions] | High throughput | no | no |
NT2NC_HUMAN | [view interactions] | High throughput | no | no |
GG6L9_HUMAN | [view interactions] | High throughput | no | no |
KRA13_HUMAN | [view interactions] | High throughput | no | no |
TGM1_HUMAN | [view interactions] | High throughput | no | no |
KHDR3_HUMAN | [view interactions] | High throughput | no | yes |
KRA11_HUMAN | [view interactions] | High throughput | no | no |
KRA57_HUMAN | [view interactions] | High throughput | no | no |
KRT34_HUMAN | [view interactions] | High throughput | no | no |
CAR10_HUMAN | [view interactions] | High throughput | no | yes |
KR171_HUMAN | [view interactions] | High throughput | no | no |
TEN4_HUMAN | [view interactions] | High throughput | no | no |
KRA31_HUMAN | [view interactions] | High throughput | no | no |
PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
KRA33_HUMAN | [view interactions] | High throughput | no | no |
HXA1_HUMAN | [view interactions] | High throughput | no | no |
KR101_HUMAN | [view interactions] | High throughput | no | no |
KR103_HUMAN | [view interactions] | High throughput | no | no |
PCSK5_HUMAN | [view interactions] | High throughput | no | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
DCPS_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKD2_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAT_HUMAN | [view interactions] | High throughput | no | no |
ZAP70_HUMAN | [view interactions] | High throughput | no | no |
PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
PLS1_HUMAN | [view interactions] | High throughput | no | no |
CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
KRA59_HUMAN | [view interactions] | High throughput | no | no |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
KR108_HUMAN | [view interactions] | High throughput | no | no |
KR109_HUMAN | [view interactions] | High throughput | no | no |
HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
K1C40_HUMAN | [view interactions] | High throughput | no | no |