Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK2_HUMAN

GO
G2C
SynGO

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
751 Arg Ser Immunodeficiency40(IMD40) -
1104 Arg Trp Immunodeficiency40(IMD40) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK2_HUMAN
GO:0019900 kinase binding 38.4615 4 no
GO:0019901 protein kinase binding 38.4615 5 no
GO:0051020 GTPase binding 30.7692 4 yes
GO:0000166 nucleotide binding 30.7692 4 no
GO:0017076 purine nucleotide binding 30.7692 5 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0043168 anion binding 30.7692 4 no
GO:0031267 small GTPase binding 23.0769 5 yes
GO:0003723 RNA binding 23.0769 4 no
GO:0045296 cadherin binding 23.0769 4 no
GO:0017124 SH3 domain binding 23.0769 4 no
GO:0016462 pyrophosphatase activity 23.0769 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.0769 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.0769 6 no
GO:0005085 guanyl-nucleotide exchange factor activity 15.3846 5 yes
GO:0005096 GTPase activator activity 15.3846 4 yes
GO:0030695 GTPase regulator activity 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK2_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 yes
GO:0010646 regulation of cell communication 61.5385 4 yes
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:1902531 regulation of intracellular signal transduction 53.8462 5 yes
GO:0006996 organelle organization 53.8462 4 yes
GO:0141124 intracellular signaling cassette 46.1538 4 yes
GO:0009892 negative regulation of metabolic process 46.1538 4 no
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0031324 negative regulation of cellular metabolic process 46.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 no
GO:0007264 small GTPase-mediated signal transduction 46.1538 5 yes
GO:0051049 regulation of transport 38.4615 4 yes
GO:0051130 positive regulation of cellular component organization 38.4615 5 yes
GO:0060627 regulation of vesicle-mediated transport 38.4615 4 yes
GO:0002684 positive regulation of immune system process 38.4615 4 no
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0009890 negative regulation of biosynthetic process 38.4615 5 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.4615 6 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0031327 negative regulation of cellular biosynthetic process 38.4615 6 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0030100 regulation of endocytosis 30.7692 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 30.7692 6 yes
GO:0061024 membrane organization 30.7692 4 yes
GO:0002685 regulation of leukocyte migration 30.7692 4 no
GO:0006915 apoptotic process 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010629 negative regulation of gene expression 30.7692 7 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0030155 regulation of cell adhesion 30.7692 4 no
GO:0030334 regulation of cell migration 30.7692 5 no
GO:0030335 positive regulation of cell migration 30.7692 6 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0040017 positive regulation of locomotion 30.7692 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:2000145 regulation of cell motility 30.7692 4 no
GO:2000147 positive regulation of cell motility 30.7692 5 no
GO:0007015 actin filament organization 30.7692 5 no
GO:0097435 supramolecular fiber organization 30.7692 4 no
GO:0032101 regulation of response to external stimulus 30.7692 4 no
GO:0032103 positive regulation of response to external stimulus 30.7692 5 no
GO:0007010 cytoskeleton organization 30.7692 5 yes
GO:0045807 positive regulation of endocytosis 23.0769 5 yes
GO:0051050 positive regulation of transport 23.0769 4 yes
GO:0098657 import into cell 23.0769 4 yes
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.0769 5 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0010810 regulation of cell-substrate adhesion 23.0769 5 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0060326 cell chemotaxis 23.0769 4 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0002687 positive regulation of leukocyte migration 23.0769 5 no
GO:0002688 regulation of leukocyte chemotaxis 23.0769 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 23.0769 6 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0050920 regulation of chemotaxis 23.0769 4 no
GO:0050921 positive regulation of chemotaxis 23.0769 5 no
GO:0031579 membrane raft organization 15.3846 5 yes
GO:0031580 membrane raft distribution 15.3846 5 yes
GO:0032943 mononuclear cell proliferation 15.3846 4 yes
GO:0042098 T cell proliferation 15.3846 5 yes
GO:0042110 T cell activation 15.3846 4 yes
GO:0044351 macropinocytosis 15.3846 5 yes
GO:0045059 positive thymic T cell selection 15.3846 4 yes
GO:0045060 negative thymic T cell selection 15.3846 4 yes
GO:0046631 alpha-beta T cell activation 15.3846 5 yes
GO:0046633 alpha-beta T cell proliferation 15.3846 6 yes
GO:0046651 lymphocyte proliferation 15.3846 4 yes
GO:0050764 regulation of phagocytosis 15.3846 6 yes
GO:0050766 positive regulation of phagocytosis 15.3846 6 yes
GO:0051665 membrane raft localization 15.3846 4 yes
GO:0001766 membrane raft polarization 15.3846 6 yes
GO:0001767 establishment of lymphocyte polarity 15.3846 4 yes
GO:0001768 establishment of T cell polarity 15.3846 5 yes
GO:0001771 immunological synapse formation 15.3846 4 yes
GO:0001773 myeloid dendritic cell activation 15.3846 4 yes
GO:0002275 myeloid cell activation involved in immune response 15.3846 4 yes
GO:0002277 myeloid dendritic cell activation involved in immune response 15.3846 5 yes
GO:0006907 pinocytosis 15.3846 4 yes
GO:0007520 myoblast fusion 15.3846 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FYB1_HUMAN [view interactions] Low throughput no no
CD3Z_HUMAN [view interactions] Low throughput no no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
VAV_HUMAN [view interactions] Low throughput no no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
LRCH2_HUMAN [view interactions] Low throughput no no
DOCK2_HUMAN [view entry] [view interactions] Low throughput yes no
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC2_HUMAN [view entry] [view interactions] Low throughput yes yes
KRA42_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
MDFI_HUMAN [view interactions] High throughput no no
KRA94_HUMAN [view interactions] High throughput no no
KRA92_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
KRA93_HUMAN [view interactions] High throughput no no
KR123_HUMAN [view interactions] High throughput no no
KR107_HUMAN [view interactions] High throughput no no
NT2NC_HUMAN [view interactions] High throughput no no
GG6L9_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
TGM1_HUMAN [view interactions] High throughput no no
KHDR3_HUMAN [view interactions] High throughput no yes
KRA11_HUMAN [view interactions] High throughput no no
KRA57_HUMAN [view interactions] High throughput no no
KRT34_HUMAN [view interactions] High throughput no no
CAR10_HUMAN [view interactions] High throughput no yes
KR171_HUMAN [view interactions] High throughput no no
TEN4_HUMAN [view interactions] High throughput no no
KRA31_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
KRA33_HUMAN [view interactions] High throughput no no
HXA1_HUMAN [view interactions] High throughput no no
KR101_HUMAN [view interactions] High throughput no no
KR103_HUMAN [view interactions] High throughput no no
PCSK5_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
DCPS_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
PRC1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
PKD2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
LAT_HUMAN [view interactions] High throughput no no
ZAP70_HUMAN [view interactions] High throughput no no
PHAG1_HUMAN [view interactions] High throughput no yes
MPIP2_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
CCDB1_HUMAN [view interactions] High throughput no yes
KRA59_HUMAN [view interactions] High throughput no no
TRI23_HUMAN [view interactions] High throughput no yes
KR108_HUMAN [view interactions] High throughput no no
KR109_HUMAN [view interactions] High throughput no no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
CACO2_HUMAN [view interactions] High throughput no yes
MTUS2_HUMAN [view interactions] High throughput no yes
KHDR2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no