Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
751 Arg Ser Immunodeficiency40(IMD40) -
1104 Arg Trp Immunodeficiency40(IMD40) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK2_HUMAN
GO:0019900 kinase binding 50.0000 4 no
GO:0019901 protein kinase binding 50.0000 5 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0003723 RNA binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 16.6667 5 yes
GO:0030695 GTPase regulator activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK2_HUMAN
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:1902531 regulation of intracellular signal transduction 58.3333 5 yes
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0007264 small GTPase mediated signal transduction 41.6667 4 yes
GO:0051049 regulation of transport 41.6667 4 yes
GO:0060627 regulation of vesicle-mediated transport 41.6667 4 yes
GO:0002684 positive regulation of immune system process 41.6667 4 no
GO:0022603 regulation of anatomical structure morphogenesis 41.6667 4 no
GO:0010468 regulation of gene expression 41.6667 5 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0051050 positive regulation of transport 33.3333 4 yes
GO:0061024 membrane organization 33.3333 4 yes
GO:0002685 regulation of leukocyte migration 33.3333 4 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0032103 positive regulation of response to external stimulus 33.3333 5 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:0010629 negative regulation of gene expression 33.3333 6 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0016192 vesicle-mediated transport 25.0000 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 yes
GO:0002687 positive regulation of leukocyte migration 25.0000 5 no
GO:0002688 regulation of leukocyte chemotaxis 25.0000 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 25.0000 6 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0007265 Ras protein signal transduction 25.0000 5 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0010810 regulation of cell-substrate adhesion 25.0000 5 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050920 regulation of chemotaxis 25.0000 4 no
GO:0050921 positive regulation of chemotaxis 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0001766 membrane raft polarization 16.6667 6 yes
GO:0001767 establishment of lymphocyte polarity 16.6667 4 yes
GO:0001768 establishment of T cell polarity 16.6667 5 yes
GO:0001771 immunological synapse formation 16.6667 4 yes
GO:0001773 myeloid dendritic cell activation 16.6667 4 yes
GO:0002275 myeloid cell activation involved in immune response 16.6667 4 yes
GO:0002277 myeloid dendritic cell activation involved in immune response 16.6667 5 yes
GO:0006897 endocytosis 16.6667 5 yes
GO:0006907 pinocytosis 16.6667 6 yes
GO:0031579 membrane raft organization 16.6667 5 yes
GO:0031580 membrane raft distribution 16.6667 5 yes
GO:0032943 mononuclear cell proliferation 16.6667 4 yes
GO:0042098 T cell proliferation 16.6667 5 yes
GO:0042110 T cell activation 16.6667 4 yes
GO:0044351 macropinocytosis 16.6667 7 yes
GO:0045059 positive thymic T cell selection 16.6667 4 yes
GO:0045060 negative thymic T cell selection 16.6667 4 yes
GO:0046631 alpha-beta T cell activation 16.6667 5 yes
GO:0046633 alpha-beta T cell proliferation 16.6667 6 yes
GO:0046651 lymphocyte proliferation 16.6667 4 yes
GO:0050764 regulation of phagocytosis 16.6667 5 yes
GO:0050766 positive regulation of phagocytosis 16.6667 5 yes
GO:0051665 membrane raft localization 16.6667 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in DOCK2_HUMAN
DOID:0111962 combined immunodeficiency 25.0000 4 yes
DOID:612 primary immunodeficiency disease 25.0000 3 yes
DOID:0111951 immunodeficiency 40 16.6667 6 yes
DOID:628 combined T cell and B cell immunodeficiency 16.6667 5 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ELMO1_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RAC2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYB1_HUMAN [view interactions] Low throughput no no
CD3Z_HUMAN [view interactions] Low throughput no no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
VAV_HUMAN [view interactions] Low throughput no no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
LRCH2_HUMAN [view interactions] Low throughput no no
DOCK2_HUMAN [view entry] [view interactions] Low throughput yes no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
LAT_HUMAN [view interactions] High throughput no no
ZAP70_HUMAN [view interactions] High throughput no no
PHAG1_HUMAN [view interactions] High throughput no yes
MPIP2_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
KRA59_HUMAN [view interactions] High throughput no no
CCDB1_HUMAN [view interactions] High throughput no yes
PLS1_HUMAN [view interactions] High throughput no no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
KR109_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
KHDR2_HUMAN [view interactions] High throughput no yes
MTUS2_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
KRA42_HUMAN [view interactions] High throughput no no
KRA92_HUMAN [view interactions] High throughput no no
KRA94_HUMAN [view interactions] High throughput no no
MDFI_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
KRA93_HUMAN [view interactions] High throughput no no
KR123_HUMAN [view interactions] High throughput no no
KR107_HUMAN [view interactions] High throughput no no
NT2NC_HUMAN [view interactions] High throughput no no
GG6L9_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
TGM1_HUMAN [view interactions] High throughput no no
KHDR3_HUMAN [view interactions] High throughput no yes
KRA11_HUMAN [view interactions] High throughput no no
KRA57_HUMAN [view interactions] High throughput no no
KRT34_HUMAN [view interactions] High throughput no no
CAR10_HUMAN [view interactions] High throughput no yes
KR171_HUMAN [view interactions] High throughput no no
KRA31_HUMAN [view interactions] High throughput no no
TEN4_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
KRA33_HUMAN [view interactions] High throughput no no
HXA1_HUMAN [view interactions] High throughput no no
KR101_HUMAN [view interactions] High throughput no no
KR103_HUMAN [view interactions] High throughput no no
PCSK5_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
DCPS_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
PRC1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
PKD2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
DCA15_HUMAN [view interactions] High throughput no no