Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABCD3_HUMAN

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ABCD3_HUMAN
GO:0017076 purine nucleotide binding 40.7895 4 yes
GO:0032555 purine ribonucleotide binding 40.7895 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 39.4737 4 yes
GO:0016462 pyrophosphatase activity 28.9474 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.9474 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.9474 6 yes
GO:0003924 GTPase activity 23.6842 7 no
GO:0005525 GTP binding 23.6842 5 no
GO:0019001 guanyl nucleotide binding 23.6842 5 no
GO:0032561 guanyl ribonucleotide binding 23.6842 5 no
GO:0046872 metal ion binding 21.0526 4 no
GO:0030554 adenyl nucleotide binding 17.1053 5 yes
GO:0032559 adenyl ribonucleotide binding 17.1053 5 yes
GO:0005524 ATP binding 15.7895 5 yes
GO:0042803 protein homodimerization activity 15.7895 4 yes
GO:0015399 primary active transmembrane transporter activity 13.1579 4 yes
GO:0016887 ATP hydrolysis activity 5.2632 7 yes
GO:0016289 CoA hydrolase activity 3.9474 5 yes
GO:0016790 thiolester hydrolase activity 3.9474 4 yes
GO:0047617 acyl-CoA hydrolase activity 3.9474 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABCD3_HUMAN
GO:0048522 positive regulation of cellular process 51.3158 4 no
GO:0006996 organelle organization 42.1053 4 yes
GO:0010646 regulation of cell communication 36.8421 4 no
GO:0060255 regulation of macromolecule metabolic process 35.5263 4 no
GO:0080090 regulation of primary metabolic process 34.2105 4 no
GO:0051128 regulation of cellular component organization 34.2105 4 no
GO:0051049 regulation of transport 32.8947 4 no
GO:0031323 regulation of cellular metabolic process 32.8947 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.8947 4 no
GO:0048523 negative regulation of cellular process 31.5789 4 no
GO:0009966 regulation of signal transduction 30.2632 4 no
GO:0071702 organic substance transport 28.9474 4 yes
GO:0009893 positive regulation of metabolic process 28.9474 4 no
GO:0008104 protein localization 28.9474 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.6316 5 no
GO:0051246 regulation of protein metabolic process 26.3158 5 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0022607 cellular component assembly 23.6842 4 no
GO:0051050 positive regulation of transport 23.6842 4 no
GO:1902531 regulation of intracellular signal transduction 23.6842 5 no
GO:0051247 positive regulation of protein metabolic process 22.3684 6 no
GO:0033043 regulation of organelle organization 22.3684 5 no
GO:0010468 regulation of gene expression 21.0526 5 no
GO:0015031 protein transport 21.0526 4 no
GO:0006811 ion transport 14.4737 4 yes
GO:0014070 response to organic cyclic compound 11.8421 4 yes
GO:0019752 carboxylic acid metabolic process 9.2105 5 yes
GO:0043436 oxoacid metabolic process 9.2105 4 yes
GO:0032787 monocarboxylic acid metabolic process 7.8947 6 yes
GO:0006631 fatty acid metabolic process 6.5789 4 yes
GO:0008610 lipid biosynthetic process 6.5789 4 yes
GO:0016053 organic acid biosynthetic process 6.5789 4 yes
GO:0046394 carboxylic acid biosynthetic process 6.5789 5 yes
GO:1901362 organic cyclic compound biosynthetic process 6.5789 4 yes
GO:0000038 very long-chain fatty acid metabolic process 5.2632 5 yes
GO:0001676 long-chain fatty acid metabolic process 5.2632 5 yes
GO:0006633 fatty acid biosynthetic process 5.2632 5 yes
GO:0006869 lipid transport 5.2632 5 yes
GO:0007031 peroxisome organization 5.2632 5 yes
GO:0015849 organic acid transport 5.2632 5 yes
GO:0015850 organic hydroxy compound transport 5.2632 5 yes
GO:0016042 lipid catabolic process 5.2632 4 yes
GO:0072330 monocarboxylic acid biosynthetic process 5.2632 6 yes
GO:1905039 carboxylic acid transmembrane transport 5.2632 4 yes
GO:0006635 fatty acid beta-oxidation 3.9474 6 yes
GO:0006820 anion transport 3.9474 5 yes
GO:0009062 fatty acid catabolic process 3.9474 5 yes
GO:0015711 organic anion transport 3.9474 5 yes
GO:0015908 fatty acid transport 3.9474 6 yes
GO:0015909 long-chain fatty acid transport 3.9474 7 yes
GO:0015910 long-chain fatty acid import into peroxisome 3.9474 5 yes
GO:0015919 peroxisomal membrane transport 3.9474 5 yes
GO:0016054 organic acid catabolic process 3.9474 4 yes
GO:0019395 fatty acid oxidation 3.9474 5 yes
GO:0030258 lipid modification 3.9474 4 yes
GO:0032365 intracellular lipid transport 3.9474 4 yes
GO:0034440 lipid oxidation 3.9474 5 yes
GO:0042760 very long-chain fatty acid catabolic process 3.9474 6 yes
GO:0043574 peroxisomal transport 3.9474 4 yes
GO:0044242 cellular lipid catabolic process 3.9474 4 yes
GO:0046395 carboxylic acid catabolic process 3.9474 5 yes
GO:0046942 carboxylic acid transport 3.9474 6 yes
GO:0072329 monocarboxylic acid catabolic process 3.9474 6 yes
GO:1902001 fatty acid transmembrane transport 3.9474 5 yes
GO:0006694 steroid biosynthetic process 2.6316 5 yes
GO:0006699 bile acid biosynthetic process 2.6316 5 yes
GO:0008202 steroid metabolic process 2.6316 4 yes
GO:0008206 bile acid metabolic process 2.6316 4 yes
GO:0015718 monocarboxylic acid transport 2.6316 7 yes
GO:0015721 bile acid and bile salt transport 2.6316 6 yes
GO:0097089 methyl-branched fatty acid metabolic process 2.6316 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 2.6316 4 yes
GO:1903512 phytanic acid metabolic process 2.6316 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ABCD3_HUMAN
DOID:0050700 cardiomyopathy 3.9474 4 no
DOID:0060036 intrinsic cardiomyopathy 3.9474 5 no
DOID:114 heart disease 3.9474 3 no
DOID:331 central nervous system disease 3.9474 3 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 3.9474 7 no
DOID:10595 Charcot-Marie-Tooth disease 3.9474 6 no
DOID:440 neuromuscular disease 3.9474 5 no
DOID:574 peripheral nervous system disease 3.9474 3 no
DOID:870 neuropathy 3.9474 4 no
DOID:2843 long QT syndrome 2.6316 6 no
DOID:12377 spinal muscular atrophy 2.6316 6 no
DOID:1289 neurodegenerative disease 2.6316 4 no
DOID:231 motor neuron disease 2.6316 5 no
DOID:0111962 combined immunodeficiency 2.6316 4 no
DOID:612 primary immunodeficiency disease 2.6316 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LACC1_HUMAN [view interactions] Low throughput no yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCD3_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCD1_HUMAN [view entry] [view interactions] Low throughput yes no
ABCD2_HUMAN [view interactions] Low throughput no no
PEX19_HUMAN [view interactions] Low throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
MKS3_HUMAN [view interactions] High throughput no no
AKIP_HUMAN [view interactions] High throughput no yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CNEP1_HUMAN [view interactions] High throughput no yes
SOX4_HUMAN [view interactions] High throughput no yes
EPHA1_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
HIPK4_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
S39A4_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
IFIX_HUMAN [view interactions] High throughput no no
ZN746_HUMAN [view interactions] High throughput no no
TPTE_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
GLP1R_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ANR55_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
ARHGG_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
DOCK2_HUMAN [view entry] [view interactions] High throughput yes no
ARHG8_HUMAN [view interactions] High throughput no yes
STAR8_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
SEC63_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
UBQL2_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
CREL1_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
SCN3B_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX3_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
MPV17_HUMAN [view interactions] High throughput no no
TAP1_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
RM41_HUMAN [view interactions] High throughput no yes
ZN454_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
NDUBB_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1A_HUMAN [view interactions] High throughput no yes
PTH2_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
MAVS_HUMAN [view interactions] High throughput no yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
LMAN1_HUMAN [view interactions] High throughput no yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
MET7A_HUMAN [view interactions] High throughput no no
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
NU155_HUMAN [view interactions] High throughput no yes
PXMP2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
UBP50_HUMAN [view entry] [view interactions] High throughput yes no
UBP32_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
MK06_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
RETR2_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
TMED2_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CSCL2_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
NMES1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
BAD_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
KPCD1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
FAF2_HUMAN [view interactions] High throughput no yes
CLK2_HUMAN [view interactions] High throughput no yes
PIM3_HUMAN [view interactions] High throughput no no
SP7_HUMAN [view interactions] High throughput no no
KLF15_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
DDR2_HUMAN [view interactions] High throughput no no
BRF2_HUMAN [view interactions] High throughput no yes
PELO_HUMAN [view interactions] High throughput no yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
MEST_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
PAHX_HUMAN [view interactions] High throughput no yes
RCAF1_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
TUFT1_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
DYR1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CBX4_HUMAN [view interactions] High throughput no yes
TFDP1_HUMAN [view interactions] High throughput no yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
RTRAF_HUMAN [view interactions] High throughput no yes
ACBG1_HUMAN [view entry] [view interactions] Computational yes yes
PM34_HUMAN [view interactions] Computational no yes
PXMP4_HUMAN [view interactions] Computational no yes
PX11B_HUMAN [view entry] [view interactions] Computational yes yes
AL3A2_HUMAN [view entry] [view interactions] Computational yes yes
GDAP1_HUMAN [view entry] [view interactions] Computational yes yes
PEX13_HUMAN [view interactions] Computational no yes
PEX16_HUMAN [view interactions] Computational no yes
ATAD1_HUMAN [view entry] [view interactions] Computational yes yes
PEX26_HUMAN [view interactions] Computational no yes
PEX2_HUMAN [view interactions] Computational no yes