NFM_HUMAN
Evidence for PS localization
Functions
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NFM_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 31.3433 | 4 | no |
| GO:0019901 | protein kinase binding | 26.8657 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.3731 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 25.3731 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.3731 | 4 | no |
| GO:0046872 | metal ion binding | 25.3731 | 4 | no |
| GO:0005524 | ATP binding | 22.3881 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.3881 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.3881 | 5 | no |
| GO:0015631 | tubulin binding | 17.9104 | 4 | yes |
| GO:0008017 | microtubule binding | 13.4328 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NFM_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 64.1791 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.1940 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.7463 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 49.2537 | 4 | no |
| GO:0022607 | cellular component assembly | 44.7761 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.2836 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.2836 | 4 | no |
| GO:0008104 | protein localization | 41.7910 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.7910 | 4 | no |
| GO:0007010 | cytoskeleton organization | 41.7910 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.8060 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8060 | 4 | no |
| GO:0030030 | cell projection organization | 35.8209 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.8209 | 4 | no |
| GO:0051049 | regulation of transport | 34.3284 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.3284 | 5 | no |
| GO:0071702 | organic substance transport | 32.8358 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.3433 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.8507 | 5 | no |
| GO:0071705 | nitrogen compound transport | 28.3582 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.3582 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 26.8657 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 26.8657 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.8657 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.3731 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.3731 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.3731 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.3731 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.3731 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.3731 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.8806 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.8806 | 4 | no |
| GO:0043269 | regulation of ion transport | 23.8806 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.8806 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.8806 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.8806 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.8806 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.8806 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.8806 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.8806 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8806 | 6 | no |
| GO:0031175 | neuron projection development | 22.3881 | 6 | no |
| GO:0009894 | regulation of catabolic process | 22.3881 | 4 | no |
| GO:0010941 | regulation of cell death | 22.3881 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3881 | 5 | no |
| GO:0036211 | protein modification process | 22.3881 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.3881 | 7 | no |
| GO:0043412 | macromolecule modification | 22.3881 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.3881 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.3881 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.3881 | 5 | no |
| GO:0015031 | protein transport | 20.8955 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.8955 | 5 | no |
| GO:0010468 | regulation of gene expression | 20.8955 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8955 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8955 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.8955 | 7 | no |
| GO:0016192 | vesicle-mediated transport | 20.8955 | 4 | no |
| GO:0045109 | intermediate filament organization | 13.4328 | 4 | yes |
| GO:0045110 | intermediate filament bundle assembly | 5.9701 | 5 | yes |
| GO:0033693 | neurofilament bundle assembly | 4.4776 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NFM_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.4627 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.9851 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.9851 | 5 | no |
| DOID:114 | heart disease | 2.9851 | 3 | no |
| DOID:2843 | long QT syndrome | 2.9851 | 6 | no |
| DOID:936 | brain disease | 2.9851 | 4 | no |
| DOID:1289 | neurodegenerative disease | 2.9851 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| APOE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| K1H2_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| EPIPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| EVI5_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| FHAD1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| NU188_HUMAN | [view interactions] | High throughput | no | yes |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI4_HUMAN | [view interactions] | High throughput | no | no |
| XPOT_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDIF1_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC106_HUMAN | [view interactions] | High throughput | no | no |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view interactions] | High throughput | no | yes |
| PSG9_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSXT_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KLC3_HUMAN | [view interactions] | Computational | no | no |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| MK12_HUMAN | [view interactions] | Computational | no | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KLC4_HUMAN | [view interactions] | Computational | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MK13_HUMAN | [view interactions] | Computational | no | yes |
| MK11_HUMAN | [view interactions] | Computational | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Computational | yes | no |