NFM_HUMAN
Evidence for PS localization
Functions
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NFM_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 34.2857 | 4 | no |
| GO:0046872 | metal ion binding | 31.4286 | 5 | no |
| GO:0019900 | kinase binding | 31.4286 | 4 | no |
| GO:0043168 | anion binding | 25.7143 | 4 | no |
| GO:0019901 | protein kinase binding | 25.7143 | 5 | no |
| GO:0000166 | nucleotide binding | 24.2857 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.2857 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.2857 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.8571 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.4286 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.4286 | 5 | no |
| GO:0015631 | tubulin binding | 14.2857 | 4 | yes |
| GO:0008017 | microtubule binding | 8.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NFM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.8571 | 4 | no |
| GO:0006996 | organelle organization | 58.5714 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.7143 | 4 | no |
| GO:0022607 | cellular component assembly | 52.8571 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.5714 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.1429 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 38.5714 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.5714 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.1429 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.7143 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.7143 | 5 | no |
| GO:0051049 | regulation of transport | 35.7143 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.8571 | 5 | no |
| GO:0030030 | cell projection organization | 32.8571 | 4 | no |
| GO:0071702 | organic substance transport | 31.4286 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 28.5714 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.1429 | 5 | no |
| GO:0043933 | protein-containing complex organization | 27.1429 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.1429 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.1429 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.7143 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.7143 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 25.7143 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.7143 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.7143 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.7143 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.2857 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.2857 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.2857 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.2857 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.2857 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 24.2857 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2857 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.2857 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 24.2857 | 5 | no |
| GO:0010468 | regulation of gene expression | 24.2857 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.2857 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.8571 | 7 | no |
| GO:0033043 | regulation of organelle organization | 22.8571 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.4286 | 7 | no |
| GO:0036211 | protein modification process | 21.4286 | 4 | no |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0045109 | intermediate filament organization | 14.2857 | 4 | yes |
| GO:0045110 | intermediate filament bundle assembly | 5.7143 | 5 | yes |
| GO:0033693 | neurofilament bundle assembly | 4.2857 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APOE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TDIF1_HUMAN | [view interactions] | High throughput | no | no |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| CC106_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG9_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSXT_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| K1H2_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| EPIPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| K1C39_HUMAN | [view interactions] | High throughput | no | no |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| EVI5_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO9B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHAD1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| ERD22_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| NU188_HUMAN | [view interactions] | High throughput | no | yes |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI4_HUMAN | [view interactions] | High throughput | no | no |
| XPOT_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |