Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLG5_HUMAN

GO
G2C
SynaptomeDB

Acts as a regulator of the Hippo signaling pathway (PubMed, PubMed). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DLG5_HUMAN
GO:0043168 anion binding 35.2113 4 no
GO:0019900 kinase binding 33.8028 4 no
GO:0019901 protein kinase binding 32.3944 5 no
GO:0000166 nucleotide binding 30.9859 4 no
GO:0017076 purine nucleotide binding 30.9859 5 no
GO:0032555 purine ribonucleotide binding 30.9859 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.5775 4 no
GO:0045296 cadherin binding 26.7606 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DLG5_HUMAN
GO:0048522 positive regulation of cellular process 70.4225 4 yes
GO:0051128 regulation of cellular component organization 63.3803 4 yes
GO:0048523 negative regulation of cellular process 61.9718 4 yes
GO:0031323 regulation of cellular metabolic process 57.7465 4 no
GO:0060255 regulation of macromolecule metabolic process 57.7465 4 no
GO:0008104 protein localization 56.3380 4 yes
GO:0006996 organelle organization 52.1127 4 no
GO:0080090 regulation of primary metabolic process 50.7042 4 no
GO:0010646 regulation of cell communication 50.7042 4 yes
GO:0022607 cellular component assembly 50.7042 4 yes
GO:0009889 regulation of biosynthetic process 46.4789 4 no
GO:0009893 positive regulation of metabolic process 45.0704 4 no
GO:0010468 regulation of gene expression 45.0704 6 no
GO:0010556 regulation of macromolecule biosynthetic process 45.0704 5 no
GO:0031326 regulation of cellular biosynthetic process 45.0704 5 no
GO:0010604 positive regulation of macromolecule metabolic process 43.6620 5 no
GO:0009966 regulation of signal transduction 43.6620 4 yes
GO:0044087 regulation of cellular component biogenesis 43.6620 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.8451 5 no
GO:0033043 regulation of organelle organization 38.0282 5 no
GO:0051130 positive regulation of cellular component organization 35.2113 5 yes
GO:1902531 regulation of intracellular signal transduction 35.2113 5 yes
GO:0051246 regulation of protein metabolic process 35.2113 5 no
GO:0007010 cytoskeleton organization 35.2113 5 no
GO:0048584 positive regulation of response to stimulus 33.8028 4 yes
GO:0009892 negative regulation of metabolic process 32.3944 4 no
GO:0030030 cell projection organization 32.3944 4 no
GO:0031344 regulation of cell projection organization 32.3944 5 no
GO:0051049 regulation of transport 32.3944 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 32.3944 6 no
GO:0010647 positive regulation of cell communication 32.3944 5 yes
GO:0051240 positive regulation of multicellular organismal process 30.9859 4 yes
GO:2000145 regulation of cell motility 30.9859 4 yes
GO:0051493 regulation of cytoskeleton organization 30.9859 6 no
GO:0023056 positive regulation of signaling 30.9859 4 yes
GO:0071702 organic substance transport 29.5775 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.5775 5 no
GO:0009891 positive regulation of biosynthetic process 29.5775 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 29.5775 6 no
GO:0031328 positive regulation of cellular biosynthetic process 29.5775 6 no
GO:0022603 regulation of anatomical structure morphogenesis 29.5775 4 no
GO:0042981 regulation of apoptotic process 29.5775 5 yes
GO:0043067 regulation of programmed cell death 29.5775 4 yes
GO:0051094 positive regulation of developmental process 28.1690 4 yes
GO:2000026 regulation of multicellular organismal development 28.1690 4 yes
GO:0071705 nitrogen compound transport 28.1690 4 no
GO:0031324 negative regulation of cellular metabolic process 28.1690 5 no
GO:0051247 positive regulation of protein metabolic process 28.1690 6 no
GO:0009967 positive regulation of signal transduction 28.1690 5 yes
GO:0030334 regulation of cell migration 28.1690 5 yes
GO:0031399 regulation of protein modification process 26.7606 6 no
GO:0045595 regulation of cell differentiation 26.7606 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.7606 5 no
GO:0032880 regulation of protein localization 26.7606 5 no
GO:0060341 regulation of cellular localization 26.7606 4 no
GO:0010648 negative regulation of cell communication 26.7606 5 yes
GO:0023057 negative regulation of signaling 26.7606 4 yes
GO:0030155 regulation of cell adhesion 26.7606 4 yes
GO:0048585 negative regulation of response to stimulus 26.7606 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.3521 5 no
GO:0006355 regulation of DNA-templated transcription 25.3521 7 no
GO:0051252 regulation of RNA metabolic process 25.3521 5 no
GO:2001141 regulation of RNA biosynthetic process 25.3521 6 no
GO:0009968 negative regulation of signal transduction 25.3521 5 yes
GO:0051241 negative regulation of multicellular organismal process 23.9437 4 yes
GO:0019220 regulation of phosphate metabolic process 23.9437 6 no
GO:0051174 regulation of phosphorus metabolic process 23.9437 5 no
GO:0071310 cellular response to organic substance 23.9437 4 no
GO:0051129 negative regulation of cellular component organization 23.9437 5 no
GO:0032970 regulation of actin filament-based process 23.9437 4 no
GO:0042127 regulation of cell population proliferation 23.9437 4 yes
GO:1902533 positive regulation of intracellular signal transduction 22.5352 6 yes
GO:0015031 protein transport 22.5352 4 no
GO:1902903 regulation of supramolecular fiber organization 22.5352 5 no
GO:0034330 cell junction organization 22.5352 4 yes
GO:0044089 positive regulation of cellular component biogenesis 22.5352 5 yes
GO:0036211 protein modification process 21.1268 4 no
GO:0040017 positive regulation of locomotion 21.1268 4 no
GO:0043412 macromolecule modification 21.1268 4 no
GO:0045785 positive regulation of cell adhesion 21.1268 5 no
GO:0060284 regulation of cell development 21.1268 5 no
GO:0009890 negative regulation of biosynthetic process 21.1268 5 no
GO:0032956 regulation of actin cytoskeleton organization 21.1268 5 no
GO:0097435 supramolecular fiber organization 21.1268 4 no
GO:0043933 protein-containing complex organization 18.3099 4 yes
GO:0051960 regulation of nervous system development 16.9014 5 yes
GO:0034329 cell junction assembly 16.9014 5 yes
GO:0045216 cell-cell junction organization 16.9014 5 yes
GO:0050807 regulation of synapse organization 15.4930 5 yes
GO:1901888 regulation of cell junction assembly 15.4930 5 yes
GO:1902532 negative regulation of intracellular signal transduction 15.4930 6 yes
GO:0022407 regulation of cell-cell adhesion 15.4930 5 yes
GO:0065003 protein-containing complex assembly 14.0845 5 yes
GO:0007043 cell-cell junction assembly 14.0845 6 yes
GO:0040013 negative regulation of locomotion 14.0845 4 yes
GO:2000146 negative regulation of cell motility 12.6761 5 yes
GO:0002009 morphogenesis of an epithelium 12.6761 4 yes
GO:0051962 positive regulation of nervous system development 11.2676 5 yes
GO:0030336 negative regulation of cell migration 11.2676 6 yes
GO:0050863 regulation of T cell activation 8.4507 6 yes
GO:0050865 regulation of cell activation 8.4507 4 yes
GO:0051249 regulation of lymphocyte activation 8.4507 5 yes
GO:1901890 positive regulation of cell junction assembly 8.4507 6 yes
GO:0002694 regulation of leukocyte activation 8.4507 4 yes
GO:0008285 negative regulation of cell population proliferation 8.4507 5 yes
GO:0030855 epithelial cell differentiation 8.4507 4 yes
GO:0051963 regulation of synapse assembly 7.0423 6 yes
GO:1902414 protein localization to cell junction 7.0423 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 7.0423 6 yes
GO:0002683 negative regulation of immune system process 7.0423 4 yes
GO:0034332 adherens junction organization 7.0423 6 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 7.0423 4 yes
GO:0048762 mesenchymal cell differentiation 5.6338 4 yes
GO:0099173 postsynapse organization 5.6338 4 yes
GO:0150105 protein localization to cell-cell junction 5.6338 6 yes
GO:0001837 epithelial to mesenchymal transition 5.6338 5 yes
GO:0007162 negative regulation of cell adhesion 5.6338 5 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 5.6338 5 yes
GO:0048754 branching morphogenesis of an epithelial tube 5.6338 4 yes
GO:0050670 regulation of lymphocyte proliferation 4.2254 6 yes
GO:0051965 positive regulation of synapse assembly 4.2254 6 yes
GO:0060441 epithelial tube branching involved in lung morphogenesis 4.2254 5 yes
GO:0070663 regulation of leukocyte proliferation 4.2254 5 yes
GO:0022408 negative regulation of cell-cell adhesion 4.2254 6 yes
GO:0030859 polarized epithelial cell differentiation 4.2254 5 yes
GO:0032944 regulation of mononuclear cell proliferation 4.2254 6 yes
GO:0045176 apical protein localization 4.2254 5 yes
GO:0050672 negative regulation of lymphocyte proliferation 2.8169 7 yes
GO:0050866 negative regulation of cell activation 2.8169 5 yes
GO:0051250 negative regulation of lymphocyte activation 2.8169 6 yes
GO:0060998 regulation of dendritic spine development 2.8169 4 yes
GO:0060999 positive regulation of dendritic spine development 2.8169 5 yes
GO:0070664 negative regulation of leukocyte proliferation 2.8169 6 yes
GO:0071896 protein localization to adherens junction 2.8169 7 yes
GO:0002065 columnar/cuboidal epithelial cell differentiation 2.8169 5 yes
GO:0002695 negative regulation of leukocyte activation 2.8169 5 yes
GO:0008589 regulation of smoothened signaling pathway 2.8169 5 yes
GO:0032945 negative regulation of mononuclear cell proliferation 2.8169 7 yes
GO:0034333 adherens junction assembly 2.8169 7 yes
GO:0042129 regulation of T cell proliferation 2.8169 7 yes
GO:0045880 positive regulation of smoothened signaling pathway 2.8169 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VINEX_HUMAN [view interactions] Low throughput no no
TGFR2_HUMAN [view interactions] Low throughput no no
TGFR1_HUMAN [view interactions] Low throughput no no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL1_HUMAN [view interactions] Low throughput no yes
SKP1_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
DYR2_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
GOGA1_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
NDC80_HUMAN [view interactions] High throughput no no
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PARD3_HUMAN [view interactions] High throughput no yes
PCM1_HUMAN [view interactions] High throughput no yes
RPB3_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
SEP10_HUMAN [view interactions] High throughput no yes
STIL_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
UTP4_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
MOB1A_HUMAN [view interactions] High throughput no yes
MOB1B_HUMAN [view interactions] High throughput no yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
MARK3_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
GTF2I_HUMAN [view interactions] High throughput no yes
RL21_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
BTBDA_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
RPGR1_HUMAN [view interactions] High throughput no no
CEP89_HUMAN [view interactions] High throughput no no
CE104_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
SAS6_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR2_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
LTK_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
CDK1_HUMAN [view interactions] High throughput no no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
CEP43_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
NAA11_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
MELT_HUMAN [view interactions] High throughput no yes
SAV1_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
TNR6A_HUMAN [view interactions] High throughput no yes
ENTR1_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
DNJB5_HUMAN [view interactions] High throughput no yes
DNJB7_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
ANC2_HUMAN [view interactions] High throughput no no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes