Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NFH_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NFH_HUMAN
GO:0019900 kinase binding 32.2581 4 yes
GO:0008017 microtubule binding 29.0323 5 yes
GO:0015631 tubulin binding 29.0323 4 yes
GO:0019901 protein kinase binding 29.0323 5 yes
GO:0005524 ATP binding 29.0323 5 no
GO:0017076 purine nucleotide binding 29.0323 4 no
GO:0030554 adenyl nucleotide binding 29.0323 5 no
GO:0032555 purine ribonucleotide binding 29.0323 4 no
GO:0032559 adenyl ribonucleotide binding 29.0323 5 no
GO:0035639 purine ribonucleoside triphosphate binding 29.0323 4 no
GO:0019894 kinesin binding 12.9032 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NFH_HUMAN
GO:0048522 positive regulation of cellular process 58.0645 4 no
GO:0006996 organelle organization 54.8387 4 yes
GO:0010646 regulation of cell communication 51.6129 4 no
GO:0071310 cellular response to organic substance 45.1613 4 yes
GO:0048523 negative regulation of cellular process 45.1613 4 no
GO:0030030 cell projection organization 41.9355 4 yes
GO:0051049 regulation of transport 41.9355 4 yes
GO:0050804 modulation of chemical synaptic transmission 41.9355 5 no
GO:0099177 regulation of trans-synaptic signaling 41.9355 4 no
GO:0051128 regulation of cellular component organization 41.9355 4 no
GO:0060255 regulation of macromolecule metabolic process 41.9355 4 no
GO:0022607 cellular component assembly 38.7097 4 yes
GO:0031175 neuron projection development 38.7097 6 yes
GO:0120036 plasma membrane bounded cell projection organization 38.7097 5 yes
GO:0031323 regulation of cellular metabolic process 38.7097 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.7097 4 no
GO:0051246 regulation of protein metabolic process 38.7097 5 no
GO:0080090 regulation of primary metabolic process 38.7097 4 no
GO:0007010 cytoskeleton organization 35.4839 5 yes
GO:0060341 regulation of cellular localization 35.4839 4 yes
GO:0009966 regulation of signal transduction 35.4839 4 no
GO:0009893 positive regulation of metabolic process 32.2581 4 no
GO:0010468 regulation of gene expression 32.2581 5 no
GO:0019220 regulation of phosphate metabolic process 32.2581 6 no
GO:0031399 regulation of protein modification process 32.2581 6 no
GO:0042325 regulation of phosphorylation 32.2581 7 no
GO:0043085 positive regulation of catalytic activity 32.2581 4 no
GO:0045595 regulation of cell differentiation 32.2581 4 no
GO:0051174 regulation of phosphorus metabolic process 32.2581 5 no
GO:0032880 regulation of protein localization 29.0323 5 no
GO:0043933 protein-containing complex organization 29.0323 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.0323 5 no
GO:0022603 regulation of anatomical structure morphogenesis 29.0323 4 no
GO:0050890 cognition 29.0323 4 no
GO:0051130 positive regulation of cellular component organization 29.0323 5 no
GO:0051338 regulation of transferase activity 29.0323 4 no
GO:0001932 regulation of protein phosphorylation 29.0323 7 no
GO:0008088 axo-dendritic transport 25.8065 5 no
GO:0008104 protein localization 25.8065 4 no
GO:0010647 positive regulation of cell communication 25.8065 5 no
GO:0010970 transport along microtubule 25.8065 4 no
GO:0023056 positive regulation of signaling 25.8065 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 25.8065 4 no
GO:0099111 microtubule-based transport 25.8065 4 no
GO:0031325 positive regulation of cellular metabolic process 25.8065 5 no
GO:0031344 regulation of cell projection organization 25.8065 5 no
GO:0043549 regulation of kinase activity 25.8065 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.8065 5 no
GO:0051247 positive regulation of protein metabolic process 25.8065 6 no
GO:1901701 cellular response to oxygen-containing compound 25.8065 4 no
GO:0048584 positive regulation of response to stimulus 25.8065 4 no
GO:0010243 response to organonitrogen compound 25.8065 4 no
GO:0097435 supramolecular fiber organization 22.5806 4 yes
GO:0043269 regulation of ion transport 22.5806 5 no
GO:0071702 organic substance transport 22.5806 4 no
GO:0071705 nitrogen compound transport 22.5806 4 no
GO:0098930 axonal transport 22.5806 6 no
GO:1903829 positive regulation of protein localization 22.5806 5 no
GO:0009892 negative regulation of metabolic process 22.5806 4 no
GO:0010562 positive regulation of phosphorus metabolic process 22.5806 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.5806 5 no
GO:0010941 regulation of cell death 22.5806 4 no
GO:0031324 negative regulation of cellular metabolic process 22.5806 5 no
GO:0033043 regulation of organelle organization 22.5806 5 no
GO:0034330 cell junction organization 22.5806 4 no
GO:0042327 positive regulation of phosphorylation 22.5806 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.5806 7 no
GO:0051094 positive regulation of developmental process 22.5806 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.5806 5 no
GO:0051240 positive regulation of multicellular organismal process 22.5806 4 no
GO:0051336 regulation of hydrolase activity 22.5806 4 no
GO:0051347 positive regulation of transferase activity 22.5806 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.5806 6 no
GO:2000026 regulation of multicellular organismal development 22.5806 4 no
GO:0009889 regulation of biosynthetic process 22.5806 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.5806 5 no
GO:0031326 regulation of cellular biosynthetic process 22.5806 5 no
GO:0045859 regulation of protein kinase activity 22.5806 6 no
GO:0016192 vesicle-mediated transport 22.5806 4 no
GO:0071417 cellular response to organonitrogen compound 22.5806 4 no
GO:1901699 cellular response to nitrogen compound 22.5806 4 no
GO:0014070 response to organic cyclic compound 22.5806 4 no
GO:0032990 cell part morphogenesis 19.3548 4 yes
GO:0034097 response to cytokine 19.3548 4 yes
GO:0048812 neuron projection morphogenesis 19.3548 7 yes
GO:0048858 cell projection morphogenesis 19.3548 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.3548 6 yes
GO:0032386 regulation of intracellular transport 16.1290 5 yes
GO:0071345 cellular response to cytokine stimulus 16.1290 5 yes
GO:0007409 axonogenesis 12.9032 8 yes
GO:0060052 neurofilament cytoskeleton organization 12.9032 4 yes
GO:0030031 cell projection assembly 9.6774 5 yes
GO:0032886 regulation of microtubule-based process 9.6774 4 yes
GO:0033693 neurofilament bundle assembly 9.6774 6 yes
GO:0045109 intermediate filament organization 9.6774 4 yes
GO:0045110 intermediate filament bundle assembly 9.6774 5 yes
GO:0061564 axon development 9.6774 7 yes
GO:1990823 response to leukemia inhibitory factor 6.4516 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 6.4516 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in NFH_HUMAN
DOID:331 central nervous system disease 6.4516 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYST_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
MK67I_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
FADD_HUMAN [view interactions] High throughput no yes
H17B6_HUMAN [view interactions] High throughput no yes
DUS7_HUMAN [view interactions] High throughput no yes
RFFL_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
ASAH1_HUMAN [view interactions] High throughput no yes
PHAF1_HUMAN [view interactions] High throughput no yes
GLYR1_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
TARB1_HUMAN [view interactions] High throughput no no
GPT2L_HUMAN [view interactions] High throughput no yes
FCF1_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
AAKG2_HUMAN [view interactions] High throughput no yes
DFFB_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
MT1M_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
TSSP_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
CERS3_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
MK14_HUMAN [view interactions] Computational no yes
KLC1_HUMAN [view entry] [view interactions] Computational yes no
MK11_HUMAN [view interactions] Computational no yes
KINH_HUMAN [view entry] [view interactions] Computational yes no
KLC2_HUMAN [view entry] [view interactions] Computational yes yes
KIF5A_HUMAN [view entry] [view interactions] Computational yes yes
MK12_HUMAN [view interactions] Computational no no
MK13_HUMAN [view interactions] Computational no yes
KLC3_HUMAN [view interactions] Computational no no
KIF5C_HUMAN [view entry] [view interactions] Computational yes yes
KLC4_HUMAN [view interactions] Computational no yes
PERI_HUMAN [view entry] [view interactions] Computational yes no