Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NFH_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NFH_HUMAN
GO:0019900 kinase binding 38.4615 4 yes
GO:0019901 protein kinase binding 30.7692 5 yes
GO:0043168 anion binding 30.7692 4 no
GO:0000166 nucleotide binding 26.9231 4 no
GO:0017076 purine nucleotide binding 26.9231 5 no
GO:0030554 adenyl nucleotide binding 26.9231 6 no
GO:0032555 purine ribonucleotide binding 26.9231 4 no
GO:0032559 adenyl ribonucleotide binding 26.9231 5 no
GO:0008017 microtubule binding 23.0769 5 yes
GO:0015631 tubulin binding 23.0769 4 yes
GO:0003779 actin binding 23.0769 4 no
GO:0005524 ATP binding 23.0769 5 no
GO:0016301 kinase activity 23.0769 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NFH_HUMAN
GO:0048522 positive regulation of cellular process 65.3846 4 no
GO:0010646 regulation of cell communication 65.3846 4 yes
GO:0031323 regulation of cellular metabolic process 53.8462 4 no
GO:0048523 negative regulation of cellular process 53.8462 4 no
GO:0006996 organelle organization 53.8462 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0071310 cellular response to organic substance 46.1538 4 yes
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0007010 cytoskeleton organization 42.3077 5 yes
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0030030 cell projection organization 38.4615 4 yes
GO:0051049 regulation of transport 34.6154 4 yes
GO:0120036 plasma membrane bounded cell projection organization 34.6154 5 yes
GO:0009889 regulation of biosynthetic process 34.6154 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.6154 5 no
GO:0031326 regulation of cellular biosynthetic process 34.6154 5 no
GO:0045595 regulation of cell differentiation 34.6154 4 no
GO:0050890 cognition 34.6154 4 no
GO:1901701 cellular response to oxygen-containing compound 34.6154 4 no
GO:0019220 regulation of phosphate metabolic process 34.6154 6 no
GO:0042325 regulation of phosphorylation 34.6154 7 no
GO:0051174 regulation of phosphorus metabolic process 34.6154 5 no
GO:0009893 positive regulation of metabolic process 34.6154 4 no
GO:0031325 positive regulation of cellular metabolic process 34.6154 5 no
GO:0031175 neuron projection development 34.6154 6 yes
GO:0010243 response to organonitrogen compound 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0060341 regulation of cellular localization 26.9231 4 yes
GO:0097435 supramolecular fiber organization 26.9231 4 yes
GO:0010647 positive regulation of cell communication 26.9231 5 no
GO:0023056 positive regulation of signaling 26.9231 4 no
GO:0031344 regulation of cell projection organization 26.9231 5 no
GO:0048584 positive regulation of response to stimulus 26.9231 4 no
GO:0071417 cellular response to organonitrogen compound 26.9231 4 no
GO:1901699 cellular response to nitrogen compound 26.9231 4 no
GO:0008104 protein localization 26.9231 4 no
GO:0051338 regulation of transferase activity 26.9231 4 no
GO:0014070 response to organic cyclic compound 26.9231 4 no
GO:0043933 protein-containing complex organization 26.9231 4 no
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0051247 positive regulation of protein metabolic process 26.9231 6 no
GO:0034097 response to cytokine 23.0769 4 yes
GO:0048812 neuron projection morphogenesis 23.0769 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.0769 4 yes
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:2000026 regulation of multicellular organismal development 23.0769 4 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0006915 apoptotic process 23.0769 4 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0051093 negative regulation of developmental process 23.0769 4 no
GO:0043549 regulation of kinase activity 23.0769 5 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0071345 cellular response to cytokine stimulus 19.2308 5 yes
GO:0007409 axonogenesis 19.2308 6 yes
GO:0045109 intermediate filament organization 15.3846 4 yes
GO:0060052 neurofilament cytoskeleton organization 15.3846 4 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 15.3846 6 yes
GO:0032386 regulation of intracellular transport 15.3846 5 yes
GO:0033693 neurofilament bundle assembly 11.5385 6 yes
GO:0045110 intermediate filament bundle assembly 11.5385 5 yes
GO:0061564 axon development 11.5385 7 yes
GO:0030031 cell projection assembly 11.5385 5 yes
GO:0032886 regulation of microtubule-based process 11.5385 4 yes
GO:1990823 response to leukemia inhibitory factor 7.6923 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 7.6923 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
DYST_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
FADD_HUMAN [view interactions] High throughput no yes
H17B6_HUMAN [view interactions] High throughput no yes
DUS7_HUMAN [view interactions] High throughput no yes
RFFL_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
ASAH1_HUMAN [view interactions] High throughput no yes
PHAF1_HUMAN [view interactions] High throughput no yes
GLYR1_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
TARB1_HUMAN [view interactions] High throughput no no
GPT2L_HUMAN [view interactions] High throughput no yes
FCF1_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
AAKG2_HUMAN [view interactions] High throughput no yes
DFFB_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
MT1M_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
TSSP_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
CERS3_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
MK67I_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes