Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DGKI_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed, PubMed). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DGKI_HUMAN
GO:0019900 kinase binding 42.8571 4 no
GO:0016301 kinase activity 28.5714 4 yes
GO:0017076 purine nucleotide binding 28.5714 4 yes
GO:0032555 purine ribonucleotide binding 28.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 yes
GO:0019901 protein kinase binding 28.5714 5 no
GO:0005524 ATP binding 21.4286 5 yes
GO:0030554 adenyl nucleotide binding 21.4286 5 yes
GO:0032559 adenyl ribonucleotide binding 21.4286 5 yes
GO:0019902 phosphatase binding 21.4286 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.2857 4 yes
GO:0046872 metal ion binding 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DGKI_HUMAN
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0051049 regulation of transport 57.1429 4 no
GO:0008104 protein localization 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0060341 regulation of cellular localization 42.8571 4 no
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0072657 protein localization to membrane 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0033674 positive regulation of kinase activity 35.7143 6 no
GO:0043085 positive regulation of catalytic activity 35.7143 4 no
GO:0043549 regulation of kinase activity 35.7143 5 no
GO:0045859 regulation of protein kinase activity 35.7143 6 no
GO:0045860 positive regulation of protein kinase activity 35.7143 7 no
GO:0051338 regulation of transferase activity 35.7143 4 no
GO:0051347 positive regulation of transferase activity 35.7143 5 no
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 no
GO:0032880 regulation of protein localization 35.7143 5 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 yes
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 yes
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0032990 cell part morphogenesis 28.5714 4 no
GO:0048812 neuron projection morphogenesis 28.5714 7 no
GO:0048858 cell projection morphogenesis 28.5714 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 6 no
GO:0008285 negative regulation of cell population proliferation 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0043113 receptor clustering 28.5714 5 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1905475 regulation of protein localization to membrane 28.5714 6 no
GO:1990778 protein localization to cell periphery 28.5714 5 no
GO:0007268 chemical synaptic transmission 28.5714 6 no
GO:0098916 anterograde trans-synaptic signaling 28.5714 5 no
GO:0099537 trans-synaptic signaling 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 yes
GO:0031175 neuron projection development 21.4286 6 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 21.4286 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 21.4286 5 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0044087 regulation of cellular component biogenesis 21.4286 4 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:0043410 positive regulation of MAPK cascade 21.4286 7 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.4286 7 no
GO:0072659 protein localization to plasma membrane 21.4286 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:1904375 regulation of protein localization to cell periphery 21.4286 6 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0032412 regulation of ion transmembrane transporter activity 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of ion transmembrane transport 21.4286 5 no
GO:0035418 protein localization to synapse 21.4286 6 no
GO:0043269 regulation of ion transport 21.4286 5 no
GO:1902414 protein localization to cell junction 21.4286 5 no
GO:1904062 regulation of cation transmembrane transport 21.4286 6 no
GO:0006355 regulation of DNA-templated transcription 21.4286 6 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0045892 negative regulation of DNA-templated transcription 21.4286 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.4286 6 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.4286 5 no
GO:0051252 regulation of RNA metabolic process 21.4286 5 no
GO:0051253 negative regulation of RNA metabolic process 21.4286 6 no
GO:1902679 negative regulation of RNA biosynthetic process 21.4286 7 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 21.4286 8 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0015031 protein transport 21.4286 4 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0016310 phosphorylation 14.2857 5 yes
GO:0046486 glycerolipid metabolic process 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
NFH_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRP3_HUMAN [view interactions] Low throughput no no
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
KEAP1_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
H11_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCB3_HUMAN [view entry] [view interactions] Computational yes no
PLCB2_HUMAN [view interactions] Computational no no