RB6I2_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RB6I2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 26.3158 | 4 | no |
| GO:0000166 | nucleotide binding | 24.5614 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.5614 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.5614 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5614 | 4 | no |
| GO:0043169 | cation binding | 24.5614 | 4 | no |
| GO:0046872 | metal ion binding | 24.5614 | 5 | no |
| GO:0019900 | kinase binding | 22.8070 | 4 | no |
| GO:0019901 | protein kinase binding | 22.8070 | 5 | no |
| GO:0045296 | cadherin binding | 19.2982 | 4 | yes |
| GO:0051020 | GTPase binding | 8.7719 | 4 | yes |
| GO:0030165 | PDZ domain binding | 7.0175 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.0175 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RB6I2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.1404 | 4 | no |
| GO:0008104 | protein localization | 50.8772 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.8772 | 4 | yes |
| GO:0006996 | organelle organization | 50.8772 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.8772 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.8596 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.8596 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 38.5965 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.5965 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.5965 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.5965 | 5 | yes |
| GO:0022607 | cellular component assembly | 38.5965 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.5789 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0071702 | organic substance transport | 29.8246 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.8246 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0702 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 28.0702 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 28.0702 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 28.0702 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 28.0702 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 28.0702 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.0702 | 5 | no |
| GO:0051049 | regulation of transport | 28.0702 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.0702 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.3158 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0030030 | cell projection organization | 26.3158 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0015031 | protein transport | 24.5614 | 4 | yes |
| GO:0036211 | protein modification process | 24.5614 | 4 | yes |
| GO:0043412 | macromolecule modification | 24.5614 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 24.5614 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.5614 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.5614 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.5614 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.8070 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.8070 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.8070 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 21.0526 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0034330 | cell junction organization | 17.5439 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 15.7895 | 4 | yes |
| GO:0016310 | phosphorylation | 14.0351 | 5 | yes |
| GO:0050808 | synapse organization | 14.0351 | 5 | yes |
| GO:0016482 | cytosolic transport | 10.5263 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 10.5263 | 4 | yes |
| GO:0006468 | protein phosphorylation | 8.7719 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 7.0175 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 7.0175 | 6 | yes |
| GO:0099536 | synaptic signaling | 7.0175 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 7.0175 | 5 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 3.5088 | 8 | yes |
| GO:0034331 | cell junction maintenance | 3.5088 | 5 | yes |
| GO:0043954 | cellular component maintenance | 3.5088 | 4 | yes |
| GO:0048790 | maintenance of presynaptic active zone structure | 3.5088 | 5 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 3.5088 | 4 | yes |
| GO:0099558 | maintenance of synapse structure | 3.5088 | 6 | yes |
| GO:1990709 | presynaptic active zone organization | 3.5088 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| MACD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERF2_HUMAN | [view interactions] | High throughput | no | no |
| ING1_HUMAN | [view interactions] | High throughput | no | yes |
| CE112_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| ADPRS_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRLF3_HUMAN | [view interactions] | High throughput | no | yes |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| TBC23_HUMAN | [view interactions] | High throughput | no | yes |
| ASC_HUMAN | [view interactions] | High throughput | no | no |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MOT7_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHSTF_HUMAN | [view interactions] | High throughput | no | yes |
| PPR21_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| TSHB_HUMAN | [view interactions] | High throughput | no | no |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK04_HUMAN | [view interactions] | High throughput | no | no |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| ULK4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK19_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK20_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |