RB6I2_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RB6I2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.6296 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 25.9259 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.9259 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0741 | 5 | no |
| GO:0005524 | ATP binding | 22.2222 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0045296 | cadherin binding | 20.3704 | 4 | yes |
| GO:0051020 | GTPase binding | 9.2593 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.4074 | 5 | yes |
| GO:0030165 | PDZ domain binding | 3.7037 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RB6I2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.7037 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.1481 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.1481 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.1481 | 4 | no |
| GO:0006996 | organelle organization | 46.2963 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.7407 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.8889 | 5 | yes |
| GO:0022607 | cellular component assembly | 38.8889 | 4 | no |
| GO:0071702 | organic substance transport | 37.0370 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.0370 | 4 | yes |
| GO:0015031 | protein transport | 35.1852 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.1852 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.1852 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.4815 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 31.4815 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 31.4815 | 6 | yes |
| GO:0043412 | macromolecule modification | 29.6296 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.6296 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.6296 | 5 | no |
| GO:0036211 | protein modification process | 27.7778 | 4 | yes |
| GO:0006886 | intracellular protein transport | 27.7778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0051049 | regulation of transport | 27.7778 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.7778 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.0741 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 24.0741 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 24.0741 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.0741 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0741 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0741 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 22.2222 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0034330 | cell junction organization | 20.3704 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 20.3704 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.3704 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.3704 | 4 | no |
| GO:0030030 | cell projection organization | 20.3704 | 4 | no |
| GO:0050808 | synapse organization | 16.6667 | 5 | yes |
| GO:0006468 | protein phosphorylation | 14.8148 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 14.8148 | 4 | yes |
| GO:0016310 | phosphorylation | 14.8148 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 9.2593 | 6 | yes |
| GO:0016197 | endosomal transport | 9.2593 | 4 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 9.2593 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 9.2593 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 9.2593 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 9.2593 | 4 | yes |
| GO:0016482 | cytosolic transport | 7.4074 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 7.4074 | 5 | yes |
| GO:1990709 | presynaptic active zone organization | 7.4074 | 4 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 3.7037 | 7 | yes |
| GO:0034331 | cell junction maintenance | 3.7037 | 5 | yes |
| GO:0043954 | cellular component maintenance | 3.7037 | 4 | yes |
| GO:0048790 | maintenance of presynaptic active zone structure | 3.7037 | 5 | yes |
| GO:0099558 | maintenance of synapse structure | 3.7037 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RB6I2_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 5.5556 | 3 | no |
| DOID:2742 | auditory system disease | 3.7037 | 4 | no |
| DOID:0050563 | nonsyndromic deafness | 3.7037 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 3.7037 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| MOT7_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHSTF_HUMAN | [view interactions] | High throughput | no | yes |
| PPR21_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| TSHB_HUMAN | [view interactions] | High throughput | no | no |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| DUS1_HUMAN | [view interactions] | High throughput | no | no |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A4_HUMAN | [view interactions] | High throughput | no | yes |
| MK04_HUMAN | [view interactions] | High throughput | no | no |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| BMX_HUMAN | [view interactions] | High throughput | no | no |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| ULK4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK19_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK20_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| MACD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERF2_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ING1_HUMAN | [view interactions] | High throughput | no | yes |
| CE112_HUMAN | [view interactions] | High throughput | no | no |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| ADPRS_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TRAF6_HUMAN | [view interactions] | Computational | no | yes |
| LIPA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SQSTM_HUMAN | [view interactions] | Computational | no | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TF65_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFKB1_HUMAN | [view interactions] | Computational | no | yes |
| TAB2_HUMAN | [view interactions] | Computational | no | yes |
| TAB1_HUMAN | [view interactions] | Computational | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| TRI40_HUMAN | [view interactions] | Computational | no | no |
| M3K3_HUMAN | [view interactions] | Computational | no | no |
| ATM_HUMAN | [view interactions] | Computational | no | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| PHLB2_HUMAN | [view interactions] | Computational | no | yes |
| UN13A_HUMAN | [view entry] [view interactions] | Computational | yes | no |